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Author : Karl Herrup
Publisher : Unknown
Page : 128 pages
File Size : 44,7 Mb
Release : 2021
Category : Alzheimer's disease
ISBN : 026236574X
"A trade book on Alzheimer's disease - its human face, some insights into its biology, the discoveries that seemed a path to prevention if not cure, 25 years without progress, and a new path forward"--
Author : Karl Herrup
Publisher : MIT Press
Page : 269 pages
File Size : 54,9 Mb
Release : 2023-03-07
Category : Health & Fitness
ISBN : 9780262546010
An authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure. For decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In How Not to Study a Disease, neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research. Herrup offers a unique insider's perspective, describing the red flags that science ignored in the rush to find a cure. He is unsparing in calling out the stubbornness, greed, and bad advice that has hamstrung the field, but his final message is a largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to imagine the brain as a series of interconnected "neighborhoods." He calls for changes in virtually every aspect of the Alzheimer's disease research effort, from the drug development process, to the mechanisms of support for basic research, to the often-overlooked role of the scientific media, and more. With How Not to Study a Disease, Herrup provides a roadmap that points us in a new direction in our journey to a cure for Alzheimer's.
Author : Yongye Huang,Jacek Z. Kubiak,Lin Yuan,Sen Wu,Feng Yue
Publisher : Frontiers Media SA
Page : 155 pages
File Size : 43,7 Mb
Release : 2023-06-21
Category : Science
ISBN : 9782832526880
Author : P. Michael Conn
Publisher : Academic Press
Page : 1108 pages
File Size : 55,9 Mb
Release : 2013-05-29
Category : Science
ISBN : 9780124159129
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
Author : Michael Greger, M.D., FACLM,Gene Stone
Publisher : Flatiron Books
Page : 352 pages
File Size : 43,8 Mb
Release : 2015-12-08
Category : Health & Fitness
ISBN : 9781250066121
From the physician behind the wildly popular NutritionFacts website, How Not to Die reveals the groundbreaking scientific evidence behind the only diet that can prevent and reverse many of the causes of disease-related death. The vast majority of premature deaths can be prevented through simple changes in diet and lifestyle. In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America-heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more-and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives. The simple truth is that most doctors are good at treating acute illnesses but bad at preventing chronic disease. The fifteen leading causes of death claim the lives of 1.6 million Americans annually. This doesn't have to be the case. By following Dr. Greger's advice, all of it backed up by strong scientific evidence, you will learn which foods to eat and which lifestyle changes to make to live longer. History of prostate cancer in your family? Put down that glass of milk and add flaxseed to your diet whenever you can. Have high blood pressure? Hibiscus tea can work better than a leading hypertensive drug-and without the side effects. Fighting off liver disease? Drinking coffee can reduce liver inflammation. Battling breast cancer? Consuming soy is associated with prolonged survival. Worried about heart disease (the number 1 killer in the United States)? Switch to a whole-food, plant-based diet, which has been repeatedly shown not just to prevent the disease but often stop it in its tracks. In addition to showing what to eat to help treat the top fifteen causes of death, How Not to Die includes Dr. Greger's Daily Dozen -a checklist of the twelve foods we should consume every day.Full of practical, actionable advice and surprising, cutting edge nutritional science, these doctor's orders are just what we need to live longer, healthier lives.
Author : Howard Marget Spiro,Mary G. McCrea Curnen,Enid Peschel,Deborah St. James
Publisher : Yale University Press
Page : 230 pages
File Size : 40,5 Mb
Release : 1993-01-01
Category : Medical
ISBN : 0300066708
The book - which includes essays by physicians, philosophers, and a nurse - is divided into three parts: one deals with how empathy is weakened or lost during the course of medical education and suggests how to remedy this; another describes the historical and philosophical origins of empathy and provides arguments for and against it; and a third section offers compelling accounts of how physicians' empathy for their patients has affected their own lives and the lives of those in their care. We hear, for example, from a physician working in a hospice who relates the ways that the staff try to listen and respond to the needs of the dying; a scientist who interviews candidates for medical school and tells how qualities of empathy are undervalued by selection committees; a nurse who considers what nursing can teach physicians about empathy; another physician who ponders whether the desire to be empathic can hinder the detachment necessary for objective care; and several contributors who show how literature and art can help physicians to develop empathy.
Author : United States. Congress. House. Committee on Veterans' Affairs
Publisher : Unknown
Page : 220 pages
File Size : 54,9 Mb
Release : 1990
Category : Agent Orange
ISBN : PURD:32754063608123
Author : Thomas H. McConnell
Publisher : Jones & Bartlett Publishers
Page : 841 pages
File Size : 41,8 Mb
Release : 2020-06-05
Category : Medical
ISBN : 9781284219869
Easy to understand and fun to read, this engaging primer on the etiology and pathogenesis of human disease will help you develop a basic understanding of pathology that will set you on the path to a successful career in the health professions. Punctuated by humor, unique case studies that link pathology to real-world clinical applications, and absorbing tales from the history of medicine, this engaging book focuses on the patient as it guides you through the causes and consequences of common diseases.
Author : Amritpal Mudher,Tracey Newman
Publisher : Taylor & Francis
Page : 233 pages
File Size : 51,8 Mb
Release : 2020-11-25
Category : Science
ISBN : 9781000115536
Drosophila gives an overview of the ways in which Drosophila is currently being used as a model organism to further our understanding of a spectrum of human neurological diseases. Each chapter is written by respected researchers and gives an excellent account of the subject that is suitable for postgraduate and postdoctoral researchers.
Author : Jerrold Tannenbaum
Publisher : Elsevier Inc. Chapters
Page : 1108 pages
File Size : 48,8 Mb
Release : 2013-05-29
Category : Medical
ISBN : 9780128071915
This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity or disagreement, and suggests considerations that are relevant for resolution of these issues. Recommendations are offered for participation by investigators in ethical discussion of their work, and of biomedical animal research generally. The general themes of the chapter are that investigators play the primary role in assuring the ethical conduct of biomedical animal research, and that a crucial foundation of ethical animal research is sound science.
Author : Sara I. Ruiz,Elizabeth E. Zumbrun,Aysegul Nalca
Publisher : Elsevier Inc. Chapters
Page : 1108 pages
File Size : 52,5 Mb
Release : 2013-05-29
Category : Medical
ISBN : 9780128072288
As the threat of exposure to emerging and reemerging viruses within a naive population increases, it is vital that the basic mechanisms of pathogenesis and immune response be thoroughly investigated. By using animal models in this endeavor, the response to viruses can be studied in a more natural context to identify novel drug targets, and assess the efficacy and safety of new products. This is especially true in the advent of the Food and Drug Administration's animal rule. Although no one animal model is able to recapitulate all the aspects of human disease, understanding the current limitations allows for a more targeted experimental design. Important facets to be considered before an animal study are the route of challenge, species of animals, biomarkers of disease, and a humane endpoint. This chapter covers the current animal models for medically important human viruses, and demonstrates where the gaps in knowledge exist.
Author : Nir Ben-Tal,Daisuke Kihara,Arun Prasad Pandurangan
Publisher : Frontiers Media SA
Page : 139 pages
File Size : 40,8 Mb
Release : 2022-01-27
Category : Science
ISBN : 9782889742127
Author : Anonim
Publisher : Unknown
Page : 580 pages
File Size : 54,6 Mb
Release : 1884
Category : College student newspapers and periodicals
ISBN : PRNC:32101077277331
Vols. 1-26 include a supplement: The University pulpit, vols. [1]-26, no. 1-661, which has separate pagination but is indexed in the main vol.
Author : F. J. Frost,T. R. Kunde
Publisher : IWA Publishing
Page : 64 pages
File Size : 46,6 Mb
Release : 2005-07-31
Category : Science
ISBN : 9781843399216
Past studies suggest that source water quality may be an important predictor of the risk of endemic waterborne infection. However, the relationship between endemic infections and the risk of illness is unclear. A primary goal of the study was to estimate endemic levels of diarrhea and gastrointestinal diseases. The primary objective of the study was to estimate the level of infectious gastrointestinal disease attributable to drinking water. A secondary objective was to determine if drinking-water-attributable endemic levels of gastrointestinal diseases are elevated in a community that uses unfiltered water from a well-protected surface water source. Originally published by AwwaRF for its subscribers in 2004. This publication can also be purchased and downloaded via Pay Per View on Water Intelligence Online - click on the Pay Per View icon below
Author : Anonim
Publisher : Unknown
Page : 1516 pages
File Size : 44,7 Mb
Release : 1891
Category : Medicine
ISBN : HARVARD:32044103079398