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Author : Simon Hunkler
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 2023
Category : Electronic
ISBN : OCLC:1419435914
Author : Ke-li Han,Xin Zhang,Ming-jun Yang
Publisher : Springer Science & Business Media
Page : 488 pages
File Size : 42,9 Mb
Release : 2014-01-20
Category : Medical
ISBN : 9783319029702
This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.
Author : Eudenilson L. Albuquerque,Umberto L. Fulco,Ewerton W. S. Caetano,Valder N. Freire
Publisher : Cambridge University Press
Page : 435 pages
File Size : 52,7 Mb
Release : 2021-02-11
Category : Science
ISBN : 9781108477796
This book covers quantum chemical simulation of molecular systems and their quantum chemical properties, alongside the most cutting-edge biomedical applications.
Author : Yutaka Ito,Volker Dötsch,Masahiro Shirakawa
Publisher : Royal Society of Chemistry
Page : 322 pages
File Size : 46,7 Mb
Release : 2019-12-13
Category : Science
ISBN : 9781788012171
In-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.
Author : Mark S. Formaneck
Publisher : Unknown
Page : 268 pages
File Size : 55,9 Mb
Release : 2006
Category : Electronic
ISBN : WISC:89095252466
Author : Wen-Yong Lou,Jun Ge,Changzhu Wu,Jesús Fernández Lucas
Publisher : Frontiers Media SA
Page : 492 pages
File Size : 45,5 Mb
Release : 2021-04-21
Category : Science
ISBN : 9782889667093
Author : Monika Fuxreiter
Publisher : CRC Press
Page : 458 pages
File Size : 45,8 Mb
Release : 2014-12-24
Category : Science
ISBN : 9781482297867
The Latest Developments on the Role of Dynamics in Protein FunctionsComputational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, an
Author : Dastmalchi, Siavoush
Publisher : IGI Global
Page : 456 pages
File Size : 45,9 Mb
Release : 2016-05-03
Category : Medical
ISBN : 9781522501169
The role of technology in the medical field has resulted in significant developments within the pharmaceutical industry. Computational approaches have emerged as a crucial method in further advancing drug design and development. Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery presents emerging research on the application of computer-assisted design methods for drugs, emphasizing the benefits and improvements that molecular docking has caused within the pharmaceutical industry. Focusing on validation methods, search algorithms, and scoring functions, this book is a pivotal resource for professionals, researchers, students, and practitioners in the field of theoretical and computational chemistry.
Author : Thomas C. Allison,Orkid Coskuner,Carlos A. Gonzalez
Publisher : CRC Press
Page : 432 pages
File Size : 47,8 Mb
Release : 2011-05-09
Category : Science
ISBN : 9781420060867
Metallic systems are ubiquitous in daily life. They play key roles, for example, in the chemistry of many biomolecules, ionic solutions, nanoparticles, and catalytic processes. They may be in solid, liquid, or gaseous form. The interactions of other molecules with metal surfaces are of considerable importance. Each of these topics is addressed in M
Author : Eva Pebay-Peyroula
Publisher : John Wiley & Sons
Page : 368 pages
File Size : 41,9 Mb
Release : 2008-06-25
Category : Science
ISBN : 9783527621231
Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is the first of its kind to present the full range of novel techniques in one resource. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopies, finishing off with an exploration of structure-function relationships in whole cells.
Author : Lichang Wang
Publisher : BoD – Books on Demand
Page : 448 pages
File Size : 55,6 Mb
Release : 2012-04-11
Category : Computers
ISBN : 9789535104445
Molecular Dynamics is a two-volume compendium of the ever-growing applications of molecular dynamics simulations to solve a wider range of scientific and engineering challenges. The contents illustrate the rapid progress on molecular dynamics simulations in many fields of science and technology, such as nanotechnology, energy research, and biology, due to the advances of new dynamics theories and the extraordinary power of today's computers. This second book begins with an introduction of molecular dynamics simulations to macromolecules and then illustrates the computer experiments using molecular dynamics simulations in the studies of synthetic and biological macromolecules, plasmas, and nanomachines. Coverage of this book includes: Complex formation and dynamics of polymers Dynamics of lipid bilayers, peptides, DNA, RNA, and proteins Complex liquids and plasmas Dynamics of molecules on surfaces Nanofluidics and nanomachines
Author : Anonim
Publisher : Academic Press
Page : 634 pages
File Size : 46,6 Mb
Release : 2015-10-08
Category : Medical
ISBN : 9780128028476
Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions Part A & B, are the latest volumes in the Methods in Enzymology series, continuing the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods centered on the use of Electron Paramagnetic Resonance (EPR) techniques to study biological structure and function. Timely contribution that describes a rapidly changing field Leading researchers in the field Broad coverage: Instrumentation, basic theory, data analysis, and applications
Author : Anonim
Publisher : Academic Press
Page : 514 pages
File Size : 50,5 Mb
Release : 2016-08-03
Category : Medical
ISBN : 9780128111086
Computational Approaches for Studying Enzyme Mechanism, Part B is the first of two volumes in the Methods in Enzymology series that focuses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of the life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, genetics, and other fields of study. Focuses on computational approaches for studying enzyme mechanism Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins, and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers
Author : DIWAKAR EDUCATION HUB
Publisher : DIWAKAR EDUCATION HUB
Page : 345 pages
File Size : 51,9 Mb
Release : 2024-03-07
Category : Science
ISBN : 8210379456XXX
Graduate Aptitude Test Biotechnology [DBT-PG] Practice Sets 3000 + Question Answer Chapter Wise Book As Per Updated Syllabus Highlights of Question Answer – Covered All 13 Chapters of Latest Syllabus Question As Per Syllabus The Chapters are- 1.Biomolecules-structure and functions 2.Viruses- structure and classification 3.Prokaryotic and eukaryotic cell structure 4.Molecular structure of genes and chromosomes 5.Major bioinformatics resources and search tools 6.Restriction and modification enzyme 7.Production of secondary metabolites by plant suspension cultures; 8.Animal cell culture; media composition and growth conditions 9.Chemical engineering principles applied to biological system 10. Engineering principle of bioprocessing – 11.Tissue culture and its application, In Each Chapter[Unit] Given 230+ With Explanation In Each Unit You Will Get 230 + Question Answer Based on Exam Pattern Total 3000 + Questions Answer with Explanation Design by Professor & JRF Qualified Faculties
Author : Sanjeev Kumar Singh
Publisher : Springer Nature
Page : 334 pages
File Size : 46,8 Mb
Release : 2021-02-02
Category : Science
ISBN : 9789811589362
This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.