Implementation Of Continuous Flow Manufacturing In United States Industries

Author : Wade H. Shafer
Publisher : Springer Science & Business Media
Page : 427 pages
File Size : 46,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461303930

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Masters Theses in the Pure and Applied Sciences by Wade H. Shafer Pdf

Masters Theses in the Pure and Applied Sciences was first conceived, published, and disseminated by the Center for Information and Numerical Data Analysis and Synthesis (CINDAS)* at Purdue University in 1957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dis semination phases of the activity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we had concluded that it was in the interest of all concerned if the printing and distribution of the volumes were handled by an international publishing house to assure improved service and broader dissemination. Hence, starting with Volume 18, Masters Theses in the Pure and Applied Sciences has been disseminated on a worldwide basis by Plenum Publishing Corporation of New York, and in the same year the coverage was broadened to include Canadian universities. All back issues can also be ordered from Plenum. We have reported in Volume 39 (thesis year 1994) a total of 13,953 thesis titles from 21 Canadian and 159 United States universities. We are sure that this broader base for these titles reported will greatly enhance the value of this impor tant annual reference work. While Volume 39 reports theses submitted in 1994, on occasion, certain uni versities do report theses submitted in previous years but not reported at the time.

Author : Mike Rother,Rick Harris
Publisher : Lean Enterprise Institute
Page : 117 pages
File Size : 48,5 Mb
Release : 2001-12
Category : Business & Economics
ISBN : 9780966784336

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Creating Continuous Flow by Mike Rother,Rick Harris Pdf

This workbook explains in simple, step-by-step terms how to introduce and sustain lean flows of material and information in pacemaker cells and lines, a prerequisite for achieving a lean value stream.A sight we frequently encounter when touring plants is the relocation of processing steps from departments (process villages) to product-family work cells, but too often these "cells" produce only intermittent and erratic flow. Output gyrates from hour to hour and small piles of inventory accumulate between each operation so that few of the benefits of cellularization are actually being realized; and, if the cell is located upstream from the pacemaker process, none of the benefits may ever reach the customer.This sequel to Learning to See (which focused on plant level operations) provides simple step-by-step instructions for eliminating waste and creating continuous flow at the process level. This isn't a workbook you will read once then relegate to the bookshelf. It's an action guide for managers, engineers, and production associates that you will use to improve flow each and every day.Creating Continuous Flow takes you to the next level in work cell design where you'll achieve even greater cost and lead time savings. You'll learn: where to focus your continuous flow efforts, how to create much more efficient work cells and lines, how to operate a pacemaker process so that a lean value stream is possible, how to sustain the gains, and keep improving.Creating Continuous Flow is the next logical step after Learning to See. The value-stream mapping process defined the pacemaker process and the overall flow of products and information in the plant. The next step is to shift your focus from the plant to the process level by zeroing in on the pacemaker process, which sets the production rhythm for the plant or value stream, and apply the principles of continuous flow.Every production facility has at least one pacemaker process. The pacemaker processes is usually where products take their final form before going to external customers. It’s called the pacemaker because how you operate here determines both how well you can serve the customer and what the demand pattern is like for your upstream supplying processes.How the pacemaker process operates is critically important. A steady and consistently flowing pacemaker places steady and consistent demands on the rest of the value stream. The continuous flow processing that results allows companies to create leaner value streams.[Source : 4e de couv.]

Author : Pierre C. Guerindon
Publisher : CRC Press
Page : 304 pages
File Size : 50,6 Mb
Release : 1995-08-08
Category : Technology & Engineering
ISBN : 0585400253

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Continuous Flow Manufacturing by Pierre C. Guerindon Pdf

This work presents the fundamental principles of continuous flow manufacturing, furnishing a corporate strategy and set of operating rules that help create an environment where continuous flow manufacturing can flourish. A 10-step methodology for converting a traditional factory to a continuous flow operation is provided, and conventional manufacturing techniques are compared with the continuous flow approach.

Author : Anonim
Publisher : DIANE Publishing
Page : 197 pages
File Size : 47,7 Mb
Release : 2001
Category : Aircraft industry
ISBN : 9781457822636

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Competitive Assessment of the U.S. Large Civil Aircraft Aerostructures Industry by Anonim Pdf

"This study was requested by the House Committee on Ways and Means in a letter dated March 8, 2000. The Committee requested that the U.S. International Trade Commission (the Commission) examine the ability of the U.S. civil aerostructures industry to compete over the short and long terms with those industries in Europe, Canada, and to the extent possible, Asia. The Commission's report examines the composition and recent trends of the large civil aircraft (LCA) aerostructures industry; the process of new aerostructures development; the means and trends of government support for research and development; and the relative strengths and weaknesses of the aerostructures industries in these countries and regions, for the period 1995-99 and to the extent possible, 2000"--Publisher description

Author : Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publisher : John Wiley & Sons
Page : 632 pages
File Size : 55,6 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781119001331

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Continuous Manufacturing of Pharmaceuticals by Peter Kleinebudde,Johannes Khinast,Jukka Rantanen Pdf

A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Author : Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publisher : John Wiley & Sons
Page : 632 pages
File Size : 48,7 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781119001355

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Continuous Manufacturing of Pharmaceuticals by Peter Kleinebudde,Johannes Khinast,Jukka Rantanen Pdf

A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Author : United States. Congress. House. Committee on Public Works and Transportation. Subcommittee on Investigations and Review
Publisher : Unknown
Page : 898 pages
File Size : 53,7 Mb
Release : 1978
Category : Water
ISBN : STANFORD:36105119579147

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Implementation of the Federal Water Pollution Control Act (regulation and Monitoring of Toxic and Hazardous Chemicals) by United States. Congress. House. Committee on Public Works and Transportation. Subcommittee on Investigations and Review Pdf

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology
Publisher : National Academies Press
Page : 69 pages
File Size : 54,8 Mb
Release : 2019-04-05
Category : Medical
ISBN : 9780309487818

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Continuous Manufacturing for the Modernization of Pharmaceutical Production by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology Pdf

On July 30-31, 2018, the National Academies of Sciences, Engineering, and Medicine held a workshop titled Continuous Manufacturing for the Modernization of Pharmaceutical Production. This workshop discussed the business and regulatory concerns associated with adopting continuous manufacturing techniques to produce biologics such as enzymes, monoclonal antibodies, and vaccines. The participants also discussed specific challenges for integration across the manufacturing system, including upstream and downstream processes, analytical techniques, and drug product development. The workshop addressed these challenges broadly across the biologics domain but focused particularly on drug categories of greatest FDA and industrial interest such as monoclonal antibodies and vaccines. This publication summarizes the presentations and discussions from the workshop.

Author : Ravendra Singh,Zhihong Yuan
Publisher : Elsevier
Page : 698 pages
File Size : 48,9 Mb
Release : 2018-03-16
Category : Technology & Engineering
ISBN : 9780444639660

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Process Systems Engineering for Pharmaceutical Manufacturing by Ravendra Singh,Zhihong Yuan Pdf

Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing

Author : Ana Patricia Ferreira,Jose C. Menezes,Mike Tobyn
Publisher : Academic Press
Page : 464 pages
File Size : 41,5 Mb
Release : 2018-04-24
Category : Medical
ISBN : 9780128110669

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Multivariate Analysis in the Pharmaceutical Industry by Ana Patricia Ferreira,Jose C. Menezes,Mike Tobyn Pdf

Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators. Targets pharmaceutical industry practitioners and regulatory staff by addressing industry specific challenges Includes case studies from different pharmaceutical companies and across product lifecycle of to introduce readers to the breadth of applications Contains information on the current regulatory framework which will shape how multivariate analysis (MVA) is used in years to come

Author : Peter L. King
Publisher : CRC Press
Page : 373 pages
File Size : 47,7 Mb
Release : 2019-06-05
Category : Business & Economics
ISBN : 9780429681738

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Lean for the Process Industries by Peter L. King Pdf

Compared to its widespread implementation across almost all areas of production, Lean improvement efforts lag within the process industries. While many innovators have successfully applied Lean principles to these industries during the past three decades, most of those pioneering efforts were never recorded to guide the improvement efforts of others. Drawing on more than 40 years of application experience at one of the world’s largest chemical and materials manufacturers, coupled with 10 years in private practice, Peter King corrects this void by providing the first comprehensive resource written explicitly for change agents within the process industries. Focusing on areas where the improvement needs of the process industry differ from parts assembly manufacturing, Lean for the Process Industries: Dealing with Complexity, Second Edition: Covers each of the eight wastes commonly described in Lean literature, looking at how they manifest themselves in process operations. Explains how to adapt value stream mapping for process operations. Shows how to identify the root causes of bottlenecks, and how to manage them to optimize flow until they can be eliminated. Provides practical techniques to overcome the barriers which have prevented the application of Cellular Manufacturing to process operations. Discusses the role of business leadership in a Lean strategy, describing both enabling and counter-productive management behaviors Since the publication of the first edition of this book, Peter King has been busy consulting with food, beverage, gasoline additive, and nutraceutical companies -- these new experiences have broadened his perspectives on certain Lean processes and have given him a richer set of examples to discuss in this new edition. While Value Stream Mapping is a very powerful tool to understand flow, bottlenecks, and waste in an operation, the traditional format as presented in many other books does not describe all of the data required to fully understand process flow and its detractors. This new edition highlights the necessary additions with examples of why they are useful. Product wheel scheduling achieves production leveling in a far more comprehensive and effective way than traditional heijunka methods. This edition has a more thorough description of the wheel concept and design steps, and more examples from actual applications.

Author : David J. am Ende,Mary T. am Ende
Publisher : John Wiley & Sons
Page : 1172 pages
File Size : 41,9 Mb
Release : 2019-04-23
Category : Technology & Engineering
ISBN : 9781119285861

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Chemical Engineering in the Pharmaceutical Industry by David J. am Ende,Mary T. am Ende Pdf

A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying Presents updated and expanded example calculations Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industryf ocuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.

Author : Philipp Weißgraeber,Frieder Heieck,Clemens Ackermann
Publisher : Springer Nature
Page : 497 pages
File Size : 41,7 Mb
Release : 2021-06-01
Category : Technology & Engineering
ISBN : 9783662629628

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Advances in Automotive Production Technology – Theory and Application by Philipp Weißgraeber,Frieder Heieck,Clemens Ackermann Pdf

This volume of the series ARENA2036 compiles the outcomes of the first Stuttgart Conference on Automotive Production (SCAP2020). It contains peer-reviewed contributions from a theoretical as well as practical vantage point and is topically structured according to the following four sections: It discusses (I) Novel Approaches for Efficient Production and Assembly Planning, (II) Smart Production Systems and Data Services, (III) Advances in Manufacturing Processes and Materials, and (IV) New Concepts for Autonomous, Collaborative Intralogistics. Given the restrictive circumstances of 2020, the conference was held as a fully digital event divided into two parts. It opened with a pre-week, allowing everyone to peruse the scientific contributions at their own pace, followed by a two-day live event that enabled experts from the sciences and the industry to engage in various discussions. The conference has proven itself as an insightful forum that allowed for an expertly exchange regarding the pivotal Advances in Automotive Production and Technology.

Author : Michael D. Holloway,Chikezie Nwaoha
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 50,5 Mb
Release : 2013-01-07
Category : Technology & Engineering
ISBN : 9781118589090

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Dictionary of Industrial Terms by Michael D. Holloway,Chikezie Nwaoha Pdf

This is the most comprehensive dictionary of maintenance and reliability terms ever compiled, covering the process, manufacturing, and other related industries, every major area of engineering used in industry, and more. The over 15,000 entries are all alphabetically arranged and include special features to encourage usage and understanding. They are supplemented by hundreds of figures and tables that clearly demonstrate the principles & concepts behind important process control, instrumentation, reliability, machinery, asset management, lubrication, corrosion, and much much more. With contributions by leading researchers in the field: Zaki Yamani Bin Zakaria Department, Chemical Engineering, Faculty Universiti Teknologi Malaysia, Malaysia Prof. Jelenka B. Savkovic-Stevanovic, Chemical Engineering Dept, University of Belgrade, Serbia Jim Drago, PE, Garlock an EnPro Industries family of companies, USA Robert Perez, President of Pumpcalcs, USA Luiz Alberto Verri, Independent Consultatnt, Verri Veritatis Consultoria, Brasil Matt Tones, Garlock an EnPro Industries family of companies, USA Dr. Reza Javaherdashti, formerly with Qatar University, Doha-Qatar Prof. Semra Bilgic, Faculty of Sciences, Department of Physical Chemistry, Ankara University, Turkey Dr. Mazura Jusoh , Chemical Engineering Department, Universiti Teknologi Malaysia Jayesh Ramesh Tekchandaney, Unique Mixers and Furnaces Pvt. Ltd. Dr. Henry Tan, Senior Lecturer in Safety & Reliability Engineering, and Subsea Engineering, School of Engineering, University of Aberdeen Fiddoson Fiddo, School of Engineering, University of Aberdeen Prof. Roy Johnsen, NTNU, Norway Prof. N. Sitaram , Thermal Turbomachines Laboratory, Department of Mechanical Engineering, IIT Madras, Chennai India Ghazaleh Mohammadali, IranOilGas Network Members' Services Greg Livelli, ABB Instrumentation, Warminster, Pennsylvania, USA Gas Processors Suppliers Association (GPSA)

Author : Modrák, Vladimír
Publisher : IGI Global
Page : 487 pages
File Size : 46,9 Mb
Release : 2014-01-31
Category : Technology & Engineering
ISBN : 9781466650404

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Handbook of Research on Design and Management of Lean Production Systems by Modrák, Vladimír Pdf

"This book explores the recent advancements in the areas of lean production, management, and the system and layout design for manufacturing environments, capturing the building blocks of lean transformation on a shop floor level"--