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Author : Paul Spearman,Eric O. Freed
Publisher : Unknown
Page : 216 pages
File Size : 41,5 Mb
Release : 2011-03-04
Category : Electronic
ISBN : 364202176X
Author : Paul Spearman,Eric O. Freed
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 51,5 Mb
Release : 2009-12-11
Category : Medical
ISBN : 9783642021756
The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.
Author : Tetsuo Tsukamoto,Santhi Gorantla,Vasco Rodrigues
Publisher : Frontiers Media SA
Page : 131 pages
File Size : 40,5 Mb
Release : 2021-12-06
Category : Science
ISBN : 9782889718054
Author : Li Wu,Olivier Schwartz
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 48,5 Mb
Release : 2012-09-13
Category : Medical
ISBN : 9781461444336
Given rapid research progress and advance of the techniques in studying HIV interactions with host cells and factors, there is a critical need for a book on HIV interactions with DCs. The proposed book will aim for a broad readership to facilitate HIV/AIDS research and provide a practical tool for HIV researchers to continuously address novel questions. Specifically, the editors will summarize the literature in this field and provide critical analysis and future directions. International researchers will be invited as contributors of the book, highlighting authors who have contributed significantly to the field from different angles and aspects of virology, cell biology and immunology, etc.
Author : Nadine Laguette,Monsef Benkirane
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 54,8 Mb
Release : 2015-05-07
Category : Electronic book
ISBN : 9782889194841
Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of cellular factors/pathways to the benefit of the viral life cycle. To gain a foothold into host cells, HIV has to take advantage of available cellular factories and overcome the numerous potential blocks opposed to its replication while ensuring cellular survival. Viral auxiliary proteins are a perfect paradigm to illustrate the complexity of the relationship between HIV and its host. Although these accessory proteins are mostly unnecessary for viral replication in permissive cells in vitro, they play a crucial role in regulating viral spread ex vivo in non-permissive cells and in vivo in hosts. Most accessory proteins are pleiotropic and instrumental in the counteraction of restriction factors and proteins involved in innate immune response. Several proteins of the “intrinsic” immune system that detect the presence of the assailant and initiate a subsequent immune response, as well as restriction factors that are directly devoted to arresting the replication cycle at precise steps have been characterized. Despite the numerous cellular mechanisms dedicated to preventing viral replication, HIV is able to efficiently replicate in humans. Indeed, as a master regulator of cellular machineries and processes, not only has HIV evolved strategies to avoid triggering of pattern recognition receptors, but HIV has also elaborated ways to counteract host restriction factors, thereby overcoming the hurdles that oppose efficient replication. This review collection is dedicated to the manipulation of host cells by HIV-1 and HIV-2, with a particular focus on viral accessory proteins.
Author : Leslie Parent
Publisher : Academic Press
Page : 528 pages
File Size : 45,5 Mb
Release : 2018-08-09
Category : Medical
ISBN : 9780128111932
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems
Author : Steven R. Bartz
Publisher : Unknown
Page : 400 pages
File Size : 49,6 Mb
Release : 1995
Category : Electronic
ISBN : WISC:89052201910
Author : Shailendra K. Saxena
Publisher : Unknown
Page : 202 pages
File Size : 49,9 Mb
Release : 2016
Category : Electronic
ISBN : 9535146025
This book gives a comprehensive overview of recent advances in Retrovirology, as well as general concepts of molecular biology of retroviral infections, immunopathology, diagnosis, and prevention, to current clinical recommendations in management of retroviruses, including endogenous retroviruses, highlighting the ongoing issues, recent advances, with future directions in diagnostic approaches and therapeutic strategies.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 54,6 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author : Thomas J. Hope,Mario Stevenson,Douglas Richman
Publisher : Unknown
Page : 128 pages
File Size : 47,9 Mb
Release : 2024-07-02
Category : AIDS (Disease)
ISBN : 1461496101
Author : Lawrence C. Kuo,Jules A. Shafer
Publisher : Gulf Professional Publishing
Page : 494 pages
File Size : 50,5 Mb
Release : 1994-09-22
Category : Medical
ISBN : 0121821420
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
Author : Bryan Cullen
Publisher : Oxford University Press
Page : 220 pages
File Size : 50,5 Mb
Release : 1993
Category : Gene Expression Regulation.
ISBN : 0199633827
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author : Michael D. Wendt
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 46,7 Mb
Release : 2012-06-26
Category : Science
ISBN : 9783642289651
Michael D. Wendt Protein-Protein Interactions as Drug Targets Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics Kurt Deshayes , Jeremy Murray , Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto Protein-Protein Interaction Targets to Inhibit HIV-1 Infection Nicholas A. Meanwell , David R. Langley Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. Wendt The Discovery of Navitoclax, a Bcl-2 Family Inhibitor
Author : Jay A. Levy
Publisher : Unknown
Page : 388 pages
File Size : 42,5 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015031765491