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MRI Atlas of MS Lesions by M.A. Sahraian,Ernst-Wilhelm Radü Pdf
MRI has become the main paraclinical test in the diagnosis and management of multiple sclerosis. We have demonstrated more than 400 pictures of different typical and atypical MS lesions in this atlas. Each image has a teaching point. New diagnostic criteria and differential diagnosis have been discussed.
Magnetic Resonance Spectroscopy in Multiple Sclerosis by M. Filippi,D.L. Arnold,G. Comi Pdf
Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".
Magnetic Resonance Techniques in Clinical Trials in Multiple Sclerosis by M. Filippi,R.I. Grossmann,G. Comi Pdf
We have entered an exciting period in the study of multiple sclerosis and its treatment. Central to this progress has been the introduction of magnetic reso nance techniques. When Young and his colleagues published the first images of the brain in multiple sclerosis at the end of 1981, it was at once obvious that magnetic resonance imaging would playa major role in diagnosis. Intuitively one felt that it would also have a role in increasing our understanding of the pathogenesis of the disease and in monitoring treatment. And so it has proved. Important problems however remain, perhaps the most important of which at present is the weak predictive power of standard magnetic resonance ima ging methods in determining the possibility of progression of impairment and disability. Recently, there have been advances which promise to overcome some of these problems, but decisions about what approach to adopt in selecting patients for clinical trials and which techniques to use in monitoring treatment during their course are still difficult. In this book, Dr. Filippi and his colleagues have assembled an outstanding group of contributors whose work is central to the progress that is being made. The coverage of the issues involved in the use of magnetic resonance techniques in assessing therapeutic effect is comprehensive and, though the field is chan ging rapidly, the principles and much of the detail in the book are likely to have lasting value.
Author : David H. Miller Publisher : Cambridge University Press Page : 216 pages File Size : 46,8 Mb Release : 1997-07-17 Category : Medical ISBN : 052147325X
Magnetic Resonance in Multiple Sclerosis by David H. Miller Pdf
Magnetic resonance (MR) imaging and spectroscopy are powerful tools for demonstrating and monitoring pathological processes of the brain and spinal cord. Multiple sclerosis (MS), a common and as yet incurable disease of the brain and spinal cord, is being studied intensively using these techniques. They perform a major role in facilitating the diagnosis, understanding the mechanisms of symptoms, and monitoring the effect of new treatments. Written by experts in the field, this extensively illustrated text provides a comprehensive review of the benefits and limitations of MR in the study of MS. Coverage ranges through the contributions of MR, the variety of techniques available, diagnosis and differential diagnosis, MR as a predictor of the clinical course, MR views of pathophysiology, and finally monitoring new treatment efficacy.
Quantitative Magnetic Resonance Imaging by Nicole Seiberlich,Vikas Gulani,Adrienne Campbell-Washburn,Steven Sourbron,Mariya Ivanova Doneva,Fernando Calamante,Houchun Harry Hu Pdf
Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches
New Frontiers of MR-based Techniques in Multiple Sclerosis by Massimo Filippi,Giancarlo Comi Pdf
In the past few years there have been impressive advances in the implementation of modern MRI techniques for the assessment of MS patients with the ultimate goal to define MRI markers of MS evolution. The authors of this volume not only review these new techniques, such as magnetization transfer (MT) MRI, diffusion-weighted (DW) MRI and proton MR spectroscopy (MRS), that are increasingly being used to monitor MS evolution, but also those, such as functional MRI (fMRI), cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, that are emerging as additional promising tools for improving our understanding of MS pathophysiology. Strengths and weaknesses of all these modern quantitative MRI techniques for the study of MS are extensively covered in this book. The book also provides a valuable summary of the state of the art.
Magnetic Resonance Imaging of the Brain and Spine by Scott W. Atlas Pdf
For more than 25 years, Magnetic Resonance Imaging of the Brain and Spine has been the leading textbook on imaging diagnosis of brain and spine disorders. The Fifth Edition continues this tradition of excellence with thorough coverage of recent trends and changes in the clinical diagnosis and treatment of CNS diseases, and how those changes relate to MRI findings. It remains a comprehensive, state-of-the-art reference for all who have an interest in neuroradiology – trainees to experts in the field, basic science researchers, and clinicians.
Advances in Imaging of Multiple Sclerosis, An Issue of Neuroimaging Clinics of North America, E-Book by Alex Rovira Pdf
This issue of Neuroimaging Clinics of North America focuses on Imaging of Multiple Sclerosis: Diagnosis and Management, and is edited by Dr. Àlex Rovira Cañellas. Articles will include: Multiple Sclerosis: Epidemiological, Clinical and Therapeutic Aspects; Brain and Spinal Cord MR Imaging Features in Multiple Sclerosis and Variants; Neuromyelitis Optica Spectrum Disorders; Radiologically Isolated Syndrome; MRI in Monitoring and Predicting Treatment Response in Multiple Sclerosis; Cortical Grey Matter MR Imaging in Multiple Sclerosis; Brain Atrophy in Multiple Sclerosis: Technical Aspects and Clinical Relevance; Iron Mapping in Multiple Sclerosis; Microstructural MR Techniques in Multiple Sclerosis; Molecular and Metabolic Imaging in Multiple Sclerosis; Insights from Ultra-high Field Imaging in Multiple Sclerosis; Pediatric Multiple Sclerosis: Distinguishing Clinical and MRI Features, and more!
MR Imaging in White Matter Diseases of the Brain and Spinal Cord by Massimo Filippi,Roland Bammer,Nicola de Stefano,Vincent Dousset,Joseph C. McGowan Pdf
In recent decades, the use of neuroimaging techniques has resulted in outstanding progress in the diagnosis and management of neurological diseases, and this is particularly true of those diseases that affect the white matter of the brain and spinal cord. This book, written by internationally acclaimed experts, comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.
Neurological Disorders and Imaging Physics by Jasjit S. Suri Pdf
Multiple sclerosis (MS) is a disease where the body's immune system attacks the brain and spinal cord, causing debilitating side effects that last a lifetime for those affected. Magnetic resonance imaging (MRI) has become an established tool in the diagnosis and monitoring of MS due to its ability to depict the pathological features of the disease in high detail. Over the past few decades, developments in MRI applications, and MRI-based visualization of demyelinated CNS lesions have become pivotal to the diagnosis and monitoring of MS. In recent years, newer MR imaging technologies, including higher-field-strength MR units, have been developed to analyse the overall MS damage and highlight potential mechanisms of recovery in patients at different stages of the disease.
Neurodegeneration in Multiple Sclerosis by M. Filippi,M. Rovaris,G. Comi Pdf
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Neurological Disorders and Imaging Physics by Jasjit S. Suri Pdf
Multiple sclerosis (MS) is a disease where the body's immune system attacks the brain and spinal cord, causing debilitating side effects that last a lifetime for those affected. Magnetic resonance imaging (MRI) has become an established tool in the diagnosis and monitoring of MS due to its ability to depict the pathological features of the disease in high detail. Over the past few decades, developments in MRI applications, and MRI-based visualization of demyelinated CNS lesions have become pivotal to the diagnosis and monitoring of MS. In recent years, newer MR imaging technologies, including higher-field-strength MR units, have been developed to analyse the overall MS damage and highlight potential mechanisms of recovery in patients at different stages of the disease.
Neurological Disorders and Imaging Physics, Volume 1 by Luca Saba,Jasjit S Suri,Ayman El-Baz Pdf
Multiple sclerosis (MS) is a disease where the body's immune system attacks the brain and spinal cord, causing debilitating side effects that last a lifetime for those affected. There is currently no cure. Magnetic resonance imaging (MRI) has become an established tool in the diagnosis and monitoring of MS because of its ability to depict the pathological features of the disease in high detail. Over the past few decades, MRI-based visualization of demyelinated CNS lesions has become pivotal to the diagnosis and monitoring of MS. In recent years, newer MR imaging technologies, including higher-field-strength MR units, have been developed to analyse the overall MS damage and highlight potential mechanisms of recovery in patients at different stages of the disease. Written by experts in the field, this first volume covers all imaging techniques applied to the analysis of MS, including the physics of CT/MR neurological imaging, MR MS, and miscellaneous MR neurological applications.
Demyelinating Disorders of the Central Nervous System in Childhood by Dorothée Chabas,Emmanuelle L. Waubant Pdf
Although multiple sclerosis and other disorders of myelin formation and repair are most commonly associated with adults, they can also occur in infants, children and adolescents. Up to 5 percent of those with MS experience symptoms before the age of 18, and the number of cases diagnosed is rising. There is a lack of awareness about these diseases in childhood, however, even amongst pediatric neurologists and MS specialists. Demyelinating Disorders of the Central Nervous System in Childhood provides comprehensive coverage of these diseases, highlighting throughout the differences between management in childhood and in adults. With sections dedicated to the diagnosis, course, treatment and biology of pediatric MS, detailed chapters on other childhood demyelinating diseases, including acute disseminated encephomyelitis, optic neuritis, acute complete transverse myelitis and neuromyelitis optica, are also provided. Essential reading for pediatric neurologists and MS specialists, this book will also be valuable reading for adult neurologists and pediatricians.
