Immunohistochemical Expression Of Dnajb9 In Igg4 Related Disease

Author : Emily Stuchfield-Denby
Publisher : Unknown
Page : 0 pages
File Size : 49,8 Mb
Release : 2022
Category : Electronic
ISBN : OCLC:1417601568

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Immunohistochemical Expression of DNAJB9 in IgG4-related Disease by Emily Stuchfield-Denby Pdf

Introduction. Immunoglobulin G4-related disease (IgG4-RD) is a rare immune-mediated condition with expansion of plasmablasts/plasma cells and possible upregulation of DNAJB9. DNAJB9 (a co-chaperone protein that governs the integrity and functions of cells) was described as a specific marker for fibrillary glomerulonephritis, a rare proliferative form of glomerulonephritis displaying histological similarities with IgG4-related kidney disease. DNAJB9 may be a putative autoantigen. We aimed to study the immunohistochemical expression of DNAJB9 in IgG4-RD to explore its role in disease pathophysiology. Methods. We selected patients with definite IgG4-RD (RCD, ACR/EULAR or ICDC classification criteria), non-auto-immune (NAI) controls and Sjögren's syndrome controls, and produced tissue slides for anti-DNAJB9 immunohistochemistry on which we performed double reading and applied our intensity scoring system ranging from 0 to 4. Our positive control was a renal sample suggestive of fibrillary glomerulonephritis. Results. We studied the tissue slides of 9 IgG4-RD patients and 15 NAI controls (including salivary gland, pancreatic, pulmonary, pleural, and retroperitoneal fibrotic tissue). Median intensity for endothelial cells was 0 in IgG4-RD and 2 in NAI controls (p

Author : Takao Saito,John H. Stone,Hitoshi Nakashima,Takako Saeki,Mitsuhiro Kawano
Publisher : Springer
Page : 298 pages
File Size : 42,7 Mb
Release : 2016-11-09
Category : Medical
ISBN : 9784431556879

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IgG4-Related Kidney Disease by Takao Saito,John H. Stone,Hitoshi Nakashima,Takako Saeki,Mitsuhiro Kawano Pdf

This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.

Author : Alexander J. Howie
Publisher : Springer Nature
Page : 305 pages
File Size : 50,7 Mb
Release : 2020-05-06
Category : Medical
ISBN : 9783030409395

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Handbook of Renal Biopsy Pathology by Alexander J. Howie Pdf

This handbook provides a short, clear, useful and interesting guide to the findings in renal biopsy specimens. Essential information needed for an understanding of renal disorders is given simply and concisely. The focus is on common conditions. The book is intended to be of practical help primarily to pathologists and trainee pathologists who look at renal biopsy specimens, but also to others who have contact with anyone with renal disorders. The handbook includes more than 240 color illustrations. Other features include practical tips on the differentiation between possible diagnoses and information about eponyms.

Author : Morie A. Gertz,S. Vincent Rajkumar
Publisher : Springer Science & Business Media
Page : 243 pages
File Size : 48,5 Mb
Release : 2010-06-14
Category : Medical
ISBN : 9781607616313

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Amyloidosis by Morie A. Gertz,S. Vincent Rajkumar Pdf

An up-to-date reference on this fascinating set of complex disorders, this book features the most comprehensive strategies for diagnosing, classifying, imaging, treating, and managing amyloidosis in multiple organ systems. Beneficial to the spectrum of practitioners from residents to sub-specialists, this book is a succinct authoritative text written by leaders in the field. The authors provide instruction on all forms of amyloidosis - including primary amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With essential treatment algorithms, Amyloidosis: Diagnosis and Treatment is the gold-standard for all hematologists, oncologists, and internists caring for patients with this complex disease.

Author : Jong Hoon Park,Curie Ahn
Publisher : Springer
Page : 126 pages
File Size : 44,9 Mb
Release : 2016-10-12
Category : Medical
ISBN : 9789811020414

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Cystogenesis by Jong Hoon Park,Curie Ahn Pdf

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Author : Z.-H. Liui,J.C. He
Publisher : Karger Medical and Scientific Publishers
Page : 274 pages
File Size : 54,6 Mb
Release : 2014-05-16
Category : Science
ISBN : 9783318026511

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Podocytopathy by Z.-H. Liui,J.C. He Pdf

The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Author : Hikaru Koide,Toshihiko Hayashi
Publisher : Unknown
Page : 244 pages
File Size : 55,8 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015032524715

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Extracellular Matrix in the Kidney by Hikaru Koide,Toshihiko Hayashi Pdf

Author : Maria Rosaria Raspollini,Antonio Lopez-Beltran
Publisher : Springer
Page : 0 pages
File Size : 50,9 Mb
Release : 2020-05-21
Category : Medical
ISBN : 3030418936

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Uropathology by Maria Rosaria Raspollini,Antonio Lopez-Beltran Pdf

The book covers all relevant topics of uropathology (tumoral and non-tumoral), from the normal histology of the genitourinary tract to pathological findings of diseases in the male genital and urinary tract. To make the content more accessible, all content is arranged alphabetically and each entry is uniformly structured, presenting the epidemiology, the clinical signs, the gross and histological features, the immunohistochemical stainings, and the molecular data for each disease. Histological pictures clarify the microscopic findings and help readers understand the differential diagnosis for genitourinary tract diseases. In addition to internationally respected experts on pathologies of the prostate, bladder, kidney and testis, researchers coming from other disciplines such as molecular biologists, soft tissue pathologists, dermatopathologists, hematopathologists and gynaecopathologists have contributed to this book, thus making it interesting for uropathologists, but also for students, residents, clinicians (surgeons, radiotherapists, oncologists, urologists, dermatologists) and researchers who deal with disciplines that call for knowledge of the pathologies of the male genital and urinary tracts.

Author : Anna Sapino,Janina Kulka
Publisher : Springer
Page : 0 pages
File Size : 54,6 Mb
Release : 2019-10-21
Category : Medical
ISBN : 3319625381

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Breast Pathology by Anna Sapino,Janina Kulka Pdf

This book covers the complete field of breast pathology - from Acinic cell carcinoma to Usual Epithelial Hyperplasia. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Author : Haijun Zhou,Charles C. Guo,Jae Y. Ro
Publisher : Springer Nature
Page : 258 pages
File Size : 48,6 Mb
Release : 2021-04-30
Category : Medical
ISBN : 9783030715090

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Urinary Bladder Pathology by Haijun Zhou,Charles C. Guo,Jae Y. Ro Pdf

This book focuses on bladder cancer pathology, including primary bladder malignancies and other tumor varieties, with an emphasis on diagnostic pitfalls and clinical relevance. It also describes normal bladder histology, benign abnormalities with cancer mimickers, and cancer carcinogenesis, which are important subject matter for understanding bladder cancers, correct diagnosis, and differential diagnoses. Accurate diagnosis of bladder cancer plays a central role in daily pathology practice, clinical management, and prognosis. Advances in immunohistochemistry and molecular pathology have enhanced the accuracy of cancer pathology diagnoses. In addition to covering the anatomic and histologic features of bladder tumors, this book also reviews recent molecular and immunohistochemical advances in these areas. Recently updated clinical management information is also presented in this book. Written by experts in the field, Urinary Bladder Pathology serves as a useful resource for practicing pathologists, pathology trainees, and other health professionals who treat patients with bladder cancers.

Author : Stuart J. Schnitt,Laura C. Collins
Publisher : Lippincott Williams & Wilkins
Page : 569 pages
File Size : 44,9 Mb
Release : 2012-10-08
Category : Medical
ISBN : 9781451178159

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Biopsy Interpretation of the Breast by Stuart J. Schnitt,Laura C. Collins Pdf

A practical guide for the diagnostic surgical pathologist, this new edition of Biopsy Interpretation of the Breast presents the diverse spectrum of pathologic alterations that occur in the breast in a manner analogous to that in which they are encountered in daily practice. Lesions are grouped together according to their histologic patterns rather than by the traditional benign-malignant categorization in order to simulate the way pathologists face these lesions as they examine microscopic slides on a daily basis. The role of adjunctive studies in solving diagnostic problems in breast pathology is emphasized where appropriate. In addition, the clinical significance and impact on patient management of the various diagnoses are discussed and key clinical and management points highlighted.

Author : Sylvia L. Asa,Stefano La Rosa,Ozgur Mete
Publisher : Springer Nature
Page : 478 pages
File Size : 41,5 Mb
Release : 2020-10-19
Category : Medical
ISBN : 9783030543914

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The Spectrum of Neuroendocrine Neoplasia by Sylvia L. Asa,Stefano La Rosa,Ozgur Mete Pdf

Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions. The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.

Author : H. Gilbert Welch
Publisher : Univ of California Press
Page : 240 pages
File Size : 45,5 Mb
Release : 2006-03-06
Category : Medical
ISBN : 9780520248366

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Should I Be Tested for Cancer? by H. Gilbert Welch Pdf

In this thought-provoking volume, a physician and public health expert challenges the notion that detecting cancer early always saves lives.

Author : Jody E. Hooper,Alex K. Williamson
Publisher : Springer
Page : 198 pages
File Size : 53,8 Mb
Release : 2018-11-08
Category : Medical
ISBN : 9783319983738

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Autopsy in the 21st Century by Jody E. Hooper,Alex K. Williamson Pdf

Autopsy as a field is enjoying an unexpected renaissance as new and improved uses are found for postmortem examination in quality improvement, education, and research. Increased interest in the autopsy is evident in the popular press as well as in national and international physician meetings.This text will provide an overview of topics the authors consider crucial to competent and effective autopsy practice in the 21st century. Each chapter will combine relevant theoretical background with current and practical experience-based guidance so that pathologists and clinicians can better utilize the autopsy to provide optimal value to families, patients, hospitals, and health systems. Distinguished contributors will provide a review of the rich history of autopsy practice, including assessments of how the past both informs autopsy practice and impedes its progress. The autopsy will be placed in the context of larger healthcare systems with chapters on the use of autopsy in quality improvement and evaluating the value of autopsy as a professional activity, as well as new technology that affects practice models. Better and more reproducible methods for reporting autopsy findings will be explored to exploit the full potential of autopsy data for cross-institutional research. Two chapters will also provide the first book-level review of the growing field of autopsies performed on an urgent basis to sample both diseased and normal control tissue for research. These “rapid research autopsies” are especially crucial to cancer research and the growth of personalized medicine, and the book will explain the science behind utilization of autopsy tissue and offer a full template for designing and delivering a successful rapid autopsy program. Additionally, pathologist and clinician contributors will highlight current recommendations for special techniques and ancillary testing in postmortem examinations to serve the needs of today’s patient populations. As resident education is re-examined by pathology and education authorities, new competency-based training models will almost certainly come to the fore. A chapter will examine approaches to the future training of medical students, residents, and fellows in an environment of changing autopsy exposure. A final chapter will summarize the vision for the autopsy as a clinical outcome measure, and valuable scientific resource. This book will be a new type of volume in the field of autopsy pathology. It differs from the presently available review references and atlases in that it provides guidance for readers to embrace transformations that are already taking place in the field. There currently is no resource that offers comprehensive guidance for modern autopsy practice and looks forward to what the field might become in the future.

Author : Ben Z. Pilch
Publisher : Lippincott Williams & Wilkins
Page : 730 pages
File Size : 47,6 Mb
Release : 2001
Category : Medical
ISBN : 0397517270

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Head and Neck Surgical Pathology by Ben Z. Pilch Pdf

Written by more than 20 acknowledged experts, this volume is the most comprehensive and authoritative reference on diagnostic surgical pathology of the head and neck. The book describes in detail the vast array of lesions and disease entities that can occur in the head and neck and presents practical approaches to establishing a diagnosis. More than 1,100 illustrations--including 535 in full color--depict the full range of pathologic findings.The contributors discuss the most useful aids to differential diagnosis, including clinical information and data from ancillary studies such as immunohistochemistry. A chapter on diagnostic fine needle aspiration cytopathology is also included.