Introduction To Biopharmaceutics

Author : Notari
Publisher : Routledge
Page : 287 pages
File Size : 47,8 Mb
Release : 2017-11-22
Category : Science
ISBN : 9781351463843

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Biopharmaceutics and Clinical Pharmacokinetics by Notari Pdf

For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics. Now, the new Fourth Edition, Revised and Expanded further enhances the preceding editions'proven features, introducing significant advances in clinical pharmacokinetics, pharmacokineticdesign of drugs and dosage forms, and model-independent analyses. Still usable without prior knowledge of calculus or kinetics, this successfully implemented workbookmaintains a carefully graduated "building block" presentation, incorporating sample problemsand exercises throughout for a thorough understanding of the material.Biopharmaceutics and Clinical Pharmacokinetics features a growth-oriented format that systematicallydevelops and interrelates all subject matter .. . introduces basic theory and fields of application... emphasizes model-independent pharmacokinetic analyses ... presents biopharmaceutical aspectsof product design and evaluation .. . offers a unique approach to teaching dosage regimen design andindividualization . .. and considers structural modification of drug molecules for problems associatedwith pharmacokinetics. As a comprehensive coverage of the basic principles and the recent achievements in the field, noother textbook does as much for students of pharmacy, pharmacology, medicinal chemistry, andmedicine, or for scientists who desire a simple but thorough introduction to theory and application.

Author : Leon Shargel,Andrew B. C. Yu
Publisher : McGraw-Hill/Appleton & Lange
Page : 625 pages
File Size : 42,8 Mb
Release : 1993
Category : Biopharmaceutics
ISBN : 0838502393

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Applied Biopharmaceutics and Pharmacokinetics by Leon Shargel,Andrew B. C. Yu Pdf

Author : Hannah Batchelor
Publisher : John Wiley & Sons
Page : 324 pages
File Size : 46,8 Mb
Release : 2021-12-20
Category : Medical
ISBN : 9781119678281

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Biopharmaceutics by Hannah Batchelor Pdf

Explore the latest research in biopharmaceutics from leading contributors in the field In Biopharmaceutics - From Fundamentals to Industrial Practice, distinguished Scientists from the UK's Academy of Pharmaceutical Sciences Biopharmaceutica Focus Group deliver a comprehensive examination of the tools used within the field of biopharmaceutics and their applications to drug development. This edited volume is an indispensable tool for anyone seeking to better understand the field of biopharmaceutics as it rapidly develops and evolves. Beginning with an expansive introduction to the basics of biopharmaceutics and the context that underpins the field, the included resources go on to discuss how biopharmaceutics are integrated into product development within the pharmaceutical industry. Explorations of how the regulatory aspects of biopharmaceutics function, as well as the impact of physiology and anatomy on the rate and extent of drug absorption, follow. Readers will find insightful discussions of physiologically based modeling as a valuable asset in the biopharmaceutics toolkit and how to apply the principles of the field to special populations. The book goes on to discuss: Thorough introductions to biopharmaceutics, basic pharmacokinetics, and biopharmaceutics measures Comprehensive explorations of solubility, permeability, and dissolution Practical discussions of the use of biopharmaceutics to inform candidate drug selection and optimization, as well as biopharmaceutics tools for rational formulation design In-depth examinations of biopharmaceutics classification systems and regulatory biopharmaceutics, as well as regulatory biopharmaceutics and the impact of anatomy and physiology Perfect for professionals working in the pharmaceutical and biopharmaceutical industries, Biopharmaceutics - From Fundamentals to Industrial Practice is an incisive and up-to-date resource on the practical, pharmaceutical applications of the field.

Author : Robert E. Notari
Publisher : Unknown
Page : 408 pages
File Size : 52,9 Mb
Release : 1980
Category : Medical
ISBN : UOM:39015000863343

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Biopharmaceutics and Clinical Pharmacokinetics by Robert E. Notari Pdf

1 Bioavailability 1; 2. Rate processes in biological systems 5; 3. Principles of pharmacokinetics 45; 4. Biopharmaceutics: clinical applications of pharmacokinetic parameters 107; 5. Dosage regimens 173; 6. Pharmacokinetic aspects of structural modification in drug design and therapy 213; 7. An overview of pharmacokinetic applications in clinical practice 290; Appendix A: Fick's law 338; Appendix B: Vd 341; Appendix C: Area under I.V. curves 346; Appendix D: Multiple-dose equations 348; Appendix E: List of symbols of general occurrence 351.

Author : Rajesh Krishna,Lawrence Yu
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 52,6 Mb
Release : 2007-09-20
Category : Medical
ISBN : 9780387723792

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Biopharmaceutics Applications in Drug Development by Rajesh Krishna,Lawrence Yu Pdf

The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.

Author : Ashutosh Kar
Publisher : Elsevier Health Sciences
Page : 370 pages
File Size : 52,5 Mb
Release : 2010-09-15
Category : Medical
ISBN : 9788131232620

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Essentials of Biopharmaceutics and Pharmacokinetics - E-Book by Ashutosh Kar Pdf

Essentials of Biopharmaceutics and Pharmacokinetics Kar’s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically. The book interrelates five different sections: Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? Section 2 Biopharmaceutics Section 3 Pharmacokinetics Section 4 Clinical Pharmacokinetics Section 5 Bioavailability and Bioequivalence Each section starts with a basic theory and fields of application, focuses on model-independent pharmacokinetic analyses, expatiates various biopharmaceutical aspects of dosage form and evaluation, provides an altogether new approach in understanding both dosage regimen design and individualization, and explains modification in drug molecules related to the pharmacokinetics. Undoubtedly, the unique blend of fundamental principles and latest breakthroughs in the field will certainly provide sufficient subject matter to the students of pharmacy, pharmacology, medicinal chemistry scientists, who need a simple as well as detailed introduction in theory and application.

Author : Kiyohiko Sugano
Publisher : John Wiley & Sons
Page : 520 pages
File Size : 53,5 Mb
Release : 2012-07-31
Category : Medical
ISBN : 9781118354322

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Biopharmaceutics Modeling and Simulations by Kiyohiko Sugano Pdf

A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs. A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses: The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS) The concept of drug concentration How to simulate key drug absorption processes The physiological and drug property data used for biopharmaceutical modeling Reliable practices for reporting results With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research—including running and interpreting models, validation, and compound and formulation selection—this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.

Author : Anonim
Publisher : John Wiley & Sons
Page : 744 pages
File Size : 44,6 Mb
Release : 2013-12-16
Category : Science
ISBN : 9781118179796

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Biotechnology and Biopharmaceuticals by Anonim Pdf

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.

Author : Milo Gibaldi
Publisher : Unknown
Page : 92 pages
File Size : 48,9 Mb
Release : 1971
Category : Biopharmaceutics
ISBN : UOM:39015072267951

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Introduction to Biopharmaceutics by Milo Gibaldi Pdf

Author : Ming-Kung Yeh,Yuan-Chuan Chen
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 50,6 Mb
Release : 2018-09-19
Category : Medical
ISBN : 9781789237184

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Biopharmaceuticals by Ming-Kung Yeh,Yuan-Chuan Chen Pdf

Biopharmaceuticals are derived from biological sources, either live organisms or their active components; nowadays, they are mainly produced by biotechnologies. Biopharmaceuticals are extensively used in the treatment of various diseases such as cardiovascular, metabolic, neurological diseases, cancer, and others for which there are no available therapeutic methods. With the advance of science, biopharmaceuticals have revolutionized the treatment, prevention, and diagnosis of many patients with disabling and life-threatening diseases. Innovative biopharmaceuticals definitely improve the life quality of patients and enhance the effectiveness of the healthcare system. This book encompasses the discovery, production, application, and regulation of biopharmaceuticals to demonstrate their research achievement, prospects, and challenges. We expect the significance of biopharmaceuticals to be revealed and emphasized by this book.

Author : Robert E. Notari
Publisher : Unknown
Page : 310 pages
File Size : 41,9 Mb
Release : 1975
Category : Medical
ISBN : UOM:39015009584767

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Biopharmaceutics and Pharmacokinetics by Robert E. Notari Pdf

Author : Alan Talevi
Publisher : Springer Nature
Page : 1209 pages
File Size : 45,7 Mb
Release : 2022-06-14
Category : Medical
ISBN : 9783030848606

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The ADME Encyclopedia by Alan Talevi Pdf

The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties

Author : Late Dr. H.P Tipnis and Dr. Amrita Bajaj
Publisher : Pharma Career Publications
Page : 425 pages
File Size : 46,6 Mb
Release : 2019-03-01
Category : Medical
ISBN : 9788188739141

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Principles and Applications of Biopharmaceutics and Pharmacokinetics by Late Dr. H.P Tipnis and Dr. Amrita Bajaj Pdf

Author : Dr. A. R. Paradkar
Publisher : Pragati Books Pvt. Ltd.
Page : 198 pages
File Size : 54,9 Mb
Release : 2008-10-06
Category : Electronic
ISBN : 818579037X

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Biopharmaceutics & Pharmacokinetics by Dr. A. R. Paradkar Pdf

Author : Alan Talevi,Pablo A. M. Quiroga
Publisher : Springer
Page : 362 pages
File Size : 50,5 Mb
Release : 2018-11-30
Category : Medical
ISBN : 9783319995939

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ADME Processes in Pharmaceutical Sciences by Alan Talevi,Pablo A. M. Quiroga Pdf

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.