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Mass Spectrometry of Biological Materials, Second Edition by Barbara S. Larsen,Charles N. McEwen Pdf
Second Edition provides up-to-the-minute discussions on the application of mass spectrometry to the biological sciences. Shows how and why experiments are performed and furnishes details to facilitate duplication of results.
Sample Preparation in Biological Mass Spectrometry by Alexander R. Ivanov,Alexander V. Lazarev Pdf
The aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.
Mass Spectrometry by Marek Smoluch,Giuseppe Grasso,Piotr Suder,Jerzy Silberring Pdf
Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.
Sample Preparation in Biological Mass Spectrometry by Alexander R. Ivanov,Alexander V. Lazarev Pdf
The aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.
Mass Spectrometry of Biological Materials by Barbara S. Larsen,Charles N. McEwen Pdf
Second Edition provides up-to-the-minute discussions on the application of mass spectrometry to the biological sciences. Shows how and why experiments are performed and furnishes details to facilitate duplication of results.
Quantitative Biological and Clinical Mass Spectrometry by Anthony I. Mallet Pdf
A basic overview of mass spectrometry relevant to life and health science applications, illustrated throughout with relevant case studies This introductory text provides information and assistance to new users of mass spectrometry (MS) working in clinical or biochemical fields who are faced with implementing and designing quantitative mass spectrometric assays for a variety of classes of molecules of biological interest. It presents a detailed discussion on how to optimize measurement parameters for a candidate reference quantitative analysis, including calibration procedures, sensitivity, reproducibility, speed of assay and compliance with regulatory authorities. Quantitative Biological and Clinical Mass Spectrometry uses examples where development has not been immediately successful but where unforeseen problems have arisen and describes the strategies used to solve these. Advances in addressing the very large numbers of clinical samples that arise on routine screening programs such as those involved in inborn errors of metabolism studies are discussed. Direct mass spectrometric based analyses applicable to point of care testing (POCT) situations are also covered. The book concludes with a short section on possible novel developments, bibliography, references, and a glossary of terms. Shows how the presence of false results can be detected and understood Describes the ‘parts’ of modern instruments from sample introduction through ionization, mass analysis and detection, and the variety of techniques of tandem mass spectrometry Discusses the requirement for specificity in an assay method Fully illustrated throughout Highly relevant to all key areas of mass spectrometric analysis Quantitative Biological and Clinical Mass Spectrometry appeals to those newly exposed to the use of combined chromatography and mass spectrometry for analysis of biological material and to scientists experienced in automated clinical analysis using immunoassays or who are new to mass spectrometry.
The Analysis of Biological Materials by L. R. P. Butler Pdf
The Analysis of Biological Materials: The Proceedings of a Conference Held in Pretoria, South Africa October 1977 by the Spectroscopic Society of South Africa focuses on the applications, processes, and methodologies involved in the analysis of biological materials. The compilation first offers information on the contributions of the analysis of biological materials in medical diagnosis and treatment and development of atomic absorption spectroscopic techniques in biological analysis. Topics include applications of biological tissues analysis in medical research; physics and chemistry in medicine; complexing characteristics and in vivo roles of metals; and metals in the treatment of disease. The book then takes a look at microprobe analysis of pathological tissues, including specimen preparation and microprobe analysis investigation. The publication discusses the application of ion microprobe mass analyzer to the analysis of biological materials; multi-element analysis of teeth and other biological materials by instrumental neutron activation; and single column gradient elution ion exchange amino acid analyzer. The text also examines biographical materials of oceanographic origin and volatile metals in biological materials. The compilation is a dependable reference for readers interested in the analysis of biological materials.
Element Analysis of Biological Samples by G. Venkatesh Iyengar,K. S. Subramanian,Joost R.W. Woittiez Pdf
Despite the development of innovative new analytical techniques for biological trace element research, today's trace element investigators face formidable obstacles to obtaining reliable data. This complete reference identifies and assesses the challenges the analyst encounters at each stage of an analysis, and discusses the effects of various techniques on the sample. Three internationally recognized scientists and authors consider the effects of the numerous collection, storage, and sample preparatory techniques used in sample analysis. Proper analytical quality control, including such critical factors as sampling and sample preparation, specimen preservation and storage, and ashing, is examined. The book also looks at sample preparation methods unique to various instruments and speciation chemistry issues, and examines the link between chemical analysis and specimen banking. A previously unrecognized source of error, presampling factors, is also discussed.
Sample Preparation in Biological Mass Spectrometry by Alexander R. Ivanov,Alexander V. Lazarev Pdf
The aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.
Imaging Mass Spectrometry by Laura M Cole,Malcolm R Clench Pdf
This second edition details new and updated chapters on key methodologies and breakthroughs in the mass spectrometry imaging (MSI) field. Chapters guide readers through nano-Desorption Electrospray Ionisation (nDESI), Matrix Assisted Laser Desorption Ionisation-2 (MALDI-2), Laser Ablation - Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) ,Imaging Mass Cytometry (IMC) with a variety of diverse samples including eye tissue, crop analysis, 3D cell culture models, and counterfeit goods analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Imaging Mass Spectrometry: Methods and Protocols, Second Edition aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Proceedings of the First Joint Services Workshop on Biological Mass Spectrometry, 28-30 July 1997, Baltimore, Maryland by Anonim Pdf
The first Joint Services Workshop on Biological Mass Spectrometry was held 28-30 July 1997, at the Hyatt Regency, Baltimore, MD. The workshop was organized by the U.S. Army Edgewood Research, Development, and Engineering Center (ERDEC) and co-sponsored by the U.S. Navy and U.S. Air Force. The overall objective of the workshop was to bring together experts and practitioners for a review of the state-of-the-art in biological mass spectrometry and related technologies to serve as the basis for the generation of a program strategy for the development of next-generation biological mass spectrometers. Such mass spectrometer systems will have significant impact not only on chemical/biological defense but also on environmental and food monitoring, the health industry, and various research and industrial endeavors. The workshop addressed a range of issues related to the development of automated, integrated mass spectrometers based on leading edge methodologies for the characterization, analysis, and identification of biological materials. Particular attention was given to applications of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), interface of separation methods, biological sample handling/processing, and potential biomarker classes. These Proceedings compile summaries of a majority of technical presentations made during the conference portion of the workshop.
Mass Spectrometry Imaging of Small Molecules by Lin He Pdf
This volume presents new developments in the field of mass spectrometry imaging, covering imaging, software, data analysis, new instrumentations, and new methodological approaches. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mass Spectrometry Imaging of Small Molecules aims to to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.
