Integrative Proteomics

Author : Hon-Chiu Leung,Tsz Kwong Man,Ricardo Flores
Publisher : BoD – Books on Demand
Page : 456 pages
File Size : 46,9 Mb
Release : 2012-02-24
Category : Science
ISBN : 9789535100706

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Integrative Proteomics by Hon-Chiu Leung,Tsz Kwong Man,Ricardo Flores Pdf

Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics, expert researchers contribute both historical perspectives, new developments in sample preparation, gel-based and non-gel-based protein separation and identification using mass spectrometry. Substantial chapters are describing studies of the sub-proteomes such as phosphoproteome or glycoproteomes which are directly related to functional outcomes of the cells. Structural proteomics related to pharmaceutics development is also a perspective of the essence. Bioinformatics tools that can mine proteomics data and lead to pathway analyses become an integral part of proteomics. Integrative proteomics covers both look-backs and look-outs of proteomics. It is an ideal reference for students, new researchers, and experienced scientists who want to get an overview or insights into new development of the proteomics field.

Author : Hon-Chiu Leung,Tsz Kwong Man,Ricardo Flores
Publisher : IntechOpen
Page : 454 pages
File Size : 50,8 Mb
Release : 2012-02-24
Category : Science
ISBN : 953510070X

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Integrative Proteomics by Hon-Chiu Leung,Tsz Kwong Man,Ricardo Flores Pdf

Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics, expert researchers contribute both historical perspectives, new developments in sample preparation, gel-based and non-gel-based protein separation and identification using mass spectrometry. Substantial chapters are describing studies of the sub-proteomes such as phosphoproteome or glycoproteomes which are directly related to functional outcomes of the cells. Structural proteomics related to pharmaceutics development is also a perspective of the essence. Bioinformatics tools that can mine proteomics data and lead to pathway analyses become an integral part of proteomics. Integrative proteomics covers both look-backs and look-outs of proteomics. It is an ideal reference for students, new researchers, and experienced scientists who want to get an overview or insights into new development of the proteomics field.

Author : Wolfgang Walz
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 51,6 Mb
Release : 2007-11-10
Category : Medical
ISBN : 9781592599257

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Integrative Physiology in the Proteomics and Post-Genomics Age by Wolfgang Walz Pdf

There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

Author : Anonim
Publisher : Unknown
Page : 178 pages
File Size : 41,5 Mb
Release : 2021-12-13
Category : Science
ISBN : 3036525823

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Integrative Multi-Omics in Biomedical Research by Anonim Pdf

Author : Usha N. Kasid,Robert Clarke
Publisher : Springer Nature
Page : 377 pages
File Size : 47,8 Mb
Release : 2023-05-16
Category : Medical
ISBN : 9781071631638

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Cancer Systems and Integrative Biology by Usha N. Kasid,Robert Clarke Pdf

This thorough volume explores recent advances that have revolutionized the field of precision oncology. The chapters, contributed by experts in the areas of cancer systems and integrative biology, provide hands-on guidance toward developing tools to monitor spatial and temporal changes in tumors, tracking tumor markers in blood, and ultimately developing precision medicine to combat cancer in real time. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that ensures successful results. Authoritative and informative, Cancer Systems and Integrative Biology serves as an invaluable resource for researchers, pharmaceutical scientists, and oncologists interested in expanding their knowledge base in the current developments in cancer research.

Author : Timothy D. Veenstra,John R. Yates, III
Publisher : John Wiley & Sons
Page : 348 pages
File Size : 48,9 Mb
Release : 2019-04-26
Category : Science
ISBN : 9781119081692

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Proteomics for Biological Discovery by Timothy D. Veenstra,John R. Yates, III Pdf

An update to the popular guide to proteomics technology applications in biomedical research Building on the strength of the original edition, this book presents the state of the art in the field of proteomics and offers students and scientists new tools and techniques to advance their own research. Written by leading experts in the field, it provides readers with an understanding of new and emerging directions for proteomics research and applications. Proteomics for Biological Discovery begins by discussing the emergence of proteomics technologies and summarizing the potential insights to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are thoroughly covered, from underlying concepts to limitations and future directions. Later chapters provide an overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, applied proteomics, and bioinformatics relevant to proteomics. Chapters cover: Quantitative Proteomics for Differential Protein Expression Profiling; Protein Microarrays; Protein Biomarker Discovery; Biomarker Discovery using Mass Spectrometry Imaging; Protein-Protein Interactions; Mass Spectrometry Of Intact Protein Complexes; Crosslinking Applications in Structural Proteomics; Functional Proteomics; High Resolution Interrogation of Biological Systems via Mass Cytometry; Characterization of Drug-Protein Interactions by Chemoproteomics; Phosphorylation; Large-Scale Phosphoproteomics; and Probing Glycoforms of Individual Proteins Using Antibody-Lectin Sandwich Arrays. Presents a comprehensive and coherent review of the major issues in proteomic technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Features new coverage of mass spectrometry for high throughput proteomic measurements, and novel quantitation strategies such as spectral counting and stable isotope labeling Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Offers new chapters on biomarker discovery, global phosphorylation analysis, proteomic profiling using antibodies, and single cell mass spectrometry Proteomics for Biological Discovery is an excellent advanced resource for graduate students, postdoctoral fellows, and scientists across all the major fields of biomedical science.

Author : Manish Kumar Gupta,Pramod Katara,Sukanta Mondal,Ram Lakhan Singh
Publisher : Elsevier
Page : 434 pages
File Size : 53,8 Mb
Release : 2024-05-10
Category : Science
ISBN : 9780443160936

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Integrative Omics by Manish Kumar Gupta,Pramod Katara,Sukanta Mondal,Ram Lakhan Singh Pdf

Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic ‘step by step’ manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to ‘translational research’, i.e., drug discovery, drug target prediction, and precision medicine Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways

Author : Ganesh K. Agrawal,Randeep Rakwal
Publisher : John Wiley & Sons
Page : 818 pages
File Size : 48,5 Mb
Release : 2008-10-03
Category : Science
ISBN : 9780470369838

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Plant Proteomics by Ganesh K. Agrawal,Randeep Rakwal Pdf

Confidently face the challenges of proteomics research specific to plant science with the information in Plant Proteomics, which will introduce you to the techniques and methodologies required for the study of representative plant species. Read about proteomics studies in Arabidopsis, rice, and legumes and find information about common technologies like mass spectrometry and gel electrophoresis. Discover expression proteomics, functional proteomics, structural proteomics, bioinformatics, and systems biology, understand how to conduct proteomics studies in developing countries and underfunded laboratories, and gain access to guidelines for sample preparation.

Author : Institute of Medicine
Publisher : National Academies Press
Page : 245 pages
File Size : 42,7 Mb
Release : 2009-10-16
Category : Medical
ISBN : 9780309147316

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Integrative Medicine and the Health of the Public by Institute of Medicine Pdf

The last century witnessed dramatic changes in the practice of health care, and coming decades promise advances that were not imaginable even in the relatively recent past. Science and technology continue to offer new insights into disease pathways and treatments, as well as mechanisms of protecting health and preventing disease. Genomics and proteomics are bringing personalized risk assessment, prevention, and treatment options within reach; health information technology is expediting the collection and analysis of large amounts of data that can lead to improved care; and many disciplines are contributing to a broadening understanding of the complex interplay among biology, environment, behavior, and socioeconomic factors that shape health and wellness. On February 25 - 27, 2009, the Institute of Medicine (IOM) convened the Summit on Integrative Medicine and the Health of the Public in Washington, DC. The summit brought together more than 600 scientists, academic leaders, policy experts, health practitioners, advocates, and other participants from many disciplines to examine the practice of integrative medicine, its scientific basis, and its potential for improving health. This publication summarizes the background, presentations, and discussions that occurred during the summit.

Author : Joshua Heazlewood,Christopher J. Petzold
Publisher : BoD – Books on Demand
Page : 280 pages
File Size : 42,8 Mb
Release : 2012-01-18
Category : Science
ISBN : 9789533076133

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Proteomic Applications in Biology by Joshua Heazlewood,Christopher J. Petzold Pdf

The past decade has seen the field of proteomics expand from a highly technical endeavor to a widely utilized technique. The objective of this book is to highlight the ways in which proteomics is currently being employed to address issues in the biological sciences. Although there have been significant advances in techniques involving the utilization of proteomics in biology, fundamental approaches involving basic sample visualization and protein identification still represent the principle techniques used by the vast majority of researchers to solve problems in biology. The work presented in this book extends from overviews of proteomics in specific biological subject areas to novel studies that have employed a proteomics-based approach. Collectively they demonstrate the power of established and developing proteomic techniques to characterize complex biological systems.

Author : Tingyun Kuang,Xuchu Wang,Xiaochun Qin,Shaojun Dai,Pingfang Yang,Ling Li
Publisher : MDPI
Page : 558 pages
File Size : 54,7 Mb
Release : 2020-05-22
Category : Science
ISBN : 9783039219605

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Plant Protein and Proteome Altlas--Integrated Omics Analyses of Plants under Abiotic Stresses by Tingyun Kuang,Xuchu Wang,Xiaochun Qin,Shaojun Dai,Pingfang Yang,Ling Li Pdf

Integrative omics of plants in response to stress conditions play more crucial roles in the post-genomic era. High-quality genomic data provide more deeper understanding of how plants to survive under environmental stresses. This book is focused on concluding the recent progress in the Protein and Proteome Atlas in plants under different stresses. It covers various aspects of plant protein ranging from agricultural proteomics, structure and function of proteins, and approaches for protein identification and quantification. A total of 27 papers including two timely reviews have contributed to this Special Issue. In the first part with the topic of “Comparative Proteomics of Different Plants”, six papers were included to describe the phenotypic changes and proteomic analyses of different plants under different conditions. Then, another six papers with the topic of “Proteomics of Plants under Osmotic Stress” were included to describe the recent comparative proteomics analyses of plants under osmotic stress, particularly the drought and salinity stresses in leaves of certain plant species. The other proteomics studies on several energy plants and economic crops were reported to demonstrate the recent omics studies on different plants during their development processes. More stress responsive genes and proteins in these plants were identified. These target genes and proteins are important candidates for further functional validation in economic plants and crops.

Author : Timothy D. Veenstra,John R. Yates, III
Publisher : John Wiley & Sons
Page : 361 pages
File Size : 41,7 Mb
Release : 2006-06-12
Category : Science
ISBN : 9780470007730

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Proteomics for Biological Discovery by Timothy D. Veenstra,John R. Yates, III Pdf

Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.

Author : Preeti Arivaradarajan,Gauri Misra
Publisher : Springer
Page : 148 pages
File Size : 50,7 Mb
Release : 2019-02-04
Category : Science
ISBN : 9789811329258

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Omics Approaches, Technologies And Applications by Preeti Arivaradarajan,Gauri Misra Pdf

This book is a concerted effort to put together the rapidly growing facets of biological data. It provides a platform for the readers to think about integrative approaches to solve complex biological problems. This fundamental book deals with the simplest concepts of omics to recent advancements in the field. The content is divided into seven chapters that provide insight into various omics approaches, omics technologies, and its applications. Each chapter delves into different molecular scales: genomics, transcriptomics, proteomics, and metabolomics. Further to provide a holistic view a chapter detailing microbiome has been included in the book. The sub-sections in the chapters is dedicated to introducing the various analytical tools such as next generation sequencing, chromatin immunoprecipitation, mass spectrometry, peptide mass fingerprinting, RNA Seq and NMR spectroscopy. It entails a chapter focused on the bioinformatics resources for analysis of the omics data. In summary, this comprehensive book emphasizes the recent advancements in the study of biomolecules spanning from DNA to metabolites.

Author : Daniel Liebler
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 54,5 Mb
Release : 2001-12-04
Category : Medical
ISBN : 9780896039919

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Introduction to Proteomics by Daniel Liebler Pdf

Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

Author : Francisco Azuaje,Joaquin Dopazo
Publisher : John Wiley & Sons
Page : 284 pages
File Size : 51,9 Mb
Release : 2005-06-24
Category : Science
ISBN : 9780470094402

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Data Analysis and Visualization in Genomics and Proteomics by Francisco Azuaje,Joaquin Dopazo Pdf

Data Analysis and Visualization in Genomics and Proteomics is the first book addressing integrative data analysis and visualization in this field. It addresses important techniques for the interpretation of data originating from multiple sources, encoded in different formats or protocols, and processed by multiple systems. One of the first systematic overviews of the problem of biological data integration using computational approaches This book provides scientists and students with the basis for the development and application of integrative computational methods to analyse biological data on a systemic scale Places emphasis on the processing of multiple data and knowledge resources, and the combination of different models and systems