Innovations In Modeling And Simulation To Advance Translational Science
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Innovations in Modeling and Simulation to Advance Translational Science by Melissa Knothe Tate,Leonardo Angelone,Christopher Basciano,Markus Reiterer Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Innovations in Biomolecular Modeling and Simulations by Tamar Schlick Pdf
The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts. With contributions from experts in the field, the books describe progress and innovation in areas including: simulation algorithms for dynamics and enhanced configurational sampling, force field development, implicit solvation models, coarse-grained models, quantum-mechanical simulations, protein folding, DNA polymerase mechanisms, nucleic acid complexes and simulations, RNA structure analysis and design and other important topics in structural biology modeling. The books are aimed at graduate students and experts in structural biology and chemistry and the emphasis is on reporting innovative new approaches rather than providing comprehensive reviews on each subject.
Advances in Computational Modeling and Simulation by Rallapalli Srinivas,Rajesh Kumar,Mainak Dutta Pdf
The book presents select proceedings of Global meet on ‘Computational Modelling and Simulation, Recent Innovations, Challenges and Perspectives, 2020. This book covers leading-edge technologies from different domains such as computation in optimization and control, multiscale and multiphysics modeling and computation analysis, environmental modeling, modeling approaches to enterprise systems and services, finite element analysis, dependability and security, high-performance computation/cloud computing applications, computational biology and chemistry and computational mechanics. The primary goal of this book is to strengthen pre-eminence in computational modeling and simulation by catalyzing the transformative use of innovative developments in a wide range of disciplines to achieve lasting societal impact. The book discusses on how to perform simulation of large complex dynamic systems in an efficient manner using advanced computational analysis. The inter-disciplinary nature of the book would be a valuable reference for academicians and research scientists, industrialists interested in modelling and simulation driven by computational technology.
Energetic Materials by Mark J. Mezger,Kay J. Tindle,Michelle Pantoya,Lori J. Groven,Dilhan Kalyon Pdf
This book will take an in-depth look at the technologies, processes, and capabilities to develop and produce "next generation" energetic materials for both commercial and defense applications, including military, mining operations, oil production and well perforation, and construction demolition. It will serve to highlight the critical technologies, latest developments, and the current capability gaps that serve as barriers to military fielding or transition to the commercial marketplace. It will also explain how the processing technologies can be spun out for use in other non-energetics related industries.
Systems Pharmacology and Pharmacodynamics by Donald E. Mager,Holly H.C. Kimko Pdf
While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
An Investigation Report on Large Public Hospital Reforms in China by Lulu Zhang,Meina Li,Feng Ye,Tao Ding,Peng Kang Pdf
This book provides a comprehensive understanding of public hospital reform in China, which is a hot topic for China’s new round of health sector reform. The authors use rich data from both health provider side and service user side and conduct a cross-sectional study in China with some comparative analysis between different locations. It provides the audience with a big picture of China’s public hospital and other components of health system as well. The book reviews the main policy measurements in the public hospital reforms and evaluates how these policies influence public hospitals' practices, especially on hospital governance and internal management.
Journal of the House of Representatives of the United States by United States. Congress. House Pdf
Some vols. include supplemental journals of "such proceedings of the sessions, as, during the time they were depending, were ordered to be kept secret, and respecting which the injunction of secrecy was afterwards taken off by the order of the House".
Advances in Molecular Pathology by Gregory J. Tsongalis Pdf
Advances in Molecular Pathology reviews the year’s most important findings and updates within the field in order to provide molecular pathologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Gregory Tsongalis, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in molecular pathology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. Provides in-depth, clinical reviews in molecular pathology, providing actionable insights for clinical practice. Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
The Emerging Discipline of Quantitative Systems Pharmacology by Tarek A. Leil,Sergey Ermakov Pdf
In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.
Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation Publisher : National Academies Press Page : 118 pages File Size : 55,5 Mb Release : 2012-05-04 Category : Medical ISBN : 9780309222143
Strengthening a Workforce for Innovative Regulatory Science in Therapeutics Development by Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation Pdf
The development and application of regulatory science - which FDA has defined as the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products - calls for a well-trained, scientifically engaged, and motivated workforce. FDA faces challenges in retaining regulatory scientists and providing them with opportunities for professional development. In the private sector, advancement of innovative regulatory science in drug development has not always been clearly defined, well coordinated, or connected to the needs of the agency. As a follow-up to a 2010 workshop, the IOM held a workshop on September 20-21, 2011, to provide a format for establishing a specific agenda to implement the vision and principles relating to a regulatory science workforce and disciplinary infrastructure as discussed in the 2010 workshop.
National Science and Technology Council (U.S.). Interagency Working Group on Information Technology Research and Development
Author : National Science and Technology Council (U.S.). Interagency Working Group on Information Technology Research and Development Publisher : Unknown Page : 64 pages File Size : 53,8 Mb Release : 2003 Category : Computer networks ISBN : IND:30000131366530
Networking and Information Technology Research and Development by National Science and Technology Council (U.S.). Interagency Working Group on Information Technology Research and Development Pdf
Competition, Strategy, and Innovation by Rafał Śliwiński,Łukasz Puślecki Pdf
Understanding the latest trends and technologies and their impact on enterprises, organizations or state administrations is essential to successfully develop a business in the age of Industry 4.0. This book presents a unique selection of topics and offers the reader an understanding of the implications of the newest technologies such as Artificial Intelligence (AI), Internet of Things (IoT), Augmented Reality (AR) and new trends like social media and sustainable competitiveness in business. It presents the impact of the newest trends on businesses, consumers, and the result on the economy. Contributions showcase the technical perspective of new technologies and provides an innovative and enriching perspective on the implementation of AI in e-commerce and the developmental barriers it can create, modern social media usage in enterprises, the newest trends in innovation management, sustainable competitiveness in the business context, the influence and effect of augmented reality, and the privacy problem of Internet of Things to consumers. This book illustrates how to develop innovation cooperation between business, academia and public institutions through the example of biopharmaceutical industry. It will be of value to researchers, academics, professionals, and students in the fields of economics, management, international business.
National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Computer Science and Telecommunications Board,Board on Energy and Environmental Systems,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics
Author : National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Computer Science and Telecommunications Board,Board on Energy and Environmental Systems,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics Publisher : National Academies Press Page : 109 pages File Size : 44,7 Mb Release : 2019-10-24 Category : Technology & Engineering ISBN : 9780309494113
Enhancing Urban Sustainability with Data, Modeling, and Simulation by National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Computer Science and Telecommunications Board,Board on Energy and Environmental Systems,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics Pdf
On January 30-31, 2019 the Board on Mathematical Sciences and Analytics, in collaboration with the Board on Energy and Environmental Systems and the Computer Science and Telecommunications Board, convened a workshop in Washington, D.C. to explore the frontiers of mathematics and data science needs for sustainable urban communities. The workshop strengthened the emerging interdisciplinary network of practitioners, business leaders, government officials, nonprofit stakeholders, academics, and policy makers using data, modeling, and simulation for urban and community sustainability, and addressed common challenges that the community faces. Presentations highlighted urban sustainability research efforts and programs under way, including research into air quality, water management, waste disposal, and social equity and discussed promising urban sustainability research questions that improved use of big data, modeling, and simulation can help address. This publication summarizes the presentation and discussion of the workshop.
