Lymphatic Metastasis And Sentinel Lymphonodectomy

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Lymphatic Metastasis and Sentinel Lymphonodectomy

P.M. Schlag,Umberto Veronesi
Lymphatic Metastasis and Sentinel Lymphonodectomy Book PDF

Author : P.M. Schlag,Umberto Veronesi
Publisher : Springer Science & Business Media
Page : 520 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642571510

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Lymphatic Metastasis and Sentinel Lymphonodectomy by P.M. Schlag,Umberto Veronesi Pdf

Metastases determine malignancy. The main attention so far has been focused upon organ metastases. The molecular mechanisms thereof, while far from being totally elucidated, are increasingly well understood. Modern diagnostic tools now enable detection and precise localization of small lesions. In contrast, our knowl edge and diagnostic capabilities regarding metastatic spread to the'lymphatic system are rather limited. However, there have re cently been a number of interesting advances. It is the aim of this volume to submit these developments to detailed analysis. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique. Surgical standards are lacking, however, and many fundamental questions pertaining to precise lymphatic mapping remain unanswered. Whether the sentinel node concept is of general relevance or whether it is applicable in only a few organs remains to be determined. This book offers intensive discussion of the concept from methodological and tu mor biological viewpoints. World-renowned experts with long term involvement in related basic and clinical research provide the reader with a broad survey of actual knowledge together with a critical appraisal of recent and future developments. We sincerely hope this book succeeds in providing an outlook as a reference for all clinicians on future prospects and serving and researchers in this extremely important field.

The Sentinel Lymph Node Concept

Alfred Schauer,Wolfgang Becker,Maximilian F Reiser,Kurt Possinger
The Sentinel Lymph Node Concept Book PDF

Author : Alfred Schauer,Wolfgang Becker,Maximilian F Reiser,Kurt Possinger
Publisher : Springer Science & Business Media
Page : 572 pages
File Size : 45,7 Mb
Release : 2005-10-28
Category : Medical
ISBN : 9783540263937

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The Sentinel Lymph Node Concept by Alfred Schauer,Wolfgang Becker,Maximilian F Reiser,Kurt Possinger Pdf

The practical application of the sentinel node concept is evaluated in this book. The concept is analyzed for breast cancer, malignant melanoma, tumors of the face, oropharynx, lung, gastrointestinal and urogenital tract. The first part of the book describes the function and use of the nuclear medicine equipment, the tracers used, colloid solutions and modern developments in histological and immunohistochemical lymph node investigations, as well as possible pitfalls. In the second part, specific tumor-related problems are described.

Sentinel Lymph Node Biopsy

Hiram S. Cody
Sentinel Lymph Node Biopsy Book PDF

Author : Hiram S. Cody
Publisher : CRC Press
Page : 300 pages
File Size : 47,7 Mb
Release : 2001-11-08
Category : Medical
ISBN : 1841840343

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Sentinel Lymph Node Biopsy by Hiram S. Cody Pdf

An intuitive, ingenious and powerful technique, sentinel lymph node biopsy has entered clinical practice with astonishing rapidity and now represents a new standard of care for melanoma and breast cancer patients, while showing great promise for the treatment of urologic, colorectal, gynecologic, and head and neck cancers. This text, written by international experts in the technique, provides a clear and comprehensive guide, presenting a detailed overview and discussing the various mapping techniques available and how these are applied in a number of leading institutions. This essential resource for surgical onocologists, pathologists, and specialists in nuclear medicine will also provide key information for those planning to start a sentinel lymph node program.

The Sentinel Node in Surgical Oncology

Mohammad R.S. Keshtgar
The Sentinel Node in Surgical Oncology Book PDF

Author : Mohammad R.S. Keshtgar
Publisher : Springer
Page : 216 pages
File Size : 52,6 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015043807745

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The Sentinel Node in Surgical Oncology by Mohammad R.S. Keshtgar Pdf

In this volume an account is given of the technologies relevant to the detection of sentinel lymph nodes in the context of surgical oncology. This is a rapidly and evolving field, and the clinical applications discussed in this volume are exciting and important. A multidisciplinary team was assembled to discuss this subject in the light of direct experience gained by each of the groups in the previous 12 months. Clinical case material is presented and the methodology of sentinel lymph node imaging and detection is discussed in detail. The authors have assembled in a single volume a significant amount of personal data and a comprehensive literature review which will serve as a single reference and teaching source for all those interested in this critical technique relevant to the management of large numbers of patients in surgical oncology.

Cancer Metastasis and the Lymphovascular System:

Stanley P. L. Leong
Cancer Metastasis and the Lymphovascular System Book PDF

Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 46,6 Mb
Release : 2007-09-05
Category : Medical
ISBN : 9780387692197

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Cancer Metastasis and the Lymphovascular System: by Stanley P. L. Leong Pdf

This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.

Atlas of Lymphatic System in Cancer

Shamil Gantsev,Kamil Gantsev,Shamil Kzyrgalin
Atlas of Lymphatic System in Cancer Book PDF

Author : Shamil Gantsev,Kamil Gantsev,Shamil Kzyrgalin
Publisher : Springer Nature
Page : 69 pages
File Size : 49,8 Mb
Release : 2020-04-01
Category : Medical
ISBN : 9783030409678

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Atlas of Lymphatic System in Cancer by Shamil Gantsev,Kamil Gantsev,Shamil Kzyrgalin Pdf

This atlas contains a large number of original photographs illustrating the anatomy, research methods, and structural features of the structure of the lymphatic apparatus in oncological diseases. The tissue complexes of the axillary region have been studied in detail. The lymphatic maps of the axillary region in cancer are presented, including those with manifestations of lymphangiogenesis; newly formed lymph nodes formed as a result of neolymphogenesis are also considered. Atlas of Lymphatic System in Cancer: Sentinel Lymph Node, Lymphangiogenesis and Neolymphogenesis is intended for oncologists, anatomists, morphologists and doctors of other specialties. The book is the result of ten years of research. The applied technology of ultrasonic isolation of anatomical structures made it possible to take a fresh look at the lymphatic apparatus in cancer and describe the phenomenon of neolymphogenesis.

Cancer Metastasis Through the Lymphovascular System

Stanley P. Leong,S. David Nathanson,Jonathan S. Zager
Cancer Metastasis Through the Lymphovascular System Book PDF

Author : Stanley P. Leong,S. David Nathanson,Jonathan S. Zager
Publisher : Springer
Page : 0 pages
File Size : 45,7 Mb
Release : 2022-06-26
Category : Medical
ISBN : 3030930831

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Cancer Metastasis Through the Lymphovascular System by Stanley P. Leong,S. David Nathanson,Jonathan S. Zager Pdf

This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.

Cancer Metastasis Through the Lymphovascular System

S. David Nathanson,Stanley P. Leong,Jonathan S. Zager
Cancer Metastasis Through the Lymphovascular System Book PDF

Author : S. David Nathanson,Stanley P. Leong,Jonathan S. Zager
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 2022
Category : Cancer
ISBN : 3030930858

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Cancer Metastasis Through the Lymphovascular System by S. David Nathanson,Stanley P. Leong,Jonathan S. Zager Pdf

This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .

From Melanocytes to Melanoma

Vincent J. Hearing,Stanley P. L. Leong
From Melanocytes to Melanoma Book PDF

Author : Vincent J. Hearing,Stanley P. L. Leong
Publisher : Springer Science & Business Media
Page : 673 pages
File Size : 54,6 Mb
Release : 2007-11-05
Category : Medical
ISBN : 9781592599943

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From Melanocytes to Melanoma by Vincent J. Hearing,Stanley P. L. Leong Pdf

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.

Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer

Stanley P. L. Leong
Atlas of Selective Sentinel Lymphadenectomy for Melanoma Breast Cancer and Colon Cancer Book PDF

Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
Page : 125 pages
File Size : 55,9 Mb
Release : 2006-04-18
Category : Medical
ISBN : 9780306478222

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Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer by Stanley P. L. Leong Pdf

Atlas of Selective Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer emphasizes a multidisciplinary approach combining the experiences of a nuclear medicine physician, surgeon, and pathologist. This is an important reference also for researchers and clinicians who want to become familiar with sentinel lymph node mapping. The underlying thesis in solid tumor biology is that metastasis in general starts in an orderly progression with lymphatic spread first to the sentinel lymph node (SLN) in the nearest lymph node basin. Therefore, the logical approach is to harvest that specific SLN for thorough analysis.

Nuclear Oncology

Cumali Aktolun,Stanley Goldsmith
Nuclear Oncology Book PDF

Author : Cumali Aktolun,Stanley Goldsmith
Publisher : Lippincott Williams & Wilkins
Page : 1964 pages
File Size : 43,9 Mb
Release : 2014-09-04
Category : Medical
ISBN : 9781469883496

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Nuclear Oncology by Cumali Aktolun,Stanley Goldsmith Pdf

Nuclear Oncology a contemporary narrative of the role of nuclear medicine in oncology with an emphasis on SPECT/CT and PET/CT with additional comments when appropriate on the potential application of PET/MR and to a lesser degree, targeted radionuclide therapy. This book focuses on the use of radionuclides in the diagnosis and treatment of malignant diseases. It describes relevant approved and investigational clinical applications, instrumentation & technology, chemistry and practical clinical issues in nuclear oncology. The basic science and current research topics of nuclear oncology are addressed in separate chapters. Nuclear medicine has become an essential component to all phases of the management of the patient with a malignant tumor and in some cases, even benign neoplasms. The standard of practice for many tumors requires PET/CT imaging at various stages of diagnosis and management. In addition to clinical applications, ongoing investigational efforts, which more and more involve multi-institutional protocols, are also presented. Features: • Focuses on the use of radionuclides in the diagnosis and treatment of malignant diseases • Emphasizes SPECT/CT and PET/CT with additional emphasis on the potential application of PET/MR • Describes relevant approved and investigational clinical applications, instrumentation & technology, chemistry and practical clinical issues in nuclear oncology

Treatment of Metastatic Melanoma

Rachael Morton
Treatment of Metastatic Melanoma Book PDF

Author : Rachael Morton
Publisher : BoD – Books on Demand
Page : 364 pages
File Size : 50,6 Mb
Release : 2011-10-05
Category : Medical
ISBN : 9789533075747

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Treatment of Metastatic Melanoma by Rachael Morton Pdf

Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma.

Surgical Oncology

David L Bartlett,Pragatheeshwar Thirunavukarasu,Matthew D Neal.,Phil Bao
Surgical Oncology Book PDF

Author : David L Bartlett,Pragatheeshwar Thirunavukarasu,Matthew D Neal.,Phil Bao
Publisher : JP Medical Ltd
Page : 628 pages
File Size : 52,9 Mb
Release : 2011-03-31
Category : Medical
ISBN : 9789350250518

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Surgical Oncology by David L Bartlett,Pragatheeshwar Thirunavukarasu,Matthew D Neal.,Phil Bao Pdf

Written by world renowned experts in surgical oncology, this book examines various types of cancer and their treatment options based on 'Level of Evidence' tables. The text provides an up-to-date review of the knowledge required by surgical oncologists, from basic biology, to the application of regional chemotherapy, minimally invasive surgery and palliative care.

Surgical Oncology

David L Bartlett, Pragatheeshwar Thirunavukarasu, Matthew D Neal, Phil Bao
Surgical Oncology Book PDF

Author : David L Bartlett, Pragatheeshwar Thirunavukarasu, Matthew D Neal, Phil Bao
Publisher : JAYPEE BROTHERS PUBLISHERS
Page : 639 pages
File Size : 42,8 Mb
Release : 2011
Category : Cancer
ISBN : 9789350256800

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Surgical Oncology by David L Bartlett, Pragatheeshwar Thirunavukarasu, Matthew D Neal, Phil Bao Pdf

The field of oncology is changing more rapidly than any other speciality and new biology as well as new therapies are constantly being tested. This entire text keeps the reader updated with these important advances in a comprehensive but readable format. This outstanding book has been authored by the world renowned experts in surgical oncology, practicing in a rising center of excellence in the field. It introduces 'Level of Evidence' tables to list the various options available for the treatment of each cancer and the strength of evidence available to support it. The text has been developed as.

Melanoma

Guy Huynh Thien Duc
Melanoma Book PDF

Author : Guy Huynh Thien Duc
Publisher : BoD – Books on Demand
Page : 734 pages
File Size : 50,6 Mb
Release : 2013-01-30
Category : Medical
ISBN : 9789535109617

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Melanoma by Guy Huynh Thien Duc Pdf

The Book "Melanoma - From Early Detection To Treatment" is aiming to present data and knowledge from most experienced experts in the field. The book covers main topics from the fundamental aspects to multiple approaches in the disease treatment as well as related features. It offers a global view concerning one of the most frequent types of cancer to which a substantial high proportion of people worldwide is confronted at some time point in life.