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Author : Ellis L. Reinherz,Barton F. Haynes,Lee M. Nadler,Irwin D. Bernstein
Publisher : Springer Science & Business Media
Page : 547 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461248484
Author : Ellis L. Reinherz,Barton F. Haynes,Lee M. Nadler,Irwin D. Bernstein
Publisher : Springer Science & Business Media
Page : 538 pages
File Size : 44,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461385875
The Second International Workshop on Human Leukocyte Differentia- tion Antigens was held in Boston, September 17-20, 1984. More than 350 people interested in leukocyte differentiation agreed to exchange reagents and participate in this joint venture. All in all, in excess of 400 antibodies directed against surface structures on T lymphocytes, B lymphocytes, and myeloid-hematopoietic stem cells were characterized. Because of the enormous quantity of serologic, biochemical, and functional data, Leuko- cyte Typing II has been divided into three volumes. These books represent the written results of workshop participants. They should be helpful to both researchers and clinicians involved in scientific endeavors dealing with these broad fields of immunobiology. To those who delve into the various sections of the volumes, it will become evident that the work speaks for itself. I am deeply indebted to the section editors, Barton F. Haynes, Volume 1, Human T Lymphocytes, Lee M. Nadler, Volume 2, Human B Lympho- cytes, and Irwin D.Bernstein, Volume 3, Human Myeloid and Hemato- poietic Cells for their major contributions in planning, executing, and summarizing the workshop, as well as council members John Hansen, Alain Bernard, Laurence Boumsell, Walter Knapp, Andrew McMichael, Cesar Milstein, and Stuart F. Schlossman. I would also like to thank the National Institutes of Health, World Health Organization, and Interna- tional Union of Immunological Societies for making this meeting possible.
Author : Ellis L. Reinherz,Barton F. Haynes,Lee M. Nadler,Irwin D. Bernstein
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461248507
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 1986
Category : Histocompatibility testing
ISBN : OCLC:873104865
Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 43,8 Mb
Release : 1986
Category : Electronic
ISBN : OCLC:834732732
Author : Alain Bernard
Publisher : Springer
Page : 848 pages
File Size : 51,6 Mb
Release : 1984
Category : Antigens
ISBN : UOM:39015006021227
Author : Andrew J. McMichael
Publisher : Oxford University Press, USA
Page : 1104 pages
File Size : 54,8 Mb
Release : 1987
Category : Law
ISBN : UOM:39015013214617
The third international workshop on leucocyte typing antigens reports the results of collaborative experiments involving over 800 antibodies. This volume contains the first and only complete account of the experiments and the subsequent analyses, which produced a careful description of fifty human leucocyte antigens, twenty-four of them fully characterized for the first time. Antigens specific for or shared by T-Cells, B-Cells, activated lymphocytes, myeloid cells and platelets are featured. The papers detail their distribution, molecular structure and function, and discuss the role that the antigens may play in investigating and understanding pathological processes, particularly in leukemias and lymphomas.
Author : Stuart F. Schlossman
Publisher : Unknown
Page : 2100 pages
File Size : 49,7 Mb
Release : 1996-04
Category : Medical
ISBN : 0198577982
Published in August 1995, in 2 volumes and over 2,000 pages, Leucocyte Typing V represented the culmination of a two year international collaboration with contributions from over 500 labs worldwide. Widely acknowledged as the 'bible' on the subject for anyone working in the field of monoclonal antibodies, this definitive reference work is now available on CD ROM. Using Adobe Acrobat software, the CD ROM version will allow the user to search and cross-reference the massive amount of data held in the book's 2,000 pages in seconds.
Author : Narinder K Mehra
Publisher : Boydell & Brewer Ltd
Page : 616 pages
File Size : 55,8 Mb
Release : 2010-11-26
Category : Medical
ISBN : 818448870X
A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.
Author : E. R. Levy,C. S. Herrington
Publisher : Unknown
Page : 268 pages
File Size : 50,5 Mb
Release : 1995
Category : Nucleic acid probes
ISBN : UOM:39015035012676
Radioactive chemicals, while playing a vital role in many research and clinical techniques for nucleic acid analysis, are considered dangerous to the laboratory worker and require specialist handling and disposal equipment. This book describes how detailed molecular analysis of DNA and RNA can be performed using a range of non-radioactive chemicals giving similar if not better results than the radioactive methods. It will be a valuable book for molecular biologists and pathologists in academic and clinical research and also those working in clinical diagnostic laboratories.
Author : Mark Wick
Publisher : CRC Press
Page : 668 pages
File Size : 46,6 Mb
Release : 1988-03-30
Category : Medical
ISBN : 0824778383
BRIEF OVERVIEW OF INTERMEDIATE FILAMENT PROTEINS -- NEUROFILAMENT PROTEINS -- GLIAL FILAMENT PROTEIN -- INTERPRETATION OF STUDIES OF HUMAN NERVOUS SYSTEM TUMORS USING ANTIBODIES TO NF AND GF PROTEINS -- FUTURE PROSPECTS FOR THE USE OF PROBES TO NF AND GF PROTEINS IN PATHOLOGY -- CONCLUSIONS -- APPENDIX: SPECIFICITY OF MONOCLONAL ANTIBODIES TO HUMAN NEUROFILAMENT AND GLIAL FILAMENT PROTEINS -- ACKNOWLEDGMENTS -- REFERENCES -- 6 Monoclonal Antibodies to Lymphorecticular and Myeloid Antigens -- METHODS UTILIZED WITH LYMPHOHEMATOPOIETIC MONOCLONAL ANTIBODIES -- T-CELL AND NATURAL KILLER CELL MONOCLONAL ANTIBODIES AND T-CELL MALIGNANCIES -- T-Cell Monoclonal Antibodies -- Natural Killer Cell Antibodies -- T-Cell Malignancies -- B-CELL MONOCLONAL ANTIBODIES AND B-CELL MALIGNANCIES -- B-Cell Monoclonal Antibodies -- B-Cell Malignancies -- Non-T Acute Lymphocytic Leukemia -- Small Noncleaved Cell Malignant Lymphoma -- Chronic Lymphocytic Leukemia and Small Lymphocytic Malignant Lymphoma -- Prolymphocytic Leukemia (Galton's Leukemia) -- Intermediate Differentiation Malignant Lymphoma -- Follicular Malignant Lymphoma with Small Cleaved and/or Large Cleaved Cells -- Diffuse Small Cleaved and Diffuse Mixed Small and Large Cell Malignant Lymphoma -- Diffuse Large Cell and Immunoblastic Malignant Lymphoma -- Hairy Cell Leukemia -- Multiple Myeloma and Plasmacytoid Lymphoma -- HODGKIN'S DISEASE -- MYELOID MONOCLONAL ANTIBODIES AND ACUTE AND CHRONIC MYELOID LEUKEMIA -- Myeloid Monoclonal Antibodies -- Acute Myeloid Leukemia -- Chronic Myelogenous Leukemia -- MONOCLONAL ANTIBODIES USED IN PARAFFIN-EMBEDDED SECTIONS -- Immunoglobulin -- Leu M1 -- LN-1 and LN-2 -- Leu 7 -- Others -- FUTURE DI RECTION -- REFERENCES -- 7 Monoclonal Antibodies to Human Milk Fat Globule Proteins
Author : Sebastian Boegel
Publisher : Humana
Page : 0 pages
File Size : 48,6 Mb
Release : 2018-06-02
Category : Medical
ISBN : 1493985450
This volume explores the rapidly evolving field of HLA typing and its use in both the laboratory setting and in silico methods. The chapters in this book discuss high-throughput methods for HLA typing; wet lab protocols; microarray data and its uses; in silico tools for the identification of HLA alleles from DNA and RNA next-generation-sequencing data, as well as HLA haplotype frequency estimation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, HLA Typing: Methods and Protocols is a valuable resource for any researcher interested in learning more about this developing field.
Author : John Lee
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 49,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461234548
This volume documents our growing understanding of the human major histocompatibility complex. The application of this information is ever more important as the limits of transplantation continue to be reduced, including the recent success of bone marrow transplantation between unrelated but closely matched individuals. In addition, the need to transfuse platelets in the face of immunologic barriers continues to challenge transfusion services. Thus, the serologic information summarized in this volume is essential for optimal patient care. At the same time, recombinant DNA technology has led to a revolution in our understanding of many aspects of basic biology. Among the advances has been the initial characterization of the structure of some HLA loci. While this will ultimately improve clinical services, constant reference to serologic data is essential so that the powerful new techniques can be applied in the most effective ways. The timing of the First Red Cross International Histocompatibility Workshop is fortunate as it brings together experts from around the world to address the state of the art. We are all grateful to Dr. John Lee and his colleagues for organizing the workshop, and for bringing together in this volume the material to be presented in Beijing during October 17-23, 1990. Leon W. Hoyer, M.D.
Author : J.L. Tiwari,P.I. Terasaki
Publisher : Springer Science & Business Media
Page : 492 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461385455
The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter national histocompatibility workshops held during this period. Although iden tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.
Author : D. Neil Granger,G. W. Schmid-Schönbein
Publisher : Oxford University Press, USA
Page : 532 pages
File Size : 42,8 Mb
Release : 1995
Category : Cell adhesion
ISBN : 0195081021
Leukocytes play an integral role in the pathogenesis of different inflammatory disorders. Recent results indicate that leukocytes are also involved in conditions that had not formerly been associated with a cytotoxic effect by leukocytes. In 27 chapters by leading investigators, this book reviews recent research on leukocyte adhesion and microvascular kinetics. Detailed descriptions of adhesive glycoproteins expressed on the surface of leukocytes and endothelial cells are given together with summaries of the current state of leukocyte rheology, kinetics and entrapment in microvessels. Since leukocytes reach all organs, the mechanisms described in this volume may apply to a wide range of cardiovascular disorders. A variety of important inflammatory and circulatory disorders are discussed including cerebral and coronary ischemia, shock, atherogenesis, chronic venous insufficiency, gastric ulcer and diabetic retinopathy. New concepts about the etiology of cardiovascular complications are presented, with emphasis on molecular, cellular, and microvascular mechanisms. The current state of endogenous anti-adhesive and pro-adhesive mediators is summarized, including interventions against leukocyte activation and adhesion.