Immune Mechanisms Of Pain And Analgesia

Author : Halina Machelska,Christoph Stein
Publisher : Springer Science & Business Media
Page : 178 pages
File Size : 49,5 Mb
Release : 2003-01-31
Category : Science
ISBN : 9780306476921

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Immune Mechanisms of Pain and Analgesia by Halina Machelska,Christoph Stein Pdf

Immune Mechanisms of Pain and Analgesia is the first volume to discuss a new concept of immune-neural interplays leading to pain or analgesia. It argues the classical view that pain and its control are restricted to the nervous system, offering a comprehensive overview of the emerging area of immune mechanisms in pain and its control. It challenges the traditional view that pain sensation or suppression is attributed exclusively to the nervous system and presents a critical analysis of this new concept. The book is written by an internationally recognized group of researchers and discusses complex and controversial issues such as cytokines and their pain-exacerbating but also analgesic effects, the production of opioids by immune cells, peripheral analgesic and anti-inflammatory actions of opioids, immunomodulatory effects of opiates, and immunosuppressive effects of pain.

Author : Joyce A. De Leo,Linda S. Sorkin,Linda R. Watkins
Publisher : Unknown
Page : 464 pages
File Size : 41,9 Mb
Release : 2007
Category : Medical
ISBN : CHI:81213074

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Immune and Glial Regulation of Pain by Joyce A. De Leo,Linda S. Sorkin,Linda R. Watkins Pdf

"Review of immune and glial factors within the peripheral and central nervous systems that relate to chronic pain states. Discussion of novel immune and glial targets for clinical pain control that may yield new analgesic drugs"--Provided by publisher.

Author : Ru-Rong Ji,Jianguo Cheng,Jasmine Ji
Publisher : Springer Nature
Page : 365 pages
File Size : 51,6 Mb
Release : 2023-05-05
Category : Medical
ISBN : 9783031292316

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Neuroimmune Interactions in Pain by Ru-Rong Ji,Jianguo Cheng,Jasmine Ji Pdf

As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.

Author : Donald D. Price
Publisher : Progress in Pain Research and
Page : 272 pages
File Size : 49,8 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015047861359

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Psychological Mechanisms of Pain and Analgesia by Donald D. Price Pdf

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 43,7 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

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Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : Joav Merrick
Publisher : Unknown
Page : 128 pages
File Size : 50,9 Mb
Release : 2022-02-15
Category : Electronic
ISBN : 1685074936

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Pain Management: Recent International Research by Joav Merrick Pdf

Before neurons and their role in pain were understood, there have been many explanations to account for pain. Hippocrates (370-460 BCE) believed that it was due to an imbalance in vital fluids and in the 11th century Avicenna (980-1037) theorized that there were a number of feeling senses including touch, pain and titillation. Today we talk about four types of pain: 1) Nociceptive pain: Typically the result of tissue injury, 2) Inflammatory pain: An abnormal inflammation caused by an inappropriate response by the body's immune system, 3) Neuropathic pain: Pain caused by nerve irritation and 4) Functional pain: Pain without obvious origin. About 20% of adults have chronic pain and 7% of adults have chronic pain that frequently limits life or work activities, which increases with age. In this book we have gathered recent international research on pain and pain management from internationally renowned researchers from around the world, which we hope will be of interest to the reader.

Author : Marzia Malcangio
Publisher : Springer Science & Business Media
Page : 500 pages
File Size : 50,9 Mb
Release : 2009-05-28
Category : Medical
ISBN : 9781441902269

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Synaptic Plasticity in Pain by Marzia Malcangio Pdf

Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse
Publisher : National Academies Press
Page : 483 pages
File Size : 51,6 Mb
Release : 2017-09-28
Category : Medical
ISBN : 9780309459570

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Pain Management and the Opioid Epidemic by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse Pdf

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Author : Raymond S. Sinatra
Publisher : Cambridge University Press
Page : 729 pages
File Size : 43,8 Mb
Release : 2009-04-27
Category : Medical
ISBN : 9780521874915

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Acute Pain Management by Raymond S. Sinatra Pdf

This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

Author : Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford
Publisher : Cambridge University Press
Page : 551 pages
File Size : 50,8 Mb
Release : 2010-10-14
Category : Medical
ISBN : 9781139491983

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The Essence of Analgesia and Analgesics by Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford Pdf

The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.

Author : Howard L. Fields
Publisher : Elsevier Publishing Company
Page : 454 pages
File Size : 55,5 Mb
Release : 1988-01-01
Category : Medical
ISBN : 0444809848

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Pain Modulation by Howard L. Fields Pdf

This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.

Author : L.R. Watkins,S.F. Maier
Publisher : Springer
Page : 248 pages
File Size : 48,6 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9783034887496

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Cytokines and Pain by L.R. Watkins,S.F. Maier Pdf

Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

Author : Sanjog Pangarkar,Quynh G. Pham,Blessen C. Eapen
Publisher : Elsevier Health Sciences
Page : 296 pages
File Size : 40,6 Mb
Release : 2020-06-30
Category : Medical
ISBN : 9780323722179

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Pain Care Essentials and Innovations by Sanjog Pangarkar,Quynh G. Pham,Blessen C. Eapen Pdf

Covering the newest trends and treatments in pain care, as well as the pain treatment strategies that have been successfully employed in the past, Pain Care Essentials and Innovations brings you fully up to date with effective treatments for acute and chronic pain. It offers expert guidance on both interventional and non-interventional strategies, provided by respected academic physiatrists who practice evidence-based medicine at UCLA and an ACGME-accredited rehabilitation and pain program. Covers cannabinoids in pain care, novel therapeutics in pain medicine, and integrative care in pain management. Discusses relevant basic science, psychological aspects of pain care, opioids and practice guidelines, geriatric pain management, and future research in the field. Consolidates today’s available information and guidance into a single, convenient resource.

Author : Kurt A. Grimm,Leigh A. Lamont,William J. Tranquilli,Stephen A. Greene,Sheilah A. Robertson
Publisher : John Wiley & Sons
Page : 1072 pages
File Size : 47,6 Mb
Release : 2015-05-11
Category : Medical
ISBN : 9781118526231

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Veterinary Anesthesia and Analgesia by Kurt A. Grimm,Leigh A. Lamont,William J. Tranquilli,Stephen A. Greene,Sheilah A. Robertson Pdf

Veterinary Anesthesia and Analgesia: the Fifth Edition of Lumb and Jones is a reorganized and updated edition of the gold-standard reference for anesthesia and pain management in veterinary patients. Provides a thoroughly updated edition of this comprehensive reference on veterinary anesthesia and analgesia, combining state-of-the-art scientific knowledge and clinically relevant information Covers immobilization, sedation, anesthesia, and analgesia of companion, wild, zoo, and laboratory animals Takes a body systems approach for easier reference to information about anesthetizing patients with existing conditions Adds 10 completely new chapters with in-depth discussions of perioperative heat balance, coagulation disorders, pacemaker implantation, cardiac output measurement, cardiopulmonary bypass, shelter anesthesia and pain management, anesthetic risk assessment, principles of anesthetic pharmacology, and more Now printed in color, with more than 400 images

Author : Deepak Narayan,Alan D Kaye,Nalini Vadivelu
Publisher : Oxford University Press
Page : 304 pages
File Size : 49,7 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9780190457020

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Perioperative Pain Management for General and Plastic Surgery by Deepak Narayan,Alan D Kaye,Nalini Vadivelu Pdf

All physicians are involved in the management of pain at some level or the other, but of the various specialties and health professions, surgeons are at the frontline of delivering perioperative pain care. Perioperative Pain Management for General and Plastic Surgery offers a concise yet comprehensive overview of the surgical pain management field to help practitioners effectively plan and enhance perioperative pain control. Chapters provide guidance on solving common dilemmas facing surgeons who are managing patients with pain related problems and clinical decision-making, and explore essential topics required for the trainee and practitioner to quickly assess the patient with pain, to diagnose pain and painful conditions, determine the feasibility and safety of surgical procedure needed, and arrange for advanced pain management consults and care if needed. This text also explores the latest evolving techniques and appropriate utilization of modern equipment and technology to safely provide care. Highly accessible and written by experts in the field, Perioperative Pain Management for General and Plastic Surgery is an ideal resource for practicing surgeons, anesthesiologists, critical care personnel, residents, medical students.