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Author : Sheldon White,Barbara Notkin White
Publisher : Unknown
Page : 132 pages
File Size : 50,8 Mb
Release : 1980
Category : Child development
ISBN : UCAL:B4516761
Author : Casey A. Mullin
Publisher : A-R Editions, Inc.
Page : 164 pages
File Size : 52,9 Mb
Release : 2024-06-11
Category : Language Arts & Disciplines
ISBN : 9780895799111
Many Pathways for Discovery is a manual for metadata practitioners learning music cataloging for the first time, as well as a ready reference tool for more experienced practitioners. It is intended to serve as a companion guide to general music cataloging instruction, focusing on what has traditionally been considered the more advanced skillset of “subject analysis.” It provides guidance for answering the “W-questions” about music content: What is it? (genre/form); What is it for, or, How is it performed? (medium of performance); Who is it by and Who is it for? (demographic aspects); When was it created? (chronological aspects); Where was it created? (geographic aspects) This book is primarily geared toward a metadata environment based on MARC 21 encoding and on vocabularies developed by the Library of Congress, namely, the Medium of Performance Thesaurus for Music (LCMPT), the Genre/Form Terms for Library and Archival Materials (LCGFT), and the Demographic Group Terms (LCDGT). Comparisons to legacy practices involving Library of Congress Subject Headings (LCSH) are included. Additional chapters address encoding of faceted descriptors in Linked Data environments, and on discovery possibilities for end users. A bibliography of foundational and supplemental resources is provided.
Author : Frederic Lawrence Holmes
Publisher : Yale University Press
Page : 268 pages
File Size : 50,6 Mb
Release : 2004-02-09
Category : Science
ISBN : 0300129688
This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various approaches to the historical study of scientific practice. He then explains three kinds of analysis of the individual scientific life: broad-scale, which examines the phases of a scientist’s career—apprenticeship, mastery, distinction, and maturity—over a lifetime; middle-scale, which explores the episodes within such a career; and fine-scale, which scrutinizes laboratory notebooks and other data to focus on the daily interplay between thought and operation. Using these analyses, Holmes presents rich examples from his studies of six preeminent scientists: Antoine-Laurent Lavoisier, Claude Bernard, Hans Krebs, Matthew Meselson, Franklin Stahl, and Seymour Benzer. The similar themes that he finds in their work and careers lead him to valuable insights into enduring issues and problems in understanding the scientific process.
Author : Gary Hardiman
Publisher : CRC Press
Page : 386 pages
File Size : 46,6 Mb
Release : 2006-10-19
Category : Medical
ISBN : 9781420015607
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as biochips to reduce the cost of drug discovery and improve drug safety. The book explores the tools and skills required at each step of the discovery process when using biochips to determine biological outcomes. The authors provide an in-depth review of the clinical and pharmacogenomic relevance of biochips, ChIP-chip assays, and high-throughput approaches. They discuss how biochips are used to develop biomarkers in the drug discovery process, primarily for gene expression profiling and Single Nucleotide Polymorphism (SNP) analysis. The book includes coverage of experimental theory, quality control, clinical laboratory sampling considerations, database concepts, industrial laboratory design, and the analysis of the resultant large data sets. It discusses the application of biochips to the study of malaria, toxicogenomics, and SNPs, as well as intellectual property and market overviews. The book concludes with a comprehensive overview of how these chips are employed from early target discovery through preclinical toxicology and on through to pharmacogenomic and proof of concept studies in humans. Written in an easily accessible style, the breadth of coverage introduces the subject to those new to the field, while the depth of coverage forms a foundation for future work. The book gives you the knowledge required to leverage the technology into bona fide discoveries. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.
Author : Jean-Francois Dufour,C. Trautwein,R. Graf,Pierre-Alain Clavien
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 50,8 Mb
Release : 2005-08-15
Category : Medical
ISBN : 9783540271949
This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Supplies in one place all the information on this active and complex research topic and may stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room. Fills the need of surgeons to understand the molecular mechanisms in hepatology. Provides a quick and comprehensive overview.
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : Unknown
Page : 2228 pages
File Size : 40,7 Mb
Release : 2005
Category : United States
ISBN : STANFORD:36105050395925
Author : Janet Zadina
Publisher : John Wiley & Sons
Page : 295 pages
File Size : 41,8 Mb
Release : 2014-06-09
Category : Education
ISBN : 9781118567616
From an award-winning neuroscience researcher with twenty years of teaching experience, Multiple Pathways to the Student Brain uses educator-friendly language to explain how the brain learns. Steering clear of “neuro-myths,” Dr. Janet Zadina discusses multiple brain pathways for learning and provides practical advice for creating a brain-compatible classroom. While there are an abundance of books and workshops that aim to integrate education and brain science, educators are seldom given concrete, actionable advice that makes a difference in the classroom. Multiple Pathways to the Student Brain bridges that divide by providing examples of strategies for day-to-day instruction aligned with the latest brain science . The book explains not only the sensory/motor pathways that are familiar to most educators (visual, auditory, and kinesthetic), it also explores the lesser known pathways--reward/survival, language, social, emotional, frontal lobe, and memory/attention--and how they can be tapped to energize and enhance instruction. Educators are forever searching for new and improved ways to convey information and inspire curiosity, and research suggests that exploiting different pathways may have a major effect on learning. Multiple Pathways to the Student Brain allows readers to see brain science through the eyes of a teacher—and teaching through the eyes of a brain scientist.
Author : National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Space Studies Board,Decadal Survey on Astronomy and Astrophysics 2020 (Astro2020)
Publisher : Unknown
Page : 615 pages
File Size : 43,7 Mb
Release : 2022-08-04
Category : Science
ISBN : 0309467349
The steering committee was specifically asked to (1) provide an overview of the current state of astronomy and astrophysics science, and technology research in support of that science, with connections to other scientific areas where appropriate; (2) identify the most compelling science challenges and frontiers in astronomy and astrophysics, which shall motivate the committee’s strategy for the future; (3) develop a comprehensive research strategy to advance the frontiers of astronomy and astrophysics for the period 2022-2032 that will include identifying, recommending, and ranking the highest-priority research activities; (4) utilize and recommend decision rules, where appropriate, that can accommodate significant but reasonable deviations in the projected budget or changes in urgency precipitated by new discoveries or unanticipated competitive activities; (5) assess the state of the profession, including workforce and demographic issues in the field, identify areas of concern and importance to the community, and where possible, provide specific, actionable, and practical recommendations to the agencies and community to address these areas. This report proposes a broad, integrated plan for space- and ground-based astronomy and astrophysics for the decade 2023-2032. It also lays the foundations for further advances in the following decade.
Author : Hassan A.H. Ibrahim,Mostafa M. El-Sheekh
Publisher : Bentham Science Publishers
Page : 448 pages
File Size : 44,9 Mb
Release : 2023-11-06
Category : Science
ISBN : 9789815050004
This reference highlights the significance of marine ecosystems, encompassing seaweed beds, seagrasses, coral reefs, mangroves, estuaries, and protected areas, as a remarkable gateway to overcoming healthcare challenges and unlocking a rich trove of bioactive compounds for drug discovery. One of the key highlights of this book is its exploration of the development of marine bio-drugs, a field that demands collaboration among scientists from both academic and industrial fronts. The editors also include a prospective review on marine environments, emphasizing the necessity for big data, collective knowledge sharing, financial support, and streamlined administrative processes, all of which contribute to enhancing innovation in the drug discovery process. Another feature includes reference lists that allow researchers to explore topics of interest in depth. With twelve comprehensive chapters, this book extensively covers marine ecosystem biodiversity, productivity, protected areas, and the intricate interplay of biotic and abiotic factors that shape these ecosystems. Readers will learn about important bioactive compounds within marine organisms and how to use this knowledge to outline a strategy for bio-drug discovery. The book caters to a diverse audience of researchers, students, ecologists, microbiologists, pharmacologists, and biotechnologists who are engaged in studying the dynamic components of marine environments. By providing the latest insights and strategies in the realm of bio-drug discovery from marine resources, this book serves as an invaluable resource for scholars and professionals seeking to tap into the potential of these unique ecosystems.
Author : Gül Dölen,Mustafa Sahin
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 41,8 Mb
Release : 2016-08-15
Category : Genetics
ISBN : 9782889199051
The Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the ability to socialize and adapt to novelty. The condition is typically identified in children around 3 years of age, however the high heritability of autism suggests that the disease process begins at conception. The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. Despite the genetic heterogeneity of ASD etiology, converging evidence suggests that these disparate genetic lesions may result in the disruption of a limited number of key biochemical pathways or circuits. Classification of patients into groups by pathogenic rather than etiological categories, will likely aid future therapeutic development and clinical trials. In this set of papers, we explore the existing evidence supporting this view. Specifically, we focus on biochemical cascades such as mTOR and ERK signaling, the mRNA network bound by FMRP and UBE3A, dorsal and ventral striatal circuits, cerebellar circuits, hypothalamic projections, as well as prefrontal and anterior cingulate cortical circuits. Special attention will be given to studies that demonstrate the necessity and/or sufficiency of genetic disruptions (e.g. by molecular deletion and/or replacement) in these pathways and circuits for producing characteristic behavioral features of autism. Necessarily these papers will be heavily weighted towards basic mechanisms elucidated in animal models, but may also include investigations in patients.
Author : Carsten Wiuf,Claus L. Andersen
Publisher : Oxford University Press
Page : 217 pages
File Size : 46,5 Mb
Release : 2009-06-18
Category : Mathematics
ISBN : 9780199532872
A collection of chapters from carefully chosen experts covering the theory behind the complex mathematical, statistical, and bioinformatics tools needed to extract, handle, and process data and their application to real data.
Author : József Dobó,Péter Gál,Brian V. Geisbrecht
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 40,6 Mb
Release : 2023-03-02
Category : Medical
ISBN : 9782832516232
Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 40,6 Mb
Release : 2011-11-12
Category : Medical
ISBN : 1461412161
In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.
Author : Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 52,7 Mb
Release : 2021-08-26
Category : Medical
ISBN : 9782889712397
Author : Anonim
Publisher : Academic Press
Page : 232 pages
File Size : 49,6 Mb
Release : 2018-11-14
Category : Medical
ISBN : 9780444641953
Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more. Presents a timely, comprehensive assessment of the field Includes helpful summaries on current knowledge, gaps and future directions in autism research