Immunobiology Of Carbohydrates

Author : Simon Wong,Gemma Arsequell
Publisher : Springer Science & Business Media
Page : 336 pages
File Size : 45,7 Mb
Release : 2003-10-31
Category : Medical
ISBN : 0306478447

Get Book

Immunobiology of Carbohydrates by Simon Wong,Gemma Arsequell Pdf

This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens. The editors selected only topics that have established basic and clinical relevance to this field. The topics from basic research are organised like a textbook, in order to guide the readers through complex sets of events that lead to clearance of or to immune responses toward carbohydrate antigens. The book is clear, concise and contains fully annotated summaries of the key basic and practical information on carbohydrate immunology from current literature. These topics are written by investigators from various disciplines (chemistry, medicine, biochemistry, glycobiology and immunology), creating a fine balance in the point of views presented in the book. It explores the challenges and rewards of understanding the importance of carbohydrates and glycoconjugates in health and disease, applying new knowledge from carbohydrate immunology in improving or developing novel sugar-based therapeutics, and vaccines and medicines. This book is most suitable for glycobiologists and immunologists, but many researchers whose interests, background and expertise are in any of the fifteen topics presented in this book will also find it appealing. It is also a valuable resource for postgraduate students, clinicians or anyone else who is curious about the role of carbohydrates in immunology, and would like to see the topics combined under one cover and in relation to each other.

Author : Albert M. Wu,L. Garry Adams
Publisher : Springer Science & Business Media
Page : 866 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461316633

Get Book

The Molecular Immunology of Complex Carbohydrates by Albert M. Wu,L. Garry Adams Pdf

During the past three decades, the sugar moiety of complex carbohydrates has been found to be involved in important interactions of immunological specificity of antigens and to participate in a variety of cellular functions. The long polysaccharide side chains of the lipopolysaccharides on the outer membrane of Gram negative organisms provide surface antigens for differential serodiagnosis. Bacterial surface lectins are important in mediating the attachment of bacteria to host cells in the of infectious diseases. The carbohydrate pathogenesis moieties of cell surface glycoconjugates (glycoproteins and glycolipids) of mammals are the sites for intercellular recognition and for the regulatory molecular interactions such as interaction of complex carbohydrate with hormones or hepatic lectins. The carbohydrate side chains of many complex carbohydrates play essential roles as antigenic determinants b of human blood group ABH, Lea, Le , I, and i activities, as the Forssman specific determinant, and as tumor associated antigenic determinants. Prompted by these and other advances in the field, a Symposium on Molecular Immunology of Complex Carbohydrates was organized as a satellite meeting of the 8th International Glycoconjugate Conference held on September 8- 13, 1985, in Houston, Texas, U. S . A. Many eminent scientists contributed their knowledge at this meeting. The lecture and poster materials of the symposium are contained in this proceeding book, which is divided into four Sections and one Appendix. Section I is entitled Antibody Specificity, Epitope, and Lectinology. Dr. Elvin A.

Author : Albert M. Wu
Publisher : Springer Science & Business Media
Page : 652 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461512677

Get Book

The Molecular Immunology of Complex Carbohydrates —2 by Albert M. Wu Pdf

Chang-Gung Univ., Tay-yuan, Taiwan. Proceedings of the 15th International Glycoconjugate Conference held August 28 to September 2, 1999, in Taiwan.

Author : Albert M. Wu
Publisher : Springer Science & Business Media
Page : 823 pages
File Size : 45,5 Mb
Release : 2011-05-27
Category : Medical
ISBN : 9781441978776

Get Book

The Molecular Immunology of Complex Carbohydrates-3 by Albert M. Wu Pdf

Based on the third symposium on “Molecular Immunology of Complex Carbohydrates,” this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.

Author : Albert M. Wu
Publisher : Springer
Page : 809 pages
File Size : 53,6 Mb
Release : 2011-08-25
Category : Medical
ISBN : 144197878X

Get Book

The Molecular Immunology of Complex Carbohydrates-3 by Albert M. Wu Pdf

Based on the third symposium on “Molecular Immunology of Complex Carbohydrates,” this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.

Author : Zhongwu Guo,Geert-Jan Boons
Publisher : John Wiley & Sons
Page : 436 pages
File Size : 49,6 Mb
Release : 2009-06-09
Category : Science
ISBN : 9780470197561

Get Book

Carbohydrate-Based Vaccines and Immunotherapies by Zhongwu Guo,Geert-Jan Boons Pdf

The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 41,9 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

Get Book

Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Author : René Roy
Publisher : ACS Symposium
Page : 0 pages
File Size : 49,9 Mb
Release : 2008
Category : Science
ISBN : 0841239835

Get Book

Carbohydrate-based Vaccines by René Roy Pdf

This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 52,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

Get Book

Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Hari G. Garg,Mary K. Cowman,Charles A. Hales
Publisher : Elsevier
Page : 432 pages
File Size : 52,6 Mb
Release : 2011-09-06
Category : Science
ISBN : 0080558143

Get Book

Carbohydrate Chemistry, Biology and Medical Applications by Hari G. Garg,Mary K. Cowman,Charles A. Hales Pdf

The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research. Explains how carbohydrates are important to life Details the chemistry, biology and medical aspects of carbohydrates Interdisciplinary and international team of authors

Author : A. Nowotny
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642673566

Get Book

Basic Exercises in Immunochemistry by A. Nowotny Pdf

Author : Azita Alavi,John S. Axford
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 41,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461518853

Get Book

Glycoimmunology by Azita Alavi,John S. Axford Pdf

Proceedings of the Third Jenner International Glycoimmunology meeting held in Il Ciocco, Tuscany, Italy, October 11-14, 1994

Author : Vinood B. Patel
Publisher : Academic Press
Page : 442 pages
File Size : 49,6 Mb
Release : 2019-10-16
Category : Technology & Engineering
ISBN : 9780128498743

Get Book

Molecular Nutrition: Carbohydrates by Vinood B. Patel Pdf

Molecular Nutrition: Carbohydrates presents the nutritional and molecular aspects of carbohydrates. As part of the Molecular Nutrition includes sections covering carbohydrate metabolism, carbohydrates in the diet, insulin resistance, dietary sugars, cardiometabolic risk, lipoproteins, low-carbohydrate diets, antioxidants, refined dietary sugars, fats, glucose transporters, glucose sensing, the role of phosphorylation, carbohydrate responsive binding protein, cyclic AMP, peroxisome proliferator-activated receptors, SIRT1, insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes rRNA and transcription, and more. In addition, the book addresses emerging fields of molecular biology and presents important discoveries relating to diet and nutritional health. Summarizes molecular nutrition in health as related to carbohydrates Addresses emerging fields of molecular biology and presents important discoveries relating to diet and nutritional health Includes key facts, a mini dictionary of terms and summary points

Author : David C. Nieman,Bente Klarlund Pedersen
Publisher : CRC Press
Page : 204 pages
File Size : 49,5 Mb
Release : 2000-03-29
Category : Health & Fitness
ISBN : 9781420041798

Get Book

Nutrition and Exercise Immunology by David C. Nieman,Bente Klarlund Pedersen Pdf

Like an army of millions ready to defend its territory, the human immune system acts as the body's primary line of defense-a complex network of interacting cells that protects us from pathogens and other foreign substances. But many components of the immune system exhibit change after prolonged, heavy exertion, indicating that it is suppressed and

Author : Nigel J. Dimmock
Publisher : Springer
Page : 0 pages
File Size : 46,7 Mb
Release : 2011-12-06
Category : Medical
ISBN : 3642778518

Get Book

Neutralization of Animal Viruses by Nigel J. Dimmock Pdf

Understanding neutralization is particularly relevant to an appreciation of the interaction between a virus and its antibody-synthesizing host since it is likely that viruses and the antibody system have evolved in response to reciprocally imposed selective pressures. Neutralization of viruses which only infect non-antibody-synthesizing hosts, while of considerable interest from of points of view is de facto without any such evolutionary signifi a number cance. In this second category are viruses of plants, invertebrates, vertebrates below fish in the evolutionary scale which do not synthesize antibody and most bacteria. Viruses of organisms parasitic on or commensal with antibody synthesizing vertebrates, such as enteric bacteria, protozoa or metazoan parasites, will be in contac, with antibody at some stage of their existence, and arthropod-borne viruses which have a higher vertebrate as second host are obviously bona fide members of the first category. There is an urgent need to understand the principles by which antibodies inactivate virus infectivity since, at present, we are unable to rationally construct effective vaccines against new agents like the human immuno deficiency viruses or to improve existing vaccines. The intention of this volume is to comprehensively review neutralization and where possible to construct a unifying theory which can be tested by experimentation.