Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models
Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models book. This book definitely worth reading, it is an incredibly well-written.
Author : Joel S. Owen,Jill Fiedler-Kelly Publisher : John Wiley & Sons Page : 0 pages File Size : 42,6 Mb Release : 2014-07-08 Category : Medical ISBN : 0470582294
Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models by Joel S. Owen,Jill Fiedler-Kelly Pdf
This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website
Author : Peter L. Bonate Publisher : Springer Science & Business Media Page : 634 pages File Size : 43,7 Mb Release : 2011-07-01 Category : Medical ISBN : 9781441994851
Pharmacokinetic-Pharmacodynamic Modeling and Simulation by Peter L. Bonate Pdf
This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.
Author : Joel S. Owen,Jill Fiedler-Kelly Publisher : John Wiley & Sons Page : 368 pages File Size : 53,9 Mb Release : 2014-06-19 Category : Medical ISBN : 9781118784617
Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models by Joel S. Owen,Jill Fiedler-Kelly Pdf
This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website
Mixed Effects Models for the Population Approach by Marc Lavielle Pdf
Wide-Ranging Coverage of Parametric Modeling in Linear and Nonlinear Mixed Effects ModelsMixed Effects Models for the Population Approach: Models, Tasks, Methods and Tools presents a rigorous framework for describing, implementing, and using mixed effects models. With these models, readers can perform parameter estimation and modeling across a whol
Principles and Practice of Clinical Trials by Steven Piantadosi,Curtis L. Meinert Pdf
This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.
Nonlinear Models for Repeated Measurement Data by Marie Davidian Pdf
Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
Fuzzy Logic in Intelligent System Design by Patricia Melin,Oscar Castillo,Janusz Kacprzyk,Marek Reformat,William Melek Pdf
This book describes recent advances in the use of fuzzy logic for the design of hybrid intelligent systems based on nature-inspired optimization and their applications in areas such as intelligent control and robotics, pattern recognition, medical diagnosis, time series prediction and optimization of complex problems. Based on papers presented at the North American Fuzzy Information Processing Society Annual Conference (NAFIPS 2017), held in Cancun, Mexico from 16 to 18 October 2017, the book is divided into nine main parts, the first of which first addresses theoretical aspects, and proposes new concepts and algorithms based on type-1 fuzzy systems. The second part consists of papers on new concepts and algorithms for type-2 fuzzy systems, and on applications of type-2 fuzzy systems in diverse areas, such as time series prediction and pattern recognition. In turn, the third part contains papers that present enhancements to meta-heuristics based on fuzzy logic techniques describing new nature-inspired optimization algorithms that use fuzzy dynamic adaptation of parameters. The fourth part presents emergent intelligent models, which range from quantum algorithms to cellular automata. The fifth part explores applications of fuzzy logic in diverse areas of medicine, such as the diagnosis of hypertension and heart diseases. The sixth part describes new computational intelligence algorithms and their applications in different areas of intelligent control, while the seventh examines the use of fuzzy logic in different mathematic models. The eight part deals with a diverse range of applications of fuzzy logic, ranging from environmental to autonomous navigation, while the ninth covers theoretical concepts of fuzzy models
Total Intravenous Anesthesia and Target Controlled Infusions by Anthony R. Absalom,Keira P. Mason Pdf
This is a comprehensive and authoritative presentation of total intravenous anesthesia (TIVA) and target controlled infusion (TCI). The editors’ international reputation has enabled them to recruit leading experts from around the world to write single-author chapters in their area of expertise. Total Intravenous Anesthesia and Target Controlled Infusions is the first multi-disciplinary, globally authored volume on the topic. Providing a single source of information on all aspects of TIVA and TCI, from pharmacologic modeling and the pharmacology of intravenous anesthetic drugs to practical considerations in the clinical setting and the requirements of special populations, Total Intravenous Anesthesia and Target Controlled Infusions examines the debate about the risks and advantages of TIVA, analyze outcome studies, and provides guidance on creating a curriculum to teach TIVA and TCI.
Neuropsychopharmacology by Jahangir Moini,Anthony LoGalbo,Jennifer G. Schnellmann Pdf
Neuropsychopharmacology reviews the principles of pharmacology with a focus on the central nervous system and autonomic nervous system. Beyond autonomic and central nervous system pharmacology, this volume uniquely discusses psychiatric disorders and the pharmacological interventions that are available for conditions including depression, schizophrenia and anxiety disorders. With a focus on these specific body systems, readers will see end-of-chapter questions that offer real-world case studies, as well as multiple-choice questions for further learning. Beneficial features and content also include two extensive examination tests, which each contain 100 questions for better learning or to be used in teaching, and a glossary. Helpful appendices cover high-alert medications and toxicology effects on the nervous system. Each chapter will contain classifications of medications, pharmacokinetics, mechanism of action, clinical indications and toxicities. Describes pharmacology principles pertaining to the central and autonomic nervous system Identifies pharmacological interventions for psychiatric disorders including current evidence-based interventions for depression, schizophrenia and anxiety disorders Features chapter outlines, end-of-chapter questions, real-world case studies and examinations for deeper learning or teaching
Exploring Computational Pharmaceutics by Defang Ouyang Pdf
Provides an extensive and up-to-date overview of the theory and application of computational pharmaceutics in the drug development process Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 introduces a variety of current and emerging computational techniques for pharmaceutical research. Bringing together experts from academia, industry, and regulatory agencies, this edited volume also explores the current state, key challenges, and future outlook of computational pharmaceutics while encouraging development across all sectors of the field. Throughout the text, the authors discuss a wide range of essential topics, from molecular modeling and process simulation to intelligent manufacturing and quantitative pharmacology. Building upon Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0, this new edition provides a multi-scale perspective that reveals the physical, chemical, mathematical, and data-driven details of pre-formulation, formulation, process, and clinical studies, in addition to in vivo prediction in the human body and precision medicine in clinical settings. Detailed chapters address both conventional dosage forms and the application of computational technologies in advanced pharmaceutical research, such as dendrimer-based delivery systems, liposome and lipid membrane research, and inorganic nanoparticles. A major contribution to the development and promotion of computational pharmaceutics, this important resource: Discusses the development track, achievements, and prospects of computational pharmaceutics Presents multidisciplinary research to help physicists, chemists, mathematicians, and computer scientists locate problems in the field of drug delivery Covers a wide range of technologies, including complex formulations for water-insoluble drugs, protein/peptide formulations, nanomedicine, and gene delivery systems Focuses on the application of cutting-edge computational technologies and intelligent manufacturing of emerging pharmaceutical technologies Includes a systematic overview of computational pharmaceutics and Pharma 4.0 to assist non-specialist readers Covering introductory, advanced, and specialist topics, Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 is an invaluable resource for computational chemists, computational analysts, pharmaceutical chemists, process engineers, process managers, and pharmacologists, as well as computer scientists, medicinal chemists, clinical pharmacists, material scientists, and nanotechnology specialists working in the field.
João M. F. Rodrigues,Pedro J. S. Cardoso,Jânio Monteiro,Roberto Lam,Valeria V. Krzhizhanovskaya,Michael H. Lees,Jack J. Dongarra,Peter M.A. Sloot
Author : João M. F. Rodrigues,Pedro J. S. Cardoso,Jânio Monteiro,Roberto Lam,Valeria V. Krzhizhanovskaya,Michael H. Lees,Jack J. Dongarra,Peter M.A. Sloot Publisher : Springer Page : 659 pages File Size : 45,5 Mb Release : 2019-06-07 Category : Computers ISBN : 9783030227340
Computational Science – ICCS 2019 by João M. F. Rodrigues,Pedro J. S. Cardoso,Jânio Monteiro,Roberto Lam,Valeria V. Krzhizhanovskaya,Michael H. Lees,Jack J. Dongarra,Peter M.A. Sloot Pdf
The five-volume set LNCS 11536, 11537, 11538, 11539, and 11540 constitutes the proceedings of the 19th International Conference on Computational Science, ICCS 2019, held in Faro, Portugal, in June 2019. The total of 65 full papers and 168 workshop papers presented in this book set were carefully reviewed and selected from 573 submissions (228 submissions to the main track and 345 submissions to the workshops). The papers were organized in topical sections named: Part I: ICCS Main Track Part II: ICCS Main Track; Track of Advances in High-Performance Computational Earth Sciences: Applications and Frameworks; Track of Agent-Based Simulations, Adaptive Algorithms and Solvers; Track of Applications of Matrix Methods in Artificial Intelligence and Machine Learning; Track of Architecture, Languages, Compilation and Hardware Support for Emerging and Heterogeneous Systems Part III: Track of Biomedical and Bioinformatics Challenges for Computer Science; Track of Classifier Learning from Difficult Data; Track of Computational Finance and Business Intelligence; Track of Computational Optimization, Modelling and Simulation; Track of Computational Science in IoT and Smart Systems Part IV: Track of Data-Driven Computational Sciences; Track of Machine Learning and Data Assimilation for Dynamical Systems; Track of Marine Computing in the Interconnected World for the Benefit of the Society; Track of Multiscale Modelling and Simulation; Track of Simulations of Flow and Transport: Modeling, Algorithms and Computation Part V: Track of Smart Systems: Computer Vision, Sensor Networks and Machine Learning; Track of Solving Problems with Uncertainties; Track of Teaching Computational Science; Poster Track ICCS 2019 Chapter “Comparing Domain-decomposition Methods for the Parallelization of Distributed Land Surface Models” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Ene I. Ette,Paul J. Williams Publisher : John Wiley & Sons Page : 1236 pages File Size : 53,7 Mb Release : 2013-03-14 Category : Medical ISBN : 9781118679517
Pharmacometrics by Ene I. Ette,Paul J. Williams Pdf
Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: Integrates theory and practice to let the reader apply principles and concepts. Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.
Author : James E. Barrett,Clive P. Page,Martin C. Michel Publisher : Springer Nature Page : 466 pages File Size : 53,9 Mb Release : 2019-12-24 Category : Medical ISBN : 9783030353629
Concepts and Principles of Pharmacology by James E. Barrett,Clive P. Page,Martin C. Michel Pdf
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Discover the Latest Statistical Approaches for Modeling Exposure-Response RelationshipsWritten by an applied statistician with extensive practical experience in drug development, Exposure-Response Modeling: Methods and Practical Implementation explores a wide range of topics in exposure-response modeling, from traditional pharmacokinetic-pharmacody
