Invertebrate Models Of Natural And Drug Sensitive Reward

Author : Robert Huber,Moira van Staaden
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 48,5 Mb
Release : 2019-10-17
Category : Electronic
ISBN : 9782889459285

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Invertebrate Models of Natural and Drug‐Sensitive Reward by Robert Huber,Moira van Staaden Pdf

The rewarding properties of drugs depend on their capacity to activate appetitive motivational states. Because the mechanisms underlying natural reward are an important life-sustaining process and strongly conserved throughout metazoan evolution, invertebrate models provide a powerful complement to the mammalian systems traditionally used in addiction research. A wide range of organizational complexity, combined with genetically manipulable, and relatively simple, accessible nervous systems, make invertebrates excellent models in which to explore general addiction principles. These include the role of natural reward systems in learning, the basic biological mechanisms of drug addiction, and the long-term effects of early drug exposure. The contributions to this e-book illustrate the current state of invertebrate addiction research. The chapters show that the reward circuits of invertebrate taxa are surprisingly sensitive to human drugs of abuse. Employing learning paradigms typically used in vertebrate studies (viz., conditioned place preference and operant, self-administration paradigms), invertebrates are shown to exhibit aspects of the addiction cycle from activational effects of common psychostimulants, sensitization with repeated application, to extinction, withdrawal, and reinstatement. This highlights the value of the comparative approach for both exploring conserved mechanisms underlying drug addiction and the utility of invertebrate models in seeking potential solutions.

Author : Robert Huber,Moira van Staaden
Publisher : Unknown
Page : 0 pages
File Size : 46,5 Mb
Release : 2019
Category : Electronic
ISBN : OCLC:1368419491

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Invertebrate Models of Natural and Drug-Sensitive Reward by Robert Huber,Moira van Staaden Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : One R. Pagan
Publisher : BenBella Books
Page : 321 pages
File Size : 41,7 Mb
Release : 2021-11-16
Category : Science
ISBN : 9781950665372

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Drunk Flies and Stoned Dolphins by One R. Pagan Pdf

From the cup of coffee that jumpstarts the day to dangerously addictive drugs, the recreational use of plants with psychoactive properties has a long history among humans. But, as with many things, it turns out that other animals got there first. From parrots to primates, consuming medicinal chemicals is an instinctive behavior that helps countless organisms fight infection and treat disease. But the similarities don't end there: Like us, many creatures also consume substances that have no apparent benefit . . . except for inducing intoxication. In fact, animals have been using drugs for recreational purposes since prehistoric times. We may even have animals to thank for the idea—legend says that coffee was discovered by observing the behavior of goats that had eaten it. In his previous book, Strange Survivors, author and biologist Oné R. Pagán introduced readers to some of the truly bizarre strategies animals use to survive in the cutthroat world of natural selection. Now, in Drunk Flies and Stoned Dolphins, he sheds light on the surprising cravings they indulge when it's time to unwind. In this book, you'll get an eye-opening glimpse into the mind-altering behavior of the non-human members of the animal kingdom, spanning insects to elephants—including the dolphin species that apparently likes to pass around an intoxicating pufferfish as if they were sharing a joint. Combining fascinating science with humor and enthusiasm, Pagán's latest is full of the kind of unforgettable stories and odd facts that you'll find yourself repeating to everyone you meet. From fruit fly happy hour to the evolutionary reasons behind nature's drugs, Drunk Flies and Stoned Dolphins takes you on a trip through the colorful world of animal intoxication—and along the way, explores what this science reveals about the surprising connections between all the world's creatures.

Author : Ann-Christine Duhaime
Publisher : Harvard University Press
Page : 337 pages
File Size : 45,7 Mb
Release : 2022-10-18
Category : Science
ISBN : 9780674287624

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Minding the Climate by Ann-Christine Duhaime Pdf

A neurosurgeon explores how our tendency to prioritize short-term consumer pleasures spurs climate change, but also how the brain’s amazing capacity for flexibility can—and likely will—enable us to prioritize the long-term survival of humanity. Increasingly politicians, activists, media figures, and the public at large agree that climate change is an urgent problem. Yet that sense of urgency rarely translates into serious remedies. If we believe the climate crisis is real, why is it so difficult to change our behavior and our consumer tendencies? Minding the Climate investigates this problem in the neuroscience of decision-making. In particular, Ann-Christine Duhaime, MD, points to the evolution of the human brain during eons of resource scarcity. Understandably, the brain adapted to prioritize short-term survival over more uncertain long-term outcomes. But the resulting behavioral architecture is poorly suited to the present, when scarcity is a lesser concern and slow-moving, novel challenges like environmental issues present the greatest danger. Duhaime details how even our acknowledged best interests are thwarted by the brain’s reward system: if a behavior isn’t perceived as immediately beneficial, we probably won’t do it—never mind that we “know” we should. This is what happens when we lament climate change while indulging the short-term consumer satisfactions that ensure the disaster will continue. Luckily, we can sway our brains, and those of others, to alter our behaviors. Duhaime describes concrete, achievable interventions that have been shown to encourage our neurological circuits to embrace new rewards. Such small, incremental steps that individuals take, whether in their roles as consumers, in the workplace, or in leadership positions, are necessary to mitigate climate change. The more we understand how our tendencies can be overridden by our brain’s capacity to adapt, Duhaime argues, the more likely we are to have a future.

Author : Carrie Markgraf,Thomas Hudzik,David Compton
Publisher : Academic Press
Page : 320 pages
File Size : 42,5 Mb
Release : 2015-07-14
Category : Medical
ISBN : 9780124202160

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Nonclinical Assessment of Abuse Potential for New Pharmaceuticals by Carrie Markgraf,Thomas Hudzik,David Compton Pdf

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy

Author : Harold Pashler
Publisher : SAGE
Page : 897 pages
File Size : 51,5 Mb
Release : 2013-01-14
Category : Language Arts & Disciplines
ISBN : 9781412950572

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Encyclopedia of the Mind by Harold Pashler Pdf

It's hard to conceive of a topic of more broad and personal interest than the study of the mind. In addition to its traditional investigation by the disciplines of psychology, psychiatry, and neuroscience, the mind has also been a focus of study in the fields of philosophy, economics, anthropology, linguistics, computer science, molecular biology, education, and literature. In all these approaches, there is an almost universal fascination with how the mind works and how it affects our lives and our behavior. Studies of the mind and brain have crossed many exciting thresholds in recent years, and the study of mind now represents a thoroughly cross-disciplinary effort. Researchers from a wide range of disciplines seek answers to such questions as: What is mind? How does it operate? What is consciousness? This encyclopedia brings together scholars from the entire range of mind-related academic disciplines from across the arts and humanities, social sciences, life sciences, and computer science and engineering to explore the multidimensional nature of the human mind.

Author : Steven M. Miller
Publisher : John Benjamins Publishing Company
Page : 473 pages
File Size : 48,6 Mb
Release : 2015-06-15
Category : Psychology
ISBN : 9789027268785

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The Constitution of Phenomenal Consciousness by Steven M. Miller Pdf

Philosophers of mind have been arguing for decades about the nature of phenomenal consciousness and the relation between brain and mind. More recently, neuroscientists and philosophers of science have entered the discussion. Which neural activities in the brain constitute phenomenal consciousness, and how could science distinguish the neural correlates of consciousness from its neural constitution? At what level of neural activity is consciousness constituted in the brain and what might be learned from well-studied phenomena like binocular rivalry, attention, memory, affect, pain, dreams and coma? What should the science of consciousness want to know and what should explanation look like in this field? How should the constitution relation be applied to brain and mind and are other relations like identity, supervenience, realization, emergence and causation preferable? Building on a companion volume on the constitution of visual consciousness (AiCR 90), this volume addresses these questions and related empirical and conceptual territory. It brings together, for the first time, scientists and philosophers to discuss this engaging interdisciplinary topic.

Author : Lee Alan Dugatkin
Publisher : University of Chicago Press
Page : 593 pages
File Size : 55,9 Mb
Release : 2020-01-15
Category : Science
ISBN : 9780226448411

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Principles of Animal Behavior, 4th Edition by Lee Alan Dugatkin Pdf

Since the last edition of this definitive textbook was published in 2013, much has happened in the field of animal behavior. In this fourth edition, Lee Alan Dugatkin draws on cutting-edge new work not only to update and expand on the studies presented, but also to reinforce the previous editions’ focus on ultimate and proximate causation, as well as the book’s unique emphasis on natural selection, learning, and cultural transmission. The result is a state-of-the-art textbook on animal behavior that explains underlying concepts in a way that is both scientifically rigorous and accessible to students. Each chapter in the book provides a sound theoretical and conceptual basis upon which the empirical studies rest. A completely new feature in this edition are the Cognitive Connection boxes in Chapters 2–17, designed to dig deep into the importance of the cognitive underpinnings to many types of behaviors. Each box focuses on a specific issue related to cognition and the particular topic covered in that chapter. As Principles of Animal Behavior makes clear, the tapestry of animal behavior is created from weaving all of these components into a beautiful whole. With Dugatkin’s exquisitely illustrated, comprehensive, and up-to-date fourth edition, we are able to admire that beauty anew.

Author : Todd E. Feinberg,Jon M. Mallatt
Publisher : MIT Press
Page : 387 pages
File Size : 46,7 Mb
Release : 2016-03-25
Category : Science
ISBN : 9780262333276

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The Ancient Origins of Consciousness by Todd E. Feinberg,Jon M. Mallatt Pdf

How consciousness appeared much earlier in evolutionary history than is commonly assumed, and why all vertebrates and perhaps even some invertebrates are conscious. How is consciousness created? When did it first appear on Earth, and how did it evolve? What constitutes consciousness, and which animals can be said to be sentient? In this book, Todd Feinberg and Jon Mallatt draw on recent scientific findings to answer these questions—and to tackle the most fundamental question about the nature of consciousness: how does the material brain create subjective experience? After assembling a list of the biological and neurobiological features that seem responsible for consciousness, and considering the fossil record of evolution, Feinberg and Mallatt argue that consciousness appeared much earlier in evolutionary history than is commonly assumed. About 520 to 560 million years ago, they explain, the great “Cambrian explosion” of animal diversity produced the first complex brains, which were accompanied by the first appearance of consciousness; simple reflexive behaviors evolved into a unified inner world of subjective experiences. From this they deduce that all vertebrates are and have always been conscious—not just humans and other mammals, but also every fish, reptile, amphibian, and bird. Considering invertebrates, they find that arthropods (including insects and probably crustaceans) and cephalopods (including the octopus) meet many of the criteria for consciousness. The obvious and conventional wisdom–shattering implication is that consciousness evolved simultaneously but independently in the first vertebrates and possibly arthropods more than half a billion years ago. Combining evolutionary, neurobiological, and philosophical approaches allows Feinberg and Mallatt to offer an original solution to the “hard problem” of consciousness.

Author : Eduardo J. Fernandez,Sally L. Sherwen
Publisher : CABI
Page : 236 pages
File Size : 45,7 Mb
Release : 2024-05-30
Category : Science
ISBN : 9781800622685

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Human-Animal Interactions in Zoos by Eduardo J. Fernandez,Sally L. Sherwen Pdf

In the past couple of decades, Animal-Visitor Interactions (AVI), a type of Human-Animal Interaction (HAI), have become one of the major topics of interest for researchers working in zoos, especially in relation to animal welfare. This thought-provoking book summarizes the latest research concerning the impacts on HAIs in zoos, including the effects of visitors on animals and the effects of animals, exhibits, and the place itself on visitors. An invaluable resource for ethologists and animal behaviour and welfare students and practitioners, as well as social scientists and indeed anyone working with zoo animals.

Author : Daniel J. Siegel,Marion F. Solomon
Publisher : W. W. Norton & Company
Page : 304 pages
File Size : 45,5 Mb
Release : 2013-11-18
Category : Psychology
ISBN : 9780393708837

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Healing Moments in Psychotherapy (Norton Series on Interpersonal Neurobiology) by Daniel J. Siegel,Marion F. Solomon Pdf

Distinguished clinicians explain what lies at the heart of change in effective psychotherapy. A wide range of distinguished scientists and clinicians discuss the nature of change in the therapeutic process. Jaak Panksepp, Ian McGilchrist, Ruth Lanius, Francine Shapiro, and other luminaries offer readers a powerful journey through mindful awareness, neural integration, affective neuroscience, and therapeutic presence to reveal the transformational nature of therapy. Healing Moments in Psychotherapy dives deep into the art and science of healing from the perspective of a variety of clinical approaches and scientific viewpoints, including interpersonal neurobiology. Through the voices of a dozen clinicians and scientists presenting their combined experiences and wisdom, it serves as a window into the process of healing. Practical examples and empowering research data support the ways in which therapeutic relationships can help catalyze health and restore wellness within psychotherapy.

Author : Jay A. Gottfried
Publisher : CRC Press
Page : 466 pages
File Size : 49,9 Mb
Release : 2011-03-28
Category : Science
ISBN : 9781420067293

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Neurobiology of Sensation and Reward by Jay A. Gottfried Pdf

Synthesizing coverage of sensation and reward into a comprehensive systems overview, Neurobiology of Sensation and Reward presents a cutting-edge and multidisciplinary approach to the interplay of sensory and reward processing in the brain. While over the past 70 years these areas have drifted apart, this book makes a case for reuniting sensation and reward by highlighting the important links and interface between the two. Emphasizing the role of reward in reinforcing behaviors, the book begins with an exploration of the history, ecology, and evolution of sensation and reward. Progressing through the five senses, contributors explore how the brain extracts information from sensory cues. The chapter authors examine how different animal species predict rewards, thereby integrating sensation and reward in learning, focusing on effects in anatomy, physiology, and behavior. Drawing on empirical research, contributors build on the themes of the book to present insights into the human sensory rewards of perfume, art, and music, setting the scene for further cross-disciplinary collaborations that bridge the neurobiological interface between sensation and reward.

Author : Ralph D. Ellis,Peter Zachar
Publisher : John Benjamins Publishing
Page : 357 pages
File Size : 41,9 Mb
Release : 2012
Category : Psychology
ISBN : 9789027241573

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Categorical Versus Dimensional Models of Affect by Ralph D. Ellis,Peter Zachar Pdf

One of the most important theoretical and empirical issues in the scholarly study of emotion is whether there is a correct list of “basic” types of affect or whether all affective states are better modeled as a combination of locations on shared underlying dimensions. Many thinkers have written on this topic, yet the views of two scientists in particular are dominant. The first is Jaak Panksepp, the father of Affective Neuroscience. Panksepp conceptualizes affect as a set of distinct categories. The leading proponent of the dimensional approach in scientific psychology is James Russell. According to Russell all affect can be decomposed into two underlying dimensions, pleasure versus displeasure and low arousal versus high arousal. In this volume Panksepp and Russell each articulate their positions on eleven fundamental questions about the nature of affect followed by a discussion of these target papers by noted emotion theorists and researchers. Russell and Panksepp respond both to each other and to the commentators. The discussion leads to some stark contrasts, with formidable arguments on both sides, and some interesting convergences between the two streams of work.

Author : Anonim
Publisher : Unknown
Page : 776 pages
File Size : 42,5 Mb
Release : 1989
Category : Medicine
ISBN : UOM:39015014022589

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Research Awards Index by Anonim Pdf

Author : National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 113 pages
File Size : 49,5 Mb
Release : 1988-02-01
Category : Science
ISBN : 9780309038393

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Use of Laboratory Animals in Biomedical and Behavioral Research by National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research Pdf

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.