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Isolation And Characterization Of Enu Induced Mutations Disrupting Normal Postimplantation Development In The Mouse Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Isolation And Characterization Of Enu Induced Mutations Disrupting Normal Postimplantation Development In The Mouse book. This book definitely worth reading, it is an incredibly well-written.
Author : Andrew Joseph Kasarskis
Publisher : Unknown
Page : 638 pages
File Size : 48,8 Mb
Release : 1998
Category : Electronic
ISBN : UCAL:C3410052
Author : Anonim
Publisher : Unknown
Page : 700 pages
File Size : 53,7 Mb
Release : 1999
Category : Dissertations, Academic
ISBN : STANFORD:36105028425226
Author : Anonim
Publisher : Unknown
Page : 784 pages
File Size : 48,5 Mb
Release : 1998
Category : Dissertation abstracts
ISBN : UOM:39015086908186
Author : Andrew F. Olshan,Donald R. Mattison
Publisher : Springer Science & Business Media
Page : 401 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461518778
The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.
Author : Ariff Bongso,Eng Hin Lee
Publisher : World Scientific
Page : 721 pages
File Size : 43,8 Mb
Release : 2011
Category : Science
ISBN : 9789814289382
Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications.
Author : Carolyn A. Staton,Claire Lewis,Roy Bicknell
Publisher : John Wiley & Sons
Page : 410 pages
File Size : 48,6 Mb
Release : 2007-01-11
Category : Medical
ISBN : 9780470029343
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author : Francisco Pelegri,Michael Danilchik,Ann Sutherland
Publisher : Springer
Page : 549 pages
File Size : 46,7 Mb
Release : 2016-12-13
Category : Science
ISBN : 9783319460956
This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.
Author : D. G. Wilkinson
Publisher : Oxford University Press, USA
Page : 224 pages
File Size : 46,6 Mb
Release : 1998
Category : Science
ISBN : 0199636583
In situ hybridization is used to reveal the location of specific nucleic acids sequences on chromosomes or in tissues. Visualization of the location of genes on chromosomes or of specific mRNAs or viruses in tissues is crucial for understanding the organization, regulation, and function of genes. It is a therefore a core technique in all areas of biomedical research. In Situ Hybridization: A Practical Approach 2/e is the second edition of one of the most successful Practical Approach books, published in 1992. Since the first edition was published, a number of important technical advances have been made. The new edition has been thoroughly updated to contain protocols detailing the major techniques of in situ hybridization currently in use: in situ hybridization to mRNA with oligonucleotide and RNA probes (radiolabelled and hapten labelled); analysis using light and electron microscopes; whole mount in situ hybridization; double detection of RNAs, and RNA plus protein; and fluorescent in situ hybridization to detect chromosomal sequences. The protocols are complemented by advice on strategies for successful results, descriptions of the theoretical basis of in situ hybridization and important new developments in gene expression databases. The procedures described are widely applicable to many systems. The use of in situ hybridization in PCR is covered in a separate volume: Herrington and O'Leary (Eds) PCR 3 - PCR in situ hybridization: A Practical Approach (OUP, 1997). All the authors have extensive practical experience of establishing reliable techniques of in situ hybridization. This book will be useful to all researchers at all levels who use in situ hybridization.
Author : Paul T. Sharpe,Ivor Mason
Publisher : Springer Science & Business Media
Page : 752 pages
File Size : 51,5 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592592708
Most people have some interest in embryos; this probably results, in part, from their interest in understanding the biological origins of themselves and their offspring and, increasingly, concerns about how environmental change such as pollution might affect human development. Obviously, et- cal considerations preclude experimental studies of human embryos and, c- sequently, the developmental biologist has turned to other species to examine this process. Fortunately, the most significant conclusion to be drawn from the experimental embryology of the last two decades is the manner in which orthologous or closely related molecules are deployed to mediate similar - velopmental processes in both vertebrates and invertebrates. The molecular mechanisms regulating processes fundamental to most animals, such as axial patterning or axon guidance, are frequently conserved during evolution. (It is now widely believed that the differences between phyla and classes are the result of new genes, arising mostly by duplication and divergence of extant sequences, regulating the appearance of derived characters. ) Other vertebrates are obviously most likely to use the same devel- mental mechanisms as humans and, within the vertebrate subphylum, the - parent degree of conservation of developmental mechanism is considerable. It has long been recognized that particular vertebrate species offer either d- tinct advantages in investigating particular stages of development or are - pecially amenable to particular manipulations. No single animal can provide all the answers because not all types of experiments can be carried out on a single species.
Author : Brigid Hogan,Frank Costantini,Elizabeth Lacy
Publisher : Cold Spring Harbor Laboratory Press
Page : 352 pages
File Size : 47,6 Mb
Release : 1986
Category : Nature
ISBN : UOM:39015012640598
Of mouse development -- Setting up a colony for the production of transgenic mice -- Recovery, culture, and transfer of embryos -- Introduction of new genetic information into the developing mouse embryo -- Iolation of pluripotential stem cell lines -- Techhniques for visualizing genes and gene products -- In vitro culture of eggs, embryos, and teratocarcinoma cels -- Chemicals, supplies, and solutions.
Author : E.L. Abel
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461307358
Most textbooks are cumbersome to carry, expensive to buy, difficult to read, and boring. They have no plot, no characterization, no suspense, no climax. What they have are facts. If Dragnet's Sgt. Friday were Scientist Friday, the script wouldn't be much different "just the facts, ma'am." Students can't escape textbooks. But like death and taxes, they are necessary evils. of old ideas makes room for new ones. Death makes room for new people and the death Taxes are the dues we pay to live in a country. Everybody gets stuck with paying some kind of dues and students are no exception. Students pay dues in the form of tuition to listen to professors lecture, and they also pay dues in what a former governor of California called' 'psychic bucks" -time, concentration, independent study, reading textbooks like this one-to come up with the correct answers to exam questions. Textbooks on economics will tell you about where our tuition bucks come from. This book is about where our psychic bucks come from and the forces that can bankrupt our psychic nest eggs.
Author : Eberhard Passarge
Publisher : Thieme
Page : 500 pages
File Size : 42,8 Mb
Release : 2011-01-01
Category : Medical
ISBN : 9781604061383
A remarkable achievement by a single author...concise but informative...No geneticist or physician interested in genetic diseases should be without a copy of this remarkable edition. --American Journal of Medical GeneticsMore than ever, a solid understanding of genetics is a fundamental element of all medical and scientific educational programs, across virtually all disciplines. And the applications--and implications--of genetic research are at the heart of current medical scientific debates. Completely updated and revised, The Color Atlas of Genetics is an invaluable guide for students of medicine and biology, clinicians, and anyone else interested in this rapidly evolving field. The latest edition of this highly praised atlas retains several popular features, such as the accessible layout and logical structure, in addition to many novel features and 20 completely new color plates on new topics, including: Cell-to-cell communication, including important signaling and metabolic pathways Taxonomy of living organisms (tree of life) Epigenetic modifications in chromatin Apoptosis RNA interference (RNAi) Comparative genomic hybridization Origins of cancer Principles of gene and stem cell therapy, etc. With more than 200 absorbing full-color plates concisely explained on facing pages, the atlas offers readers an easy-to-use, yet remarkably detailed guide to key molecular, theoretical, and medical aspects of genetics and genomics. Brief descriptions of numerous genetic diseases are included, with references for more detailed information.Readers will find that this incomparable book presents a comprehensive picture of the field from its fascinating history to its most advanced applications.
Author : Concezio Di Rocco,Dachling Pang,James T. Rutka
Publisher : Springer
Page : 0 pages
File Size : 53,8 Mb
Release : 2020-07-14
Category : Medical
ISBN : 3319721674
This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.
Author : Food and Agriculture Organization of the United Nations,World Health Organization
Publisher : Food & Agriculture Org.
Page : 839 pages
File Size : 42,8 Mb
Release : 2021-09-06
Category : Technology & Engineering
ISBN : 9789251335048
A Joint Meeting of the Food and Agriculture Organization of the United Nations (FAO) Panel of experts on Pesticide Residues in Food and the Environment and the World Health Organization (WHO) Core assessment Group on Pesticide Residues (JMPR) was held in Geneva, Switzerland, from 17 to 26 September 2019. The FAO Panel Members met in preparatory sessions from 12 to 16 September. The Meeting evaluated 30 pesticides, including eight new compounds and three compounds that were re-evaluated for toxicity or residues, or both, within the periodic review programme of the Codex Committee on Pesticide Residues (CCPR). The Meeting established ADIs and ARfDs, estimated maximum residue levels and recommended them for use by CCPR, and estimated supervised trials median residue (STMR) and highest residue (HR) levels as a basis for estimating dietary exposures. The Meeting also estimated the dietary exposures (both acute and long-term) to the pesticides reviewed and, on this basis, performed a dietary risk assessment in relation to the relevant ADI and where necessary the ARfD. Cases in which ADIs or ARfDs may be exceeded, if they occur, are clearly indicated in order to facilitate the decision-making process by CCPR. The Meeting considered a number of general issues addressing procedures for the evaluation and risk assessment of pesticide residues.
Author : Robert E. Anderson,Joe G. Hollyfield,Matthew M LaVail
Publisher : Springer Science & Business Media
Page : 715 pages
File Size : 54,5 Mb
Release : 2010-03-19
Category : Medical
ISBN : 9781441913982
This is the proceedings of the XIIIth International Symposium on Retinal Degenerations, which will be held in Emeishan, Sichuan, China on September 18 - 23, 2008. The themes will include "Molecular and genetic mechanisms in photoreceptor degeneration", "Age-related macular degeneration", "New diagnostic techniques for retinal degenerations". "Neuroprotection in the prevention of retinal degeneration", "Gene therapy and the correction of gene defects", as well as other emerging topics that may develop over the next few months.