Mass Spectrometry In Sports Drug Testing

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Mass Spectrometry in Sports Drug Testing

Mario Thevis
Mass Spectrometry in Sports Drug Testing Book PDF

Author : Mario Thevis
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 52,9 Mb
Release : 2010-12-13
Category : Science
ISBN : 9781118035146

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Mass Spectrometry in Sports Drug Testing by Mario Thevis Pdf

Enables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.

Mass Spectrometry in Sports Drug Testing

Mario Thevis
Mass Spectrometry in Sports Drug Testing Book PDF

Author : Mario Thevis
Publisher : Wiley
Page : 360 pages
File Size : 48,5 Mb
Release : 2010-08-02
Category : Science
ISBN : 0470413271

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Mass Spectrometry in Sports Drug Testing by Mario Thevis Pdf

Enables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.

Pharmacology, Doping and Sports

Jean L. Fourcroy
Pharmacology Doping and Sports Book PDF

Author : Jean L. Fourcroy
Publisher : Routledge
Page : 237 pages
File Size : 51,6 Mb
Release : 2008-10-27
Category : Medical
ISBN : 9781134088799

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Pharmacology, Doping and Sports by Jean L. Fourcroy Pdf

The work of dope testers is constantly being obstructed by the development of ever harder-to-trace new forms of banned substances. Organisations such as the World Anti-Doping Association and the United States Anti-Doping Agency are pioneering cutting-edge techniques designed to keep competition at the highest level fair and safe, and must ensure that their drug testing laboratories adhere to the highest scientific standards. In Pharmacology, Doping and Sports these techniques and procedures are explained by the anti-doping experts who practice them. Broad-ranging in scope, this book examines the effects of performance-enhancing substances on the athlete’s health; the role of anti-doping procedures as an ethical question, and explains the background to, and the emergence of, the anti-doping movement. The book also offers in-depth analysis of key scientific matters, such as: standard analytical and diagnostic tests for sports doping regulatory standards for laboratory proficiency common performance-enhancing techniques such as anabolic and designer steroids, blood doping, growth hormones, and gene doping carbon-isotope ratio testing. Written by some of the world's leading authorities on the science of sports doping, Pharmacology, Doping and Sports provides an invaluable study of up-to-the-minute anti-doping techniques. This book is essential reading for all sports scientists, coaches, policy-makers, students and athletes interested in the science or ethics of doping in sport.

Karch's Drug Abuse Handbook

Steven Karch,Bruce A. Goldberger
Karch s Drug Abuse Handbook Book PDF

Author : Steven Karch,Bruce A. Goldberger
Publisher : CRC Press
Page : 671 pages
File Size : 48,8 Mb
Release : 2022-11-29
Category : Law
ISBN : 9781420095005

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Karch's Drug Abuse Handbook by Steven Karch,Bruce A. Goldberger Pdf

Karch’s Drug Abuse Handbook, Third Edition remains the quintessential compendium addressing the pharmacological, medical, and legal aspects of drugs and informing the forensic community of the latest scientific advances and emergent practices. For this edition, Dr. Karch has brought on clinical and forensic toxicology expert Dr. Bruce Goldberger, editor-in-chief of the Journal of Analytical Toxicology and president of the American Board of Forensic Toxicology, to serve as co-editor. In addition, world-renowned scientists and medical professionals have contributed their work and expertise in tackling the latest developments in drug testing, drug-related medical emergencies, and the drug toxicology. Topics addressed include genetic testing in drug death investigation, pathology, toxicogenetics, alcohol, post-mortem toxicology, new psychoactive substances, the latest legal issues and challenges as well as drugs and drug testing in sports, and the ethical, legal, and practical issues involved. Vivid pictures and diagrams throughout illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. With unparalleled detail, the latest research and the highest level of authoritative medical scientific information, The Drug Abuse Handbook, Third Edition remains the definitive resource for drug related issues.

Mass Spectrometry

Mahmood Aliofkhazraei
Mass Spectrometry Book PDF

Author : Mahmood Aliofkhazraei
Publisher : BoD – Books on Demand
Page : 284 pages
File Size : 54,9 Mb
Release : 2017-06-07
Category : Science
ISBN : 9789535132233

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Mass Spectrometry by Mahmood Aliofkhazraei Pdf

Mass spectrometry is an analytical technique that can be used for the structural characterization and quantification of a wide range of molecules. The technique is extensively used by chemists for the analysis of small and volatile organic compounds. Mass spectrometry has long been an important technique for the identification of materials ranging from pure compounds to complex mixtures. Mass spectrometry can be used to determine molecular weight of compounds or using different ionization conditions, can provide more structural details through the analysis of fragmentation patterns. This level of detail can be attained for pure compounds and some mixtures. Mass spectrometry can also be combined with separation techniques such as gas chromatography or liquid chromatography to allow more complex mixtures to be examined. These hyphenated techniques provide a range of options for the characterization of complex materials.

Critical Issues in Alcohol and Drugs of Abuse Testing

Amitava Dasgupta
Critical Issues in Alcohol and Drugs of Abuse Testing Book PDF

Author : Amitava Dasgupta
Publisher : Academic Press
Page : 560 pages
File Size : 53,8 Mb
Release : 2019-01-10
Category : Science
ISBN : 9780128156087

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Critical Issues in Alcohol and Drugs of Abuse Testing by Amitava Dasgupta Pdf

Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians

Sports Ethics for Sports Management Professionals

Patrick Thornton,Walter T. Champion Jr.,Lawrence Ruddell,Larry Ruddell
Sports Ethics for Sports Management Professionals Book PDF

Author : Patrick Thornton,Walter T. Champion Jr.,Lawrence Ruddell,Larry Ruddell
Publisher : Jones & Bartlett Publishers
Page : 518 pages
File Size : 48,5 Mb
Release : 2011-04-22
Category : Business & Economics
ISBN : 9780763743840

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Sports Ethics for Sports Management Professionals by Patrick Thornton,Walter T. Champion Jr.,Lawrence Ruddell,Larry Ruddell Pdf

Directed at future sports executives and sports managers, the book contains numerous case studies that allow students to apply the ethical decision-making process to a sports-related ethical dispute. Unlike other texts that spend too much time discussing ethical theories, Sports Ethics for Sports Management Professionals addresses the important issues sports professionals may actually encounter during their career --Book Jacket.

Doping in Sports

Detlef Thieme,Peter Hemmersbach
Doping in Sports Book PDF

Author : Detlef Thieme,Peter Hemmersbach
Publisher : Springer Science & Business Media
Page : 543 pages
File Size : 51,9 Mb
Release : 2009-12-18
Category : Medical
ISBN : 9783540790884

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Doping in Sports by Detlef Thieme,Peter Hemmersbach Pdf

Doping in sports and the fight against it has gained increasing attention in recent years. The pharmacological basis for a possible performance enhancement in competitive sport through the administration of prohibited substances and methods as well as the analytical disclosure of such practices are comprehensively covered in 21 contributions by outstanding and distinctive authors.

Mass Spectrometry

Agnieszka Kraj,Dominic M. Desiderio,Nico M. Nibbering
Mass Spectrometry Book PDF

Author : Agnieszka Kraj,Dominic M. Desiderio,Nico M. Nibbering
Publisher : John Wiley & Sons
Page : 358 pages
File Size : 45,6 Mb
Release : 2008-12-01
Category : Science
ISBN : 9780470395806

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Mass Spectrometry by Agnieszka Kraj,Dominic M. Desiderio,Nico M. Nibbering Pdf

With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation, and Applications serves as a forum to introduce students to the whole world of mass spectrometry and to the many different perspectives that each scientific field brings to its use. The book emphasizes the use of this important analytical technique in many different fields, including applications for organic and inorganic chemistry, forensic science, biotechnology, and many other areas. After describing the history of mass spectrometry, the book moves on to discuss instrumentation, theory, and basic applications.

LC-MS in Drug Analysis

Loralie J. Langman,Christine L. H. Snozek
LC MS in Drug Analysis Book PDF

Author : Loralie J. Langman,Christine L. H. Snozek
Publisher : Humana Press
Page : 0 pages
File Size : 54,6 Mb
Release : 2012-07-06
Category : Medical
ISBN : 1617799335

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LC-MS in Drug Analysis by Loralie J. Langman,Christine L. H. Snozek Pdf

Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.

Interpretation of MS-MS Mass Spectra of Drugs and Pesticides

Wilfried M. A. Niessen,Ricardo A. Correa C.
Interpretation of MS MS Mass Spectra of Drugs and Pesticides Book PDF

Author : Wilfried M. A. Niessen,Ricardo A. Correa C.
Publisher : John Wiley & Sons
Page : 416 pages
File Size : 43,6 Mb
Release : 2017-01-09
Category : Science
ISBN : 9781119294252

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Interpretation of MS-MS Mass Spectra of Drugs and Pesticides by Wilfried M. A. Niessen,Ricardo A. Correa C. Pdf

Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

Liquid Chromatography Time-of-Flight Mass Spectrometry

Imma Ferrer,E. Michael Thurman
Liquid Chromatography Time of Flight Mass Spectrometry Book PDF

Author : Imma Ferrer,E. Michael Thurman
Publisher : John Wiley & Sons
Page : 281 pages
File Size : 41,8 Mb
Release : 2009-05-06
Category : Science
ISBN : 9780470429952

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Liquid Chromatography Time-of-Flight Mass Spectrometry by Imma Ferrer,E. Michael Thurman Pdf

Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants—such as antibiotics, steroids, analgesics—using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.

Acute Topics in Anti-Doping

O. Rabin,Y. Pitsiladis
Acute Topics in Anti Doping Book PDF

Author : O. Rabin,Y. Pitsiladis
Publisher : Karger Medical and Scientific Publishers
Page : 206 pages
File Size : 53,9 Mb
Release : 2017-06-02
Category : Psychology
ISBN : 9783318060447

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Acute Topics in Anti-Doping by O. Rabin,Y. Pitsiladis Pdf

Doping represents the dark side of amateur and professional sports – in order to protect athletes around the globe, anti-doping rules are continuously revised and improved. This publication reviews the current regulatory framework, scientific aspects, future approaches, and social and ethical dimensions of the fight against doping in sport. Prominent experts on the implementation of anti-doping strategies, as well as leading researchers in science and medicine, have contributed to this publication. In keeping with its interdisciplinary origin, the book is intended for athletes, coaches, students, scientists, anti-doping officials, and all others interested in anti-doping and sports. Ranging from legal and educational to scientific and medical issues, this collection emphasizes the need for a multidisciplinary approach and the importance of preventative strategies in the fight against doping in sports.

Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research

Henk Schierbeek
Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research Book PDF

Author : Henk Schierbeek
Publisher : John Wiley & Sons
Page : 416 pages
File Size : 44,7 Mb
Release : 2017-01-23
Category : Science
ISBN : 9781119341246

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Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research by Henk Schierbeek Pdf

A guide for scientists, pediatricians and students involved in metabolic studies in pediatric research Addresses the availability of modern analytical techniques and how to apply these techniques in metabolic studies Covers the whole range of available mass spectrometric techniques used for metabolic studies including Stable Isotope Methodology Presents the relevance of mass spectrometry and stable isotope methodology in pediatric research covering applications in Nutrition, Obesity, Metabolic Disorders, and Kidney Disorders Focuses on the interactions between nutrients and the endogenous metabolism within the body and how these factors affect the health of a growing infant

Hormone Use and Abuse by Athletes

Ezio Ghigo,Fabio Lanfranco,Christian J. Strasburger
Hormone Use and Abuse by Athletes Book PDF

Author : Ezio Ghigo,Fabio Lanfranco,Christian J. Strasburger
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 51,9 Mb
Release : 2010-10-28
Category : Medical
ISBN : 9781441970145

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Hormone Use and Abuse by Athletes by Ezio Ghigo,Fabio Lanfranco,Christian J. Strasburger Pdf

Physical activity exerts an important influence on the endocrine system, modulating synthesis and secretion of several hormones. Almost every organ and system in the body is affected by physical activity and exercise, mainly through the endocrine and neuroendocrine system. Mode, intensity, and duration of the exercise bout, age, gender and fitness level of the individual as well as environmental and psychological factors may affect the endocrine response to physical activity. On the other hand, several hormones are able to influence physical performance and body composition. Thus, a bi-univocal interrelationship between exercise and hormones exists. In this book new developments on metabolic and endocrine response to exercise are revised and introduce the "hot topic" of hormonal doping in sports. In the past decades, hormone abuse has become a widespread habit among professional and – most of all and more frequently – recreational athletes. A substantial part of this volume is devoted to the effects of exogenous hormones on performance. Anabolic steroids, growth hormone and erythropoietin properties, use and misuse in sports are widely described. Specific methods to detect hormone abuse are presented and discussed. The contributors to this volume are well-known experts and dedicated researchers in the fields of sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection. The purpose of this volume is to provide all professionals involved in sports medicine and endocrinology a state-of-the-art overview of the complex interactions between physical activity and the endocrine system and to focus on hormone abuse in sports at competitive and recreational level highlighting its negative consequences for long-term health.