Microsomes Drug Oxidations And Chemical Carcinogenesis

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Microsomes, Drug Oxidations and Chemical Carcinogenesis

Author : Minor Coon
Publisher : Elsevier
Page : 655 pages
File Size : 55,8 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323143875

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Microsomes, Drug Oxidations and Chemical Carcinogenesis by Minor Coon Pdf

Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Microsomes, Drug Oxidations, and Chemical Carcinogenesis

Author : Minor Jesser Coon
Publisher : Unknown
Page : 664 pages
File Size : 50,6 Mb
Release : 1980
Category : Medical
ISBN : UOM:39015000318702

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Microsomes, Drug Oxidations, and Chemical Carcinogenesis by Minor Jesser Coon Pdf

Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 ...

Microsomes and Drug Oxidations

Author : Volker Ullrich,Alfred Hildebrandt,Ivar Roots
Publisher : Elsevier
Page : 802 pages
File Size : 42,7 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483159089

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Microsomes and Drug Oxidations by Volker Ullrich,Alfred Hildebrandt,Ivar Roots Pdf

Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-function oxidation reactions. Pharmacologists, toxicologists, biochemists, and researchers in the pharmaceutical industry will find the book highly insightful.

Microsomes, Drug Oxidations and Drug Toxicology

Author : Ryo Sato,Ryuichi Kato
Publisher : John Wiley & Sons
Page : 668 pages
File Size : 48,8 Mb
Release : 1982
Category : Medical
ISBN : UOM:39015016021654

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Microsomes, Drug Oxidations and Drug Toxicology by Ryo Sato,Ryuichi Kato Pdf

Proceedings of the Fifth International Symposium on Microsomes and Drug Oxidations held in Tokyo, July 1981. Researchers from a wide range of disciplines discuss recent developments in the field. Emphasizes the characterization and mechanisms of action of cytochrome P-450 and related enzymes; microsomal metabolism of endogenous substrates; regulation of microsomal metabolism; and metabolic activation and drug toxicity.

Microsomes and Drug Oxidations

Author : A. R. Boobis
Publisher : Taylor & Francis Group
Page : 448 pages
File Size : 48,8 Mb
Release : 1985
Category : Cytochrome P-450
ISBN : UOM:39015012531250

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Microsomes and Drug Oxidations by A. R. Boobis Pdf

Microsomes, Drug Oxidations and Chemical Carcinogenesis

Author : Minor Coon
Publisher : Elsevier
Page : 644 pages
File Size : 50,9 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323144094

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Microsomes, Drug Oxidations and Chemical Carcinogenesis by Minor Coon Pdf

Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Molecular Aspects of Oxidative Drug Metabolizing Enzymes

Author : Emel Arinc,John B. Schenkman,Ernest Hodgson
Publisher : Springer Science & Business Media
Page : 615 pages
File Size : 46,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642795282

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Molecular Aspects of Oxidative Drug Metabolizing Enzymes by Emel Arinc,John B. Schenkman,Ernest Hodgson Pdf

Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.

Microsomes and Drug Oxidations

Author : James R. Gillette
Publisher : Unknown
Page : 572 pages
File Size : 48,8 Mb
Release : 1969
Category : Cytology
ISBN : UCAL:B4344180

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Microsomes and Drug Oxidations by James R. Gillette Pdf

P-450 and Chemical Carcinogenesis

Author : Yusaku Tagashira,Tsuneo Ōmura
Publisher : Springer
Page : 200 pages
File Size : 47,5 Mb
Release : 1985-06
Category : Medical
ISBN : CHI:28088137

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P-450 and Chemical Carcinogenesis by Yusaku Tagashira,Tsuneo Ōmura Pdf

This book is one of a GANN Monograph on Cancer Research series and is based on a Japanese Cancer Association-sponsored symposium entitled "Multiplicity of Chemical Carcinogen-Activating Enzymes· with Particular Emphasis on Cytochrome P-450" which was held in Tokyo on November 21, 1983. The principal role of microsomal cytochrome P-450 in the metabolic activation of various chemical carcinogens in animal cells has been well established. The activated chemical carcinogens induce mutations of the cells, which is an essential part of the initiation of chemical carcinogenesis. Since microsomal cytochrome P-450 in various animal tissues includes multiple molecular species with different substrate specificities and different responses to chemical inducers, knowledge of the molecular and catalytic properties and the inducibilities of those cytochrome P-450 forms is surely a most important base from which to elucidate the mechanism of chemical carcinogenesis. The focus of the symposium was this area of molecular diversity and inducibility of microsomal cytochrome P-450 in animal tissues. The mechanism of activation of various types of chemical carcinogens by cytochrome P-450 and related enzymes was another main topic. The editors, who were also the symposium organizers, hope these summaries of current research in this field in Japan will stimulate future development of studies on the mechanism of chemical carcinogenesis.

Departments of Labor, Health and Human Services, Education, and related agencies appropriations for fiscal year 1984

Author : United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : Unknown
Page : 1626 pages
File Size : 50,5 Mb
Release : 1983
Category : Electronic
ISBN : UCAL:B4292868

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Departments of Labor, Health and Human Services, Education, and related agencies appropriations for fiscal year 1984 by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies Pdf

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1984

Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : Unknown
Page : 836 pages
File Size : 55,8 Mb
Release : 1983
Category : United States
ISBN : SRLF:AA0000539676

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Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1984 by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies Pdf

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for Fiscal Year 1984

Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : Unknown
Page : 852 pages
File Size : 42,9 Mb
Release : 1983
Category : United States
ISBN : UOM:39015004254085

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Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for Fiscal Year 1984 by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies Pdf

Biological Oxidations

Author : H. Sund,V. Ullrich
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642694677

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Biological Oxidations by H. Sund,V. Ullrich Pdf

N-Oxidation of Drugs

Author : P. Hlavica,L.A. Damani
Publisher : Springer Science & Business Media
Page : 487 pages
File Size : 51,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401131124

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N-Oxidation of Drugs by P. Hlavica,L.A. Damani Pdf

Biological Reactive Intermediates—II

Author : Robert Snyder
Publisher : Springer
Page : 844 pages
File Size : 54,6 Mb
Release : 2014-11-14
Category : Science
ISBN : 9781475706741

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Biological Reactive Intermediates—II by Robert Snyder Pdf