Intracellular Messengers

Author : C.M. Taylor
Publisher : Newnes
Page : 508 pages
File Size : 51,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080966946

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Intracellular Messengers by C.M. Taylor Pdf

This important new reference work offers an outstanding collection of articles devoted to the discussion of "intracellular messengers". Extracellular stimuli ("first messengers") bind to receptors on the plasma membrane of cells to trigger changes in the concentration of intracellular messengers ("second messengers") which leads, in turn, to changes in cellular activity. However, the intracellular activities of so called "third messengers" may also be involved complicating the concept of a rigid sequence of events between receptor and response. The preference for the term "intracellular messengers", and, hence, the title of this volume, recognizes that a complex web of interactions between intercellular messengers determines the concentrations and ultimate effects of each.

Author : Alan A. Boulton,Glen B. Baker,Colin W. Taylor
Publisher : Neuromethods
Page : 608 pages
File Size : 52,7 Mb
Release : 1992-02-27
Category : Medical
ISBN : UCAL:B4494624

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Intracellular Messengers by Alan A. Boulton,Glen B. Baker,Colin W. Taylor Pdf

This timely new volume in the highly acclaimed Neuromethods series focuses on major new advances in understanding the signaling mechanisms employed by neural tissues. Chapters, contributed by experts in the field, provide thorough, up-to-date coverage of a variety of topics and techniques, including: single-cell imaging technology • phosphorylation of target proteins • analysis of phosphoinositides and inositol phosphates • inositol trisphosphate and intracellular calcium • guanine nucleotide-binding proteins • ion channel gating • measurement of intracellular calcium with fluorescent calcium indicators • protein kinase C • synthetic analogs of intracellular messengers • cyclic nucleotides • caged intracellular messengers • intracellular regulators and components of the exocytotic pathway • intracellular messengers in vertebrate and invertebrate photoreceptors. Neuromethods 20 • Intracellular Messengers is an essential resource for neurobiologiests at all levels of research.

Author : D. Hardie
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 43,6 Mb
Release : 2013-12-01
Category : Science
ISBN : 9789401131087

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Biochemical Messengers by D. Hardie Pdf

The central theme of this book is that systems of cell-cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism. These topics therefore can and should be discussed in an integrated manner, and the division of cell signalling studies into separate pigeonholes such as neuroscience, endocrinology or cancer biology is unnecessary, if not counterproductive. I also believe it to be unfortunate that there is not a collective term to describe neurotransmitters, hormones, local mediators and growth factors, other than clumsy phrases such as "extracellular signal molecule". The lack of a short and distinctive word for these entities genuinely hampers people from thinking about them in an integrated way. Having decided that it was presumptuous to invent a new term, I have chosen in this book the term first messenger to cover all types of extracellular signal molecule, because of the widespread acceptance of the term second messenger to represent the intracellular signal molecules that are produced in response to many of them. I have given the book the title "biochemical messengers", which is a global term to cover both first and second messengers. The impetus for writing the book came, as must often be the case, when I had to put together a course on cell-cell signalling for biochemistry students at the University of Dundee.

Author : Robert M. Bell,John H. Exton,Stephen M. Prescott
Publisher : Springer Science & Business Media
Page : 344 pages
File Size : 49,9 Mb
Release : 1996-05-31
Category : Medical
ISBN : 0306451743

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Lipid Second Messengers by Robert M. Bell,John H. Exton,Stephen M. Prescott Pdf

Scientists in lipid biochemistry research have increasingly recognized the role of lipids as signaling molecules, aside from their importance in forming cellular membranes and storing energy. This book provides the latest findings on a wide variety of complex lipids in cells that function either as intracellular or intercellular messengers. International investigators present current data on the most extensively studied examples of both intracellular and intercellular messengers generated from lipids, and describe their basic mechanisms, which also utilize receptors in the G-protein-coupled family. The in-depth discussions address such topics as lipid signaling for protein kinase C activation, phosphatidic acid and lyso-phosphatidic acid, ceramide as a messenger, bioactive properties of Sphingosine and structurally related compounds, platelet-activating factor and PAF-like mimetics, and prostaglandins and related compounds. Lipid Second Messengers is an up-to-date reference on developments in the expanding field of lipid-derived signals and will be of interest to biochemists, physiologists, pharmacologists, geneticists, and biologists.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : P. Michael Conn,Anthony R. Means
Publisher : Springer Science & Business Media
Page : 474 pages
File Size : 43,6 Mb
Release : 2000-07-28
Category : Medical
ISBN : 9781592590322

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Principles of Molecular Regulation by P. Michael Conn,Anthony R. Means Pdf

With the dramatic growth in our knowledge of hormone action and the mechanisms of cell regulation, the need for an up-to-date broad-ranging survey of these processes has become pressing. In Principles of Molecular Regulation, P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear receptor-initiated gene regulation. Chosen for the excellence of their research as well as their demonstrated writing skills, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. They also discuss the molecular regulation of cell proliferation and death, as well as the impact of new technologies on rational drug discovery. Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.

Author : Dianna A. Redburn,Herminia Pasantes-Morales
Publisher : Unknown
Page : 336 pages
File Size : 52,6 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015013207934

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Extracellular and Intracellular Messengers in the Vertebrate Retina by Dianna A. Redburn,Herminia Pasantes-Morales Pdf

Author : S. R. Nahorski
Publisher : Unknown
Page : 272 pages
File Size : 42,8 Mb
Release : 1990-05-11
Category : Science
ISBN : UOM:39015019662785

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Transmembrane Signalling, Intracellular Messengers and Implications for Drug Development by S. R. Nahorski Pdf

The concept of membrane receptors as components that recognize extracellular ligands and translate their binding into appropriate intracellular responses has been central to pharmacology for more than a century. However, the last few years have seen developments at the molecular level, transforming the discipline of pharmacology. This study examines the latest developments in receptor structure, transmembrane signalling, second messenger generation and second messenger action. It provides access to each of these areas and gives an overview for the future drug manipulation of transmembrane signalling.

Author : Robert M. Bell,John H. Exton,Stephen M. Prescott
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 40,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781489913616

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Lipid Second Messengers by Robert M. Bell,John H. Exton,Stephen M. Prescott Pdf

Lipids traditionally have been viewed as serving two functions: to form cellular membranes and to serve as energy stores. During the last two decades, a new role for lipids has taken center stage: lipids can act as signalling molecules. This book deals with a variety of lipids that have been shown to be messengers. Leading scientists explore all known lipid classes except steroid hormones. Researchers and educators in biochemistry as well as in molecular and cellular biology will appreciate this volume.

Author : Maurice B. Hallett
Publisher : CRC Press
Page : 280 pages
File Size : 55,8 Mb
Release : 1989-01-31
Category : Science
ISBN : 0849348080

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The Neutrophil by Maurice B. Hallett Pdf

A synthesis and collation of the recent material regarding the role of the neutrophil in basic pathological processes is presented in this volume. The mechanisms of chemotaxis, secretion, phagocytosis, intracellular killing, oxygen radical production and arachidonate production are comprehensively reviewed. Stimulus response coupling in the neutrophil, with chapters on intracellular Ca2+, C-Kinase, phospholipid metabolism, microfilaments and membrane electrophysiology are extensively discussed. Each chapter provides a critical review by experts with over 1,000 cited references. Invaluable to graduate students and medical and scientific researchers, this book provides a unique, up-to-date account of cellular biochemistry and physiology of the neutrophil.

Author : Z. Kmiec
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 42,9 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642565533

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Cooperation of Liver Cells in Health and Disease by Z. Kmiec Pdf

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Author : Howard Rasmussen
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 46,6 Mb
Release : 1981
Category : Medical
ISBN : UCAL:B4494628

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Calcium and CAMP as Synarchic Messengers by Howard Rasmussen Pdf

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 46,7 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

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The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author : Steven E. Hyman,Eric Jonathan Nestler
Publisher : American Psychiatric Pub
Page : 270 pages
File Size : 45,6 Mb
Release : 1993
Category : Medical
ISBN : 0880483539

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The Molecular Foundations of Psychiatry by Steven E. Hyman,Eric Jonathan Nestler Pdf

This text offers a comprehensive introduction to molecular biology, genetics, and neurobiology relevant to psychiatry. Generously illustrated chapters are organized to be read at both an introductory and a more advanced level. Both beginners and advanced professionals will benefit from this text's discussion of how psychotropic drugs work and how gene-environment interactions may contribute to the pathogenesis of psychiatric disorders. The authors demonstrate how molecular investigations in psychiatry will revolutionize the field by leading to improved diagnostic testing, to new and more effective treatments, and ultimately to the development of preventive measures for mental illness.

Author : Morales
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 40,8 Mb
Release : 1988-12-01
Category : Electronic
ISBN : 0471504483

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Extracellular and Intracellular Messengers in the Vertebrate Retina by Morales Pdf