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Mathematical Modeling for the Life Sciences by Jacques Istas Pdf
Provides a wide range of mathematical models currently used in the life sciences Each model is thoroughly explained and illustrated by example Includes three appendices to allow for independent reading
Mathematics for the Life Sciences by Glenn Ledder Pdf
Mathematics for the Life Sciences provides present and future biologists with the mathematical concepts and tools needed to understand and use mathematical models and read advanced mathematical biology books. It presents mathematics in biological contexts, focusing on the central mathematical ideas, and providing detailed explanations. The author assumes no mathematics background beyond algebra and precalculus. Calculus is presented as a one-chapter primer that is suitable for readers who have not studied the subject before, as well as readers who have taken a calculus course and need a review. This primer is followed by a novel chapter on mathematical modeling that begins with discussions of biological data and the basic principles of modeling. The remainder of the chapter introduces the reader to topics in mechanistic modeling (deriving models from biological assumptions) and empirical modeling (using data to parameterize and select models). The modeling chapter contains a thorough treatment of key ideas and techniques that are often neglected in mathematics books. It also provides the reader with a sophisticated viewpoint and the essential background needed to make full use of the remainder of the book, which includes two chapters on probability and its applications to inferential statistics and three chapters on discrete and continuous dynamical systems. The biological content of the book is self-contained and includes many basic biology topics such as the genetic code, Mendelian genetics, population dynamics, predator-prey relationships, epidemiology, and immunology. The large number of problem sets include some drill problems along with a large number of case studies. The latter are divided into step-by-step problems and sorted into the appropriate section, allowing readers to gradually develop complete investigations from understanding the biological assumptions to a complete analysis.
Mathematical Modeling in the Life Sciences by Paul Doucet,Peter B. Sloep Pdf
Combining mathematics, biology, statistics and computer applications, this text applies mathematical methods to the solution of biological and related problems. It demonstrates how to formulate mathematical models of dynamic processes and how to study their behaviour analytically and numerically.
Mathematical Modeling of Biological Processes by Avner Friedman,Chiu-Yen Kao Pdf
This book on mathematical modeling of biological processes includes a wide selection of biological topics that demonstrate the power of mathematics and computational codes in setting up biological processes with a rigorous and predictive framework. Topics include: enzyme dynamics, spread of disease, harvesting bacteria, competition among live species, neuronal oscillations, transport of neurofilaments in axon, cancer and cancer therapy, and granulomas. Complete with a description of the biological background and biological question that requires the use of mathematics, this book is developed for graduate students and advanced undergraduate students with only basic knowledge of ordinary differential equations and partial differential equations; background in biology is not required. Students will gain knowledge on how to program with MATLAB without previous programming experience and how to use codes in order to test biological hypothesis.
Modeling and Simulation in Medicine and the Life Sciences by Frank C. Hoppensteadt,Charles S. Peskin Pdf
The result of lectures given by the authors at New York University, the University of Utah, and Michigan State University, the material is written for students who have had only one term of calculus, but it contains material that can be used in modeling courses in applied mathematics at all levels through early graduate courses. Numerous exercises are given as well as solutions to selected exercises, so as to lead readers to discover interesting extensions of that material. Throughout, illustrations depict physiological processes, population biology phenomena, corresponding models, and the results of computer simulations. Topics covered range from population phenomena to demographics, genetics, epidemics and dispersal; in physiological processes, including the circulation, gas exchange in the lungs, control of cell volume, the renal counter-current multiplier mechanism, and muscle mechanics; to mechanisms of neural control. Each chapter is graded in difficulty, so a reading of the first parts of each provides an elementary introduction to the processes and their models.
Mathematics in Medicine and the Life Sciences by Frank C. Hoppensteadt,Charles S. Peskin Pdf
The aim of this book is to introduce the subject of mathematical modeling in the life sciences. It is intended for students of mathematics, the physical sciences, and engineering who are curious about biology. Additionally, it will be useful to students of the life sciences and medicine who are unsatisfied with mere description and who seek an understanding of biological mechanism and dynamics through the use of mathematics. The book will be particularly useful to premedical students, because it will introduce them not only to a collection of mathematical methods but also to an assortment of phenomena involving genetics, epidemics, and the physiology of the heart, lung, and kidney. Because of its introductory character, mathematical prerequisites are kept to a minimum; they involve only what is usually covered in the first semester of a calculus sequence. The authors have drawn on their extensive experience as modelers to select examples which are simple enough to be understood at this elementary level and yet realistic enough to capture the essence of significant biological phenomena drawn from the areas of population dynamics and physiology. Because the models presented are realistic, the book can serve not only as an introduction to mathematical methods but also as a mathematical introduction to the biological material itself. For the student, who enjoys mathematics, such an introduction will be far more stimulating and satisfying than the purely descriptive approach that is traditional in the biological sciences.
Mathematical Modeling of Collective Behavior in Socio-Economic and Life Sciences by Giovanni Naldi,Lorenzo Pareschi,Giuseppe Toscani Pdf
Using examples from finance and modern warfare to the flocking of birds and the swarming of bacteria, the collected research in this volume demonstrates the common methodological approaches and tools for modeling and simulating collective behavior. The topics presented point toward new and challenging frontiers of applied mathematics, making the volume a useful reference text for applied mathematicians, physicists, biologists, and economists involved in the modeling of socio-economic systems.
Modeling Life by Alan Garfinkel,Jane Shevtsov,Yina Guo Pdf
This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?
Mathematical Modeling in Systems Biology by Brian P. Ingalls Pdf
An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.
Calculus for the Life Sciences: A Modeling Approach by James L. Cornette,Ralph A. Ackerman Pdf
Calculus for the Life Sciences is an entire reimagining of the standard calculus sequence with the needs of life science students as the fundamental organizing principle. Those needs, according to the National Academy of Science, include: the mathematical concepts of change, modeling, equilibria and stability, structure of a system, interactions among components, data and measurement, visualization, and algorithms. This book addresses, in a deep and significant way, every concept on that list. The book begins with a primer on modeling in the biological realm and biological modeling is the theme and frame for the entire book. The authors build models of bacterial growth, light penetration through a column of water, and dynamics of a colony of mold in the first few pages. In each case there is actual data that needs fitting. In the case of the mold colony that data is a set of photographs of the colony growing on a ruled sheet of graph paper and the students need to make their own approximations. Fundamental questions about the nature of mathematical modeling—trying to approximate a real-world phenomenon with an equation—are all laid out for the students to wrestle with. The authors have produced a beautifully written introduction to the uses of mathematics in the life sciences. The exposition is crystalline, the problems are overwhelmingly from biology and interesting and rich, and the emphasis on modeling is pervasive. An instructor's manual for this title is available electronically to those instructors who have adopted the textbook for classroom use. Please send email to [email protected] for more information. Online question content and interactive step-by-step tutorials are available for this title in WebAssign. WebAssign is a leading provider of online instructional tools for both faculty and students.
Mathematical Modeling in the Life Sciences by Paul Doucet,Peter B. Sloep Pdf
Combining mathematics, biology, statistics and computer applications, this text applies mathematical methods to the solution of biological and related problems. It demonstrates how to formulate mathematical models of dynamic processes and how to study their behaviour analytically and numerically.
Mathematical Modeling in the Social and Life Sciences by Michael Olinick Pdf
Olinick’s Mathematical Models in the Social and Life Sciences concentrates not on physical models, but on models found in biology, social science, and daily life. This text concentrates on a relatively small number of models to allow students to study them critically and in depth, and balances practice and theory in its approach. Each chapter concluded with suggested projects that encourage students to build their own models, and space is set aside for historical and biographical notes about the development of mathematical models.
A Biologist's Guide to Mathematical Modeling in Ecology and Evolution by Sarah P. Otto,Troy Day Pdf
Thirty years ago, biologists could get by with a rudimentary grasp of mathematics and modeling. Not so today. In seeking to answer fundamental questions about how biological systems function and change over time, the modern biologist is as likely to rely on sophisticated mathematical and computer-based models as traditional fieldwork. In this book, Sarah Otto and Troy Day provide biology students with the tools necessary to both interpret models and to build their own. The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction. Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists. A how-to guide for developing new mathematical models in biology Provides step-by-step recipes for constructing and analyzing models Interesting biological applications Explores classical models in ecology and evolution Questions at the end of every chapter Primers cover important mathematical topics Exercises with answers Appendixes summarize useful rules Labs and advanced material available
Mathematical Models for Society and Biology by Edward Beltrami Pdf
Mathematical Models for Society and Biology, 2e, is a useful resource for researchers, graduate students, and post-docs in the applied mathematics and life science fields. Mathematical modeling is one of the major subfields of mathematical biology. A mathematical model may be used to help explain a system, to study the effects of different components, and to make predictions about behavior. Mathematical Models for Society and Biology, 2e, draws on current issues to engagingly relate how to use mathematics to gain insight into problems in biology and contemporary society. For this new edition, author Edward Beltrami uses mathematical models that are simple, transparent, and verifiable. Also new to this edition is an introduction to mathematical notions that every quantitative scientist in the biological and social sciences should know. Additionally, each chapter now includes a detailed discussion on how to formulate a reasonable model to gain insight into the specific question that has been introduced. Offers 40% more content – 5 new chapters in addition to revisions to existing chapters Accessible for quick self study as well as a resource for courses in molecular biology, biochemistry, embryology and cell biology, medicine, ecology and evolution, bio-mathematics, and applied math in general Features expanded appendices with an extensive list of references, solutions to selected exercises in the book, and further discussion of various mathematical methods introduced in the book
Mathematical Methods and Models in Biomedicine by Urszula Ledzewicz,Heinz Schättler,Avner Friedman,Eugene Kashdan Pdf
Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phenomena in various temporal and spatial settings. This book illustrates the breadth and depth of research opportunities that exist in the general field of mathematical biomedicine by highlighting some of the fascinating interactions that continue to develop between the mathematical and biomedical sciences. It consists of five parts that can be read independently, but are arranged to give the reader a broader picture of specific research topics and the mathematical tools that are being applied in its modeling and analysis. The main areas covered include immune system modeling, blood vessel dynamics, cancer modeling and treatment, and epidemiology. The chapters address topics that are at the forefront of current biomedical research such as cancer stem cells, immunodominance and viral epitopes, aggressive forms of brain cancer, or gene therapy. The presentations highlight how mathematical modeling can enhance biomedical understanding and will be of interest to both the mathematical and the biomedical communities including researchers already working in the field as well as those who might consider entering it. Much of the material is presented in a way that gives graduate students and young researchers a starting point for their own work.
