Immunological And Molecular Diagnosis Of Infectious Disease
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Immunological and Molecular Diagnosis of Infectious Disease by Carel J. van Oss Pdf
Written by world-renowned experts, this book addresses immunological and molecular methodologies of diagnosis as well as clinical aspects of diseases. It book discusses DNA and RNA amplification methods, explains ELISA approaches, and introduces rapid diagnosis techniques, biosensors, and flow cytometry. The book examines bacterial and parasitic in
Molecular Diagnosis of Infectious Diseases by Jochen Decker,Udo Reischl Pdf
In this second edition of a much-acclaimed classic laboratory manual, Molecular Diagnosis of Infectious Diseases, leading experts from academia and industry describe cutting-edge methods for the protein-based diagnosis of infectious diseases. Explaining the latest developments in genomics, proteomics, bioinformatics, biosensors, high-throughput devices, and recombinant technology, the authors demonstrate the power of these new methodologies in both established and novel procedures by applying them successfully to the identification and characterization of valuable diagnostic markers, immunomodulatory components, epitope mapping, the production and purification of recombinant antigens, and their use in diagnostic reagents in immunological assays. Basic problems of serological laboratory diagnostics and the use of immunoproteomics for discovering target proteins are also addressed. Each readily reproducible protocol is described in step-by-step detail and includes a background introduction, equipment and reagent lists, tips on troubleshooting and avoiding known pitfalls, and extensive references. Comprehensive and up-to-date, Molecular Diagnosis of Infectious Diseases, Second Edition offers novice investigators an easy entry into the field and experienced researchers a broad array of time saving tools that will not only elucidate new principles, but also greatly facilitate the development and successful application of rapid diagnostic methods.
Immunological Methods in Microbiology by Anonim Pdf
Immunological Methods in Microbiology, Volume 47 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on Immunological Techniques in the Clinical laboratory, Immunologic Diagnosis of HIV and Opportunistic Infections, Combining Antigen Detection and Serology for the Diagnosis of Selected Infectious Diseases, Immunologic Detection of Lyme Disease and Related Borrelioses, Immunodetection of Bacteria Causing Brucellosis, Immunological Diagnostic Techniques Used to Identify and Type Pasteurella, Immunological Tests for Diarrhea caused by Diarrheagenic Escherichia coli Targeting Their Main Virulence Factors, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Microbiology series Includes the latest information on Immunological Methods in Microbiology
Consultations in Infectious Disease by Daniel Caplivski,W. Michael Scheld Pdf
Infectious diseases have plagued man throughout history. In the era of modern medicine antibiotics and vaccines brought the hope of liberation from the great scourges of smallpox, polio, and tuberculosis. Yet, in the ensuing decades as we hoped to close the book on infectious diseases, we have instead been confronted by wave upon wave of new assailants. AIDS, SARS, pandemic influenza, and multi-drug resistant bacteria demonstrated how our technological advances have either fallen short in halting or even enhanced the spread of emerging pathogens. International air travel has collapsed geographic boundaries that once confined tropical infections to distant latitudes. Novel forms of immunosuppression, advances in organ transplantation, and victories in the cancer wars have led to an ever-expanding population at risk for opportunistic infections. In this collection of illustrated cases we give a cross-sectional view of the growing challenges that face the infectious diseases consultant. The modern physician is empowered by high resolution imaging and molecular diagnostic techniques that confer diagnostic capabilities Osler could have only dreamed of. Nevertheless we continue to grapple with the timeless struggles illuminated by Pasteur, Koch, and Fleming between man and the microscopic organisms of the world. Part of the new Oxford American Infectious Disease Library series, this book of illustrative cases will appeal to anyone working in a busy infectious diseases consultation service or practice including students, residents, fellows, faculty and other ID practitioners. Featuring numerous high-quality images and illustrations guiding diagnosis and case discussion, the handbook is meant to serve as a highly practical guide covering current approaches and new developments in the diagnosis, treatment, and management of a cross section of infectious diseases, including community-acquired and healthcare-associated infections.
Diagnostic Pathology of Infectious Disease E-Book by Richard L. Kradin Pdf
Diagnostic Pathology of Infectious Disease presents a comprehensive, organ-based approach to the effective and accurate diagnosis of infectious diseases. Dr. Richard L. Kradin covers the latest information on H1N1, as well as the use of immunohistochemical stains, PCR, Immunoperoxidase, and other molecular techniques for a current representation of the field. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion so you can quickly identify and diagnose whatever you see. This reference is an invaluable tool for the accurate diagnosis of any infectious disease—from the common to the most challenging. Covers the latest techniques in immunohistochemistry and molecular genetics integrated throughout the text for comprehensive information on all investigative contexts relevant to ensuring diagnostic accuracy. Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. Provides a complete visual guide to suspect lesions through superb, high-quality, full-color illustrations of key aspects of various diseases that facilitate the rapid identification of biopsy specimen. Presents contents organized by organ as opposed to pathogen to more effectively address diagnostic and management issues. Features tables that list differential diagnosis for each lesion for quick summaries of key points in problem areas. Highlights morphological characteristics and landmarks of tissue samples throughout the text for easy access to information necessary for signing out specimen. Focuses on clinicopathologic features and correlations so you can deal with the diagnostic problems you face every day.
Barbara Detrick,Robert G. Hamilton,John L. Schmitz
Author : Barbara Detrick,Robert G. Hamilton,John L. Schmitz Publisher : John Wiley & Sons Page : 1240 pages File Size : 51,6 Mb Release : 2020-07-16 Category : Medical ISBN : 9781555818722
Manual of Molecular and Clinical Laboratory Immunology by Barbara Detrick,Robert G. Hamilton,John L. Schmitz Pdf
THE authoritative guide for clinical laboratory immunology For over 40 years the Manual of Molecular and Clinical Laboratory Immunology has served as the premier guide for the clinical immunology laboratory. From basic serology testing to the present wide range of molecular analyses, the Manual has reflected the exponential growth in the field of immunology over the past decades. This eighth edition reflects the latest advances and developments in the diagnosis and treatment of patients with infectious and immune-mediated disorders. The Manual features detailed descriptions of general and specific methodologies, placing special focus on the interpretation of laboratory findings, and covers the immunology of infectious diseases, including specific pathogens, as well as the full range of autoimmune and immunodeficiency diseases, cancer, and transplantation. Written to guide the laboratory director, the Manual will also appeal to other laboratory scientists, especially those working in clinical immunology laboratories, and pathologists. It is also a useful reference for physicians, mid-level providers, medical students, and allied health students with an interest in the role that immunology plays in the clinical laboratory.
Application and Integration of Omics-powered Diagnostics in Clinical and Public Health Microbiology by Jacob Moran-Gilad,Yael Yagel Pdf
Various “omics” methods have recently revolutionized molecular diagnostics. Next-generation sequencing (NGS) makes it possible to sequence a human genome in just one day. Whole genome sequencing (WGS) greatly improves the ability to investigate the outbreaks of numerous pathogens. Metagenomics helps to analyze the microbiome, which aids greatly in identifying the pathogenesis of infectious diseases. Proteomic-based methods, namely matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF-MS), have a promising role in identifying myctobacteria and fungi, and predicting antimicrobial resistance. While there are numerous scientific publications on “omics” applications for microbiology, there are relatively few books that review this topic from a clinical diagnostics perspective. This book looks at this field from a holistic viewpoint, instead of limiting by type of “omics” technology, in order to cover the body of knowledge needed for practitioners and academics interested in clinical and public health microbiology. Additionally, it addresses the management, economical, regulatory and operational aspects of integrating these technologies into routine diagnostics.
Molecular Infection Biology by Jörg Hinrich Hacker,Jürgen Heesemann Pdf
This comprehensive volume focuses on molecular methods and principles of prokaryotic and eukaryotic pathogens. The authors present the molecular and cellular aspects by focusing on the interactions between pathogenic microorganisms and their hosts. The publication begins with an overview of the most important and dangerous causative agents of infectious diseases. Next are discussions of how microbial "weapons," pathogenicity factors, protein secretion machines, and surface variation systems work, presenting the molecular and genetic methods that are used by scientists for their discovery and analysis. Furthermore, infectious diseases are discussed in light of the newly formed research areas of evolutionary and cellular microbiology and genomics. Future aspects on diagnostic techniques, therapy, and vaccine development are also presented.
Diagnostic Pathology: Infectious Diseases E-Book by Danny A Milner Pdf
Diagnostic Pathology: Infectious Diseases takes a comprehensive look at infectious diseases, their anatomic manifestations, and how to ensure a complete and accurate sign out at the microscope. A user-friendly chapter landscape and thousands of high-quality images combine to make this medical reference book a key companion for the general surgical pathologist or resident in training. Comprehensive discussions on how to sign out cases. Formatted into sections by organism type (Virus, Bacteria, Fungi, and Parasite), and further divided by those that can be diagnosed on histological appearance. Species-specific pathologies for finding "zebra" cases. Essential information is listed in a bulleted format with numerous high-quality images to facilitate learning. "Key Facts" highlight the quick criteria needed for diagnosis or adequacy evaluation at the time of a procedure. Features clear pictures of diagnostic forms, ancillary diagnostic tools, including microbiology and molecular diagnostics, pathological reaction patterns expected for given organisms, and important common and uncommon pathogens. Explains when and when not to use molecular diagnostics, and discusses histological limitations and how to address them at sign out.
Clinical Laboratory Immunology by Connie R. Mahon,Diane G. Tice Pdf
This unique resource is the first covering molecular diagnostic technology that is specifically geared to the needs of those in clinical laboratory sciene or medical technology. This book covers molecular diagnostic technology and the multidisciplinary clinical applications of this technology. Topics include: immunology; infectious and autoimmune diseases; clinical applications of the flow of cytometry; organ transplantation; molecular methods and more. Clinical Laboratory Science / Medical Technology students.
Basic and Applied Aspects of Biotechnology by Varsha Gupta,Manjistha Sengupta,Jaya Prakash,Baishnab Charan Tripathy Pdf
This book explores the journey of biotechnology, searching for new avenues and noting the impressive accomplishments to date. It has harmonious blend of facts, applications and new ideas. Fast-paced biotechnologies are broadly applied and are being continuously explored in areas like the environmental, industrial, agricultural and medical sciences. The sequencing of the human genome has opened new therapeutic opportunities and enriched the field of medical biotechnology while analysis of biomolecules using proteomics and microarray technologies along with the simultaneous discovery and development of new modes of detection are paving the way for ever-faster and more reliable diagnostic methods. Life-saving bio-pharmaceuticals are being churned out at an amazing rate, and the unraveling of biological processes has facilitated drug designing and discovery processes. Advances in regenerative medical technologies (stem cell therapy, tissue engineering, and gene therapy) look extremely promising, transcending the limitations of all existing fields and opening new dimensions for characterizing and combating diseases.
Microbiology and Molecular Diagnosis in Pathology by Audrey Wanger,Violeta Chavez,Richard Huang,Amer Wahed,Amitava Dasgupta,Jeffrey K. Actor Pdf
Microbiology and Molecular Diagnosis in Pathology: A Comprehensive Review for Board Preparation, Certification and Clinical Practice reviews all aspects of microbiology and molecular diagnostics essential to successfully passing the American Board of Pathology exam. This review book will also serve as a first resource for residents who want to become familiar with the diagnostic aspects of microbiology and molecular methods, as well as a refresher course for practicing pathologists. Opening chapters discuss issues of laboratory management, including quality control, biosafety, regulations, and proper handling and reporting of laboratory specimens. Review chapters give a quick overview of specific clinical infections as well as different types of bacteria, viruses, fungal infections, and infections caused by parasites. Following these, coverage focuses on diagnostic tools and specific tests: media for clinical microbiology, specific stains and tests for microbial identifications, susceptibility testing and use of antimicrobial agents, tests for detecting antibodies, antigens, and microbial infections. Two final chapters offer overviews on molecular diagnostics principles and methods as well as the application of molecular diagnostics in clinical practice. Takes a practical and easy-to-read approach to understanding microbiology at an appropriate level for both board preparation as well as a professional refresher course Covers all important clinical information found in larger textbooks in a more succinct and easy-to-understand manner Covers essential concepts in microbiology in such a way that residents, fellows, and clinicians understand the methods and tests without having to become specialists in the field Offers a quick overview of specific clinical infections as well as different types of bacteria, viruses, fungal infections, and infections caused by parasites
Author : Steven A. Frank Publisher : Princeton University Press Page : 364 pages File Size : 55,5 Mb Release : 2002-07-21 Category : Medical ISBN : 0691095957
Case Studies in Infectious Disease by Peter Lydyard,Michael Cole,John Holton,Will Irving,Nino Porakishvili,Pradhib Venkatesan,Kate Ward Pdf
Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the differential diagnosis? How is the infection managed, and what preventative measures can be taken to avoid infection? This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms, fully integrating microbiology and immunology throughout.
Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats Publisher : National Academies Press Page : 284 pages File Size : 48,6 Mb Release : 2007-11-11 Category : Medical ISBN : 9780309111140
Global Infectious Disease Surveillance and Detection by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf
Early detection is essential to the control of emerging, reemerging, and novel infectious diseases, whether naturally occurring or intentionally introduced. Containing the spread of such diseases in a profoundly interconnected world requires active vigilance for signs of an outbreak, rapid recognition of its presence, and diagnosis of its microbial cause, in addition to strategies and resources for an appropriate and efficient response. Although these actions are often viewed in terms of human public health, they also challenge the plant and animal health communities. Surveillance, defined as "the continual scrutiny of all aspects of occurrence and spread of a disease that are pertinent to effective control", involves the "systematic collection, analysis, interpretation, and dissemination of health data." Disease detection and diagnosis is the act of discovering a novel, emerging, or reemerging disease or disease event and identifying its cause. Diagnosis is "the cornerstone of effective disease control and prevention efforts, including surveillance." Disease surveillance and detection relies heavily on the astute individual: the clinician, veterinarian, plant pathologist, farmer, livestock manager, or agricultural extension agent who notices something unusual, atypical, or suspicious and brings this discovery in a timely way to the attention of an appropriate representative of human public health, veterinary medicine, or agriculture. Most developed countries have the ability to detect and diagnose human, animal, and plant diseases. Global Infectious Disease Surveillance and Detection: Assessing the Challenges-Finding Solutions, Workshop Summary is part of a 10 book series and summarizes the recommendations and presentations of the workshop.
