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Author : Atsushi Asakura,Masatoshi Suzuki,Katsumasa Goto
Publisher : Frontiers Media SA
Page : 150 pages
File Size : 50,8 Mb
Release : 2023-09-07
Category : Science
ISBN : 9782832533802
Author : Steve J. Winder
Publisher : CRC Press
Page : 250 pages
File Size : 45,8 Mb
Release : 2006-01-26
Category : Science
ISBN : 9781498713962
There is no doubt that the study of the muscular dystrophies in recent years has been exciting and rewarding. It has attracted the attention of many investigators of international repute, and this is reflected in the various contributions to this volume. Molecular Mechanisms of Muscular Dystrophies represents a personal collection of chapters cover
Author : National Institute of Neurological Diseases and Stroke
Publisher : Unknown
Page : 26 pages
File Size : 46,8 Mb
Release : 1971
Category : Muscular dystrophy
ISBN : MINN:31951D03894033U
Author : Alan E. H. Emery,Francesco Muntoni,Rosaline C. M. Quinlivan
Publisher : OUP Oxford
Page : 320 pages
File Size : 50,7 Mb
Release : 2015-02-19
Category : Medical
ISBN : 9780191503665
Duchenne Muscular Dystrophy, an inherited and progressive muscle wasting disease, is one of the most common single gene disorders found in the developed world. In this fourth edition of the classic monograph on the topic, Alan Emery and Francesco Muntoni are joined by Rosaline Quinlivan, Consultant in Neuromuscular Disorders, to provide a thorough update on all aspects of the disorder. Recent understanding of the nature of the genetic defect responsible for Duchenne Muscular Dystrophy and isolation of the protein dystrophin has led to the development of new theories for the disease's pathogenesis. This new edition incorporates these advances from the field of molecular biology, and describes the resultant opportunities for screening, prenatal diagnosis, genetic counselling and from recent pioneering work with anti-sense oligonucleotides, the possibility of effective RNA therapy. Although there is still no cure for the disorder, there have been significant developments concerning the gene basis, publication of standards of care guidelines, and improvements in management leading to significantly longer survival, particularly with cardio-pulmonary care. The authors also investigate other forms of pharmacological, cellular and gene therapies. Duchenne Muscular Dystrophy will be essential reading not only for scientists and clinicians, but will also appeal to therapists and other professionals involved in the care of patients with muscular dystrophy.
Author : Alan E. H. Emery
Publisher : Unknown
Page : 338 pages
File Size : 41,6 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015054284123
The muscular dystrophies are an important group of inherited disorders. They are characterized by muscle wasting and weakness, but vary considerably in their clinical manifestations and severity. This text reviews our understanding of the most important of these disorders. In many instances, the genes and protein products responsible for the dystrophies have been identified and it is now possible to establish a precise diagnosis, detect preclinical cases, identify carriers and offer prenatal dianostic testing. The book goes on to describe the opportunities for management of the symptoms through respiratory care, physiotherapy and surgical correction of contracture, and examines the potential, in the future, for effective treatment utilizing the new techniques of gene and cell therapy. Professor Emery has invited chapters from the leading international experts in the field providing a unique insight into the current situation and the hopes for the future.
Author : Peter M. Tiidus
Publisher : Human Kinetics
Page : 360 pages
File Size : 50,8 Mb
Release : 2008
Category : Muscles
ISBN : 0736058672
Attempts to cover a wide range of both basic research and applied clinical topics related to skeletal muscle damage and repair mechanisms and their application. This book examines muscle damage and repair mechanisms and issues in specific populations including older adults and special populations.
Author : Gustav Mattsson,Peter Magnusson
Publisher : Unknown
Page : 0 pages
File Size : 52,6 Mb
Release : 2021
Category : Myocardium
ISBN : 1789852242
Cardiomyopathies are diseases of the heart muscle with diverse etiologies ranging from myocarditis to gene mutations. They are classified according to morphology and function, and then further categorized based on whether they are familial or non-familial and based on specific etiologies. This book examines the various cardiomyopathies, including arrhythmogenic cardiomyopathy, hypertrophic cardiomyopathy, and dilated cardiomyopathy, as well as their genetic basis.
Author : Basil T. Darras,H. Royden Jones Jr.,Monique M. Ryan,Darryl C. De Vivo
Publisher : Elsevier
Page : 1156 pages
File Size : 43,7 Mb
Release : 2014-12-03
Category : Medical
ISBN : 9780124171275
Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference. Carefully revised new edition of the classic reference on neuromuscular disorders in infancy, childhood and adolescence. Definitive coverage of the basic science of neuromuscular disease and the latest diagnosis and treatment best practices. Includes coverage of clinical phenomenology, electrophysiology, histopathology, molecular genetics and protein chemistry
Author : George Karpati,David Hilton-Jones,Robert C. Griggs
Publisher : Cambridge University Press
Page : 800 pages
File Size : 50,8 Mb
Release : 2001-07-12
Category : Medical
ISBN : 0521650623
Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Author : Alexander Mauro
Publisher : Raven Press (ID)
Page : 582 pages
File Size : 53,8 Mb
Release : 1979
Category : Medical
ISBN : UOM:39015015064226
Author : Antonio Musarò
Publisher : MDPI
Page : 500 pages
File Size : 53,9 Mb
Release : 2020-11-20
Category : Science
ISBN : 9783039434367
The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.
Author : National Organization for Rare Disorders
Publisher : Lippincott Williams & Wilkins
Page : 982 pages
File Size : 53,9 Mb
Release : 2003
Category : Medical
ISBN : 0781730635
NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.
Author : Gisela Gaina
Publisher : Unknown
Page : 128 pages
File Size : 44,8 Mb
Release : 2020
Category : Muscular dystrophy
ISBN : 1839684763
Author : Stefano Govoni,Pierluigi Politi,Emilio Vanoli
Publisher : Springer
Page : 0 pages
File Size : 49,7 Mb
Release : 2020-07-31
Category : Medical
ISBN : 3030280071
This ambitious and comprehensive handbook represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling. Written by leading international experts in their respective research areas, the book presents a variety of perspectives on the core topic: from social and philosophical to gender-related aspects. It is designed for a broad readership and includes dedicated sections for cardiologists, psychiatrists, neurologists and psychotherapists looking for a more insightful and targeted approach to neuro-cardiovascular disease.
Author : Abraham Z. Reznick
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 50,7 Mb
Release : 1998
Category : Medical
ISBN : 3764358203
Free radicals and oxidative damage in biology and medicine: An introduction.- Oxidative metabolism in skeletal muscle.- Strategies to assess oxidative stress.- The course of exercise-induced skeletal muscle fibre injury.- Free radical mechanisms in exercise-related muscle damage.- The effects of exercise, ageing and caloric restriction on protein oxidation and DNA damage in skeletal muscle.- Antioxidant enzyme response to exercise and training in the skeletal muscle.- Glutathione: A key role in skeletal muscle metabolism.- Vitamin E and its effect on skeletal muscle.- Differential susceptibility of skeletal muscle proteins to free radical-induced oxidative damage in vitro.- Oxidative stress and Ca2+ transport in skeletal and cardiac sarcoplasmic reticulum.- Oxidative stress in skeletal muscle atrophy induced by immobilization.- Effect of growth hormone on oxidative stress in immobilized muscles of old animals.- The diaphragm and oxidative stress.- Oxidative damage after ischemia/reperfusion in skeletal muscle.- Oxidative damage in rat skeletal muscle after excessive L-tryptophan and atherogenic diets.- Oxidative stress and muscle wasting of cachexia.- Free radicals and antioxidants in the pathogenesis of alcoholic myopathy.- Drug-induced muscle damage.- Free radicals and diseases of animal muscle.- Therapeutic trials of antioxidants in muscle diseases.