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Radiopharmaceuticals are increasingly used for the treatment of various cancers with novel radionuclides, compounds, tracer molecules, and administration techniques. The goal of radiation therapy, including therapy with radiopharmaceuticals, is to optimise the relationship between tumour control probability and potential complications in normal organs and tissues. This report provides an overview of therapy procedures and a framework for calculating radiation doses for various treatment approaches.
National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I
Author : National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I Publisher : National Academies Press Page : 424 pages File Size : 43,9 Mb Release : 2012-06-29 Category : Medical ISBN : 9780309255714
Analysis of Cancer Risks in Populations Near Nuclear Facilities by National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I Pdf
In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.
Guidance on the Personal Monitoring Requirements for Personnel Working in Healthcare by Colin John Martin,David Temperton,Anthony Hughes (Physicist),Thomas Jupp Pdf
Arrangements for personal monitoring have evolved as dose limits and practices using radiation have developed. Therefore, new approaches involving more personal dosimetry are required, and methods are needed that can be used to predict probable dose levels so that risk assessments can be prepared to determine the level of dose monitoring for individual staff members. The authors set out recommendations designed to help radiation protection practitioners and healthcare workers assess exposure levels for personnel and determine monitoring requirements based on established rules. This book is essential reading for medical physicists in radiation protection, diagnostic radiology and nuclear medicine, as well as radiographers and technologists due to changes in global dosimetry requirements. Additionally, it presents guidelines for medical physicists and others using radiation. Part of IPEM-IOP Series in Physics and Engineering in Medicine and Biology.
Reducing Environmental Cancer Risk by Suzanne H. Reuben Pdf
Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.
Radiation Oncology Physics by International Atomic Energy Agency Pdf
This publication is aimed at students and teachers involved in teaching programmes in field of medical radiation physics, and it covers the basic medical physics knowledge required in the form of a syllabus for modern radiation oncology. The information will be useful to those preparing for professional certification exams in radiation oncology, medical physics, dosimetry or radiotherapy technology.
National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V)
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Publisher : National Academies Page : 436 pages File Size : 54,8 Mb Release : 1990-02-01 Category : Science ISBN : 9780309039956
Health Effects of Exposure to Low Levels of Ionizing Radiation by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Pdf
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Handbook of Nuclear Medicine and Molecular Imaging for Physicists by Michael Ljungberg Pdf
Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It also includes computer models of patient dosimetry. Two chapters of this book are devoted towards introducing the concept of biostatistics and radiobiology. These chapters are followed by chapters detailing dosimetry procedures commonly used in the context of diagnostic imaging, as well as patient-specific dosimetry for radiotherapy treatments. For safety reasons, many of the methods used in nuclear medicine and molecular imaging are tightly regulated. Therefore, this volume also highlights the basic principles for radiation protection. It discusses the process of how guidelines and regulations aimed at minimizing radiation exposure are determined and implemented by international organisations. Finally, this book describes how different dosimetry methods may be utilized depending on the intended target, including whole-body or organ-specific imaging, as well as small-scale to cellular dosimetry. This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Radiation Protection in Nuclear Medicine by Sören Mattsson,Christoph Hoeschen Pdf
This book explains clearly and in detail all aspects of radiation protection in nuclear medicine, including measurement quantities and units, detectors and dosimeters, and radiation biology. Discussion of radiation doses to patients and to embryos, fetuses, and children forms a central part of the book. Phantom models, biokinetic models, calculations, and software solutions are all considered, and a further chapter is devoted to quality assurance and reference levels. Occupational exposure also receives detailed attention. Exposure resulting from the production, labeling, and injection of radiopharmaceuticals and from contact with patients is discussed and shielding calculations are explained. The book closes by considering exposure of the public and summarizing the "rules of thumb" for radiation protection in nuclear medicine. This is an ideal textbook for students and a ready source of useful information for nuclear medicine specialists and medical physics experts.
Clinical Nuclear Medicine Physics with MATLAB® by Maria Lyra Georgosopoulou Pdf
The use of MATLAB® in clinical Medical Physics is continuously increasing, thanks to new technologies and developments in the field. However, there is a lack of practical guidance for students, researchers, and medical professionals on how to incorporate it into their work. Focusing on the areas of diagnostic Nuclear Medicine and Radiation Oncology Imaging, this book provides a comprehensive treatment of the use of MATLAB in clinical Medical Physics, in Nuclear Medicine. It is an invaluable guide for medical physicists and researchers, in addition to postgraduates in medical physics or biomedical engineering, preparing for a career in the field. In the field of Nuclear Medicine, MATLAB enables quantitative analysis and the visualization of nuclear medical images of several modalities, such as Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), or a hybrid system where a Computed Tomography system is incorporated into a SPECT or PET system or similarly, a Magnetic Resonance Imaging system (MRI) into a SPECT or PET system. Through a high-performance interactive software, MATLAB also allows matrix computation, simulation, quantitative analysis, image processing, and algorithm implementation. MATLAB can provide medical physicists with the necessary tools for analyzing and visualizing medical images. It is useful in creating imaging algorithms for diagnostic and therapeutic purposes, solving problems of image reconstruction, processing, and calculating absorbed doses with accuracy. An important feature of this application of MATLAB is that the results are completely reliable and are not dependent on any specific γ-cameras and workstations. The use of MATLAB algorithms can greatly assist in the exploration of the anatomy and functions of the human body, offering accurate and precise results in Nuclear Medicine studies. KEY FEATURES Presents a practical, case-based approach whilst remaining accessible to students Contains chapter contributions from subject area specialists across the field Includes real clinical problems and examples, with worked through solutions Maria Lyra Georgosopoulou, PhD, is a Medical Physicist and Associate Professor at the National and Kapodistrian University of Athens, Greece. Photo credit: The Antikythera Mechanism is the world’s oldest known analog computer. It consisted of many wheels and discs that could be placed onto the mechanism for calculations. It is possible that the first algorithms and analog calculations in mathematics were implemented with this mechanism, invented in the early first centuries BC. It has been selected for the cover to demonstrate the importance of calculations in science.
This report provides a compendium of current information relating to radiation dose to patients, including biokinetic models, biokinetic data, dose coefficients for organ and tissue absorbed doses, and effective dose for major radiopharmaceuticals based on ICRP radiation protection guidance. These data were compiled from ICRP Publications 53, 80, and 106 and related amendments and corrections. This report also includes new information for 82Rb-chloride, iodide (123I, 124I, 125I, and 131I) and 123I labelled 2ß-carbomethoxy 3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (FPCIT). The data presented in this report are intended for diagnostic nuclear medicine and not for therapeutic applications.
Handbook of Parameter Values for the Prediction of Radionuclide Transfer to Wildlife by International Atomic Energy Agency Pdf
This handbook provides generic parameter values for estimating the transfer of radionuclides from environmental media to wildlife for the purpose of assessing potential radiation exposure under equilibrium conditions. These data are intended for use where site specific data are either not available or not required, and to parameterize generic assessment models. They are based on a comprehensive review of the available literature, including many Russian language publications that have not previously been available in English. The publication addresses the limitations of the parameter values and the applicability of data. Some general background information on the assessment of potential impacts of radioactive releases on wildlife is also included. It complements the existing handbook in the same IAEA series with parameter to assess the radiological impact to humans.
Radiation Protection and Safety of Radiation Sources by International Atomic Energy Agency Pdf
This publication is the new edition of the International Basic Safety Standards. The edition is co-sponsored by seven other international organizations European Commission (EC/Euratom), FAO, ILO, OECD/NEA, PAHO, UNEP and WHO. It replaces the interim edition that was published in November 2011 and the previous edition of the International Basic Safety Standards which was published in 1996. It has been extensively revised and updated to take account of the latest finding of the United Nations Scientific Committee on the Effects of Atomic Radiation, and the latest recommendations of the International Commission on Radiological Protection. The publication details the requirements for the protection of people and the environment from harmful effects of ionizing radiation and for the safety of radiation sources. All circumstances of radiation exposure are considered.
