Lupus Erythematosus

Author : Peter H. Schur,Elena M. Massarotti
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 43,8 Mb
Release : 2012-07-06
Category : Medical
ISBN : 9781461411895

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Lupus Erythematosus by Peter H. Schur,Elena M. Massarotti Pdf

Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.

Author : Zahi Touma
Publisher : Springer Nature
Page : 418 pages
File Size : 46,8 Mb
Release : 2021-07-22
Category : Medical
ISBN : 9783030733032

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Outcome Measures and Metrics in Systemic Lupus Erythematosus by Zahi Touma Pdf

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that manifests with a myriad of clinical and laboratory features. The assessment of SLE is comprehensive and includes different core set domains; disease activity, damage, health-related quality of life, adverse events and economic impact. This comprehensive book is focused on the instruments and outcome measures utilized in the assessment of SLE. It targets different audiences including physicians, scientists/researchers and different health professionals interested in learning about the art of measurement in SLE. The book highlights the importance of measurement in the assessment of SLE in a clinical settings, research and clinical trials. Each of the chapters provide a systematic approach to the instruments utilized in the assessment of a specific construct in SLE (e.g., disease activity, fatigue, etc.) and incorporate a comprehensive coverage of disease specific and disease generic measures. It also discusses different patient-reported outcomes that are crucial to reflect patient perceptions of their health condition and cover constructs such as fatigue, pain, anxiety and depression, cognition, frailty, and many others.

Author : Alberta Hoi
Publisher : Springer Nature
Page : 192 pages
File Size : 45,7 Mb
Release : 2021-11-15
Category : Medical
ISBN : 9783030851613

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Pathogenesis of Systemic Lupus Erythematosus by Alberta Hoi Pdf

The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Author : Robert G. Lahita
Publisher : Elsevier
Page : 730 pages
File Size : 40,8 Mb
Release : 2021-07-27
Category : Medical
ISBN : 9780128205839

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Lahita's Systemic Lupus Erythematosus by Robert G. Lahita Pdf

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Author : Paul Eggleton,Frank J. Ward
Publisher : Humana
Page : 0 pages
File Size : 41,8 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493952625

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Systemic Lupus Erythematosus by Paul Eggleton,Frank J. Ward Pdf

Systemic Lupus Erythematosus: Methods and Protocols describe a number of genetic, biochemical and immunological techniques. These techniques provide an advancing understanding of the pathology, breakdown of the immune system and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Systemic Lupus Erythematosus: Methods and Protocols appeal to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level.

Author : Daniel Wallace,Bevra Hannahs Hahn
Publisher : Elsevier Health Sciences
Page : 752 pages
File Size : 54,9 Mb
Release : 2018-08-16
Category : Medical
ISBN : 9780323550642

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Dubois' Lupus Erythematosus and Related Syndromes - E-Book by Daniel Wallace,Bevra Hannahs Hahn Pdf

For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

Author : Caroline Gordon,David Isenberg
Publisher : Oxford University Press
Page : 161 pages
File Size : 46,5 Mb
Release : 2016
Category : Medical
ISBN : 9780198739180

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Systemic Lupus Erythematosus by Caroline Gordon,David Isenberg Pdf

Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

Author : Robert George Lahita
Publisher : Unknown
Page : 1068 pages
File Size : 47,9 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015025263735

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Systemic Lupus Erythematosus by Robert George Lahita Pdf

An updated edition which covers basic science (immunology, immunopathology and genetics), clinical and therapeutic approaches and organ systems. It contains much interdisciplinary clinical detail and has contributions from well-known specialists.

Author : Josef S. Smolen,Christoph C. Zielinski
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642716423

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Systemic Lupus Erythematosus by Josef S. Smolen,Christoph C. Zielinski Pdf

More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub lished at a time of renewed interest in SLE, elicited by the descrip tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac terized by an abnormal immune response, although its pathogenetic implications were still unclear.

Author : Irvine Turner
Publisher : Unknown
Page : 90 pages
File Size : 42,5 Mb
Release : 2017
Category : HEALTH & FITNESS
ISBN : 1536106909

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Systemic Lupus Erythematosus (SLE) by Irvine Turner Pdf

Being diagnosed with Systemic Lupus Erythematosus (SLE) can be a severe disappointment, and life after diagnosis can be defined as an existence filled with uncertainty as to the short-and long-term impact of the disease. SLE is a chronic multi-system autoimmune disease that is persistent and recurrent and has the potential of becoming life threatening. The manifestations and severity of the disease varies between individuals. SLE can potentially influence nearly all of the body's organ systems. In this book, Chapter One reviews, Raynaud's phenomenon (RP), one of the nonspecific skin changes that occur in SLE. Chapter Two presents the debate on the causes of fatigue in SLE and factors that increase fatigue. Chapter Three reviews and illustrates the important findings of musculoskeletal diseases in SLE. Chapter Four examines SLE in young adults and reviews information about the pain, social impact, and interventions to improve functioning of these young adults.

Author : Carrie Kane
Publisher : Unknown
Page : 237 pages
File Size : 41,9 Mb
Release : 2020-09-22
Category : Medical
ISBN : 1632429160

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Current Research in Systemic Lupus Erythematosus by Carrie Kane Pdf

Systemic lupus erythematosus is an autoimmune disease characterized by fever, painful and swollen joints, chest pain, swollen lymph nodes, red rash, etc. This condition is caused because the immune system of the body attacks many healthy tissues of the body. It is believed to arise due to a combination of genetic and environmental factors. Some of the risk factors associated with the incidence of this disease are vitamin D deficiency, female sex hormones, smoking, certain infections and sunlight. It can be diagnosed through serologic testing. Clinically indirect immunofluorescence is the most widely used method. Testing for complement system levels, liver enzymes, electrolytes and kidney function, and complete blood count also aid in the diagnosis. The treatment of systemic lupus erythematosus involves the use of corticosteroids and anti-malarial drugs. Some forms of lupus nephritis may require intermittent cytotoxic drugs. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of systemic lupus erythematosus. It presents researches and studies performed by experts across the globe. Through this book, we attempt to enlighten the readers about the new concepts in the diagnosis and treatment of systemic lupus erythematosus.

Author : George C. Tsokos,Caroline Gordon,Josef S. Smolen
Publisher : Elsevier Health Sciences
Page : 602 pages
File Size : 42,7 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9780323044349

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Systemic Lupus Erythematosus by George C. Tsokos,Caroline Gordon,Josef S. Smolen Pdf

This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Author : Annegret Kuhn,Percy Mario Lehmann,Thomas Ruzicka
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 41,9 Mb
Release : 2005-12-05
Category : Medical
ISBN : 9783540265818

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Cutaneous Lupus Erythematosus by Annegret Kuhn,Percy Mario Lehmann,Thomas Ruzicka Pdf

- Based on multidisciplinary knowledge and written by leading clinicians and scientists. - Includes chapters on classification and clinical aspects, pathologic features, and treatment and management of lupus erythematosus. - Although the lupus erythematosus is primarily a skin disease, because it can affect other areas such as joints, kidneys, lungs, heart, liver, brain, and blood vessels this book is also useful to specialists in internal medicine.

Author : René Mauricio Barría
Publisher : Unknown
Page : 73 pages
File Size : 43,8 Mb
Release : 2018-09
Category : Cohort analysis
ISBN : 9781789236941

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Cohort Studies in Health Sciences by René Mauricio Barría Pdf

Author : Daniel Jeffrey Wallace,Bevra Hahn
Publisher : Lippincott Williams & Wilkins
Page : 1516 pages
File Size : 41,6 Mb
Release : 2007
Category : Medical
ISBN : 0781793947

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Dubois' Lupus Erythematosus by Daniel Jeffrey Wallace,Bevra Hahn Pdf

Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.