Industrial Process Scale Up

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Industrial Process Scale-up

Jan Harmsen
Industrial Process Scale up Book PDF

Author : Jan Harmsen
Publisher : Elsevier
Page : 129 pages
File Size : 43,5 Mb
Release : 2013-04-25
Category : Technology & Engineering
ISBN : 9780444627391

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Industrial Process Scale-up by Jan Harmsen Pdf

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Industrial Process Scale-up

Jan Harmsen
Industrial Process Scale up Book PDF

Author : Jan Harmsen
Publisher : Elsevier
Page : 0 pages
File Size : 53,6 Mb
Release : 2013-05-06
Category : Technology & Engineering
ISBN : 044462726X

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Industrial Process Scale-up by Jan Harmsen Pdf

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses.

Scale-Up Processes

Jamal Chaouki,Rahmat Sotudeh-Gharebagh
Scale Up Processes Book PDF

Author : Jamal Chaouki,Rahmat Sotudeh-Gharebagh
Publisher : Walter de Gruyter GmbH & Co KG
Page : 350 pages
File Size : 52,5 Mb
Release : 2021-09-20
Category : Technology & Engineering
ISBN : 9783110713985

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Scale-Up Processes by Jamal Chaouki,Rahmat Sotudeh-Gharebagh Pdf

Common scale-up methods are conventional where the blind piloting is essential. This imposes huge investment and leads to failures mostly in solid processing. However, the limitations of resources, current shortcomings, short time-to-market demand are forced companies to minimize piloting. With these situations in mind, current digitalization outlook and computational facilities, we proposed and developed a novel iterative scale up method with case studies which highly expedites the process innovation through the following key sequences:

Scale-up Methodology for Chemical Processes

Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier
Scale up Methodology for Chemical Processes Book PDF

Author : Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier
Publisher : Editions TECHNIP
Page : 266 pages
File Size : 41,7 Mb
Release : 1993
Category : Science
ISBN : 2710806460

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Scale-up Methodology for Chemical Processes by Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier Pdf

Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Scale-up in Chemical Engineering

Marko Zlokarnik
Scale up in Chemical Engineering Book PDF

Author : Marko Zlokarnik
Publisher : John Wiley & Sons
Page : 296 pages
File Size : 40,9 Mb
Release : 2006-08-21
Category : Science
ISBN : 9783527607761

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Scale-up in Chemical Engineering by Marko Zlokarnik Pdf

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Pharmaceutical Process Scale-Up, Third Edition

Michael Levin
Pharmaceutical Process Scale Up Third Edition Book PDF

Author : Michael Levin
Publisher : CRC Press
Page : 0 pages
File Size : 52,6 Mb
Release : 2011-02-02
Category : Medical
ISBN : 1616310014

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Pharmaceutical Process Scale-Up, Third Edition by Michael Levin Pdf

The third edition of Pharmaceutical Process Scale-Up deals with the theory and practice of scale-up in the pharmaceutical industry. This thoroughly revised edition reflects the rapid changes in the field and includes: New material on tableting scale-up and compaction. Regulatory appendices that cover FDA and EU Guidelines. New chapters on risk evaluation and validation as related to scale-up. Practical advice on scale-up solutions from world renowned experts in the field. Pharmaceutical Process Scale-Up, Third Edition will provide an excellent insight in to the practical aspects of the process scale-up and will be an invaluable source of information on batch enlargement techniques for formulators, process engineers, validation specialists and quality assurance personnel, as well as production managers. It will also provide interesting reading material for anyone involved in Process Analytical Technology (PAT), technology transfer and product globalization.

Industrial Process Scale-up

Jan Harmsen
Industrial Process Scale up Book PDF

Author : Jan Harmsen
Publisher : Elsevier
Page : 142 pages
File Size : 46,7 Mb
Release : 2019-05-16
Category : Technology & Engineering
ISBN : 9780444642844

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Industrial Process Scale-up by Jan Harmsen Pdf

Industrial Process Scale-up: A Practical Innovation Guide from Idea to Commercial Implementation, Second Edition helps industrial process innovators in research, development and commercial start-ups assess the risks of commercial-scale implementation, also providing them with practical guidelines and methods to reduce the risks to acceptable levels. In addition, the book can be used in cooperation with industrial R&D people and academic researchers to shape open innovation programs, and in education as a reference book. This updated edition has the latest literature and has been expanded with a scale-up of pharmaceutical processes and their history in both academia and the process industries. Offers easily accessible, step-by-step and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel, from research, development, demonstration and commercial implementation for any process type and branch Based on industrial experiences and practices that reduce the risks of commercial scale implementation of new processes to acceptable levels and reduce cost and time of process innovation

Process Understanding

Ian Houson
Process Understanding Book PDF

Author : Ian Houson
Publisher : John Wiley & Sons
Page : 346 pages
File Size : 53,9 Mb
Release : 2011-04-08
Category : Science
ISBN : 9783527637157

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Process Understanding by Ian Houson Pdf

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Process Scale Bioseparations for the Biopharmaceutical Industry

Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam
Process Scale Bioseparations for the Biopharmaceutical Industry Book PDF

Author : Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam
Publisher : CRC Press
Page : 600 pages
File Size : 40,8 Mb
Release : 2006-07-07
Category : Medical
ISBN : 9781420016024

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Process Scale Bioseparations for the Biopharmaceutical Industry by Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam Pdf

The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceut

Scaleup of Chemical Processes

Attilio Bisio,Robert L. Kabel
Scaleup of Chemical Processes Book PDF

Author : Attilio Bisio,Robert L. Kabel
Publisher : Wiley-Interscience
Page : 760 pages
File Size : 54,6 Mb
Release : 1985-07-25
Category : Science
ISBN : UOM:39015010893249

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Scaleup of Chemical Processes by Attilio Bisio,Robert L. Kabel Pdf

The focus of this book is on the technical factors that are critical to th e design and startup of a commercial manufacturing facility.

Polymorphism in the Pharmaceutical Industry

Rolf Hilfiker,Markus von Raumer
Polymorphism in the Pharmaceutical Industry Book PDF

Author : Rolf Hilfiker,Markus von Raumer
Publisher : John Wiley & Sons
Page : 618 pages
File Size : 53,7 Mb
Release : 2019-01-04
Category : Science
ISBN : 9783527697854

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Polymorphism in the Pharmaceutical Industry by Rolf Hilfiker,Markus von Raumer Pdf

"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

Practical Process Research and Development

Neal G. Anderson
Practical Process Research and Development Book PDF

Author : Neal G. Anderson
Publisher : Academic Press
Page : 489 pages
File Size : 48,6 Mb
Release : 2012-05-23
Category : Science
ISBN : 9780123865380

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Practical Process Research and Development by Neal G. Anderson Pdf

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Chemical Projects Scale Up

Joe M. Bonem
Chemical Projects Scale Up Book PDF

Author : Joe M. Bonem
Publisher : Elsevier
Page : 232 pages
File Size : 46,8 Mb
Release : 2018-05-31
Category : Technology & Engineering
ISBN : 9780128137284

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Chemical Projects Scale Up by Joe M. Bonem Pdf

Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Chemical Engineering in the Pharmaceutical Industry

Mary T. am Ende,David J. am Ende
Chemical Engineering in the Pharmaceutical Industry Book PDF

Author : Mary T. am Ende,David J. am Ende
Publisher : John Wiley & Sons
Page : 1435 pages
File Size : 40,5 Mb
Release : 2019-04-08
Category : Technology & Engineering
ISBN : 9781119285502

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Chemical Engineering in the Pharmaceutical Industry by Mary T. am Ende,David J. am Ende Pdf

A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology

Alexandru Mihai Grumezescu
Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology Book PDF

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 696 pages
File Size : 47,5 Mb
Release : 2017-12-11
Category : Science
ISBN : 9780128136300

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Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology by Alexandru Mihai Grumezescu Pdf

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry