Interleukin 2

Author : Kendall A Smith
Publisher : Elsevier
Page : 264 pages
File Size : 52,8 Mb
Release : 2012-12-02
Category : Health & Fitness
ISBN : 9780323139946

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Interleukin 2 by Kendall A Smith Pdf

Interleukin 2 focuses on interleukin 2 (IL-2) and its impact on immunology. Topics covered include IL-2's mechanism of action, the structure of the IL-2 receptor, the characteristics of natural and recombinant human IL-2, regulation of IL-2 production by the T cell antigen receptor, how IL-2 binding induces the transcription of a novel set of genes, and the pathological roles of IL-2 receptor inducers in adult T cell leukemia. This book is comprised of 12 chapters and begins with a historical overview of IL-2, from the discovery of soluble mitogenic factors in culture media of stimulated lymphocytes to the discovery of IL-2 as the molecule responsible for stimulating T cell proliferation. The physicochemical and biological properties of purified recombinant IL-2 are then described, paying particular attention to natural IL-2 derived from human peripheral blood leukocytes. The chapters that follow discuss the different techniques used to gain insight into the functionally important regions of IL-2, the role of the T cell antigen receptor in regulating the production of IL-2, and the structure of the human high-affinity IL-2 receptor. The book also describes transmembrane signaling by IL-2, IL-2-inducible gene expression in T lymphocytes, abnormal IL-2 receptor expression in adult T cell leukemia, the use of IL-2 receptors in immunosuppressive therapy, and the use of IL-2 as a pharmacologic reagent. This book will be of interest to students and researchers in immunology and biochemistry.

Author : J. Wagstaff
Publisher : Springer Science & Business Media
Page : 191 pages
File Size : 46,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401117531

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The role of interleukin-2 in the treatment of cancer patients by J. Wagstaff Pdf

Recombinant human interleukin-2 became available for clinical use in the mid 1980s. Recent years have seen an enormous amount of clinical research with this cytokine and interleukin-2 has now been registered for use in a number of European countries for the treatment of metastatic renal cell carcinoma. This book is designed to provide the clinical oncologist wishing to use interleukin-2 with a basic background concerning the biology of the agent, a discussion concerning practical aspects, of its clinical use including management of toxicity and an overview of the clinical results together with a description of how this internesting cytokine might be developed in the future.

Author : Eva Lotzova
Publisher : CRC Press
Page : 381 pages
File Size : 46,5 Mb
Release : 2018-02-01
Category : Science
ISBN : 9781351082242

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Interleukin-2 and Killer Cells in Cancer by Eva Lotzova Pdf

This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.

Author : Steven Gillis
Publisher : Springer Science & Business Media
Page : 305 pages
File Size : 40,6 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9781468448382

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The Interleukins by Steven Gillis Pdf

Investigations of the activation, proliferation, and, in some cases, differentia tion of mononuclear cells involved in the immune response are proceeding rapidly. These studies have resulted in the discovery of several factors that promote these cellular events, some of which have been characterized biochemically to various extents. Because of the considerable interest in understanding these cellular changes at the molecular level, we chose to produce the first thematic volume for Contemporary Topics in Molecular Immunology; the theme deals with certain regulatory factors that promote proliferation and differentiation. We have com piled contributions from numerous scientists well known for their work with several regulatory factors. In the following paragraphs, the reader will find an overview of the contents of this volume. Greene and Robb review data they have generated over the past 2-3 years with respect to characterization of hormone-specific Interleukin-2 (IL-2) recep tors on the surface of activated T cells. Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro ducer leukemic cells. The authors then describe an alternate approach, the prep aration of a monoclonal antibody previously determined to be directed against a T -cell-activation antigen. This so-called anti-Tac antibody was later found to recognize a determinant on or near the IL-2 receptor.

Author : Dorothea Busse
Publisher : Logos Verlag Berlin GmbH
Page : 114 pages
File Size : 46,5 Mb
Release : 2010
Category : Science
ISBN : 9783832526931

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Dynamics of the Il-2 Cytokine Network and T-cell Proliferation by Dorothea Busse Pdf

This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction. This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an autocrine positive feedback loop on both cell types. However, its differential regulation results in a switch-like up-regulation of the receptors on T helper cells and a gradual adaptation of the receptor levels to extracellular interleukin 2 supply on regulatory T cells. This difference enables regulatory T cells to efficiently compete for interleukin 2 and deprive T helper cells of their growth factor. Cell culture experiments verify these findings. It can be shown that the antigen stimulus and the intercellular distance are relevant control parameters for competition. Other mechanisms are described for suppression of T helper cell action by regulatory T cells; competition for interleukin 2 may act in concert with them.

Author : National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff
Publisher : Unknown
Page : 20 pages
File Size : 48,6 Mb
Release : 1989
Category : Cancer
ISBN : UCR:31210023584467

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Managing Interleukin-2 Therapy by National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff Pdf

Author : Jonathan Waxman,FR Balkwill
Publisher : Wiley-Blackwell
Page : 256 pages
File Size : 49,7 Mb
Release : 1992-11-16
Category : Medical
ISBN : 0632030429

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Interleukin-2 by Jonathan Waxman,FR Balkwill Pdf

Interleukin-2 "supercharges" the immune system by promoting the growth of activated T-lymphocytes and augmenting their cell-killing activities. It, therefore, has a role in cancer and infection and has been licensed for use in the former. The book will focus on the areas of molecular biology, immunoregulation and the generation of specific or non-specific cytotoxic effector cells and their role in tumour immunotherapy. Dr Balkwill is one of the UK's leading experts in cytokine research and Dr Waxman is an experienced oncologist working with cytokines in a clinical setting. The book will therefore be balanced between a scientific and a clinical angle

Author : Robert C. Rees
Publisher : IRL Press
Page : 208 pages
File Size : 47,7 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015019819179

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The Biology and Clinical Applications of Interleukin-2 by Robert C. Rees Pdf

The molecular structure of interleukin-2 (IL-2) and that of its receptor subunits provide a basis for understanding lymphocyte activation by IL-2 and the generation of effector cells capable of mediating cytotoxicity towards tumors. This book provides an up-to-date account of IL-2, its effect on lymphocyte function, and clinical applications. Internationally know experts review the molecular aspects of cell signalling, giving insight on the in vivo pathways of activation likely to be important in determining clinical responses. They also examine the use of cytokines, particularly IL-2, in the treatment of cancer, and describe the results of recent clinical trials using IL-2, as well as of adoptive cell therapy. Providing a clear account of recent progress, the book also reviews the problems involved in attempting to improve the therapeutic benefit of IL-2, along with the importance of mechanisms which subverse IL-2 responses. This is the most up-to-date account of molecular research and clinical trials in this area, and will be of great benefit to students and researchers in immunology, pharmacology, biochemistry, and oncology who are interested in this vitally important topic.

Author : J. Wagstaff
Publisher : Unknown
Page : 204 pages
File Size : 53,8 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 9401117543

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The Role of Interleukin-2 in the Treatment of Cancer Patients by J. Wagstaff Pdf

Author : Anonim
Publisher : Birkhäuser
Page : 0 pages
File Size : 40,7 Mb
Release : 2016-09-15
Category : Medical
ISBN : 3764385308

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Encyclopedia of Inflammatory Diseases by Anonim Pdf

Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.

Author : Ilana Löwy
Publisher : Harvard University Press
Page : 396 pages
File Size : 55,7 Mb
Release : 1996
Category : Cancer
ISBN : 0674068092

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Between Bench and Bedside by Ilana Löwy Pdf

Between Bench and Bedside is a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Löwy's book offers a remarkable insider's view of the culture of clinical experimentation in oncology.

Author : Eva Lotzova
Publisher : CRC Press
Page : 384 pages
File Size : 50,6 Mb
Release : 1989-12-21
Category : Science
ISBN : 0849353882

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Interleukin-2 and Killer Cells in Cancer by Eva Lotzova Pdf

This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.

Author : Anthony R. Mire-Sluis,Robin Thorpe
Publisher : Academic Press
Page : 584 pages
File Size : 50,7 Mb
Release : 1998-04-15
Category : Medical
ISBN : 0080530214

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Cytokines by Anthony R. Mire-Sluis,Robin Thorpe Pdf

This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book. Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information. Genetic information and sequences Protein structure Cell sources and production Biological activity Cytokine receptor structure and signal transduction Discussion of the role of cytokines in disease and the potential for therapy Summary table of essential facts Comprehensive bibliography

Author : Lucine Ohanes Bosnoyan
Publisher : Unknown
Page : 224 pages
File Size : 52,7 Mb
Release : 1986
Category : B cells
ISBN : OCLC:70313727

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Role of Interleukin-2 and Interleukin-2 Receptor in B Cell Proliferation by Lucine Ohanes Bosnoyan Pdf

Author : Anonim
Publisher : Unknown
Page : 1440 pages
File Size : 48,6 Mb
Release : 1990
Category : Medicine
ISBN : OSU:32436011073523

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Cumulated Index Medicus by Anonim Pdf