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Author : Anonim
Publisher : World Health Organization
Page : 40 pages
File Size : 46,7 Mb
Release : 2022-04-28
Category : Medical
ISBN : 9789240042575
Author : world health organization
Publisher : Unknown
Page : 0 pages
File Size : 43,6 Mb
Release : 2022
Category : Electronic
ISBN : OCLC:1396884552
Author : World Health Organization
Publisher : World Health Organization
Page : 96 pages
File Size : 50,8 Mb
Release : 2020-06-22
Category : Medical
ISBN : 9789240007284
Author : Anonim
Publisher : World Health Organization
Page : 172 pages
File Size : 46,9 Mb
Release : 2021-07-06
Category : Medical
ISBN : 9789240030589
Author : World Health Organization
Publisher : World Health Organization
Page : 156 pages
File Size : 45,9 Mb
Release : 2024-03-15
Category : Medical
ISBN : 9789240089501
The “WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition” is the latest edition replacing the one issued in 2021. A new class of technologies for drug susceptibility testing is endorsed by WHO and included in this edition: targeted next generation sequencing. The operational handbook aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB. It provides practical information on existing and new tests recommended by WHO, step-by-step advice on implementing and scale-up testing to achieve local and national impact and lastly, model diagnostic algorithms, which are updated to incorporate the latest recommendations. An overview of budgetary considerations and information sheets on each of the newly recommended tests is provided. The class of targeted next generation sequencing is recommended for the detection of resistance to a number of first- and second-line anti-TB drugs, rather than culture-based phenotypic drug susceptibility testing. The recommendations will open for faster detection of resistance to a range of anti-TB drugs directly from sputum samples.
Author : World Health Organization
Publisher : World Health Organization
Page : 106 pages
File Size : 40,5 Mb
Release : 2020-06-22
Category : Medical
ISBN : 9789240007307
The political declaration of the first United Nations (UN) high-level meeting on tuberculosis (TB) calls countries to diagnose and treat 40 million people with TB globally between 2018 and 2022. Traditionally, in most countries, TB diagnosis has been performed using sputum-smear microscopy, a method developed more than 100 years ago, with suboptimal sensitivity. In recent years new technologies have emerged based on the detection of mycobacterial DNA or mycobacterial antigens. Over the past decade the World Health Organization (WHO) has published a number of guidelines developed by WHO-convened Guideline Development Groups (GDGs), using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to summarize the evidence and to formulate policy recommendations and accompanying remarks. The present document "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection" consolidates five guidelines developed by WHO between 2016 and 2020. Earlier guidelines on diagnostics that were not developed according to the GRADE approach have not been included in this document. The WHO Consolidated Guidelines on Tuberculosis will group all TB recommendations in one document and will be complemented by matching modules of an operational handbook. The handbook will provide practical advice on how to put in place the recommendations at the scale needed to achieve national and global impact. A range of new diagnostic technologies have been endorsed by WHO during the past decade. These are listed below: - real-time polymerase chain reaction (PCR) assays - for example, Xpert MTB/RIF(r) (Ultra) (cartridge-based) and TruenatTM (chip-based);- line probe assays (LPAs) - for example, GenoType(r) MTBDRplus v1 and v2, GenoscholarTM NTM+MDRTB II and GenoType(r) MTBDRsl;- loop-mediated isothermal amplification (LAMP) - for example, TB-LAMP; and- antigen detection in a lateral flow format (biomarker-based detection) - for example, Alere DetermineTM TB LAM Ag. The present "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection" provides background, justification and recommendations on these technologies. The document includes new recommendations on molecular assays intended as initial tests for the diagnosis of pulmonary and extrapulmonary TB and rifampicin resistance in adults and children.
Author : World Health Organization
Publisher : World Health Organization
Page : 237 pages
File Size : 51,6 Mb
Release : 2023-10-11
Category : Medical
ISBN : 9789240081093
Technical report of the fourth meeting of the WHO Strategic Advisory Group of Experts on In Vitro Diagnostics, 2022 (including the fourth WHO model list of essential in vitro diagnostics (EDL 4)). This report also includes the applications received for the EDL 4 and a summary of the deliberations and recommendations by the SAGE IVD members and the methodologist that assessed the supportive evidence for the EDL 4 applications.
Author : World Health Organization
Publisher : World Health Organization
Page : 164 pages
File Size : 55,8 Mb
Release : 2021-07-05
Category : Medical
ISBN : 9789240029415
The "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update" is the latest document replacing the one issued in 2020. Three new nucleic acid amplification test (NAAT) classes are endorsed by WHO and included in the latest consolidated guideline: 1. moderate complexity automated NAATs, recommended for the initial detection of TB and resistance to rifampicin and isoniazid, providing more options for early diagnosis of TB and rifampicin-resistant TB but also addressing an important gap in the rapid diagnosis of isoniazid-resistant and rifampicin-susceptible TB;2. low complexity automated NAATs, recommended for the detection of resistance to isoniazid and second-line anti-TB agents, which will improve access to testing of resistance to fluoroquinolones at peripheral level; and3. high complexity reverse hybridization-based NAATs, recommended for the detection of pyrazinamide resistance, representing the first molecular tests for resistance determination to this drug. The consolidated guideline provides background, justification and recommendations on these and earlier endorsed TB diagnostic technologies. This document is accompanied by the "WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update", which aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB.
Author : World Health Organization
Publisher : World Health Organization
Page : 156 pages
File Size : 40,7 Mb
Release : 2022-10-31
Category : Medical
ISBN : 9789240061507
Author : Alberto L. García-Basteiro,Füsun Öner Eyüboglu,Molebogeng X. Rangaka
Publisher : European Respiratory Society
Page : 315 pages
File Size : 48,7 Mb
Release : 2023-09-01
Category : Medical
ISBN : 9781849841702
Recent years have witnessed key developments in the diagnosis and treatment of tuberculosis. Alongside this, and running in direct opposition to this progress, was the COVID-19 pandemic, which had an unprecedented detrimental effect on tuberculosis control and the achievement of targets set by the End TB Strategy. This timely and important Monograph provides a crucial update on recent changes, developments and setbacks in the field, and calls for a re-commitment to the achievement of the End TB Strategy and Sustainable Development Goals. Written by authors from across the world, the Monograph covers: diagnosis; advances in treatment; prevention; and tuberculosis control challenges in different populations and contexts.
Author : Rafael Laniado-Laborín
Publisher : Bentham Science Publishers
Page : 123 pages
File Size : 41,9 Mb
Release : 2015-06-04
Category : Medical
ISBN : 9781681080666
This book is a concise, straightforward practical guide to the clinical management of patients having drug resistant tuberculosis infections. It covers every aspect of drug resistant tuberculosis, starting from epidemiology and bacteriology to a description of the latest diagnostic tests and a list of tuberculosis drugs. Readers will find clear guidelines for selection and administration of treatment regimens for the different types of drug resistant infections as well as instructions on follow-up procedures for such cases. The book also includes a series of clinical cases illustrating some of the most frequent problems encountered by doctors while treating drug resistant tuberculosis in a clinical setting. Drug Resistant Tuberculosis: Practical guide for clinical management is a useful handbook for general practitioners and medical students interested in learning about multi drug resistant tuberculosis and pulmonary care of patients having advanced infections.
Author : World Health Organization
Publisher : World Health Organization
Page : 184 pages
File Size : 41,9 Mb
Release : 2024-03-08
Category : Medical
ISBN : 9789240089488
The “WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition” is the latest document replacing the one issued in 2021. This latest edition includes new recommendations on the use of a new class of diagnostic technologies: targeted next-generation sequencing (NGS) tests for the diagnosis of drug-resistant tuberculosis (TB). The recommendations provide a novel approach for the rapid detection of drug resistance to new anti-TB drugs using the latest technologies. The consolidated guideline provides background, justification and recommendations on these and earlier endorsed TB diagnostic technologies. This document is accompanied by the “WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition”, which aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB.
Author : World Health Organization
Publisher : World Health Organization
Page : 68 pages
File Size : 48,5 Mb
Release : 2021-03-22
Category : Medical
ISBN : 9789240022676
The WHO consolidated guidelines on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease is an updated and consolidated summary of WHO recommendations on systematic screening for tuberculosis (TB) disease, containing 17 recommendations for populations in which TB screening should be conducted and tools to be used for TB screening. TB screening is strongly recommendations for household and close contacts of individuals with TB, people living with HIV, miners exposed to silica dust, and prisoners. In addition, screening is conditionally recommended for people with risk factors for TB attending health care, and for communities with risk factors for TB and limited access to care (e.g. homeless, urban poor, refugees, migrants). General population screening is recommended in high-burden settings (0.5% prevalence or higher). Symptoms, chest radiography (CXR), and molecular WHO-recommended rapid diagnostic tests for TB are recommended as screening tools for all adults eligible for screening. Computer-aided detection programmes are recommended as alternatives to human interpretation of CXR in settings where trained personnel are scarce. For people living with HIV, C-reactive protein is also a good screening tool. This guideline document is accompanied by an operational handbook, the WHO operational handbook on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease, that presents principles of screening, steps in planning and implementing a screening programme, and algorithm options for screening different populations.
Author : World Health Organization
Publisher : Unknown
Page : 0 pages
File Size : 53,5 Mb
Release : 2015-04-20
Category : Medical
ISBN : 9241506709
In December 2010, WHO first recommended the use of the Xpert MTB/RIF assay. The WHO's policy statement was supported by a rapid implementation document, which provided the technical "how-to" and operational considerations for rolling out the use of the assay. An unprecedented uptake of this new technology followed the release of WHO's policy: by the end of March 2014, more than 2,300 GeneXpert instruments and more than 6 million Xpert MTB/RIF cartridges had been procured in the public sector in 104 countries eligible for concessional prices. An Expert Group was convened by WHO in May 2013 to review the current body of evidence on use of Xpert MTB/RIF. The resulting recommendations from the Expert Group are included in the WHO Policy update, which widens the recommended use of Xpert MTB/RIF, including for the diagnosis of paediatric TB and on selected specimens for the diagnosis of extrapulmonary TB, and includes an additional recommendation on the use of Xpert MTB/RIF as the initial diagnostic test in all individuals presumed to have pulmonary TB. The accompanying Xpert MTB/RIF implementation manual has been developed to replace the first edition and takes into consideration the current body of evidence and operational experiences available, in the context of the Policy update.
Author : World Health Organization
Publisher : World Health Organization
Page : 110 pages
File Size : 45,5 Mb
Release : 2022-12-15
Category : Medical
ISBN : 9789240065116
Operational handbook on tuberculosis. Module 4: Treatment of drug-resistant tuberculosis treatment, is a derivative product arising from the guideline on the same topic. This operational handbook is designed to facilitate implementation of the policy at country level. The target audience includes, implementing partners, programme managers, clinicians and other stakeholders engaged in TB care. The 2022 updated version of the operational handbook includes a new section stemming from the most recent round of guidelines development – the recommendation for 6-month regimen, and a new composition of the 9-month regimen for the treatment of DR-TB. Besides, the updated operational handbook includes three new web annexes: Tuberculosis medicines information sheets, management of adverse events and Active TB drug safety monitoring and management (aDSM).