Manual Of Stroke Models In Rats

Author : Yanlin Wang-Fischer
Publisher : CRC Press
Page : 437 pages
File Size : 52,8 Mb
Release : 2008-07-31
Category : Science
ISBN : 9780203881088

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Manual of Stroke Models in Rats by Yanlin Wang-Fischer Pdf

During the last few years, exciting new insights into mechanisms and treatment of stroke have been obtained from animal experiments. Hence, the use of animal models to induce stroke are of paramount importance as research tools. While a few articles on this topic have been published in select journals, until now there has not been a systematic technical book available which assists researchers in building upon commonly known knowledge. The Manual of Stroke Models in Rats explains in great detail the methods and techniques for accomplishing different stroke models in rats, as well as some techniques using mice. Expert contributors to this text include the most recent research information available, as well as generally recognized facts, making this volume an imperative tool for those researchers seeking to identify new areas of exploration. The first text in 20 years to detail new techniques in rat stroke models The book begins with a statistical update of stroke in America, and proceeds to discuss the rationale for using ischemic stroke models. Major sections include different surgical models of stroke induced by the occlusion of the distal middle cerebral artery, by intraluminal filament or embolic implantation, by photochemically induced thrombosis, global cerebral ischemia induced by asphyxia cardiac arrest or by four-vessel occlusion, and brain hemorrhage. The book also includes anesthesia procedures, general principles of microsurgery, and a study of microsurgical instruments. Numerous tables, figures, and color images are used to supplement the material. The editor, Dr. Yanlin Wang-Fischer, has published more than 40 scientific articles in various medical journals and contributed to several projects related to animal models and surgeries. In this volume, she brings together contributors who represent the cutting edge of research in the field. By reviewing the methods in this detailed technical treatise, researchers will be armed with the latest strategies in preparing their own experimental stroke models.

Author : Ulrich Dirnagl
Publisher : Humana
Page : 286 pages
File Size : 49,9 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493958070

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Rodent Models of Stroke by Ulrich Dirnagl Pdf

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

Author : Amit Kumar Tripathi,Abhishek Kumar Singh
Publisher : Springer Nature
Page : 115 pages
File Size : 44,7 Mb
Release : 2021-03-30
Category : Medical
ISBN : 9789813366794

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Models and Techniques in Stroke Biology by Amit Kumar Tripathi,Abhishek Kumar Singh Pdf

This book summarizes various tools and techniques used to provide insights into the cellular and molecular pathophysiology of stroke. It also presents rodent animal models to help shed light on the pathophysiology of ischemic stroke. Presenting the latest information on the different types of stroke, including embolic, filament, photothrombotic, and bilateral common carotid artery, the book also describes techniques that are used for confirmation of stroke surgery, such as laser speckle imaging (LSI) and laser Doppler flowmetry (LDF), and discusses the non-human primates that are used in stroke surgery, cerebral venous sinuous thrombosis, and neurobehavioral assessment. Lastly, it analyzes various neuroprotective agents to treat and prevent ischemic stroke, and examines the challenges and advances in treating and preventing acute ischemic stroke.

Author : Nirmal Mazumder,Gireesh Gangadharan,Yury V. Kistenev
Publisher : Springer Nature
Page : 265 pages
File Size : 49,8 Mb
Release : 2022-05-19
Category : Medical
ISBN : 9789811913525

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Advances in Brain Imaging Techniques by Nirmal Mazumder,Gireesh Gangadharan,Yury V. Kistenev Pdf

The book reviews the recent developments in brain imaging and their technological advancements to understand molecular mechanisms associated with neurological disorders and basic behaviors in humans and rodents at the structural, molecular, and functional levels. It discusses the usefulness of advanced optical microscopy techniques, including optical coherence tomography (OCT), miniscope, multiphoton fluorescence (2PF & 3PF), adaptive optics, harmonic generation, and Raman microscopy for understanding pathomechanism of brain disorders and pathological and physiological changes associated with neurodegenerative diseases. Also, the book presents conventional imaging modalities, including Magnetic Resonance Imaging (MRI), for delineating underlying mechanisms and precise early diagnosis of neurological disorders. This book is a useful resource for neuroscientists and researchers working in biomedical engineering and optics.

Author : Ruoli Wang,Elena Marie Gutierrez Farewik,Le Li,Lynn Bar-On,Ping Zhou
Publisher : Frontiers Media SA
Page : 143 pages
File Size : 43,8 Mb
Release : 2021-08-03
Category : Science
ISBN : 9782889711406

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Neuromechanical Property Identification in Spastic Muscles: Perspectives for Instrumented Assessment, Modeling and Intervention Evaluation by Ruoli Wang,Elena Marie Gutierrez Farewik,Le Li,Lynn Bar-On,Ping Zhou Pdf

Author : Alfredo Rigalli,Veronica Di Loreto
Publisher : CRC Press
Page : 232 pages
File Size : 53,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420093278

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Experimental Surgical Models in the Laboratory Rat by Alfredo Rigalli,Veronica Di Loreto Pdf

An All-Inclusive Guide to Surgical Techniques on RatsThe design of an adequate surgical model, like the choice of the animal model itself, is extremely important for obtaining reliable valuable data. Experimental Surgical Models in the Laboratory Rat summarizes a series of techniques that were applied in the Bone Biology Laboratories, School of Med

Author : Anonim
Publisher : Academic Press
Page : 4744 pages
File Size : 51,9 Mb
Release : 2014-04-29
Category : Medical
ISBN : 9780123851581

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Encyclopedia of the Neurological Sciences by Anonim Pdf

The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Author : Marie Kubiak
Publisher : John Wiley & Sons
Page : 524 pages
File Size : 50,9 Mb
Release : 2020-08-24
Category : Medical
ISBN : 9781119389958

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Handbook of Exotic Pet Medicine by Marie Kubiak Pdf

Easy-to-use, comprehensive reference covering the less common species encountered in general veterinary practice Handbook of Exotic Pet Medicine provides easy-to-access, detailed information on a wide variety of exotic species that can be encountered in general veterinary practice. Offering excellent coverage of topics such as basic techniques, preventative health measures, and a formulary for each species, each chapter uses the same easy-to-follow format so that users can find information quickly while working in the clinic. Presented in full colour, with over 400 photographs, the book gives small animal practitioners the confidence to handle and treat more familiar pets such as budgerigars, African grey parrots, bearded dragons, corn snakes, tortoises, pygmy hedgehogs, hamsters and rats. Other species that may be presented less frequently including skunks, marmosets, sugar gliders, koi carp, chameleons and terrapins are also covered in detail to enable clinicians to quickly access relevant information. Provides comprehensive coverage of many exotic pet species that veterinarians may encounter in general practice situations Presents evidence-based discussions of topics including biological parameters, husbandry, clinical evaluation, hospitalization requirements, common medical and surgical conditions, radiographic imaging, and more The Handbook of Exotic Pet Medicine is an ideal one-stop reference for the busy general practitioner seeing the occasional exotic animal, veterinary surgeons with an established exotic animal caseload, veterinary students and veterinary nurses wishing to further their knowledge.

Author : Graham A. Webb
Publisher : Springer Science & Business Media
Page : 1889 pages
File Size : 55,6 Mb
Release : 2007-05-26
Category : Technology & Engineering
ISBN : 9781402039102

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Modern Magnetic Resonance by Graham A. Webb Pdf

A comprehensive collection of the applications of Nuclear Magnetic Resonance (NMR), Magnetic Resonance Imaging (MRI) and Electron-Spin Resonance (ESR). Covers the wide ranging disciplines in which these techniques are used: * Chemistry; * Biological Sciences; * Pharmaceutical Sciences; * Medical uses; * Marine Science; * Materials Science; * Food Science. Illustrates many techniques through the applications described, e.g.: * High resolution solid and liquid state NMR; * Low resolution NMR, especially important in food science; * Solution State NMR, especially important in pharmaceutical sciences; * Magnetic Resonance Imaging, especially important for medical uses; * Electron Spin Resonance, especially important for spin-labelling in food, marine and medical studies.

Author : Giuseppe Mancia
Publisher : Unknown
Page : 728 pages
File Size : 53,5 Mb
Release : 2002
Category : Medical
ISBN : UOM:39015051598970

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Manual of Hypertension by Giuseppe Mancia Pdf

The aim is to produce a really practical manual that gives clearly presented guidelines to the ordinary practitioner about what to do in given circumstances. It will be a "bench book" on hypertension, in which its various aspects are dealt with from a clinical perspective, and where the text is constructed, laid out, and illustrated, in such a way as to make the work of maximum utility and readability to the practitioner.

Author : Jun Chen,Zao C. Xu,Xiao Ming Xu,John H. Zhang
Publisher : Springer
Page : 544 pages
File Size : 44,6 Mb
Release : 2019-07-23
Category : Medical
ISBN : 9783030160821

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Animal Models of Acute Neurological Injury by Jun Chen,Zao C. Xu,Xiao Ming Xu,John H. Zhang Pdf

Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The book’s focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field.

Author : Jun Chen,Xiao-Ming Xu,Zao C. Xu
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 52,9 Mb
Release : 2008-12-16
Category : Medical
ISBN : 9781603271851

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Animal Models of Acute Neurological Injuries by Jun Chen,Xiao-Ming Xu,Zao C. Xu Pdf

Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Author : Jun Chen,Xiao-Ming Xu,Zao C. Xu,John H. Zhang
Publisher : Humana Press
Page : 724 pages
File Size : 47,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493962221

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Animal Models of Acute Neurological Injuries II by Jun Chen,Xiao-Ming Xu,Zao C. Xu,John H. Zhang Pdf

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Author : Renuka Ramachandra,Thyagarajan Subramanian
Publisher : CRC Press
Page : 188 pages
File Size : 46,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 143984013X

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Atlas of the Neonatal Rat Brain by Renuka Ramachandra,Thyagarajan Subramanian Pdf

Atlas of the Neonatal Rat Brain provides photographic, histological illustrations of the anatomical features of the neonatal rat brain at postnatal (P) days P-1, P-7, and P-14. The sections are Nissl stained with Cresyl violet, creating photomicrographs with high resolution and clarity. The structures are directly labeled on the images, making it easier to correlate data. Additional images are available as electronic resources for individuals who seek images not represented in this volume, and the electronic version allows labels to be removed so the atlas can be used as a teaching tool. The P-1 section contains 30 coronal plates and 14 sagittal plates and the P-7 section includes 27 coronal plates and 24 sagittal plates. The final P-14 section shows 41 coronal plates and 21 sagittal plates. Each set consists of contiguous sections from individual animals, and selections were based on the structural variability represented.

Author : Daniel Alonso-Alconada,Silvia Carloni,Francisco J. Alvarez
Publisher : Frontiers Media SA
Page : 184 pages
File Size : 52,5 Mb
Release : 2022-07-04
Category : Science
ISBN : 9782889764921

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Neonatal Brain Injury and the Search for New Therapies by Daniel Alonso-Alconada,Silvia Carloni,Francisco J. Alvarez Pdf