Lymphatic Transport Of Drugs

Author : William N. Charman
Publisher : Routledge
Page : 348 pages
File Size : 42,6 Mb
Release : 2019-05-23
Category : Medical
ISBN : 9781351434447

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Lymphatic Transport of Drugs by William N. Charman Pdf

Lymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery.

Author : Jennifer B. Dressman,Christos Reppas
Publisher : CRC Press
Page : 432 pages
File Size : 43,9 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420077346

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Oral Drug Absorption by Jennifer B. Dressman,Christos Reppas Pdf

Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 51,9 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808

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Anatomy and Physiology by J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Pdf

Author : Ronald T. Borchardt,Philip L. Smith,Glynn Wilson
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 53,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489918635

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Models for Assessing Drug Absorption and Metabolism by Ronald T. Borchardt,Philip L. Smith,Glynn Wilson Pdf

Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.

Author : Hans Schreier
Publisher : CRC Press
Page : 320 pages
File Size : 40,7 Mb
Release : 2001-08-09
Category : Medical
ISBN : 9780203908563

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Drug Targeting Technology by Hans Schreier Pdf

Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver! This book discusses physical, chemical, and biological approaches to drug targeting technology, focusing on oral, dispersed system, topical, dermal, transdermal, and inh

Author : Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis
Publisher : Morgan & Claypool Publishers
Page : 86 pages
File Size : 42,9 Mb
Release : 2010
Category : Science
ISBN : 9781615040667

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Capillary Fluid Exchange by Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis Pdf

The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation

Author : Deepak Kaushik, Ravinder Verma
Publisher : Bentham Science Publishers
Page : 211 pages
File Size : 54,8 Mb
Release : 2021-07-01
Category : Medical
ISBN : 9789814998017

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A Comprehensive Text Book on Self-emulsifying Drug Delivery Systems by Deepak Kaushik, Ravinder Verma Pdf

This text book is a guide for pharmaceutical academics (students and teachers) as well as industry professionals learning about drug delivery and formulation. Chapters presents comprehensive information about self-emulsifying formulations by providing an in-depth understanding of the basic concepts and formulation mechanisms. This information is supplemented by details about current research and development in this field. Readers will learn about the types of self-emulsifying drug delivery systems, evaluation parameters and digestion models, among other topics. Key Features: - 9 chapters organized in a reader-friendly layout - complete guide on self-emulsifying drug delivery formulations, including lipid based systems, SMEDOs, surfactants, and oral dosage forms - includes basic concepts and current developments in research and industrial applications - presents information on conventional and herbal formulations - references for further reading

Author : Jayvadan K. Patel,Yashwant V. Pathak
Publisher : Springer Nature
Page : 437 pages
File Size : 51,9 Mb
Release : 2022-03-07
Category : Science
ISBN : 9783030833954

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Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems by Jayvadan K. Patel,Yashwant V. Pathak Pdf

A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

Author : Giuliano Mariani,Armando E. Giuliano,H. William Strauss
Publisher : Springer Science & Business Media
Page : 319 pages
File Size : 41,8 Mb
Release : 2010-05-10
Category : Medical
ISBN : 9780387383279

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Radioguided Surgery by Giuliano Mariani,Armando E. Giuliano,H. William Strauss Pdf

This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.

Author : Binghe Wang,Longqin Hu,Teruna J. Siahaan
Publisher : John Wiley & Sons
Page : 740 pages
File Size : 46,5 Mb
Release : 2016-04-18
Category : Science
ISBN : 9781118833360

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Drug Delivery by Binghe Wang,Longqin Hu,Teruna J. Siahaan Pdf

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Author : Ronald Borchardt,Edward Kerns,Michael Hageman,Dhrien Thakker,James Stevens
Publisher : Springer Science & Business Media
Page : 522 pages
File Size : 42,9 Mb
Release : 2007-12-31
Category : Medical
ISBN : 9780387449616

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Optimizing the "Drug-Like" Properties of Leads in Drug Discovery by Ronald Borchardt,Edward Kerns,Michael Hageman,Dhrien Thakker,James Stevens Pdf

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.

Author : Nirmal Shah
Publisher : Springer Nature
Page : 483 pages
File Size : 52,6 Mb
Release : 2021-01-22
Category : Medical
ISBN : 9789813344976

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Nanocarriers: Drug Delivery System by Nirmal Shah Pdf

A suitable drug delivery system is an essential element in achieving efficient therapeutic responses of drug molecules. With this desirability in mind, the book unites different techniques through which extremely small-sized particles can be utilized as a successful carrier for curing chronic as well as life-threatening diseased conditions. This is a highly informative and prudently organized book, providing scientific insight for readers with an interest in nanotechnology. Beginning with an overview of nanocarriers, the book impetuses on to explore other essential ways through which these carriers can be employed for drug delivery to varieties of administrative routes. This book discusses the functional and significant features of nanotechnology in terms of Lymphatic and other drug targeting deliveries. The book is presenting depth acquaintance for various vesicular and particulate nano-drug delivery carriers, utilized successfully in Pharmaceutical as well as in Cosmeceutical industries along with brief information on their related toxicities. In addition, the work also explores the potential applications of nanocarriers in biotechnology sciences for the prompt and safe delivery of nucleic acid, protein, and peptide-based drugs. An exclusive section in the book illuminates the prominence and competent applicability of nanotechnology in the treatment of oral cancer. The persistence of this book is to provide basic to advanced information for different novel carriers which are under scale-up consideration for the extensive commercialization. The book also includes recent discoveries and the latest patents of such nanocarriers. The cutting-edge evidence of these nanocarriers available in this book is beneficial to students, research scholars, and fellows for promoting their advanced research.

Author : Ambikanandan Misra,Aliasgar Shahiwala
Publisher : Springer Nature
Page : 448 pages
File Size : 40,8 Mb
Release : 2020-02-12
Category : Medical
ISBN : 9789811336423

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Novel Drug Delivery Technologies by Ambikanandan Misra,Aliasgar Shahiwala Pdf

The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.

Author : David J. Hauss
Publisher : CRC Press
Page : 370 pages
File Size : 48,6 Mb
Release : 2007-06-08
Category : Medical
ISBN : 9781420017267

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Oral Lipid-Based Formulations by David J. Hauss Pdf

Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem

Author : Wolfgang A. Ritschel
Publisher : Unknown
Page : 616 pages
File Size : 44,5 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015028448358

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Handbook of Basic Pharmacokinetics-- Including Clinical Applications by Wolfgang A. Ritschel Pdf