Continuous Flow Manufacturing

Continuous Flow Manufacturing Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Continuous Flow Manufacturing book. This book definitely worth reading, it is an incredibly well-written.

Creating Continuous Flow

Author : Mike Rother,Rick Harris
Publisher : Lean Enterprise Institute
Page : 117 pages
File Size : 49,8 Mb
Release : 2001-12
Category : Business & Economics
ISBN : 9780966784336

Get Book

Creating Continuous Flow by Mike Rother,Rick Harris Pdf

This workbook explains in simple, step-by-step terms how to introduce and sustain lean flows of material and information in pacemaker cells and lines, a prerequisite for achieving a lean value stream.A sight we frequently encounter when touring plants is the relocation of processing steps from departments (process villages) to product-family work cells, but too often these "cells" produce only intermittent and erratic flow. Output gyrates from hour to hour and small piles of inventory accumulate between each operation so that few of the benefits of cellularization are actually being realized; and, if the cell is located upstream from the pacemaker process, none of the benefits may ever reach the customer.This sequel to Learning to See (which focused on plant level operations) provides simple step-by-step instructions for eliminating waste and creating continuous flow at the process level. This isn't a workbook you will read once then relegate to the bookshelf. It's an action guide for managers, engineers, and production associates that you will use to improve flow each and every day.Creating Continuous Flow takes you to the next level in work cell design where you'll achieve even greater cost and lead time savings. You'll learn: where to focus your continuous flow efforts, how to create much more efficient work cells and lines, how to operate a pacemaker process so that a lean value stream is possible, how to sustain the gains, and keep improving.Creating Continuous Flow is the next logical step after Learning to See. The value-stream mapping process defined the pacemaker process and the overall flow of products and information in the plant. The next step is to shift your focus from the plant to the process level by zeroing in on the pacemaker process, which sets the production rhythm for the plant or value stream, and apply the principles of continuous flow.Every production facility has at least one pacemaker process. The pacemaker processes is usually where products take their final form before going to external customers. It’s called the pacemaker because how you operate here determines both how well you can serve the customer and what the demand pattern is like for your upstream supplying processes.How the pacemaker process operates is critically important. A steady and consistently flowing pacemaker places steady and consistent demands on the rest of the value stream. The continuous flow processing that results allows companies to create leaner value streams.[Source : 4e de couv.]

Continuous Flow Manufacturing

Author : Pierre C. Guerindon
Publisher : CRC Press
Page : 304 pages
File Size : 54,7 Mb
Release : 1995-08-08
Category : Technology & Engineering
ISBN : 0585400253

Get Book

Continuous Flow Manufacturing by Pierre C. Guerindon Pdf

This work presents the fundamental principles of continuous flow manufacturing, furnishing a corporate strategy and set of operating rules that help create an environment where continuous flow manufacturing can flourish. A 10-step methodology for converting a traditional factory to a continuous flow operation is provided, and conventional manufacturing techniques are compared with the continuous flow approach.

The Basics of Self-Balancing Processes

Author : Gordon Ghirann
Publisher : CRC Press
Page : 108 pages
File Size : 54,7 Mb
Release : 2017-07-27
Category : Business & Economics
ISBN : 9781466552586

Get Book

The Basics of Self-Balancing Processes by Gordon Ghirann Pdf

Self-Balancing is not just a tweak or change to assembly line balancing, but a completely transformed method for achieving continuous flow. Among the reasons you should try Self-Balancing is that you can expect a productivity improvement of at least 30 percent with improvements of 50-60 percent quite common.Using a well-tested method for successful

Fundamentals of Flow Manufacturing

Author : Gerard Leone,Richard D. Rahn
Publisher : Flow Publishing
Page : 211 pages
File Size : 40,7 Mb
Release : 2002
Category : Business & Economics
ISBN : 9780971303188

Get Book

Fundamentals of Flow Manufacturing by Gerard Leone,Richard D. Rahn Pdf

Making materials flow

Author : Rick Harris,Chris Harris,Earl Wilson
Publisher : Lean Enterprise Institute
Page : 107 pages
File Size : 53,5 Mb
Release : 2003
Category : Lean manufacturing
ISBN : 9780974182490

Get Book

Making materials flow by Rick Harris,Chris Harris,Earl Wilson Pdf

Flow Chemistry

Author : Santiago V Luis,Eduardo Garcia-Verdugo
Publisher : Royal Society of Chemistry
Page : 560 pages
File Size : 49,9 Mb
Release : 2019-10-18
Category : Science
ISBN : 9781788014984

Get Book

Flow Chemistry by Santiago V Luis,Eduardo Garcia-Verdugo Pdf

In flow chemistry reactions are performed in a reactor with the reactants pumped through it. It has the benefit of being easily scaled up and it is straightforward to integrate synthesis, workup and analysis into one system. This volume provides an update on recent advances in the field of flow chemistry, with special emphasis on new, integrated approaches for green and efficient chemistry. This book is a valuable resource for researchers in green chemistry, chemical engineers and Industrial chemists working in the pharmaceutical and fine chemicals industries.

One-Piece Flow vs. Batching

Author : Charles Protzman,Joe McNamara,Dan Protzman
Publisher : CRC Press
Page : 256 pages
File Size : 50,7 Mb
Release : 2017-07-27
Category : Business & Economics
ISBN : 9781498726955

Get Book

One-Piece Flow vs. Batching by Charles Protzman,Joe McNamara,Dan Protzman Pdf

Although batching often appears more efficient than one-piece flow for individual tasks, the practice creates waste for other parts of the organization that more than offset its perceived benefits. A silent productivity killer, batching is an extremely difficult mindset to overcome and, as a result, numerous Lean initiatives have been destroyed by

Continuous Manufacturing of Pharmaceuticals

Author : Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publisher : John Wiley & Sons
Page : 645 pages
File Size : 47,9 Mb
Release : 2017-09-05
Category : Science
ISBN : 9781119001324

Get Book

Continuous Manufacturing of Pharmaceuticals by Peter Kleinebudde,Johannes Khinast,Jukka Rantanen Pdf

A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

One-Piece Flow vs. Batching

Author : Charles Protzman,Joe McNamara,Dan Protzman
Publisher : CRC Press
Page : 141 pages
File Size : 49,5 Mb
Release : 2017-07-27
Category : Business & Economics
ISBN : 9781040081853

Get Book

One-Piece Flow vs. Batching by Charles Protzman,Joe McNamara,Dan Protzman Pdf

Although batching often appears more efficient than one-piece flow for individual tasks, the practice creates waste for other parts of the organization that more than offset its perceived benefits. A silent productivity killer, batching is an extremely difficult mindset to overcome and, as a result, numerous Lean initiatives have been destroyed by

Learning to See

Author : Mike Rother,John Shook
Publisher : Lean Enterprise Institute
Page : 115 pages
File Size : 45,6 Mb
Release : 2003
Category : Business & Economics
ISBN : 9780966784305

Get Book

Learning to See by Mike Rother,John Shook Pdf

Lean production is the gold standard in production systems, but has proven famously difficult to implement in North America. Mass production relies on large inventories, uses "push" processes and struggles with long lead times. Moving towards a system that eliminates muda ("waste") caused by overproduction, while challenging, proves necessary for improved efficiency. Often overlooked, value stream mapping is the essential planning stage for any Lean transformation. In Mike Rother and John Shook's essential guide, you follow the value stream mapping undertaken for Acme Stamping, for its current and future state. Fully illustrated and well-organized, Learning to See is a must-see for the value stream manager.

Continuous Manufacturing for the Modernization of Pharmaceutical Production

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology
Publisher : National Academies Press
Page : 69 pages
File Size : 53,9 Mb
Release : 2019-04-05
Category : Medical
ISBN : 9780309487818

Get Book

Continuous Manufacturing for the Modernization of Pharmaceutical Production by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology Pdf

On July 30-31, 2018, the National Academies of Sciences, Engineering, and Medicine held a workshop titled Continuous Manufacturing for the Modernization of Pharmaceutical Production. This workshop discussed the business and regulatory concerns associated with adopting continuous manufacturing techniques to produce biologics such as enzymes, monoclonal antibodies, and vaccines. The participants also discussed specific challenges for integration across the manufacturing system, including upstream and downstream processes, analytical techniques, and drug product development. The workshop addressed these challenges broadly across the biologics domain but focused particularly on drug categories of greatest FDA and industrial interest such as monoclonal antibodies and vaccines. This publication summarizes the presentations and discussions from the workshop.

How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems

Author : Fernando Muzzio,Sarang Oka
Publisher : Elsevier
Page : 442 pages
File Size : 43,7 Mb
Release : 2022-04
Category : Medical
ISBN : 9780128134795

Get Book

How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems by Fernando Muzzio,Sarang Oka Pdf

How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems provides a comprehensive overview on the considerations necessary for the design of continuous pharmaceutical manufacturing processes. The book covers both the theory and design of continuous processing of associated unit operations, along with their characterization and control. In addition, it discusses practical insights and strategies that the editor and chapter authors have learned. Chapters cover Process Analytical Technology (PAT) tools and the application of PAT data to enable distributed process control. With numerous case studies throughout, this valuable guide is ideal for those engaged in, or learning about, continuous processing in pharmaceutical manufacturing. Discusses the development of strategy blueprints in the design of continuous processes Shows how to create process flowsheet models from individual unit operation models Includes a chapter on characterization methods for materials, the use of statistical methods to analyze material property data, and the use of material databases Covers the evolving regulatory expectations for continuous manufacturing Provides readers with ways to more effectively navigate these expectations

The Lean Manager

Author : Freddy Ballé,Michael Ballé
Publisher : Lean Enterprise Institute
Page : 473 pages
File Size : 42,9 Mb
Release : 2011-09-15
Category : Business & Economics
ISBN : 9781934109311

Get Book

The Lean Manager by Freddy Ballé,Michael Ballé Pdf

In this groundbreaking sequel to The Gold Mine, authors Michael and Freddy Ballé present a compelling story that teaches readers the most important lean lesson of all: how to transform themselves and their workers through the discipline of learning the lean system. The Lean Manager: A Novel of Lean Transformation reveals how individuals can go beyond the short-term gains from tools, and realize a deeper, sustainable path of improvement. Full of human moments that capture the excitement and drama of lean implementation, as well as clear explanations of how tools and systems go hand-in-hand, this book will teach and inspire every person working to make lean a reality in their organization today. This book will help you learn both the how of doing lean, as well as the why behind the tools, enabling you to become lean. Lean is the most important business model for competitive success today. Yet companies still struggle to sustain enduring and deep-rooted business success from their lean implementation efforts. The most important problem for these companies is becoming lean: how can they advance beyond realizing isolated gains from deploying lean tools, to fundamentally changing how they operate, think, and learn? In other words, how can companies learn to go beyond lean turnaround to achieve lean transformation? The Lean Manager: A Novel of Lean Transformation, by lean experts Michael and Freddy Ballé, addresses this critical problem. As we move from what Jim Womack, author, lean management authority, and LEI founder, calls “the era of lean tools to the era of lean management,” The Lean Manager gives companies a definitive guide for sustaining their ability to learn and improve operations and financial performance, while continually developing people. “The only way to become and stay lean is to produce lean managers,” says Womack. “Every isolated effort will recede—or fail—unless companies learn to use the lean process as a way of developing individual problem-solvers with the ownership, initiative, and know-how to solve problems, learn, and ultimately coach new individuals in this discipline. That’s why this book matters so much.” The Lean Manager, the sequel to the Ballé’s international bestselling business novel The Gold Mine, tells the compelling story of plant manager Andrew Ward as he goes through the challenging but rewarding journey to becoming a lean manager. Under the guidance of Phil Jenkinson (whose own lean journey was at the core of The Gold Mine), Ward learns to use a deep understanding of lean tools, as well as a technical know-how of his plant’s operations, to foster a lean attitude that sustains continuous improvement. Where The Gold Mine shows you how to introduce a complete lean system, The Lean Manager demonstrates how to sustain it. Ward moves beyond fluency with tools to changing his behavior as a manager and leader. He shifts from giving orders and answers to asking the right questions so people identify and address problems. He learns how to use tools to unleash the creativity and motivation of people, so they learn how to solve problems as well as coach and teach others to solve problems. Ward learns how to create lean managers. “I am excited and have hopes that this book will enlighten readers about what it really means to live a business transformation that puts customers first and does this through developing people,” said Jeffrey Liker, author of The Toyota Way and professor of Industrial and Operations Engineering at the University of Michigan. “People who do the work have to improve the work. There are tools, but they are not tools for ‘improving the process.’ They are tools for making problems visible and for helping people think about how to solve those problems.”