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Homology Modeling Of The Accessory Subunit Of Drosophila Mitochondrial Dna Polymerase And Subunit Interaction Studies Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Homology Modeling Of The Accessory Subunit Of Drosophila Mitochondrial Dna Polymerase And Subunit Interaction Studies book. This book definitely worth reading, it is an incredibly well-written.
Author : Li Fan
Publisher : Unknown
Page : 340 pages
File Size : 47,6 Mb
Release : 2000
Category : DNA polymerases
ISBN : MSU:31293020489138
Author : Anonim
Publisher : Unknown
Page : 782 pages
File Size : 43,6 Mb
Release : 2000
Category : Dissertations, Academic
ISBN : STANFORD:36105110578759
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Anonim
Publisher : Unknown
Page : 2984 pages
File Size : 49,6 Mb
Release : 1997
Category : Agriculture
ISBN : PSU:000056923070
Author : R.D. Wells,R.B. Inman
Publisher : Springer
Page : 0 pages
File Size : 45,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9401161321
This book contains the papers presented at the Second Annual Harry Steenbock Symposium. The Symposium, and this book, have been entitled DNA Synthesis in Vitro. Knowledge gained in recent years has led to an ill-defined division between in vitro and in vivo studies as applied to DNA replication. Consequently the reader, depending on his particular point of view, will find new and useful information on many aspects of this most interesting subject. We have divided the subject matter into five parts, and these correspond to the sessions of the Symposium. Following many of the papers we have inserted any discussion which might be of use to the reader. The Symposium was supported by funds derived from the Harry Steenbock Symposium Trust Fund of the Department of Biochemistry, University of Wisconsin, made available by Mrs. Harry Steenbock from the Wisconsin Alumni Research Foundation. Professor Harry Steenbock was a distinguished professor of biochemistry from 1916 to 1956 and is world renowned for his pioneering work in the discovery of various vitamins. Of particular note is his discovery that irradiation of foods with ultraviolet light induces vitamin D activity, a discovery responsible for the elimination of rickets as a major medical problem. The proceedings from the first Steenbock Symposium have been published: H. F. DeLuca and J. W. Suttie (eds.), The Fat-Soluble Vitamins, The University of Wisconsin Press, Madison, Wisconsin, 1969.
Author : Alma Balestrazzi,V. Mohan Murali Achary,Anca Macovei,Kaoru Okamoto Yoshiyama,Ayako N Sakamoto
Publisher : Frontiers Media SA
Page : 131 pages
File Size : 48,8 Mb
Release : 2016-05-06
Category : Botany
ISBN : 9782889198207
Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.
Author : Maga Giovanni,Spadari Silvio,Villani Giuseppe
Publisher : World Scientific
Page : 400 pages
File Size : 47,9 Mb
Release : 2017-11-10
Category : Science
ISBN : 9789813226425
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes. Contents: PrefaceAbout the AuthorsHistory of DNA PolymerasesDNA Polymerases: General AspectsHuman DNA Polymerases: From Structure to FunctionHuman DNA Polymerases in Different DNA TransactionsDNA Polymerases and Human DiseasesHuman DNA Polymerases and ChemotherapyPolymerases Chain Reaction and Heat-Stable DNA Polymerases: The History and the Potential of Evolved DNA PolymerasesSynthetic Evolution of DNA Polymerases for Novel PropertiesMarket for Evolved DNA Polymerases in Routine and Medical Applications Readership: Academic and industry research scientists, from PhD students to senior professors, as well as R&D specialists and marketing experts working in biotech and pharmaceutical companies. Keywords: DNA Polymerase;DNA Replication;DNA Repair;DNA Recombination, PCR;Cancer;Neurological Diseases;Medicine;Biology;Chemotherapy;Structural Biology;Enzymology;BiotechnologyReview: Key Features: The only book to merge basic science, biotechnological applications and marketing opportunities of DNA polymerasesThe most extensive literature coverage of the field, with more than 1,000 cited references and updated with the most recent contributions received by scientists all over the worldWritten by four leading experts in DNA polymerases, it gives the most complete overview of the field from its historical origins to the latest developments
Author : Anonim
Publisher : Unknown
Page : 1120 pages
File Size : 46,8 Mb
Release : 1990
Category : Agriculture
ISBN : UIUC:30112102098123
Author : Charles J. Epstein,Robert P. Erickson,Anthony Joseph Wynshaw-Boris
Publisher : Oxford University Press, USA
Page : 1110 pages
File Size : 43,8 Mb
Release : 2004
Category : Medical
ISBN : 9780195145021
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Author : Ian James Holt
Publisher : Unknown
Page : 0 pages
File Size : 43,9 Mb
Release : 2023
Category : Mitochondrial DNA
ISBN : 1383021961
This text summarises the advances in human mitochondrial genetics made at the end of the 20th century. Numerous mutations of mitochondrial DNA have been discovered as well as mitochondrial diseases, which have been linked to a number of nuclear gene mutations.
Author : Anonim
Publisher : Unknown
Page : 1828 pages
File Size : 43,9 Mb
Release : 2000
Category : Medicine
ISBN : OSU:32436010864997
Author : Jeffrey A Stuart
Publisher : Humana Press
Page : 0 pages
File Size : 53,8 Mb
Release : 2009-09-29
Category : Science
ISBN : 1934115606
Since the publication of the first edition, the number of unique heritable mtDNA mutations recognized as being associated with bioenergetic dysfunction, cell death and disease has grown. Likewise, our understanding of the basic biology of somatic mtDNA mutations continues to improve. In Mitochondrial DNA: Methods and Protocols, Second Edition, specialists from eight countries share their expertise, providing detailed protocols for studying many aspects of mtDNA. The volume is divided into three sections, which cover the transduction of information from mtDNA to functionally active respiratory complexes, mitochondrial reactive oxygen species (ROS) production as well as mtDNA damage and its repair, and the identification and quantification of heteroplasmic mtDNA mutations. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes sections, highlighting tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Mitrochondrial DNA: Methods and Protocols, Second Edition promises to aid researchers in further expanding our knowledge of this vital area of cell biology.
Author : National Institute of General Medical Sciences (U.S.). Division of Research Grants
Publisher : Unknown
Page : 346 pages
File Size : 52,8 Mb
Release : 1975
Category : Medicine
ISBN : UOM:39015072165361
Author : National Institute of General Medical Sciences (U.S.)
Publisher : Unknown
Page : 346 pages
File Size : 48,9 Mb
Release : 1975
Category : Medicine
ISBN : IND:30000090352570
Author : Keshav K. Singh
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 43,6 Mb
Release : 2013-03-09
Category : Science
ISBN : 9783662125090
Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.