Microrna Cancer Regulation

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MicroRNA Cancer Regulation

Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
MicroRNA Cancer Regulation Book PDF

Author : Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 40,8 Mb
Release : 2013-02-03
Category : Medical
ISBN : 9789400755901

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MicroRNA Cancer Regulation by Ulf Schmitz,Olaf Wolkenhauer,Julio Vera Pdf

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

MicroRNAs in Cancer

César López-Camarillo,Laurence A. Marchat
MicroRNAs in Cancer Book PDF

Author : César López-Camarillo,Laurence A. Marchat
Publisher : CRC Press
Page : 428 pages
File Size : 40,7 Mb
Release : 2013-02-22
Category : Science
ISBN : 9781466576766

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MicroRNAs in Cancer by César López-Camarillo,Laurence A. Marchat Pdf

MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.

MicroRNAs in Development and Cancer

Frank J. Slack
MicroRNAs in Development and Cancer Book PDF

Author : Frank J. Slack
Publisher : World Scientific
Page : 299 pages
File Size : 42,5 Mb
Release : 2011
Category : Science
ISBN : 9781848163669

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MicroRNAs in Development and Cancer by Frank J. Slack Pdf

MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.

MicroRNA in Development and in the Progression of Cancer

Shree Ram Singh,Pranela Rameshwar
MicroRNA in Development and in the Progression of Cancer Book PDF

Author : Shree Ram Singh,Pranela Rameshwar
Publisher : Springer Science & Business
Page : 407 pages
File Size : 45,5 Mb
Release : 2014-04-21
Category : Medical
ISBN : 9781489980656

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MicroRNA in Development and in the Progression of Cancer by Shree Ram Singh,Pranela Rameshwar Pdf

miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

MicroRNAs: Key Regulators of Oncogenesis

Sadegh Babashah
MicroRNAs Key Regulators of Oncogenesis Book PDF

Author : Sadegh Babashah
Publisher : Springer
Page : 433 pages
File Size : 54,7 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783319037257

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MicroRNAs: Key Regulators of Oncogenesis by Sadegh Babashah Pdf

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.

MicroRNAs in Cancer Translational Research

William C.S. Cho
MicroRNAs in Cancer Translational Research Book PDF

Author : William C.S. Cho
Publisher : Springer Science & Business Media
Page : 557 pages
File Size : 51,8 Mb
Release : 2011-01-25
Category : Medical
ISBN : 9789400702981

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MicroRNAs in Cancer Translational Research by William C.S. Cho Pdf

MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field. The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented. This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.

MicroRNAs in Medicine

Charles H. Lawrie
MicroRNAs in Medicine Book PDF

Author : Charles H. Lawrie
Publisher : John Wiley & Sons
Page : 702 pages
File Size : 53,5 Mb
Release : 2013-10-30
Category : Science
ISBN : 9781118300343

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MicroRNAs in Medicine by Charles H. Lawrie Pdf

MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.

MicroRNA Targeted Cancer Therapy

Fazlul H. Sarkar
MicroRNA Targeted Cancer Therapy Book PDF

Author : Fazlul H. Sarkar
Publisher : Springer Science & Business
Page : 351 pages
File Size : 50,5 Mb
Release : 2014-04-22
Category : Medical
ISBN : 9783319051345

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MicroRNA Targeted Cancer Therapy by Fazlul H. Sarkar Pdf

Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

MicroRNA Profiling in Cancer

Yuriy Gusev
MicroRNA Profiling in Cancer Book PDF

Author : Yuriy Gusev
Publisher : CRC Press
Page : 257 pages
File Size : 41,6 Mb
Release : 2019-09-06
Category : Medical
ISBN : 9789814267540

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MicroRNA Profiling in Cancer by Yuriy Gusev Pdf

This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.

miRNA and Cancer

Anonim
miRNA and Cancer Book PDF

Author : Anonim
Publisher : Academic Press
Page : 230 pages
File Size : 44,5 Mb
Release : 2017-09-04
Category : Science
ISBN : 9780128119235

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miRNA and Cancer by Anonim Pdf

miRNA and Cancer, Volume 135, the latest volume in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, and includes specific chapters on Non-coding RNAs as Biomarkers of Cancer, The Enigma of microRNA Regulation in Cancer, Animal Models to Study microRNA functions, Non-coding RNAs and Cancer, microRNAs in Cancer Susceptibility, ts-RNAs versus microRNAs, microRNAs and AML, and microRNAs and Epigenetics. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Regulatory microRNA

Y-h. Taguchi,Hsiuying Wang
Regulatory microRNA Book PDF

Author : Y-h. Taguchi,Hsiuying Wang
Publisher : MDPI
Page : 348 pages
File Size : 41,6 Mb
Release : 2019-04-16
Category : Science
ISBN : 9783038977681

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Regulatory microRNA by Y-h. Taguchi,Hsiuying Wang Pdf

This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.

MicroRNA and Cancer

Wei Wu
MicroRNA and Cancer Book PDF

Author : Wei Wu
Publisher : Humana Press
Page : 273 pages
File Size : 55,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493957740

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MicroRNA and Cancer by Wei Wu Pdf

The tiny microRNAs (miRNAs) can have huge impacts on the regulation of a variety of genes and play crucial roles in the fundamental cellular processes. Recent miRNA studies change the landscape of cancer genetics by scrutinizing the alterations of genome-wide miRNA expressions in most common cancers and their regulatory functions during the development of cancer. The connections between miRNAs and cancer are widespread enough to warrant more comprehensive investigations in the systems biology perspective. In MicroRNA and Cancer: Methods and Protocols, internationally renowned experts provide the latest miRNA knowledge, the various techniques and methodologies currently available for cancer research application. Ranging from the fundamental concepts to practical applications, this book presents: • Overview of microRNA biogenesis, computational prediction of new miRNAs in the cancer genome, and miRNA-based therapeutic approaches for cancer treatment • Detailed experimental protocols in miRNA detection with novel and high-throughput technology, miRNA library cloning, miRNA epigenetic regulation, and miRNA pathway study • Stepwise computational and bioinformatic procedures for miRNA complex networks in cancer genomes with a variety of softwares and programs • Cross-cited notes on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, MicroRNA and Cancer: Methods and Protocols serves researchers with the basic principles of experimental and computational methods for microRNA study in cancer research and provides a firm grounding for those who wish to further develop their own applications and tailor them to their own specific research needs.

Regulation of microRNAs

Helge Großhans
Regulation of microRNAs Book PDF

Author : Helge Großhans
Publisher : Springer Science & Business Media
Page : 160 pages
File Size : 53,8 Mb
Release : 2010-12-10
Category : Science
ISBN : 9781441978233

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Regulation of microRNAs by Helge Großhans Pdf

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.

Role of MicroRNAs in Cancers

DKV Prasad,Pinninti Santosh Sushma
Role of MicroRNAs in Cancers Book PDF

Author : DKV Prasad,Pinninti Santosh Sushma
Publisher : Springer Nature
Page : 183 pages
File Size : 47,9 Mb
Release : 2022-06-07
Category : Medical
ISBN : 9789811691867

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Role of MicroRNAs in Cancers by DKV Prasad,Pinninti Santosh Sushma Pdf

This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.

RNA and Cancer

Jane Y. Wu
RNA and Cancer Book PDF

Author : Jane Y. Wu
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 51,5 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9783642316593

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RNA and Cancer by Jane Y. Wu Pdf

Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.