Ion Channels In The Cardiovascular System

Author : Anonim
Publisher : Unknown
Page : 580 pages
File Size : 55,5 Mb
Release : 1994
Category : Heart
ISBN : 0871685221

Get Book

Ion Channels in the Cardiovascular System by Anonim Pdf

Author : M. Morad,S. Ebashi,W. Trautwein,Yoshihisa Kurachi
Publisher : Springer Science & Business Media
Page : 586 pages
File Size : 40,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401139908

Get Book

Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters by M. Morad,S. Ebashi,W. Trautwein,Yoshihisa Kurachi Pdf

Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

Author : PM Spooner
Publisher : Wiley-Blackwell
Page : 616 pages
File Size : 51,6 Mb
Release : 1994-10-27
Category : Medical
ISBN : 087993591X

Get Book

Ion Channels in the Cardiovascular System by PM Spooner Pdf

A state-of-the-art presentation of the technology for studying human chromosomes. The book serves as a basic techniques manual designed to concisely present the current working protocols in cytogenetics. Beginning with a decription of tissue culture procedures for all tissue types from blood to solid tumors, subsequent chapters provide extensive coverage of chromosome preparations, differential staining techniques, chromosome sorting, high-resolution banding, fragile X analysis, sister chromatoid exchanges and DNA replication. A new chapter entitled "Molecular Cytogenetic Techniques" covers the latest fluorescent in-site hybridization (FISH) procedures illustrated by 20 colour plates. Summarizes latest research on the structure, organization, function, and regulation of ion channels in the cardiovascular system. This text deals with the fundamental biology and clinical implications of the function and dysfunction of major ion channel types. Particular focus is given to channels in the heart. The material presented will provide an increased understanding of channel biology and provide a stronger interdisciplinary appreciation of its potential role in treating cardiovascular disease

Author : Roland N. Pittman
Publisher : Biota Publishing
Page : 117 pages
File Size : 49,6 Mb
Release : 2016-08-18
Category : Medical
ISBN : 9781615047215

Get Book

Regulation of Tissue Oxygenation, Second Edition by Roland N. Pittman Pdf

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Author : Ihor Gussak,Charles Antzelevitch,Stephen C. Hammill,Win K. Shen,Preben Bjerregaard
Publisher : Springer Science & Business Media
Page : 549 pages
File Size : 53,8 Mb
Release : 2003-03-13
Category : Medical
ISBN : 9781592593620

Get Book

Cardiac Repolarization by Ihor Gussak,Charles Antzelevitch,Stephen C. Hammill,Win K. Shen,Preben Bjerregaard Pdf

A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

Author : Dierk Thomas,Carol Ann Remme
Publisher : Springer
Page : 436 pages
File Size : 50,5 Mb
Release : 2018-09-10
Category : Medical
ISBN : 9783319778129

Get Book

Channelopathies in Heart Disease by Dierk Thomas,Carol Ann Remme Pdf

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.

Author : Geoffrey S. Pitt
Publisher : Academic Press
Page : 392 pages
File Size : 47,9 Mb
Release : 2016-10-04
Category : Science
ISBN : 9780128020173

Get Book

Ion Channels in Health and Disease by Geoffrey S. Pitt Pdf

Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

Author : Stephen L. Archer,Nancy J. Rusch
Publisher : Springer Science & Business Media
Page : 899 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461513032

Get Book

Potassium Channels in Cardiovascular Biology by Stephen L. Archer,Nancy J. Rusch Pdf

Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K+ channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation. They are also promising targets for antihypertensive treatments with drugs which open and close specific types of K+ channels, making for an active field of research. With their ability to control vascular tone, voltage-gated K+ channels play a significant role in both pulmonary and systemic hypertension as well as in cardiac arrhythmias. This book will highlight the latest discoveries by leading researchers pertaining to the role of K+ channels in the heart and blood vessels in normal physiology and a variety of disease states.

Author : Jie Zheng,Matthew C. Trudeau
Publisher : CRC Press
Page : 246 pages
File Size : 54,5 Mb
Release : 2023-06-28
Category : Medical
ISBN : 9781000857849

Get Book

Textbook of Ion Channels Volume III by Jie Zheng,Matthew C. Trudeau Pdf

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium–calmodulin regulation, regulation by G pro- teins, and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consid- eration of ion channels in epilepsy, cystic fibrosis and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and includecoverage of key examples of regulatory, physiological, and disease roles for ion channels.

Author : Anonim
Publisher : Academic Press
Page : 370 pages
File Size : 49,6 Mb
Release : 2020-05-22
Category : Science
ISBN : 9780128200902

Get Book

Ion Channels and Calcium Signaling in the Microcirculation by Anonim Pdf

Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more. Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels. Presents the latest volume in the Current Topics in Membranes series, with a novel focus on smooth muscle and endothelial cells in the peripheral microcirculation Provides authoritative contributions from an international team of leading experts actively studying the microcirculation Includes a unique focus on regional heterogeneity in ion channel expression and function in the peripheral microcirculation

Author : Bertil Hille
Publisher : Sinauer Associates, Incorporated
Page : 632 pages
File Size : 55,9 Mb
Release : 1992
Category : Excitable membranes
ISBN : UOM:39015024124383

Get Book

Ionic Channels of Excitable Membranes by Bertil Hille Pdf

This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.

Author : John M Evans
Publisher : CRC Press
Page : 449 pages
File Size : 53,9 Mb
Release : 1996-04-01
Category : Medical
ISBN : 9781482272840

Get Book

Potassium Channels And Their Modulators by John M Evans Pdf

Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in th

Author : Michitoshi Inoue,Masatsugu Hori,Shoichi Imai,Robert M. Berne
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 50,7 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9784431683674

Get Book

Regulation of Coronary Blood Flow by Michitoshi Inoue,Masatsugu Hori,Shoichi Imai,Robert M. Berne Pdf

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Yoshihisa Kurachi,Andre Terzic,Michael V. Cohen
Publisher : Elsevier
Page : 1286 pages
File Size : 47,5 Mb
Release : 2000-10-09
Category : Science
ISBN : 9780080533889

Get Book

Heart Physiology and Pathophysiology by Yoshihisa Kurachi,Andre Terzic,Michael V. Cohen Pdf

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology