Immune Metabolism In Health And Tumor

Immune Metabolism In Health And Tumor Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Immune Metabolism In Health And Tumor book. This book definitely worth reading, it is an incredibly well-written.

Immune Metabolism in Health and Tumor

Bin Li,Fan Pan
Immune Metabolism in Health and Tumor Book PDF

Author : Bin Li,Fan Pan
Publisher : Springer
Page : 223 pages
File Size : 49,6 Mb
Release : 2017-09-05
Category : Medical
ISBN : 9789402411706

Get Book

Immune Metabolism in Health and Tumor by Bin Li,Fan Pan Pdf

This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.

Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment

Yongsheng Li,Bo Zhu
Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment Book PDF

Author : Yongsheng Li,Bo Zhu
Publisher : Frontiers Media SA
Page : 87 pages
File Size : 51,6 Mb
Release : 2019-03-20
Category : Electronic
ISBN : 9782889457854

Get Book

Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment by Yongsheng Li,Bo Zhu Pdf

Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 53,9 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

Get Book

The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Immuno-Oncology Crosstalk and Metabolism

Muzafar Ahmad Macha,Ajaz Ahmad Bhat,Nissar Ahmad Wani
Immuno Oncology Crosstalk and Metabolism Book PDF

Author : Muzafar Ahmad Macha,Ajaz Ahmad Bhat,Nissar Ahmad Wani
Publisher : Springer Nature
Page : 223 pages
File Size : 51,8 Mb
Release : 2022-05-16
Category : Medical
ISBN : 9789811662263

Get Book

Immuno-Oncology Crosstalk and Metabolism by Muzafar Ahmad Macha,Ajaz Ahmad Bhat,Nissar Ahmad Wani Pdf

This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.

Essential Aspects of Immunometabolism in Health and Disease

Niels Olsen Saraiva Camara,Jose C Alves-Filho,Pedro Manoel Mendes de Moraes-Vieira,Vinicius Andrade-Oliveira
Essential Aspects of Immunometabolism in Health and Disease Book PDF

Author : Niels Olsen Saraiva Camara,Jose C Alves-Filho,Pedro Manoel Mendes de Moraes-Vieira,Vinicius Andrade-Oliveira
Publisher : Springer Nature
Page : 285 pages
File Size : 44,7 Mb
Release : 2021-10-21
Category : Medical
ISBN : 9783030866846

Get Book

Essential Aspects of Immunometabolism in Health and Disease by Niels Olsen Saraiva Camara,Jose C Alves-Filho,Pedro Manoel Mendes de Moraes-Vieira,Vinicius Andrade-Oliveira Pdf

Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.

The Metabolic Challenges of Immune Cells in Health and Disease

Claudio Mauro,Christian Frezza
The Metabolic Challenges of Immune Cells in Health and Disease Book PDF

Author : Claudio Mauro,Christian Frezza
Publisher : Frontiers Media SA
Page : 82 pages
File Size : 54,6 Mb
Release : 2015-07-13
Category : Electronic book
ISBN : 9782889196227

Get Book

The Metabolic Challenges of Immune Cells in Health and Disease by Claudio Mauro,Christian Frezza Pdf

Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism.

Cancer as a Metabolic Disease

Thomas Seyfried
Cancer as a Metabolic Disease Book PDF

Author : Thomas Seyfried
Publisher : John Wiley & Sons
Page : 482 pages
File Size : 45,5 Mb
Release : 2012-05-18
Category : Science
ISBN : 9781118310304

Get Book

Cancer as a Metabolic Disease by Thomas Seyfried Pdf

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Inflammation, Aging and Cancer

Mahin Khatami
Inflammation Aging and Cancer Book PDF

Author : Mahin Khatami
Publisher : Springer
Page : 389 pages
File Size : 55,9 Mb
Release : 2018-01-17
Category : Medical
ISBN : 9783319664750

Get Book

Inflammation, Aging and Cancer by Mahin Khatami Pdf

This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 50,9 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

Get Book

The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Cancer Immunology and Immunotherapy

Mansoor M. Amiji,Lara Scheherazade Milane
Cancer Immunology and Immunotherapy Book PDF

Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Page : 550 pages
File Size : 51,5 Mb
Release : 2021-08-18
Category : Business & Economics
ISBN : 9780128236376

Get Book

Cancer Immunology and Immunotherapy by Mansoor M. Amiji,Lara Scheherazade Milane Pdf

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions

Debabrata Banerjee,Raj K. Tiwari
Tumor Microenvironment Cellular Metabolic and Immunologic Interactions Book PDF

Author : Debabrata Banerjee,Raj K. Tiwari
Publisher : Unknown
Page : 0 pages
File Size : 41,7 Mb
Release : 2021
Category : Electronic
ISBN : 3030832848

Get Book

Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions by Debabrata Banerjee,Raj K. Tiwari Pdf

Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor microenvironment's various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 45,6 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

Get Book

Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Lipid Metabolism in Tumor Immunity

Yongsheng Li
Lipid Metabolism in Tumor Immunity Book PDF

Author : Yongsheng Li
Publisher : Springer Nature
Page : 211 pages
File Size : 40,8 Mb
Release : 2021-03-19
Category : Medical
ISBN : 9789813367852

Get Book

Lipid Metabolism in Tumor Immunity by Yongsheng Li Pdf

This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery.

Innate Immunity in Health and Disease

Shailendra K. Saxena,Hridayesh Prakash
Innate Immunity in Health and Disease Book PDF

Author : Shailendra K. Saxena,Hridayesh Prakash
Publisher : BoD – Books on Demand
Page : 416 pages
File Size : 50,5 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9781838807658

Get Book

Innate Immunity in Health and Disease by Shailendra K. Saxena,Hridayesh Prakash Pdf

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Metabolism in Cancer

Thorsten Cramer,Clemens A. Schmitt
Metabolism in Cancer Book PDF

Author : Thorsten Cramer,Clemens A. Schmitt
Publisher : Springer
Page : 272 pages
File Size : 50,8 Mb
Release : 2016-08-24
Category : Medical
ISBN : 9783319421186

Get Book

Metabolism in Cancer by Thorsten Cramer,Clemens A. Schmitt Pdf

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.