Inflammation Oxidative Stress And Cancer

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Inflammation, Oxidative Stress, and Cancer

Ah-Ng Tony Kong
Inflammation Oxidative Stress and Cancer Book PDF

Author : Ah-Ng Tony Kong
Publisher : CRC Press
Page : 640 pages
File Size : 53,8 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781466503717

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Inflammation, Oxidative Stress, and Cancer by Ah-Ng Tony Kong Pdf

Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals. Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics. The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 50,6 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Oxidative Stress, Inflammation, and Health

Young-Joon Surh
Oxidative Stress Inflammation and Health Book PDF

Author : Young-Joon Surh
Publisher : CRC Press
Page : 660 pages
File Size : 45,8 Mb
Release : 2005-05-24
Category : Science
ISBN : 9781420028256

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Oxidative Stress, Inflammation, and Health by Young-Joon Surh Pdf

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

Role of Oxidative Stress in Pathophysiology of Diseases

Pawan K. Maurya,Kamal Dua
Role of Oxidative Stress in Pathophysiology of Diseases Book PDF

Author : Pawan K. Maurya,Kamal Dua
Publisher : Springer Nature
Page : 297 pages
File Size : 46,6 Mb
Release : 2020-06-15
Category : Science
ISBN : 9789811515682

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Role of Oxidative Stress in Pathophysiology of Diseases by Pawan K. Maurya,Kamal Dua Pdf

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics

Jordi Camps
Oxidative Stress and Inflammation in Non communicable Diseases Molecular Mechanisms and Perspectives in Therapeutics Book PDF

Author : Jordi Camps
Publisher : Springer
Page : 223 pages
File Size : 55,7 Mb
Release : 2014-07-19
Category : Medical
ISBN : 9783319073200

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Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics by Jordi Camps Pdf

Oxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress and Inflammation in Non-communicable Diseases: Molecular Mechanisms and Perspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine.

Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approches in Non Communicable Diseases

Chiara Nediani,Lisa Giovannelli
Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approches in Non Communicable Diseases Book PDF

Author : Chiara Nediani,Lisa Giovannelli
Publisher : MDPI
Page : 270 pages
File Size : 52,9 Mb
Release : 2020-12-02
Category : Medical
ISBN : 9783039289356

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Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approches in Non Communicable Diseases by Chiara Nediani,Lisa Giovannelli Pdf

Non-communicable diseases (NCDs) are chronic diseases that include most ageing-related diseases, representing the main cause of death and disability in the general population. Inflammation and oxidative stress are common features in NCDs, responsible for the cell, tissue, and organ damage that contributes to the progression of these diseases. They may be also key targets for the development of novel preventive and therapeutic strategies. This Special Issue includes 14 peer-reviewed papers, including 12 original research papers and 2 reviews. Together, they represent the most recent progress in the field of several degenerative disorders, aiming to establish specific biomarkers, detailing the pathogenesis and the evolution of these diseases, making a correct diagnosis, and opening up new therapeutic strategies. Of relevance, many studies report the beneficial effects of natural compounds, derived from several plants, leaves, and fruits; their antioxidant and anti-inflammatory properties suggest their use as a dietary supplement for prevention and/or complement to standard therapies.

Flavonoids, Inflammation and Cancer

Hollie Swanson
Flavonoids Inflammation and Cancer Book PDF

Author : Hollie Swanson
Publisher : World Scientific
Page : 212 pages
File Size : 51,6 Mb
Release : 2015-08-28
Category : Medical
ISBN : 9789814651950

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Flavonoids, Inflammation and Cancer by Hollie Swanson Pdf

This book provides an insightful analysis of the chemopreventive actions of flavonoids. Flavonoids are naturally occurring constituents of plants that have been traditionally used as anti-inflammatory and anti-cancer medicines. In addition, human consumption of vegetables and fruits with high concentrations of flavonoids is associated with decreased cancer mortalities rates. Flavonoids, Inflammation and Cancer presents an in-depth analysis of the mechanisms by which flavonoids are thought to prevent inflammation and the development of GI and steroid-responsive cancers. In addition, the promise and pitfalls associated with using flavonoids as chemopreventive agents are discussed. This book is an invaluable reference for basic and clinical scientists who are interested in exploring the link between nutrition and cancer. Contents:Introduction to Flavonoids and ChemopreventionMechanisms by Which Flavonoids Exert Their Beneficial Anti-cancer EffectsFlavonoids and the Inflammatory ResponseFlavonoids and Cancers of the Gastrointestinal TractFlavonoids and Steroid-responsive CancersSummary and Future Directions Readership: Researchers in the pharmaceutical industry, cancer researchers, immunologists, biochemists, natural product researchers. Key Features:Links the biochemical properties of flavonoids to the events associated with the carcinogenic processExamines both the promise and pitfalls associated with the potential use of flavonoids as chemopreventive therapiesThe results obtained from clinical and preclinical (in vitro and in vivo) studies are compared and contrastedKeywords:Flavonoid;Tumor;Proliferation;Chemoprevention

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Sajal Chakraborti
Handbook of Oxidative Stress in Cancer Therapeutic Aspects Book PDF

Author : Sajal Chakraborti
Publisher : Springer Nature
Page : 4078 pages
File Size : 50,8 Mb
Release : 2022-09-28
Category : Medical
ISBN : 9789811654220

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by Sajal Chakraborti Pdf

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Oxidative Stress and Chronic Degenerative Diseases

Jose Antonio Morales-Gonzalez
Oxidative Stress and Chronic Degenerative Diseases Book PDF

Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 48,5 Mb
Release : 2013-05-22
Category : Science
ISBN : 9789535111238

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Oxidative Stress and Chronic Degenerative Diseases by Jose Antonio Morales-Gonzalez Pdf

This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Inflammation, Lifestyle and Chronic Diseases

Bharat B. Aggarwal,Sunil Krishnan,Sushovan Guha
Inflammation Lifestyle and Chronic Diseases Book PDF

Author : Bharat B. Aggarwal,Sunil Krishnan,Sushovan Guha
Publisher : CRC Press
Page : 504 pages
File Size : 43,9 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439839904

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Inflammation, Lifestyle and Chronic Diseases by Bharat B. Aggarwal,Sunil Krishnan,Sushovan Guha Pdf

Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource.

Cancer and Inflammation Mechanisms

Yusuke Hiraku,Shosuke Kawanishi,Hiroshi Ohshima
Cancer and Inflammation Mechanisms Book PDF

Author : Yusuke Hiraku,Shosuke Kawanishi,Hiroshi Ohshima
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 43,7 Mb
Release : 2014-03-19
Category : Science
ISBN : 9781118826553

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Cancer and Inflammation Mechanisms by Yusuke Hiraku,Shosuke Kawanishi,Hiroshi Ohshima Pdf

A new perspective on the link between inflammation andcancer Inflammation is the human body’s normal biologicalresponse to threats in the modern world, as well as a defenseagainst the harmful influence of pathogens, the environment, andpoor nutrition. But what happens when the inflammatory response istriggered repeatedly and sustained for long periods of time?Cancer and Inflammation Mechanisms: Chemical, Biological, andClinical Aspects discusses the mechanisms by which chronicinflammation can lead to cancer, the various causative agents, andpossible prevention methods. A compilation of the latest information coming out of thevarious fields of cancer research, this book provides a detailedlook at inflammation-related carcinogenesis from the perspective ofresearchers at the forefront of the field. It takes aninterdisciplinary approach to the topic, and provides comprehensiveinformation about the major factors at work in inflammation,cancer, and the intersection of the two conditions. Topicsinclude: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA incarcinogenesis Specific causative agents including oncogenic viruses,asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventativemeasures A deeper understanding of the mechanisms behindinflammation-related carcinogenesis can lead to better patientoutcomes by improving diagnostics and prevention, as well asaltering the approach to treatment. Cancer and InflammationMechanisms: Chemical, Biological, and Clinical Aspects providesthe knowledge base researchers need to push the field forward.

Role of Capsaicin in Oxidative Stress and Cancer

Sanjay K. Srivastava
Role of Capsaicin in Oxidative Stress and Cancer Book PDF

Author : Sanjay K. Srivastava
Publisher : Springer Science & Business Media
Page : 178 pages
File Size : 46,5 Mb
Release : 2013-04-23
Category : Medical
ISBN : 9789400763173

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Role of Capsaicin in Oxidative Stress and Cancer by Sanjay K. Srivastava Pdf

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Oxidative Stress, Inflammation and Angiogenesis in the Metabolic Syndrome

Raquel Soares,Carla Costa
Oxidative Stress Inflammation and Angiogenesis in the Metabolic Syndrome Book PDF

Author : Raquel Soares,Carla Costa
Publisher : Springer Science & Business Media
Page : 213 pages
File Size : 46,7 Mb
Release : 2009-02-25
Category : Medical
ISBN : 9781402097010

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Oxidative Stress, Inflammation and Angiogenesis in the Metabolic Syndrome by Raquel Soares,Carla Costa Pdf

Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. This book fills the gap between basic science and medical care, and provides the reader with the skills to apply rigorous basic science to clinical settings of metabolic syndrome-associated disorders.

Cellular Oxidative Stress

Silvia Dossena,Angela Marino
Cellular Oxidative Stress Book PDF

Author : Silvia Dossena,Angela Marino
Publisher : MDPI
Page : 529 pages
File Size : 43,5 Mb
Release : 2021-09-06
Category : Science
ISBN : 9783036516448

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Cellular Oxidative Stress by Silvia Dossena,Angela Marino Pdf

This book collects 17 original research papers and 9 reviews that are part of the Special Issue “Cellular Oxidative Stress”, published in the journal Antioxidants. Oxidative stress on a cellular level affects the function of tissues and organs and may eventually lead to disease. Therefore, a precise understanding of how oxidative stress develops and can be counteracted is of utmost importance. The scope of the book is to emphasize the latest findings on the cellular targets of oxidative stress and the potential beneficial effect of antioxidants on human health.

Inflammation, Aging and Cancer

Mahin Khatami
Inflammation Aging and Cancer Book PDF

Author : Mahin Khatami
Publisher : Springer
Page : 389 pages
File Size : 53,5 Mb
Release : 2018-01-17
Category : Medical
ISBN : 9783319664750

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Inflammation, Aging and Cancer by Mahin Khatami Pdf

This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.