Immunopathogenesis Of Hiv Infection

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Immunopathogenesis of HIV Infection

Author : Anthony S. Fauci,Guiseppe Pantaleo
Publisher : Springer Science & Business Media
Page : 159 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642608674

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Immunopathogenesis of HIV Infection by Anthony S. Fauci,Guiseppe Pantaleo Pdf

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.

HIV and the Pathogenesis of AIDS

Author : Jay A. Levy
Publisher : Wiley-Blackwell
Page : 628 pages
File Size : 49,5 Mb
Release : 1998
Category : Medical
ISBN : UOM:39015040142302

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HIV and the Pathogenesis of AIDS by Jay A. Levy Pdf

The second edition of HIV and the Pathogenesis of AIDS updates this important, well–annotated text on HIV pathogenesis. with valuable insights and written with clarity and succinctness, the history and background of human immunodeficiency virus (HIV) and the steps involved in its infection of cells and the development of AIDS are discussed. Aspects of HIV epidemiology and transmission and the HIV–associated cancers that are prominent in infection are also covered. Regarding treatment, Dr Levy discusses the most recent approaches for antiviral therapy that have shown promise in controling infection and presents the challenges faced in developing a vaccine for blocking the transmission of this deadly virus. This book, which was extremely well–received by the scientific community in its initial volume four years ago, provides the most current information on HIV and AIDS and captures the spirit of this virologic and immunologic disease. It defines the future directions that must be taken to find a solution to this devastating illness.

Immunology of HIV Infection

Author : Sudhir Gupta
Publisher : Springer Science & Business Media
Page : 618 pages
File Size : 47,5 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489901910

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Immunology of HIV Infection by Sudhir Gupta Pdf

Leading experts provide the only comprehensive book examining all aspects of immune response and immune-based treatments for HIV infection. Contributions, divided into three sections, discuss basic mechanisms, immunopathogenesis of HIV infection, and immune-based therapies. Researchers thoroughly review vaccine-including prospects of T cell vaccine-and gene therapy for HIV infection. Additional topics include organization of HIV genes, the role of co-receptors in signaling of lymphocytes, and biological response modifiers. This reference is designed for basic and clinical researchers, internists, pediatricians, infectious disease specialists, neuropathologists, oncologists, and rheumatologists.

AIDS Pathogenesis

Author : H. Schuitemaker,Frank Miedema
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 53,9 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9789401706858

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AIDS Pathogenesis by H. Schuitemaker,Frank Miedema Pdf

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Cell Activation and Apoptosis in HIV Infection

Author : Jean-Marie Andrieu,Wei Lu
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461519959

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Cell Activation and Apoptosis in HIV Infection by Jean-Marie Andrieu,Wei Lu Pdf

In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune cell-targeted therapeutic interventions.

The Biology of Dendritic Cells and HIV Infection

Author : Sandra Gessani,Filippo Belardelli
Publisher : Springer Science & Business Media
Page : 562 pages
File Size : 49,6 Mb
Release : 2007-03-09
Category : Science
ISBN : 9780387337852

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The Biology of Dendritic Cells and HIV Infection by Sandra Gessani,Filippo Belardelli Pdf

Dendritic cells play the most vital part in inducing anti-viral immune responses in HIV and AIDS among many other viruses. Research on dendritic cells (DCs) is emerging as a fundamental aspect for the comprehension of the mechanisms underlying the pathogenesis of viral diseases. This volume focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It is the only comprehensive volume on pathogenesis and immunity of Dendritic Cells that also focuses on HIV.

HIV Infection in Children and Adolescents

Author : Raziya Bobat
Publisher : Springer Nature
Page : 322 pages
File Size : 42,6 Mb
Release : 2020-02-27
Category : Medical
ISBN : 9783030354336

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HIV Infection in Children and Adolescents by Raziya Bobat Pdf

This book serves as a reference work on pediatric HIV infection and covers the full bandwidth of topics from an introduction to pathogenesis and epidemiology, over the transmission of the HI virus, to clinical manifestations, treatment, and prevention strategies. Diseases and disorders occurring in HIV infected persons are discussed in detail. The book covers special populations, such as neonates born to an HIV positive mother and adolescents and examines the specific ways of managing HIV disease in these patient groups. This is the first book to cover palliative care as well as ethical, legal and social issues of HIV infection.

HIV and AIDS

Author : K.E. Nye,J.M. Parkin
Publisher : Garland Science
Page : 188 pages
File Size : 43,7 Mb
Release : 2004-03-01
Category : Science
ISBN : 9781135319076

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HIV and AIDS by K.E. Nye,J.M. Parkin Pdf

A comprehensive account of HIV and AIDS, the management of the disease and potential vaccines. This book is essential reading for medical students and clinicians, and of major interest to students and researchers in the life sciences.

HIV and the New Viruses

Author : Angus G. Dalgleish,Robin A. Weiss
Publisher : Academic Press
Page : 620 pages
File Size : 52,9 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015043779092

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HIV and the New Viruses by Angus G. Dalgleish,Robin A. Weiss Pdf

HIV and the New Viruses presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time. These cover recently discovered viruses such as HHV-6, HHV-8 and HCV, as well as the latest research on HIV. This comprehensive and updated reference includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses and management of conditions associated with those viruses. Information on new pharmaceuticals and vaccine developments is also included. Edited by the leading experts in the field, HIV and the New Viruses will be essential reading for postgraduates, clinicians and researchers in virology, immunology, cancer, molecular biology and the pharmaceutical industry. Presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time Includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses, and management of conditions associated with those viruses

In vivo Models of HIV Disease and Control

Author : Herman Friedman,Steven Specter,Mauro Bendinelli
Publisher : Springer Science & Business Media
Page : 445 pages
File Size : 49,9 Mb
Release : 2007-04-27
Category : Medical
ISBN : 9780387257419

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In vivo Models of HIV Disease and Control by Herman Friedman,Steven Specter,Mauro Bendinelli Pdf

An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.

Current Perspectives in HIV Infection

Author : Shailendra K. Saxena
Publisher : BoD – Books on Demand
Page : 484 pages
File Size : 51,6 Mb
Release : 2013-04-10
Category : Medical
ISBN : 9789535110576

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Current Perspectives in HIV Infection by Shailendra K. Saxena Pdf

This book gives a comprehensive overview of HIV and AIDS including NeuroAIDS, as well as general concepts of pathology, immunity and immunopathology, diagnosis, treatment, epidemiology and etiology to current clinical recommendations in management of HIV/AIDS including NeuroAIDS, highlighting the ongoing issues, recent advances and future directions in diagnostic approaches and therapeutic strategies.

Human Retroviruses

Author : Bryan Cullen
Publisher : Oxford University Press
Page : 220 pages
File Size : 54,5 Mb
Release : 1993
Category : Gene Expression Regulation.
ISBN : 0199633827

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Human Retroviruses by Bryan Cullen Pdf

The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.

HIV and Dementia

Author : Michael B.A. Oldstone,Ljubisa Vitkovic
Publisher : Springer Science & Business Media
Page : 285 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642796579

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HIV and Dementia by Michael B.A. Oldstone,Ljubisa Vitkovic Pdf

The National Institute of Mental Health (NIMH) AIDS Program is the fourth largest acquired immune deficiency syndrome (AIDS) program within the National Institutes of Health (NIH). Since 1983, our program's contributions have concentrated on two major areas. The first has been to develop effective strategies to prevent or reduce behaviors that place individuals at risk for human immunodeficiency virus type 1 (HIV-1) infection. The second has been to support and foster research to enhance our understanding of the profound impact of H IV-1 infection on the central nervous system (eNS). The brain appears to be a prime target of the virus and may serve as a reservoir for the virus. Post mortem examination of brain tissue has provided evidence of eNS cell damage in 80%-90% of people who die with AIDS. For about 10%-20% of people with AI DS, mild neuropsychological symptoms are the first signs of the disease. Approximately 20% of individuals infected with HIV-1 develop AIDS dementia complex. The symptoms include apathy, difficulty concentrat ing, irritability, depression, and personality changes. In the later stages of the disease, people may experience psychiatric disor ders. Death usually occurs within 6 months of the appearance of those more severe symptoms. Up to 90% of children infected with H IV-1 experience attention and concentration difficulties and often experience neurodevelopmental delay or regression over time.

New Concepts in AIDS Pathogenesis

Author : Luc Montagnier,Marie-Lise Gougeon
Publisher : CRC Press
Page : 344 pages
File Size : 50,7 Mb
Release : 1993-08-02
Category : Medical
ISBN : 0824791274

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New Concepts in AIDS Pathogenesis by Luc Montagnier,Marie-Lise Gougeon Pdf

This resource offers comprehensive explanations of current theories on the pathogenesis of AIDS, examining in detail current data on the role that HIV and its possible cofactors play in the decline of immune system function and the progressive depletion of T lymphocytes. Information is provided on mycoplasmas - a potentially critical component in virus replication and immune activation.;Revealing research studies in support of the theoretical approaches presented, this volume: updates the mechanisms of HIV latency and activation of expression at both the viral and cellular levels in the human and primate systems; emphasizes the role of cytokines in the dysfunction of the immune and central nervous systems; describes the mechanisms of immune activation that result in anergy and programmed cell death involving the viral external glycoprotein and possible other foreign antigens or superantigens; and explicates original hypotheses on pathogenesis where virus glycoproteins may mimic allogenic stimulation and disturb the immune system network.;This reference is intended for immunologists, infectious disease specialists, microbiologists, virologists, molecular and cell biologists, parasitologists and pathologists.

Host and Viral Factors Controlling HIV Pathogenesis

Author : Jason F. Kreisberg
Publisher : Unknown
Page : 278 pages
File Size : 48,6 Mb
Release : 2006
Category : Electronic
ISBN : UCAL:X85551

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Host and Viral Factors Controlling HIV Pathogenesis by Jason F. Kreisberg Pdf

HIV pathogenesis also critically depends on Nef. Prior studies suggested that Nef activates target cells and thereby provides an improved microenvironment for viral replication and spread. Although HIV-infected cells exhibit increased activation, this phenotype proved independent of Nef expression.