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Author : Edward J. Calabrese
Publisher : DIANE Publishing
Page : 20 pages
File Size : 47,8 Mb
Release : 2008-06
Category : Science
ISBN : 9781437902235
Author : A. Wallace Hayes,Claire L. Kruger
Publisher : CRC Press
Page : 2186 pages
File Size : 53,9 Mb
Release : 2014-10-10
Category : Medical
ISBN : 9781842145364
Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Author : Ching-Hung Hsu,Todd Stedeford
Publisher : John Wiley & Sons
Page : 727 pages
File Size : 51,6 Mb
Release : 2010-12-08
Category : Science
ISBN : 9781118035122
With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.
Author : A. Wallace Hayes,Tetyana Kobets
Publisher : CRC Press
Page : 2143 pages
File Size : 40,9 Mb
Release : 2023-07-03
Category : Medical
ISBN : 9781000875775
Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Author : Kevin C. Elliott
Publisher : OUP USA
Page : 259 pages
File Size : 45,9 Mb
Release : 2011-03
Category : Language Arts & Disciplines
ISBN : 9780199755622
Could low-level exposure to polluting chemicals be analogous to exercise - a beneficial source of stress that strengthens the body? Some scientists studying the phenomenon of hormesis claim that that this may be the case. This text critically examines the current evidence for hormesis.
Author : Nicholas Askounes Ashford,Charles C. Caldart
Publisher : MIT Press
Page : 1125 pages
File Size : 53,6 Mb
Release : 2008
Category : Environmental law
ISBN : 9780262012386
The past twenty-five years have seen a significant evolution in environmental policy, with new environmental legislation and substantive amendments to earlier laws, significant advances in environmental science, and changes in the treatment of science (and scientific uncertainty) by the courts. This book offers a detailed discussion of the important issues in environmental law, policy, and economics, tracing their development over the past few decades through an examination of environmental law cases and commentaries by leading scholars. The authors focus on pollution, addressing both pollution control and prevention, but also emphasize the evaluation, design, and use of the law to stimulate technical change and industrial transformation, arguing that there is a need to address broader issues of sustainable development. Environmental Law, Policy, and Economics,which grew out of courses taught by the authors at MIT, treats the traditional topics covered in most classes in environmental law and policy, including common law and administrative law concepts and the primary federal legislation. But it goes beyond these to address topics not often found in a single volume: the information-based obligations of industry, enforcement of environmental law, market-based and voluntary alternatives to traditional regulation, risk assessment, environmental economics, and technological innovation and diffusion. Countering arguments found in other texts that government should play a reduced role in environmental protection, this book argues that clear, stringent legal requirements--coupled with flexible means for meeting them--and meaningful stakeholder participation are necessary for bringing about environmental improvements and technologicial transformations.
Author : Bruce Anderson,Ann de Peyster,Shayne C. Gad,P.J. Bert Hakkinen,Michael Kamrin,Betty Locey,Harihara M. Mehendale,Carey Pope,Lee Shugart
Publisher : Elsevier
Page : 9894 pages
File Size : 50,7 Mb
Release : 2005-05-31
Category : Medical
ISBN : 9780080548005
The second edition of the Encyclopedia of Toxicology continues its comprehensive survey of toxicology. This new edition continues to present entries devoted to key concepts and specific chemicals. There has been an increase in entries devoted to international organizations and well-known toxic-related incidents such as Love Canal and Chernobyl. Along with the traditional scientifically based entries, new articles focus on the societal implications of toxicological knowledge including environmental crimes, chemical and biological warfare in ancient times, and a history of the U.S. environmental movement. With more than 1150 entries, this second edition has been expanded in length, breadth and depth, and provides an extensive overview of the many facets of toxicology. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. *Second edition has been expanded to 4 volumes *Encyclopedic A-Z arrangement of chemicals and all core areas of the science of toxicology *Covers related areas such as organizations, toxic accidents, historical and social issues, and laws *New topics covered include computational toxicology, cancer potency factors, chemical accidents, non-lethal chemical weapons, drugs of abuse, and consumer products and many more!
Author : Anonim
Publisher : Unknown
Page : 522 pages
File Size : 46,7 Mb
Release : 2003
Category : Business
ISBN : UCSD:31822034030783
Author : C. Streffer,H. Bolt,D. Follesdal,P. Hall,J.G. Hengstler,P. Jacob,D Oughton,K. Prieß,E. Rehbinder,E. Swaton
Publisher : Springer Science & Business Media
Page : 481 pages
File Size : 41,7 Mb
Release : 2013-11-11
Category : Social Science
ISBN : 9783662084229
The ever-increasing release of harmful agents due to human activities have led in some areas of the world to heavy pollution. In order to protect human health and the environment, environmental standards that shall limit the release and the concentration of those toxic agents in the environment and hence the exposure to it have to be established. The related assessment and decision-making procedures have to be based on solid scientific data about the effects and mechanisms of these agents as well as on ethical, social and economic aspects. For risk evaluation, the knowledge of the dose response curve is an essential prerequisite. Dose responses without a threshold dose are most critical in this connection. Such dose responses are assumed for mutagenic and carcinogenic effects, which, therefore, dominate also the discussion in this book. In the environmentally important low dose range, risk estimation can only be achieved by extrapolation from higher doses with measurable effects. The extrapolation is accompanied with uncertainties which makes risk evaluation as well as risk communication frequently problematic. In order to ensure rational efficient and fair decisions beyond a sound scientific assessment the dialogue between disciplines, with the affected people and with the general public is necessary. In this book, the whole range of relevant and essential aspects of risk evaluation and standard setting is addressed. Starting with the ethical foundations, the sound analysis of recent scientific findings sets the frame for further reflections by theory of cognition, psychosocial sciences, and jurisprudence. The authors end up with concluding recommendations for coping with the recent problems of standard setting in the field of environmentally relevant low doses. The book is designed to a readership of scientists, legislators, administrators, and the interested public.
Author : Anonim
Publisher : John Wiley & Sons
Page : 2163 pages
File Size : 49,9 Mb
Release : 2008-09-02
Category : Mathematics
ISBN : 9780470035498
Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety, investment theory, public policy applications, transportation safety, public perception of risk, epidemiological risk, national defence and security, critical infrastructure, and program management. This major publication is easily accessible for all those involved in the field of risk assessment and analysis. For ease-of-use it is available in print and online.
Author : Aynsley J. Kellow
Publisher : Edward Elgar Publishing
Page : 229 pages
File Size : 51,8 Mb
Release : 2007-01-01
Category : Political Science
ISBN : 9781847208767
Argues that the virtual nature of much environmental science and the application of non-science principles such as the precautionary principle facilitate the virtuous corruption of environmental science. This book illustrates that the problem is widespread than this area alone would suggest and is common in the important field of climate science.
Author : Anonim
Publisher : Unknown
Page : 1178 pages
File Size : 54,8 Mb
Release : 2001
Category : Law
ISBN : STANFORD:36105060756116
Author : National Research Council,Commission on Geosciences, Environment, and Resources,Board on Radioactive Waste Management,Committee on the Remediation of Buried and Tank Wastes
Publisher : National Academies Press
Page : 179 pages
File Size : 54,6 Mb
Release : 2000-11-09
Category : Science
ISBN : 9780309071864
It is now becoming clear that relatively few U.S. Department of Energy (DOE) waste sites will be cleaned up to the point where they can be released for unrestricted use. "Long-term stewardship" (activities to protect human health and the environment from hazards that may remain at its sites after cessation of remediation) will be required for over 100 of the 144 waste sites under DOE control (U.S. Department of Energy, 1999). After stabilizing wastes that remain on site and containing them as well as is feasible, DOE intends to rely on stewardship for as long as hazards persistâ€"in many cases, indefinitely. Physical containment barriers, the management systems upon which their long-term reliability depends, and institutional controls intended to prevent exposure of people and the environment to the remaining site hazards, will have to be maintained at some DOE sites for an indefinite period of time. The Committee on Remediation of Buried and Tank Wastes finds that much regarding DOE's intended reliance on long-term stewardship is at this point problematic. The details of long-term stewardship planning are yet to be specified, the adequacy of funding is not assured, and there is no convincing evidence that institutional controls and other stewardship measures are reliable over the long term. Scientific understanding of the factors that govern the long-term behavior of residual contaminants in the environment is not adequate. Yet, the likelihood that institutional management measures will fail at some point is relatively high, underscoring the need to assure that decisions made in the near term are based on the best available science. Improving institutional capabilities can be expected to be every bit as difficult as improving scientific and technical ones, but without improved understanding of why and how institutions succeed and fail, the follow-through necessary to assure that long-term stewardship remains effective cannot reliably be counted on to occur. Long-Term Institutional Management of U.S. Department of Energy Legacy Waste Sites examines the capabilities and limitations of the scientific, technical, and human and institutional systems that compose the measures that DOE expects to put into place at potentially hazardous, residually contaminated sites.
Author : Barbara Bartlik,Geovanni Espinosa,Janet Mindes
Publisher : Oxford University Press
Page : 585 pages
File Size : 48,8 Mb
Release : 2018
Category : Medical
ISBN : 9780190225889
Integrative Sexual Health explores beyond the standard topics in men's and women's health, drawing on a diverse research literature to provide an overview of sexual biology and sexual dysfunction, diverse lifespan, lifestyle and environmental impacts on sexual function, integrative medicine solutions to sexual problems, and traditional eastern and western treatment approaches to healing sexual difficulties. This comprehensive guide written by experts in the field provides clinical vignettes, detailed treatment strategies for mitigating the side effects of both medications and sexual dysfunction associated with medical illness and poor lifestyle habits, and extensive further reading resources. Integrative treatment modalities not typically consulted in mainstream medicine, such as traditional Chinese medicine, Ayurvedic medicine, aromatherapy, and botanical medicine, are presented with the best evidence, in a clinically relevant manner. Part of the Weil Integrative Medicine Library, this volume is a must read for the specialist and non-specialist alike who wish to address sexual problems using an integrative medicine approach, and acquire tools to maintain lifetime optimal health and vitality that supports healthy sexuality. Integrative medicine is defined as healing-oriented medicine that takes account of the whole person (body, mind, and spirit) as well as all aspects of lifestyle; it emphasizes the therapeutic relationship and makes use of appropriate therapies, both conventional and alternative. Series editor Andrew Weil, MD, is Professor and Director of the Arizona Center for Integrative Medicine at the University of Arizona. Dr. Weil's program was the first such academic program in the U.S., and its stated goal is to combine the best ideas and practices of conventional and alternative medicine into cost effective treatments without embracing alternative practices uncritically.
Author : Kristin Shrader-Frechette
Publisher : Oxford University Press
Page : 304 pages
File Size : 40,9 Mb
Release : 2014-09-15
Category : Philosophy
ISBN : 9780199396429
Three-fourths of scientific research in the United States is funded by special interests. Many of these groups have specific practical goals, such as developing pharmaceuticals or establishing that a pollutant causes only minimal harm. For groups with financial conflicts of interest, their scientific findings often can be deeply flawed. To uncover and assess these scientific flaws, award-winning biologist and philosopher of science Kristin Shrader-Frechette uses the analytical tools of classic philosophy of science. She identifies and evaluates the concepts, data, inferences, methods, models, and conclusions of science tainted by the influence of special interests. As a result, she challenges accepted scientific findings regarding risks such as chemical toxins and carcinogens, ionizing radiation, pesticides, hazardous-waste disposal, development of environmentally sensitive lands, threats to endangered species, and less-protective standards for workplace-pollution exposure. In so doing, she dissects the science on which many contemporary scientific controversies turn. Demonstrating and advocating "liberation science," she shows how practical, logical, methodological, and ethical evaluations of science can both improve its quality and credibility -- and protect people from harm caused by flawed science, such as underestimates of cancers caused by bovine growth hormones, cell phones, fracking, or high-voltage wires. This book is both an in-depth look at the unreliable scientific findings at the root of contemporary debates in biochemistry, ecology, economics, hydrogeology, physics, and zoology -- and a call to action for scientists, philosophers of science, and all citizens.