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Author : Madhuri S. Salker,Dorothy K. Sojka,Biserka Mulac Jericevic,Christos Stournaras
Publisher : Frontiers Media SA
Page : 265 pages
File Size : 50,5 Mb
Release : 2022-02-25
Category : Science
ISBN : 9782889745227
Author : Valentina Lucia La Rosa,Antonio Simone Lagana
Publisher : Mdpi AG
Page : 162 pages
File Size : 50,8 Mb
Release : 2022-02-09
Category : Electronic
ISBN : 3036527990
Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%-10% of women of reproductive age, to 50% of infertile women. Its etiopathogenesis of endometriosis still remains controversial-immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it. This book aims to summarize recent ground-breaking studies that may open new scenarios and change the perspective of the topic, including cutting-edge elements about diagnosis, pharmacologic and surgical treatments, as well as basic/translational science (immunology, cell biology, genetics, and epigenetics) pieces of evidence, to unravel new pathways to follow for the future diagnosis and management of endometriosis, and to improve our current knowledge of its aetiology.
Author : Signe Altmäe,Lusine Aghajanova,Anna Sokalska
Publisher : Frontiers Media SA
Page : 198 pages
File Size : 43,8 Mb
Release : 2023-11-27
Category : Medical
ISBN : 9782832539842
Infertility is a widespread condition with significant consequences on both individual and societal levels. It has a prevalence of 9-18% of the general population, a rate that is seen in similar levels in different countries and continents. While significant progress has already been made in understanding the etiologies, pathogenesis, and management of a variety of conditions that can affect both male and female infertility at various levels, infertility remains a challenging problem for physicians and society. Even in advanced centers, the success rate of infertility treatments lingers at about 60%, and we believe that with more research we can tackle the most difficult situations. Although our understanding of embryo development and selection has greatly improved, knowledge of uterine and endometrial function and dysfunction is still insufficient. We welcome basic and translational research contributions that focus on the advancement of the field of uterine and endometrial physiology and pathology, aiming to address current challenges and unsolved issues. We welcome basic and translational studies on diagnosis and potential therapeutic management of a variety of issues affecting female reproduction at the level of the uterus, such as but not limited to: • endometriosis and adenomyosis, • immunology of endometrium, • endometritis, • implantation failure, • unexplained infertility, • studies on endometrial function/dysfunction, endometrial receptivity, uterine microbiota; • studies that focus on possible implementation and advancement of personalized medicine in management of uterine disorders of reproduction.
Author : C.W. Patrick,A.G. Mikos,L.V. McIntire
Publisher : Elsevier
Page : 700 pages
File Size : 51,9 Mb
Release : 1998-02-20
Category : Technology & Engineering
ISBN : 0080532055
Frontiers in Tissue Engineering is a carefully edited compilation of state-of-the-art contributions from an international authorship of experts in the diverse subjects that make up tissue engineering. A broad representation of the medical, scientific, industrial and regulatory community is detailed in the book. The work is an authoritative and comprehensive reference source for scientists and clinicians working in this emerging field. The book is divided into three parts: fundamentals and methods of tissue engineering, tissue engineering applied to specialised tissues, and tissue engineering applied to organs. The text offers many novel approaches, including a detailed coverage of cell-tissue interactions at cellular and molecular levels; cell-tissue surface, biochemical, and mechanical environments; biomaterials; engineering design; tissue-organ function; new approaches to tissue-organ regeneration and replacement of function; ethical considerations of tissue engineering; and government regulation of tissue-engineered products.
Author : Anonim
Publisher : Unknown
Page : 1876 pages
File Size : 50,9 Mb
Release : 2004
Category : Medicine
ISBN : MINN:31951P00992550P
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : Ronald Matteotti,Stanley W. Ashley
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 55,5 Mb
Release : 2011-06-15
Category : Medical
ISBN : 9783540450214
Minimally Invasive Surgical Oncology is aimed at the minimal invasive surgeon as well as at the general surgeon and surgical trainee who wish to explore this field. It covers disciplines like gastroenterology, gynecology, urology, thoracic and pediatrics and builds bridges to oncologists and internal medicine. It gives a state-of-the art overview and perspectives for future developments and research as well. The book serves as an operative guide for a new generation of surgeons and offers the extraordinary feature being a text book, an operative atlas and a quick reference guide as well. The reader is provided with a tool in hand which synthesizes the latest knowledge in traditional therapies like chemotherapies and gives a comprehensive overview how to proceed in treating a cancer patient using minimal access techniques.
Author : Benedetta Artegiani,Delilah Hendriks,Kai Kretzschmar
Publisher : Frontiers Media SA
Page : 383 pages
File Size : 45,7 Mb
Release : 2022-09-29
Category : Science
ISBN : 9782832501191
Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 54,9 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Author : Harold P. Drutz,Sender Herschorn,Nicholas E. Diamant
Publisher : Springer Science & Business Media
Page : 519 pages
File Size : 53,8 Mb
Release : 2007-12-31
Category : Medical
ISBN : 9781846282386
This text includes sections on anatomy, normal and abnormal physiology, investigation techniques, inflammatory conditions and treatment options. The international panel of contributors is at the forefront of research in the field; the editors have assembled these contributors and topics that span the entire range of pelvic floor disorders in women. Throughout, the emphasis is on an evidence-based approach to the treatment of pelvic floor problems. Indispensable for gynecologists and urologists.
Author : Carlo Bulletti,Erlio Gurpide,Carlo Flamigni
Publisher : Unknown
Page : 522 pages
File Size : 50,6 Mb
Release : 1994
Category : Medical
ISBN : STANFORD:36105009761052
The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.
Author : Le'Nise Brothers
Publisher : Watkins Media Limited
Page : 212 pages
File Size : 42,9 Mb
Release : 2022-03-08
Category : Health & Fitness
ISBN : 9781786786203
A practical guide to understanding your cycle and balancing your hormones with nutrition and yoga, for a calm and pain-free period. Written by Le’Nise Brothers, a nutritional therapist, yoga teacher and popular women’s health, hormone and wellbeing coach. You Can Have A Better Period is a straight-talking resource to help women understand their menstrual cycles and finally get answers to questions such as: “why am I so moody right before my period?”, “are periods supposed to be so painful?”, “why is my period so heavy?”, “is it normal to get headaches right before my period?” Le'Nise Brothers takes us through each phase of our cycle, including a clear programme of nutrition and lifestyle changes. The book explains which supplements work and the key stress management habits we can implement, to bring long-lasting and sustainable changes to our hormonal balance and menstrual health. In Western society, we have accepted a cultural narrative that periods are supposed to be painful, emotional and messy. This book will be a practical guide that helps women change the way they look at their period, and finally harness the power of the fifth vital sign.
Author : Efstratios M. Kolibianakis,Christos A. Venetis
Publisher : CRC Press
Page : 434 pages
File Size : 45,7 Mb
Release : 2019-07-30
Category : Medical
ISBN : 9781351677905
Implantation is a complex phenomenon, still not thoroughly understood, involving the embryo and the endometrium. Successful implantation is considered to stem from an efficient combination of various embryo and/or maternal factors. Repeated failure of any of these factors or of their combination might decrease the chance of implantation and eventually lead to recurrent implantation failure. Despite technological advances, only about a quarter of In Vitro Fertilization procedures will result in live birth, leading many couples to experience multiple failures. This text from international experts explores the various factors at play and offers a helpful summary of the state of knowledge to help guide clinicians in their management of this complex and important problem. Contents: What is Recurrent Implantation Failure? * The psychosocial aspects of recurrent implantation failure * The role of life-style factors in RIF * Endocrine causes of recurrent implantation failure * Congenital uterine anomalies and recurrent implantation failure * Immunological causes of recurrent implantation failure * Acquired uterine conditions, reproductive surgery, and RIF? * Thrombophilia: diagnosis and management in women with recurrent implantation failure * Andrological causes of RIF * Diagnostic evaluation of RIF? (Modalities and algorithm) * Optimizing embryo culture for RIF? * Optimizing endometrial receptivity for patients with recurrent implantation failure: The role of progesterone on the day of triggering final oocyte maturation * Is there a role of follicular phase LH and E2 on the day of triggering final oocyte maturation for embryo implantation? * Manipulating the endometrium: Can RIF be managed by inducing endometrial inflammation or by the use of novel research therapies * The embryo in RIF: Genetic selection and strategies for improving its implantation potential * Is oocyte donation efficient in patients with RIF? * Sperm donation and RIF? * Optimizing embryo transfer technique for RIF management * Proposed management of patients with recurrent implantation failure and directions for future research * When should patients abandon treatment?
Author : Jeffrey M. Gimble,Bruce A. Bunnell
Publisher : Humana Press
Page : 474 pages
File Size : 42,9 Mb
Release : 2011-08-24
Category : Science
ISBN : 1617379611
During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular BiologyTM series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs.
Author : Constantinos Koumenis,Ester Hammond,Amato Giaccia
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 51,5 Mb
Release : 2013-11-23
Category : Medical
ISBN : 9781461459156
The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Author : Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Publisher : Springer Science & Business Media
Page : 527 pages
File Size : 50,5 Mb
Release : 2010-01-29
Category : Medical
ISBN : 9789048132614
A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.