Measuring Heavy Metal Contaminants In Cannabis And Hemp

Author : Robert J. Thomas
Publisher : CRC Press
Page : 672 pages
File Size : 51,6 Mb
Release : 2020-09-30
Category : Science
ISBN : 9781000193411

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Measuring Heavy Metal Contaminants in Cannabis and Hemp by Robert J. Thomas Pdf

The surge of interest in cannabis-based medicinal products has put an extremely high demand on testing capabilities, particularly for contaminants such as heavy metals, which are naturally taken up through the roots of the plants from the soil, growing medium, and fertilizers but can also be negatively impacted by the grinding equipment and extraction/distillation process. Unfortunately, many state regulators do not have the necessary experience and background to fully understand all the safety and toxicological issues regarding the cultivation and production of cannabis and hemp products on the market today. Measuring Heavy Metal Contaminants in Cannabis and Hemp offers a comprehensive guide to the entire cannabis industry for measuring elemental contaminants in cannabis and hemp. For testing labs, it describes fundamental principles and practical capabilities of ICP-MS and other AS techniques for measuring heavy metals in cannabis. For state regulators, it compares maximum contaminant limits of heavy metals with those for federally regulated pharmaceutical materials. For cultivators and processors, it helps them to better understand the many sources of heavy metals in cannabis. And for consumers of medical cannabis, it highlights the importance of choosing cannabis products that are safe to use. Other key topics include: The role of other analytical techniques for the comprehensive testing of cannabis products Tips to optimize analytical procedures to ensure the highest quality data Guidance on how to characterize elemental contaminants in vaping liquids and aerosols Suggestions on how to reduce errors using plasma spectrochemistry The role of certified reference materials to validate standard methods Easy-to-read sections on instrumental hardware components, calibration and measurement protocols, typical interferences, routine maintenance, and troubleshooting procedures Written with the cannabis testing community in mind, this book is also an invaluable resource for growers, cultivators, processors, testers, regulators, and even consumers who are interested in learning more about the potential dangers of heavy metal contaminants in cannabis and hemp.

Author : Robert Thomas
Publisher : CRC Press
Page : 474 pages
File Size : 46,6 Mb
Release : 2018-01-29
Category : Medical
ISBN : 9781351984409

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Measuring Elemental Impurities in Pharmaceuticals by Robert Thomas Pdf

Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters , , and , together with Q3D, Step 4 guidelines for elemental impurities, drafted by the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use), a consortium of global pharmaceutical associations, including the European Pharmacopeia (Ph.Eur.), the Japanese Pharmacopeia (JP) and the USP. This book provides a complete guide to the analytical methodology, instrumental techniques and sample preparation procedures used for measuring elemental impurities in pharmaceutical and nutraceutical materials. It offers readers the tools to better understand plasma spectrochemistry to optimize detection capability for the full suite of elemental PDE (Permitted Daily Exposure) levels in the various drug delivery categories. Other relevant information covered in the book includes: The complete guide to measuring elemental impurities in pharmaceutical and nutraceutical materials. Covers heavy metals testing in the pharmaceutical industry from an historical perspective. Gives an overview of current USP Chapters and and ICH Q3D Step 4 Guidelines. Explains the purpose of validation protocols used in Chapter , including how J-values are calculated Describes fundamental principles and practical capabilities of ICP-MS and ICP-OES. Offers guidelines about the optimum strategy for risk assessment Provides tips on how best to prepare and present your data for regulatory inspection. An indispensable resource, the fundamental principles and practical benefits of ICP-OES and ICP-MS are covered in a reader-friendly format that a novice, who is carrying out elemental impurities testing in the pharmaceutical and nutraceutical communities, will find easy to understand.

Author : Suman Chandra,Hemant Lata,Mahmoud A. ElSohly
Publisher : Springer
Page : 474 pages
File Size : 42,9 Mb
Release : 2017-05-23
Category : Science
ISBN : 9783319545646

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Cannabis sativa L. - Botany and Biotechnology by Suman Chandra,Hemant Lata,Mahmoud A. ElSohly Pdf

This book highlights current Cannabis research: its botany, authentication, biotechnology, in vitro propagation, chemistry, cannabinoids biosynthesis, metabolomics, genomics, biomass production, quality control, and pharmacology. Cannabis sativa L. (Family: Cannabaceae) is one of the oldest sources of fiber, food and medicine. This plant has been of interest to researchers, general public and media not only due to its medicinal properties but also the controversy surrounding its illicit use. Cannabis has a long history of medicinal use in the Middle East and Asia, being first introduced as a medicine in Western Europe in the early 19th century. Due to its numerous natural constituents, Cannabis is considered a chemically complex species. It contains a unique class of terpeno-phenolic compounds (cannabinoids or phytocannabinoids), which have been extensively studied since the discovery of the chemical structure of tetrah ydrocannabinol (Δ9-THC), commonly known as THC, the main constituent responsible for the plant’s psychoactive effects. An additionally important cannabinoid of current interest is Cannabidiol (CBD). There has been a significant interest in CBD and CBD oil (extract of CBD rich Cannabis) over the last few years because of its reported activity as an antiepileptic agent, particularly its potential use in the treatment of intractable epilepsy in children.

Author : Kuldeep Bauddh,Bhaskar Singh,John Korstad
Publisher : Springer
Page : 472 pages
File Size : 52,6 Mb
Release : 2017-03-29
Category : Technology & Engineering
ISBN : 9789811030840

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Phytoremediation Potential of Bioenergy Plants by Kuldeep Bauddh,Bhaskar Singh,John Korstad Pdf

The globally escalating population necessitates production of more goods and services to fulfil the expanding demands of human beings which resulted in urbanization and industrialization. Uncontrolled industrialization caused two major problems – energy crisis and accelerated environmental pollution throughout the world. Presently, there are technologies which have been proposed or shown to tackle both the problems. Researchers continue to seek more cost effective and environmentally beneficial pathways for problem solving. Plant kingdom comprises of species which have the potential to resolve the couple problem of pollution and energy. Plants are considered as a potential feedstock for development of renewable energy through biofuels. Another important aspect of plants is their capacity to sequester carbon dioxide and absorb, degrade, and stabilize environmental pollutants such as heavy metals, poly-aromatic hydrocarbons, poly-aromatic biphenyls, radioactive materials, and other chemicals. Thus, plants may be used to provide renewable energy generation and pollution mitigation. An approach that could amalgamate the two aspects can be achieved through phytoremediation (using plants to clean up polluted soil and water), and subsequent generation of energy from the phyto-remediator plants. This would be a major advance in achieving sustainability that focuses on optimizing ‘people’ (social issues), ‘planet’ (environmental issues), and ‘profit’ (financial issues). The “Phytoremediation-Cellulosic Biofuels” (PCB) process will be socially beneficial through reducing pollution impacts on people, ecologically beneficial through pollution abatement, and economically viable through providing revenue that supplies an energy source that is renewable and also provides less dependence on importing foreign energy (energy-independence). The utilization of green plants for pollution remediation and energy production will also tackle some other important global concerns like global climate change, ocean acidification, and land degradation through carbon sequestration, reduced emissions of other greenhouse gases, restoration of degraded lands and waters, and more. This book addresses the overall potential of major plants that have the potential to fulfil the dual purposes of phytoremediation and energy generation. The non-edible bioenergy plants that are explored for this dual objective include Jatropha curcas, Ricinus communis, Leucaena leucocephalla, Milletia pinnata, Canabis sativa, Azadirachta indica, and Acacia nilotica. The book addresses all possible aspects of phyto-remediaton and energy generation in a holistic way. The contributors are one of most authoritative experts in the field and have covered and compiled the best content most comprehensively. The book is going to be extremely useful for researchers in the area, research students, academicians and also for policy makers for an inclusive understanding and assessment of potential in plant kingdom to solve the dual problem of energy and pollution.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 50,5 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda
Publisher : National Academies Press
Page : 487 pages
File Size : 47,7 Mb
Release : 2017-03-31
Category : Science
ISBN : 9780309453073

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The Health Effects of Cannabis and Cannabinoids by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda Pdf

Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Author : Mazen Nazal,Hongbo Zhao
Publisher : BoD – Books on Demand
Page : 282 pages
File Size : 55,9 Mb
Release : 2021-11-03
Category : Technology & Engineering
ISBN : 9781839681219

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Heavy Metals by Mazen Nazal,Hongbo Zhao Pdf

In recent years, urbanization and industrialization have produced large amounts of heavy metals, which are highly toxic to both humans and the environment. This book presents a comprehensive overview of heavy metals including their physiochemical properties, toxicity, transfer in the environment, legislation, environmental impacts, and mitigation measures. Written by experts in the field, chapters include scientific research as well as case studies.

Author : Xuebin Yin,Linxi Yuan
Publisher : Springer Science & Business Media
Page : 89 pages
File Size : 49,5 Mb
Release : 2012-07-25
Category : Science
ISBN : 9789400714397

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Phytoremediation and Biofortification by Xuebin Yin,Linxi Yuan Pdf

Phytoremediation consists of using plants and their associated microbes for environmental cleanup. Over the past 10 years, this treatment has gained recognition as a cost-effective, non-invasive, alternative or complimentary technology to engineering-based remediation methods. Biofortification, on the other hand, is an agricultural process that increases the uptake and accumulation of mineral nutrients in agricultural products through plant breeding, genetic engineering, or manipulation of agricultural practices. This book shows how, despite having different goals, both phytoremediation and biofortification technologies can be closely connected as they are both based on the phytoextraction process that involves plant uptake, accumulation, and transformation of nutrient elements from soil. More specifically, this brief offers a comprehensive introduction to Phytoremediation and Biofortification of selenium (Se), zinc (Zn), iron (Fe), cadium (Cd) and copper (Cu), and illustrates the emerging integration of these two bio-technologies. Phytoremediation and Biofortification: Two Sides of One Coin is a valuable resource to students, technicians, and academics who are interested in the treatment of environmental problems (bioremediation) through the use of plants, and in the field of biofortification.

Author : Irena Sherameti,Ajit Varma
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 46,8 Mb
Release : 2011-09-01
Category : Science
ISBN : 9783642214080

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Detoxification of Heavy Metals by Irena Sherameti,Ajit Varma Pdf

Heavy metals are severe environmental pollutants, and many of them are toxic even at very low concentrations. With industrial development, soil pollution with heavy metal elements have dramatically increased. The uptake of heavy metals via plants that are exposed to contaminated soils is a risk for human health and a major hazard for the ecosystem as a whole, including soil microorganisms. On the other hand, plants may be used in the decontamination of soils. The topics presented in this book include: sources of heavy metals contaminants in soils; plant species that can grow on contaminated soils; the phytoremediation of contaminated soils; tolerance, accumulation and detoxification mechanisms of zinc, copper, arsenic, cadmium and vanadium in plants; the critical role of sulfur metabolism in heavy metal tolerance; the role of aquatic macrophytes, plant growth-promoting bacteria, sugar crops and earthworms in detoxification; and heavy metal stabilization by promoting zeolite synthesis in soils.

Author : Otto Warburg
Publisher : Hassell Street Press
Page : 254 pages
File Size : 44,9 Mb
Release : 2021-09-10
Category : Electronic
ISBN : 1015049494

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Heavy Metal Prosthetic Groups And Enzyme Action by Otto Warburg Pdf

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author : Anonim
Publisher : Unknown
Page : 105 pages
File Size : 52,6 Mb
Release : 2007
Category : Herbs
ISBN : 9241594446

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WHO Guidelines for Assessing Quality of Herbal Medicines with Reference to Contaminants and Residues by Anonim Pdf

Author : Jaco Vangronsveld,Scott D. Cunningham
Publisher : Springer
Page : 288 pages
File Size : 41,7 Mb
Release : 1998-11-20
Category : Nature
ISBN : STANFORD:36105028533730

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Metal-Contaminated Soils by Jaco Vangronsveld,Scott D. Cunningham Pdf

An unfortunate by-product of industrialization is the contamination of soil and water resources with toxic metals, which becomes an environmental concern when the concentration in soils begins to affect human health. Current remediation methods applicable to contaminated soils are expensive and environmentally invasive since they are based primarily on civil-engineering techniques. This book represents an overview of efforts in exploiting biological and chemical processes to reduce the inherent risk associated with metal-contaminated soils. It presents a comprehensive, up-to-date analysis of in situ immobilization and inactivation of toxic metals by means of plants, microorganisms and invertebrates.

Author : William J. Langston,Maria J. Bebianno
Publisher : Springer Science & Business Media
Page : 480 pages
File Size : 49,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475727616

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Metal Metabolism in Aquatic Environments by William J. Langston,Maria J. Bebianno Pdf

Metal Metabolism in Aquatic Environments is a synthesis of recent developments in the field of metal ecotoxicology and features a number of contemporary issues arising from the interaction of metals and biota, such as pathways of assimilation and food chain transfer, metal accumulation and detoxification in humans and biotransformation of elements such as mercury and arsenic.

Author : Nelson Marmiroli,Borys Samotokin,Marta Marmiroli
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 47,6 Mb
Release : 2007-05-03
Category : Technology & Engineering
ISBN : 9781402055201

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Advanced Science and Technology for Biological Decontamination of Sites Affected by Chemical and Radiological Nuclear Agents by Nelson Marmiroli,Borys Samotokin,Marta Marmiroli Pdf

This book presents a comprehensive and integrated approach toward solving the ever growing problem of soil and water contamination by radioactive and chemical wastes from military facilities, weapons industries, and weapons storage. The authors combine theory and practice in specific contamination examples. This is a monograph born out of a unique combination of expertise and practical advice and is ideal for operators in the field of decontamination.

Author : Shaun R. Opie
Publisher : Springer Nature
Page : 325 pages
File Size : 43,7 Mb
Release : 2021-03-09
Category : Medical
ISBN : 9783030627164

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Cannabis Laboratory Fundamentals by Shaun R. Opie Pdf

The legislative requirement for cannabis to undergo laboratory testing has followed legalization of medical and recreational use in every U.S. state to date. Cannabis safety testing is a new investment opportunity within the emerging cannabis market that is separate from cultivation, processing, and distribution, allowing individuals and organizations who may have been reluctant to enter previously a new entry route to the cannabis space. However, many of the costs, timelines, operational requirements, and compliance issues are overlooked by people who have not been exposed to regulated laboratory testing. Cannabis Laboratory Fundamentals provides an in-depth review of the key issues that impact cannabis testing laboratories and provides recommendations and solutions to avoid common – but expensive – mistakes. The text goes beyond methodology to include sections on economics, regulation, and operational challenges, making it useful for both new and experienced cannabis laboratory operators, as well as all those who want to understand the opportunities and risks of this industry.