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We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing, and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.
We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.
Graphical Models, Exponential Families, and Variational Inference by Martin J. Wainwright,Michael Irwin Jordan Pdf
The core of this paper is a general set of variational principles for the problems of computing marginal probabilities and modes, applicable to multivariate statistical models in the exponential family.
Theory of Statistical Inference by Anthony Almudevar Pdf
Theory of Statistical Inference is designed as a reference on statistical inference for researchers and students at the graduate or advanced undergraduate level. It presents a unified treatment of the foundational ideas of modern statistical inference, and would be suitable for a core course in a graduate program in statistics or biostatistics. The emphasis is on the application of mathematical theory to the problem of inference, leading to an optimization theory allowing the choice of those statistical methods yielding the most efficient use of data. The book shows how a small number of key concepts, such as sufficiency, invariance, stochastic ordering, decision theory and vector space algebra play a recurring and unifying role. The volume can be divided into four sections. Part I provides a review of the required distribution theory. Part II introduces the problem of statistical inference. This includes the definitions of the exponential family, invariant and Bayesian models. Basic concepts of estimation, confidence intervals and hypothesis testing are introduced here. Part III constitutes the core of the volume, presenting a formal theory of statistical inference. Beginning with decision theory, this section then covers uniformly minimum variance unbiased (UMVU) estimation, minimum risk equivariant (MRE) estimation and the Neyman-Pearson test. Finally, Part IV introduces large sample theory. This section begins with stochastic limit theorems, the δ-method, the Bahadur representation theorem for sample quantiles, large sample U-estimation, the Cramér-Rao lower bound and asymptotic efficiency. A separate chapter is then devoted to estimating equation methods. The volume ends with a detailed development of large sample hypothesis testing, based on the likelihood ratio test (LRT), Rao score test and the Wald test. Features This volume includes treatment of linear and nonlinear regression models, ANOVA models, generalized linear models (GLM) and generalized estimating equations (GEE). An introduction to decision theory (including risk, admissibility, classification, Bayes and minimax decision rules) is presented. The importance of this sometimes overlooked topic to statistical methodology is emphasized. The volume emphasizes throughout the important role that can be played by group theory and invariance in statistical inference. Nonparametric (rank-based) methods are derived by the same principles used for parametric models and are therefore presented as solutions to well-defined mathematical problems, rather than as robust heuristic alternatives to parametric methods. Each chapter ends with a set of theoretical and applied exercises integrated with the main text. Problems involving R programming are included. Appendices summarize the necessary background in analysis, matrix algebra and group theory.
Simultaneous Statistical Inference by Thorsten Dickhaus Pdf
This monograph will provide an in-depth mathematical treatment of modern multiple test procedures controlling the false discovery rate (FDR) and related error measures, particularly addressing applications to fields such as genetics, proteomics, neuroscience and general biology. The book will also include a detailed description how to implement these methods in practice. Moreover new developments focusing on non-standard assumptions are also included, especially multiple tests for discrete data. The book primarily addresses researchers and practitioners but will also be beneficial for graduate students.
This graduate textbook covers topics in statistical theory essential for graduate students preparing for work on a Ph.D. degree in statistics. This new edition has been revised and updated and in this fourth printing, errors have been ironed out. The first chapter provides a quick overview of concepts and results in measure-theoretic probability theory that are useful in statistics. The second chapter introduces some fundamental concepts in statistical decision theory and inference. Subsequent chapters contain detailed studies on some important topics: unbiased estimation, parametric estimation, nonparametric estimation, hypothesis testing, and confidence sets. A large number of exercises in each chapter provide not only practice problems for students, but also many additional results.
Statistics for High-Dimensional Data by Peter Bühlmann,Sara van de Geer Pdf
Modern statistics deals with large and complex data sets, and consequently with models containing a large number of parameters. This book presents a detailed account of recently developed approaches, including the Lasso and versions of it for various models, boosting methods, undirected graphical modeling, and procedures controlling false positive selections. A special characteristic of the book is that it contains comprehensive mathematical theory on high-dimensional statistics combined with methodology, algorithms and illustrations with real data examples. This in-depth approach highlights the methods’ great potential and practical applicability in a variety of settings. As such, it is a valuable resource for researchers, graduate students and experts in statistics, applied mathematics and computer science.
Statistical Inference in Science by D.A. Sprott Pdf
A treatment of the problems of inference associated with experiments in science, with the emphasis on techniques for dividing the sample information into various parts, such that the diverse problems of inference that arise from repeatable experiments may be addressed. A particularly valuable feature is the large number of practical examples, many of which use data taken from experiments published in various scientific journals. This book evolved from the authors own courses on statistical inference, and assumes an introductory course in probability, including the calculation and manipulation of probability functions and density functions, transformation of variables and the use of Jacobians. While this is a suitable text book for advanced undergraduate, Masters, and Ph.D. statistics students, it may also be used as a reference book.
Scalable and Efficient Probabilistic Topic Model Inference for Textual Data by Måns Magnusson Pdf
Probabilistic topic models have proven to be an extremely versatile class of mixed-membership models for discovering the thematic structure of text collections. There are many possible applications, covering a broad range of areas of study: technology, natural science, social science and the humanities. In this thesis, a new efficient parallel Markov Chain Monte Carlo inference algorithm is proposed for Bayesian inference in large topic models. The proposed methods scale well with the corpus size and can be used for other probabilistic topic models and other natural language processing applications. The proposed methods are fast, efficient, scalable, and will converge to the true posterior distribution. In addition, in this thesis a supervised topic model for high-dimensional text classification is also proposed, with emphasis on interpretable document prediction using the horseshoe shrinkage prior in supervised topic models. Finally, we develop a model and inference algorithm that can model agenda and framing of political speeches over time with a priori defined topics. We apply the approach to analyze the evolution of immigration discourse in the Swedish parliament by combining theory from political science and communication science with a probabilistic topic model. Probabilistiska ämnesmodeller (topic models) är en mångsidig klass av modeller för att estimera ämnessammansättningar i större corpusar. Applikationer finns i ett flertal vetenskapsområden som teknik, naturvetenskap, samhällsvetenskap och humaniora. I denna avhandling föreslås nya effektiva och parallella Markov Chain Monte Carlo algoritmer för Bayesianska ämnesmodeller. De föreslagna metoderna skalar väl med storleken på corpuset och kan användas för flera olika ämnesmodeller och liknande modeller inom språkteknologi. De föreslagna metoderna är snabba, effektiva, skalbara och konvergerar till den sanna posteriorfördelningen. Dessutom föreslås en ämnesmodell för högdimensionell textklassificering, med tonvikt på tolkningsbar dokumentklassificering genom att använda en kraftigt regulariserande priorifördelningar. Slutligen utvecklas en ämnesmodell för att analyzera "agenda" och "framing" för ett förutbestämt ämne. Med denna metod analyserar vi invandringsdiskursen i Sveriges Riksdag över tid, genom att kombinera teori från statsvetenskap, kommunikationsvetenskap och probabilistiska ämnesmodeller.
A Turing Award-winning computer scientist and statistician shows how understanding causality has revolutionized science and will revolutionize artificial intelligence "Correlation is not causation." This mantra, chanted by scientists for more than a century, has led to a virtual prohibition on causal talk. Today, that taboo is dead. The causal revolution, instigated by Judea Pearl and his colleagues, has cut through a century of confusion and established causality -- the study of cause and effect -- on a firm scientific basis. His work explains how we can know easy things, like whether it was rain or a sprinkler that made a sidewalk wet; and how to answer hard questions, like whether a drug cured an illness. Pearl's work enables us to know not just whether one thing causes another: it lets us explore the world that is and the worlds that could have been. It shows us the essence of human thought and key to artificial intelligence. Anyone who wants to understand either needs The Book of Why.
