Medical Research With Children

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Clinical Research Involving Children
Publisher : National Academies Press
Page : 445 pages
File Size : 41,8 Mb
Release : 2004-07-09
Category : Medical
ISBN : 9780309133388

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Ethical Conduct of Clinical Research Involving Children by Institute of Medicine,Board on Health Sciences Policy,Committee on Clinical Research Involving Children Pdf

In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.

Author : Jess Prior,Jo Van Herwegen
Publisher : Routledge
Page : 309 pages
File Size : 41,8 Mb
Release : 2016-06-03
Category : Psychology
ISBN : 9781317384045

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Practical Research with Children by Jess Prior,Jo Van Herwegen Pdf

Practical Research with Children is designed to help the reader understand techniques for research with children, based on real world experience. The book describes a wide range of research methods, focusing equally on quantitative and qualitative approaches, and considers how different methods can be integrated. It highlights the benefits and challenges of each method and gives emphasis to best practice, with expert guidance on how to avoid potential pitfalls in order to obtain valuable insights into how children develop. The volume includes fifteen chapters arranged over three sections. Each chapter explores a particular method, or combination of methods, and discusses both theoretical and practical issues, using a diversity of domains, including different ages, cultures, populations and settings. Uniquely, the book includes newer methods (such as eye tracking and digital technologies) alongside well-established behavioural methods which are used for research with children. With contributions from internationally renowned researchers and practitioners from a range of disciplines, the book will be indispensable reading for a wide audience, including for students in psychology, education and nursing undertaking research projects with children, and also for anyone looking to understand the research behind current theories in child development.

Author : Lainie Friedman Ross
Publisher : OUP Oxford
Page : 300 pages
File Size : 48,5 Mb
Release : 2006-02-09
Category : Philosophy
ISBN : 9780191534218

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Children in Medical Research by Lainie Friedman Ross Pdf

Lainie Ross presents a rigorous critical investigation of the development of policy governing the involvement of children in medical research. She examines the shift in focus from protection of medical research subjects, enshrined in post-World War II legislation, to the current era in which access is assuming greater precedence. Infamous studies such as Willowbrook (where mentally retarded children were infected with hepatitis) are evidence that before the policy shift protection was not always adequate, even for the most vulnerable groups. Additional safeguards for children were first implemented in many countries in the 1970s and 1980s; more recent policies and guidelines are trying to promote greater participation. Ross considers whether the safeguards work, whether they are fair, and how they apply in actual research practice. She goes on to offer specific recommendations to modify current policies and guidelines. Ross examines the regulatory structures (e.g. federal regulations and institutional review boards), the ad hoc policies (e.g. payment in pediatric research and the role of schools as research venues), the actual practices of researchers (e.g. the race/ethnicity of enrolled research subjects or the decision to enroll newborns) as well as the decision-making process (both parental permission and the child's assent), in order to provide a broad critique. Some of her recommendations will break down current barriers to the enrolment of children (e.g. permitting the payment of child research subjects; allowing healthy children to be exposed to research that entails more than minimal risk without requiring recourse to 407 panels); whereas other recommendations may create new restrictions (e.g., the need for greater protection for research performed in schools; restrictions on what research should be done in the newborn nursery). The goal is to ensure that medical research is done in a way that promotes the health of current and future children without threatening, to use the words of Hans Jonas, 'the erosion of those moral values whose loss . . . would make its most dazzling triumphs not worth having'.

Author : Kimberly Hoagwood,Peter S. Jensen,Celia B. Fisher
Publisher : Routledge
Page : 334 pages
File Size : 49,9 Mb
Release : 2014-06-03
Category : Psychology
ISBN : 9781317824602

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Ethical Issues in Mental Health Research With Children and Adolescents by Kimberly Hoagwood,Peter S. Jensen,Celia B. Fisher Pdf

Studies involving children with mental, emotional, or behavioral problems--or their families--have to meet certain standards of research ethics. This book contains chapters on the kinds of ethical dilemmas that typically occur in different types of studies of children, and then presents 65 real-world cases from experts who study children's mental health. These experts offer practical suggestions for how to handle these dilemmas. Chapters on the perspectives of parents, regulators, and bioethicists provide additional points of view on these issues. Written in down-to-earth language, this book will be useful for professionals who study children, for those who train students in research methods, and for parents who are thinking about participating in research studies. In attempting to bridge the apparent gap between ethics and science, the editors close this volume on a note commonly sounded by researchers: more research is needed. Yet in this area, a new kind of research is required. The science of scientific ethics must be developed and expanded, and better understanding of the determinants and circumstances under which children can comprehend and evaluate risks and benefits is needed. Likewise, fuller knowledge of the contextual factors affecting children's and families' consent to participate in research is essential. In particular, development of scales to assess children's ability to comprehend risk-benefit issues, studies of families' reactions to research procedures, and empirical data on the impact of various forms of participant reimbursement will advance both science and ethics. This volume should spur further research, serving as a guide for current investigators, participating families, institutional review boards, and policymakers who shape the research enterprise.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Clinical Research Involving Children
Publisher : National Academies Press
Page : 446 pages
File Size : 44,6 Mb
Release : 2004-08-09
Category : Medical
ISBN : 9780309091817

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Ethical Conduct of Clinical Research Involving Children by Institute of Medicine,Board on Health Sciences Policy,Committee on Clinical Research Involving Children Pdf

In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.

Author : Eric Kodish,Robert M. Nelson
Publisher : Oxford University Press, USA
Page : 345 pages
File Size : 54,6 Mb
Release : 2018-12-14
Category : Medical
ISBN : 9780190647254

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Ethics and Research with Children by Eric Kodish,Robert M. Nelson Pdf

Fundamental questions about the morality of pediatric medical research persist despite years of debate and the establishment of strict codes of ethics. Is it ever permissible to use a child as a means to an end? How much authority should parents have over decisions about research involving their children? Should children or their parents be paid for participation in research? Most importantly, how can the twin goals of access to the benefits of clinical research and protection from research risk be reconciled? Promoting more thoughtful attention to the complex ethical problems that arise when research involves children, this fully updated new edition of Ethics and Research with Children presents 14 case studies featuring some of the most challenging and fascinating ethical dilemmas in pediatric research. Each chapter begins with a unique case vignette, followed by rich discussion and incisive ethical analysis. Chapters represent a host of current controversies and are contributed by leading scholars from a variety of disciplines that must grapple with how to best protect children from research risk while driving innovation in the fight against childhood diseases. Chapters end with questions for discussion, providing faculty and students with accessible starting points from which to explore more in depth the thorny issues that are raised. In the final chapter, the editors provide a synthesis and summary that serve as a capstone and companion to the case-based chapters. Unique in its specific focus on research, Ethics and Research with Children provides a balanced and thorough account of the enduring dilemmas that arise when children become research subjects, and will be essential reading for those involved with pediatric research in any context.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA)
Publisher : National Academies Press
Page : 432 pages
File Size : 52,7 Mb
Release : 2012-10-13
Category : Medical
ISBN : 9780309225496

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Safe and Effective Medicines for Children by Institute of Medicine,Board on Health Sciences Policy,Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) Pdf

The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.

Author : Len Doyal,Jeffrey S. Tobias
Publisher : BMJ Books
Page : 334 pages
File Size : 47,9 Mb
Release : 2000-12-19
Category : Medical
ISBN : 0727914863

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Informed Consent in Medical Research by Len Doyal,Jeffrey S. Tobias Pdf

This is a comprehensive discussion of the ethical issues involved in informing patients on their rights and participation in medical research and treatment. With 30 chapters contributed by internationally recognised medical ethicists, Informed Consent provides an authoritative reference on a subject of major importance in medical ethics

Author : Pia Christensen,Allison James
Publisher : Routledge
Page : 286 pages
File Size : 52,6 Mb
Release : 2012-10-02
Category : Education
ISBN : 9781135699949

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Research With Children by Pia Christensen,Allison James Pdf

Research with Children is a unique resource book on the methodology of childhood research. Leading and new researchers within the social studies of childhood discuss central questions of epistemology and methodology, demonstrating the links between theory and practice. The theoretical and practical questions are set out in a clear and well-argued fashion and will therefore appeal both to the newcomer to childhood studies and to experienced researchers in the field.

Author : David Oppenheim,Douglas F. Goldsmith
Publisher : Guilford Press
Page : 273 pages
File Size : 54,8 Mb
Release : 2007-03-08
Category : Psychology
ISBN : 9781606237496

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Attachment Theory in Clinical Work with Children by David Oppenheim,Douglas F. Goldsmith Pdf

Attachment research has tremendous potential for helping clinicians understand what happens when parent–child bonds are disrupted, and what can be done to help. Yet there remains a large gap between theory and practice in this area. This book reviews what is known about attachment and translates it into practical guidelines for therapeutic work. Leading scientist-practitioners present innovative strategies for assessing and intervening in parent–child relationship problems; helping young children recover from maltreatment or trauma; and promoting healthy development in adoptive and foster families. Detailed case material in every chapter illustrates the applications of research-based concepts and tools in real-world clinical practice.

Author : Sandy Fraser,Open University
Publisher : SAGE
Page : 308 pages
File Size : 42,8 Mb
Release : 2004
Category : Medical
ISBN : 0761943811

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Doing Research with Children and Young People by Sandy Fraser,Open University Pdf

Doing Research with Children and Young People introduces researchers to the key considerations involved in working with children and young people.

Author : United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research
Publisher : Unknown
Page : 184 pages
File Size : 49,9 Mb
Release : 1977
Category : Children
ISBN : UOM:39015004345818

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Research Involving Children by United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research Pdf

Author : Ann Farrell
Publisher : McGraw-Hill Education (UK)
Page : 200 pages
File Size : 50,6 Mb
Release : 2005-11-16
Category : Education
ISBN : 9780335224982

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Ethical research with children by Ann Farrell Pdf

This book focuses on doing ethical research with children in today's climate of increased globalization, surveillance and awareness of children as competent research participants. It covers a range of conceptual, methodological and procedural issues, and provides a framework for doing ethical research with children. Written by international experts in the fields of early childhood research and ethics, this book supports students, practitioner-researchers and research gatekeepers with resources on how to conduct and evaluate ethical research with children. The contributors: Use key examples of cutting-edge research from a range of countries to examine research ethics with children and those around them Provide strategies for planning, conducting and evaluating research in an ethical way Explore theoretical approaches to children and childhood that are relevant to ethical research Ethical Research with Children is key reading for students in childhood studies, teacher education, public health, nursing, human services, legal studies, psychology and social sciences, as well as practitioner-researchers in these fields.

Author : National Research Council,Institute of Medicine,Board on Population Health and Public Health Practice,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on National Statistics,Panel to Review the National Children's Study Research Plan
Publisher : National Academies Press
Page : 166 pages
File Size : 46,8 Mb
Release : 2008-08-16
Category : Social Science
ISBN : 9780309120562

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The National Children's Study Research Plan by National Research Council,Institute of Medicine,Board on Population Health and Public Health Practice,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on National Statistics,Panel to Review the National Children's Study Research Plan Pdf

The National Children's Study (NCS) is planned to be the largest long-term study of environmental and genetic effects on children's health ever conducted in the United States. It proposes to examine the effects of environmental influences on the health and development of approximately 100,000 children across the United States, following them from before birth until age 21. By archiving all of the data collected, the NCS is intended to provide a valuable resource for analyses conducted many years into the future. This book evaluates the research plan for the NCS, by assessing the scientific rigor of the study and the extent to which it is being carried out with methods, measures, and collection of data and specimens to maximize the scientific yield of the study. The book concludes that if the NCS is conducted as proposed, the database derived from the study should be valuable for investigating hypotheses described in the research plan as well as additional hypotheses that will evolve. Nevertheless, there are important weaknesses and shortcomings in the research plan that diminish the study's expected value below what it might be.

Author : Michelle O'Reilly,Nicola Parker
Publisher : SAGE
Page : 296 pages
File Size : 53,7 Mb
Release : 2014-07-07
Category : Social Science
ISBN : 9781473908475

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Doing Mental Health Research with Children and Adolescents by Michelle O'Reilly,Nicola Parker Pdf

Researching child and adolescent mental health can be a daunting task, but with the right practical skills and knowledge your students can transform the way they work with children and young people, giving them a ‘voice’ through their research in the wider community. Michelle O'Reilly and Nikki Parker combine their clinical, academic and research expertise to take your students step-by-step through each stage of the research process. From first inception to data collection and dissemination, they’ll guide them through the key issues faced when undertaking their research, highlighting the dilemmas, challenges and debates, and exploring the important questions asked when doing research with this population. Providing practical advice and strategies for dealing with the reality of conducting research in practice, this book will; - Provide your students with an overview of the theories that underpin methodological choice and the value of using qualitative research. - Guide them through the planning stage of your project, clearly outlining important ethical and legal issues. - Take them though the most popular qualitative data collection techniques and support them with their analysis. - Help them write up their findings and demonstrate how research evidence translates into effective clinical practice. Supported by helpful hints and tips, case examples and definitions of keys terms, this highly practical and accessible guide throws a lifebelt to any students or mental health practitioner learning about the research process for the first time.