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Medicinal Plants For Preventing And Treating Cardiovascular Diseases And The Discovery Of Active Natural Products Advanced Models Novel Paradigms And New Mechanisms Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Medicinal Plants For Preventing And Treating Cardiovascular Diseases And The Discovery Of Active Natural Products Advanced Models Novel Paradigms And New Mechanisms book. This book definitely worth reading, it is an incredibly well-written.
Author : Ling Zhang,Yi Wang,Mirko Baruscotti
Publisher : Frontiers Media SA
Page : 236 pages
File Size : 46,9 Mb
Release : 2023-03-16
Category : Science
ISBN : 9782832502341
Author : Brahmachari Goutam
Publisher : World Scientific
Page : 356 pages
File Size : 45,5 Mb
Release : 2017-10-27
Category : Medical
ISBN : 9789813231177
Cardioprotective Natural Products: Promises and Hopes focuses on the recent advances in the research of bioactive natural products with cardioprotective potential against various cardiovascular diseases/disorders. The aim of this book is to underline the promise and future hope in bioactive natural molecules, herbal formulations, natural dietary supplements and related materials in the prevention and cure of cardiovascular diseases in a scientific way. This book, which comprises a variety of about 9 chapters written by active researchers and leading experts, brings together an overview of current discoveries and trends in this field. This volume is also an outstanding source of information with regard to the industrial application of natural products for medicinal purposes. The broad interdisciplinary approach adopted in this book ensures that it is much more interesting to scientists deeply engaged in the research and/or use of bioactive natural products. It will serve not only as a valuable resource for researchers in their own fields to predict promising leads for developing pharmaceuticals to prevent and treat disease manifestations, but will hopefully also motivate young scientists to engage in the dynamic field of natural products research. Contents: Cardioprotective Natural Products: Promises and Hopes — An Overview (Goutam Brahmachari) Naturally Occurring Matrix Metalloproteinase Inhibitors: A Group of Promising Cardioprotective Agents (Tayebeh Anajafi, Abbas Sedigh and Sanku Mallik ) Promising Natural Cardioprotective Agents in Drug- and Toxin-Induced Pathophysiology (Semantee Bhattacharya and Parames C Sil) Natural Products Against Drug-Induced Cardiotoxicity (Meghana Koneru, Nasiruddin Nalban, Bidya Dhar Sahu and Ramakrishna Sistla ) Cardioprotective Potential of Medicinal Plants in Attenuating Doxorubicin-Induced Cardiotoxicity (Sameer N Goyal, C R Patil, Nimisha Mishra, Rajesh Mohanraj and Shreesh Ojha) The Role of Dietary Supplements in Cardiovascular Diseases (Essam Abdel-Sattar, Soheir M El Zalabani and Manal M Sabry) Beneficial Role of Antioxidant Molecules with Therapeutic Potential in Cardiac Disease (Jyotirmoy Ghosh, Krishnendu Sinha and Parames C Sil) Small Molecule Phytocompounds as Promoters of LDL-Receptor and PCSK9 Inhibition: Potential Role as Non-Statin Based Cardio-Protective Agents (Ajoy Basak, Paul O'Reilly, Bethel Ozed Williams and Sarmistha Basak) 7,8-Dihydroxy-3-methylisochroman-4-one: A Promising Anti-Hypertensive Lead-Molecule from Banana (Musa sapientun L) Peel (Goutam Brahmachari) Readership: Phytochemists; combinatorial chemists; pharmacologists; institutes for drug research (drug discovery and development); industrial research groups developing drugs from medicinal plants; pharmaceutical companies; manufacturers of herbal and ayurvedic medicines and cosmetic products; manufacturers of natural products; advanced and research students. Keywords: Cardioprotective Natural Products;Cardiovascular Diseases and Related Symphtoms;Protection and Therapies;Ayurvedic/Herbal Formulations;Medicinal Compounds of Natural Origins;Therapeutic Targets;Mode of Actions;Pharmacokinetics;Drug Discovery and DevelopmentsReview: Key Features: Contains a variety of 10-12 chapters with written by active researchers and leading experts deeply engaged in the research field with medicinal natural products and herbal formulations Recent cutting-edge advances on medicinal natural products as the preventives and therapies against deadly cardiovascular diseases in a single volume Exhaustive and authoritative presentations of research outcomes on medicinal natural product
Author : Shao Li
Publisher : Springer Nature
Page : 480 pages
File Size : 41,5 Mb
Release : 2021-09-29
Category : Medical
ISBN : 9789811607530
This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
Author : Singh, Ajeet,Singh, Padam,Bithel, Navneet
Publisher : IGI Global
Page : 442 pages
File Size : 51,9 Mb
Release : 2020-02-21
Category : Medical
ISBN : 9781799820956
A vast majority of the world’s population lacks access to essential medicines and the provision of safe healthcare services. Medicinal plants and herbal medicines can be applied for pharmacognosy, or the discovery of new drugs, or as an aid for plant physiology studies. In recent years, there has been increased interest in the search for new chemical entities and the expression of resistance of many drugs available in the market has led to a shift in paradigm towards medicinal research. Herbal treatments, the most popular form of folk medicine, may become an important way of increasing access to healthcare services. Advanced Pharmacological Uses of Medicinal Plants and Natural Products provides emerging research exploring the theoretical and practical aspects of drug discovery from natural sources that allow for the effective treatment of human health problems without any side effects, toxicity, or drug resistance. Featuring coverage on a broad range of topics such as ethnobotany, therapeutic applications, and bioactive compounds, this book is ideally designed for pharmacologists, scientists, ethnobotanists, botanists, health researchers, professors, industry professionals, and health students in fields that include pharmaceutical drug development and discovery.
Author : World Health Organization
Publisher : World Health Organization
Page : 228 pages
File Size : 55,9 Mb
Release : 2019-05-16
Category : Business & Economics
ISBN : 9789241515436
This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).
Author : Ramarao Poduri
Publisher : Springer Nature
Page : 522 pages
File Size : 53,9 Mb
Release : 2021-02-15
Category : Medical
ISBN : 9789811555343
This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
Publisher : Springer
Page : 496 pages
File Size : 47,8 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9783319283838
Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
Author : Goutam Brahmachari
Publisher : Elsevier
Page : 332 pages
File Size : 41,6 Mb
Release : 2016-10-11
Category : Science
ISBN : 9780128096925
Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab
Author : Lixin Zhang,Arnold L. Demain
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 50,6 Mb
Release : 2007-11-17
Category : Medical
ISBN : 9781592599769
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Author : Herminia Dominguez,Maria Jesus Gonzalez Munoz
Publisher : Elsevier
Page : 530 pages
File Size : 52,9 Mb
Release : 2017-09-20
Category : Science
ISBN : 9780128096154
Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources. The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. The book is a detailed guide to the fundamental concepts and necessary equipment needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables. Part 1 begins with a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals, the need for standardization and a move toward more rational and greener techniques in the field, the development of plant-based extraction processes and pretreatments for the efficient extraction. Part 2 then reviews a broad range of available techniques, including sections on conventional hot water extraction and pressurized hot water extraction in a range of settings. Intensified processes are then discussed in detail, including sections on microwave-assisted processes, ultrasound-assisted processes and enzyme assisted extraction. Covers the theoretical background and range of techniques available to researchers, helping them to select the most appropriate extraction method for their needs Presents up-to-date and cutting edge applications by international experts Highlights current use and future potential for industrial scale applications Offers a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals
Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 54,8 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662040423
Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.
Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 50,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461546498
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Author : Bhushan Patwardhan,Rathnam Chaguturu
Publisher : Academic Press
Page : 480 pages
File Size : 52,6 Mb
Release : 2016-10-03
Category : Medical
ISBN : 9780128018224
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Author : Amritpal Singh
Publisher : CRC Press
Page : 440 pages
File Size : 53,7 Mb
Release : 2011-04-11
Category : Health & Fitness
ISBN : 9781439853610
Bridging the gap between the ancient art of herbalism and the emerging sciences of ethnopharmocology and phytopharmacotherapy, this book highlights the major breakthroughs in the history of the field and focuses on future directions in the discovery and application of herb-derived medicines. Implementing the concept of reverse pharmacology, it inte
Author : Raffaele Capasso,Lorenzo Di Cesare Mannelli
Publisher : MDPI
Page : 554 pages
File Size : 40,6 Mb
Release : 2021-04-29
Category : Medical
ISBN : 9783039439874
Plant extracts are widely used for therapeutic purposes. The vegetal origin of these products satisfies people’s desire to cure themselves with natural drugs; this aspect, together with effectiveness and regulatory opportunities, is the base of the broad modern use of medicinal plants. Traditional uses and novel biological effects allow the availability of an extraordinarily high number of different compounds with formidable therapeutic potential. Nevertheless, pitfalls are hidden behind poor pharmacological and toxicological knowledge of plant extracts, nonstandardized methods of extraction, and undefined and nonrepeatable qualitative and quantitative composition. In this context, novel experimental studies on plant products and appreciated and are necessary to reinforce the scientific soundness of phytotherapy. This book aims to respond to this medical need comprehensively highlighting the newest discoveries in vegetal resources with an emphasis on pharmacological activity.