Integration Of Biomaterials For Gene Therapy

Author : Rishabha Malviya,Sonali Sundram,Neelam Jain
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 51,9 Mb
Release : 2023-10-10
Category : Science
ISBN : 9781394175611

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Integration of Biomaterials for Gene Therapy by Rishabha Malviya,Sonali Sundram,Neelam Jain Pdf

INTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will help the research community expedite the clinical application of these therapies for various diseases and conditions. Audience A broad range of researchers, scientists, and engineers in diverse fields such as materials science, biomedicine, biomedical engineering, biology, chemistry, physics, biotechnology, pharmacology, toxicology, and formulation scientists.

Author : Rishabha Malviya,Sonali Sundram,Neelam Jain
Publisher : John Wiley & Sons
Page : 468 pages
File Size : 47,7 Mb
Release : 2023-11-14
Category : Science
ISBN : 9781394174737

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Integration of Biomaterials for Gene Therapy by Rishabha Malviya,Sonali Sundram,Neelam Jain Pdf

INTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will help the research community expedite the clinical application of these therapies for various diseases and conditions. Audience A broad range of researchers, scientists, and engineers in diverse fields such as materials science, biomedicine, biomedical engineering, biology, chemistry, physics, biotechnology, pharmacology, toxicology, and formulation scientists.

Author : Rolando Barbucci
Publisher : Springer Science & Business Media
Page : 1048 pages
File Size : 48,9 Mb
Release : 2007-05-08
Category : Technology & Engineering
ISBN : 9780306475832

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Integrated Biomaterials Science by Rolando Barbucci Pdf

Integrated Biomaterials Science provides an intriguing insight into the world of biomaterials. It explores the materials and technology which have brought advances in new biomaterials, highlighting the way in which modern biology and medicine are synergistically linked to other key scientific disciplines-physics, chemistry, and engineering. In doing so, Integrated Biomaterials Science contains chapters on tissue engineering and gene therapy, standards and parameters of biomaterials, applications and interactions within the industrial world, as well as potential aspects of patent regulations. Integrated Biomaterials Science serves as a comprehensive guide to understanding this dynamic field, yet is designed so that chapters may be read and understood independently, depending on the needs of the reader. Integrated Biomaterials Science is attractive to a broad audience interested in a deeper understanding of this evolving field, and serves as a key resource for researchers and students of biomaterials courses, providing all with an opportunity to probe further.

Author : Michael J. Yaszemski,Debra J. Trantolo,Kai-Uwe Lewandrowski,Vasif Hasirci,David E. Altobelli,Donald L. Wise
Publisher : CRC Press
Page : 660 pages
File Size : 53,7 Mb
Release : 2003-11-04
Category : Medical
ISBN : 0203913337

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Tissue Engineering And Novel Delivery Systems by Michael J. Yaszemski,Debra J. Trantolo,Kai-Uwe Lewandrowski,Vasif Hasirci,David E. Altobelli,Donald L. Wise Pdf

Essential to anyone working in the field, this reference focuses on latest advancements in tissue construction, repair and regeneration focusing on developments in gene and drug therapy, the evolution of tissue-engineered products, and new technologies for the design of functional tissues and organ systems.

Author : Rolando Barbucci
Publisher : Springer
Page : 1037 pages
File Size : 53,5 Mb
Release : 2013-06-26
Category : Technology & Engineering
ISBN : 1475776829

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Integrated Biomaterials Science by Rolando Barbucci Pdf

Integrated Biomaterials Science provides an intriguing insight into the world of biomaterials. It explores the materials and technology which have brought advances in new biomaterials, highlighting the way in which modern biology and medicine are synergistically linked to other key scientific disciplines-physics, chemistry, and engineering. In doing so, Integrated Biomaterials Science contains chapters on tissue engineering and gene therapy, standards and parameters of biomaterials, applications and interactions within the industrial world, as well as potential aspects of patent regulations. Integrated Biomaterials Science serves as a comprehensive guide to understanding this dynamic field, yet is designed so that chapters may be read and understood independently, depending on the needs of the reader. Integrated Biomaterials Science is attractive to a broad audience interested in a deeper understanding of this evolving field, and serves as a key resource for researchers and students of biomaterials courses, providing all with an opportunity to probe further.

Author : Ravin Narain
Publisher : Woodhead Publishing
Page : 302 pages
File Size : 47,9 Mb
Release : 2016-01-09
Category : Science
ISBN : 9780081005217

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Polymers and Nanomaterials for Gene Therapy by Ravin Narain Pdf

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Author : Ram I. Mahato
Publisher : CRC Press
Page : 911 pages
File Size : 54,7 Mb
Release : 2004-12-28
Category : Medical
ISBN : 9781135487843

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Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids by Ram I. Mahato Pdf

Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases. Introducing the principles of polymer science and chemistry, this book delineates the basic biology required for understanding how biomaterials can be used as drug-deliver vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Leading experts from around the world discuss the physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The book includes coverage biological barriers to extravasation and cellular uptake of proteins and nucleic acids.

Author : Y. Murat Elçin
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 9781461500636

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Tissue Engineering, Stem Cells, and Gene Therapies by Y. Murat Elçin Pdf

Recent years have seen an upsurge of significant interest in cell-based technologies. A range of productive and lively debate have taken place relating to tissue engineering, namely the construction of tissues and whole organs using molecularly-designed resorbable biomaterials to create tissue de novo, the potential use of human embryonic stem cells for transplantation and regenerative medicine, with similar potential for adult-derived stem cells, and gene therapy, in relation to cell transplantation. New findings in biomimetic materials, cell signalling pathways, extracellular matrix receptors and ligands, growth factors, and the human genome project, all present particularly motivating sources for the development of research in the evergrowing biomedical field. The purpose of this book is to stimulate further the work in biomedicine and to make the issues of related scientific disciplines accessible to a wider readership by characterising the current state of research in the biomedical field. The lectures and a selection of the presentations from BlOMED 200- th The 9 International Symposium on Biomedical Science and Technology, held in September 2002 in Turkey- constitute the basis for the volume. Tissue engineering, stem cells, cell and gene therapies were the major topics presented and discussed in the symposium. This book is intended to serve as an up-to-date synopsis of the major developments of our area through the work reflected in BlOMED 2002, though not covering all aspects of the topics, due to the natural restrictions within a volume of this kind.

Author : Mirjana Pavlovic
Publisher : Springer
Page : 298 pages
File Size : 50,8 Mb
Release : 2014-10-10
Category : Technology & Engineering
ISBN : 9783319107981

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Bioengineering by Mirjana Pavlovic Pdf

This book explores critical principles and new concepts in bioengineering, integrating the biological, physical and chemical laws and principles that provide a foundation for the field. Both biological and engineering perspectives are included, with key topics such as the physical-chemical properties of cells, tissues and organs; principles of molecules; composition and interplay in physiological scenarios; and the complex physiological functions of heart, neuronal cells, muscle cells and tissues. Chapters evaluate the emerging fields of nanotechnology, drug delivery concepts, biomaterials, and regenerative therapy. The leading individuals and events are introduced along with their critical research. Bioengineering: A Conceptual Approach is a valuable resource for professionals or researchers interested in understanding the central elements of bioengineering. Advanced-level students in biomedical engineering and computer science will also find this book valuable as a secondary textbook or reference.

Author : Yitzhak Rosen,Noel Elman
Publisher : CRC Press
Page : 330 pages
File Size : 47,7 Mb
Release : 2012-06-06
Category : Medical
ISBN : 9781439804056

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Biomaterials Science by Yitzhak Rosen,Noel Elman Pdf

"This book is essential when designing, developing and studying biomedical materials. provides an excellent review-from a patient, disease, and even genetic point of view-of materials engineering for the biomedical field. This well presented book strongly insists on how the materials can influence patients' needs, the ultimate drive for biomedic

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 46,9 Mb
Release : 2003
Category : Electronic
ISBN : OCLC:1292671403

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Tissue Engineering,stem Cells,and Gene Therapies by Anonim Pdf

Author : Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Page : 3659 pages
File Size : 46,5 Mb
Release : 2015-08-28
Category : Technology & Engineering
ISBN : 9780080552941

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Comprehensive Biomaterials by Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick Pdf

Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Author : Lei Yang,Sarit Bhaduri,Thomas J. Webster
Publisher : Academic Press
Page : 358 pages
File Size : 44,5 Mb
Release : 2018-11-30
Category : Technology & Engineering
ISBN : 9780128134788

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Biomaterials in Translational Medicine by Lei Yang,Sarit Bhaduri,Thomas J. Webster Pdf

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Author : Brian Ceresa
Publisher : BoD – Books on Demand
Page : 470 pages
File Size : 46,6 Mb
Release : 2012-07-06
Category : Science
ISBN : 9789535106623

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Molecular Regulation of Endocytosis by Brian Ceresa Pdf

Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.

Author : Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Page : 4865 pages
File Size : 40,6 Mb
Release : 2017-05-18
Category : Technology & Engineering
ISBN : 9780081006924

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Comprehensive Biomaterials II by Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick Pdf

Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications