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Author : Seshiah
Publisher : Elsevier Health Sciences
Page : 147 pages
File Size : 50,7 Mb
Release : 2009
Category : Electronic
ISBN : 9788131221723
Author : V Seshiah
Publisher : Elsevier Health Sciences
Page : 187 pages
File Size : 55,9 Mb
Release : 2009-09-15
Category : Medical
ISBN : 9788131232125
The pathogenesis of microvascular complications is complex and multifactorial. Yet, hyperglycemia emerges as the most important single cause, which has been proved by the Diabetes Control and Complications Trial (DCCT). Thus, the importance of protecting the body from hyperglycemia cannot be overstated; the direct and indirect effects on the human vascular tree are the major source of morbidity and mortality in both type 1 and type 2 diabetes. Generally, the injurious effects of hyperglycemia are separated into macrovascular complications (coronary artery disease, peripheral arterial disease, and stroke) and microvascular complications (diabetic nephropathy, neuropathy, and retinopathy). It is important for physicians to understand the relationship between diabetes and vascular disease because the prevalence of diabetes continues to increase in our country, and the clinical requirements for primary and secondary prevention of these complications are also expanding.
Author : Francesco Tecilazich
Publisher : John Wiley & Sons
Page : 280 pages
File Size : 43,8 Mb
Release : 2020-02-14
Category : Science
ISBN : 9781119309611
Presents comprehensive coverage of the many microvascular complications of diabetes Diabetes remains one of the main causes, in the western world, of legal blindness, end stage renal disease, and amputation, despite the implementation of tight glycemic control and the great progress in the management and care of our patients. This book provides a useful and handy tool to professionals and students in the field of diabetes and its microvascular complications by integrating information from clinical settings as well as from the frontlines of diabetic research. It provides readers with up-to-date diagnostic criteria, classifications, and therapeutic approaches. and recent discoveries on mechanisms of disease, experimental therapeutic agents, and biomarkers of disease. Written by top experts in the field, Microvascular Disease in Diabetes offers in-depth chapters covering pathophysiology; the genetics of diabetic microvascular disease; and the epigenetics of diabetic microvascular disease. It then provides sections featuring both clinical and research information on diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic foot. It also looks at coronary microvascular dysfunction and cerebral microvascular disease. Integrates new and accessible material on diabetic microvascular comorbidities Covers all relevant microvascular systems Provides a much-needed resource synthesizing research and clinical applications to treating microvascular complications of diabetes Presents current diagnostic criteria, classifications, and therapeutic approaches, as well as recent discoveries on the mechanisms of disease, experimental therapeutic agents, and biomarkers of disease Assembled in an easily consultable manner, Microvascular Disease in Diabetes is an excellent text for investigators, clinicians, and students looking to improve their understanding of diabetic complications.
Author : Richard Donnelly,Nick J. M. London
Publisher : John Wiley & Sons
Page : 117 pages
File Size : 45,9 Mb
Release : 2009-04-08
Category : Medical
ISBN : 9781444312409
Structural and functional abnormalities of arteries and veinsmanifest clinically in a broad spectrum of disorders, includinganeurysmal disease, atherosclerosis, vasculitis, venousinsufficiency, microvascular complications, thrombo-embolism andlower limb ulceration. Many of these are common and/orchronic conditions which present for initial assessment by primaryhealth care workers. This new edition is a practical guide to the most commonlypresenting disorders, and provides a structured approach toclinical assessment, investigations and management. The lastfew years have seen major changes in the use of non-invasive orminimally-invasive techniques, e.g wider use of CT and MRangiography, and increasing use of percutaneous interventions forcarotid, lower limb and reno-vascular disease. The ABC of Arterial and Venous Disease (Second Edition)explains the underlying technology and the applications of newminimally-invasive methods, especially CT and MRI, and provides anup-dated, evidence-based guide to the modern day management ofpatients with common, life-threatening diseases involving differentparts of the circulation. This authoritative, full-colour, illustrated ABC is anideal reference for the primary care, non-specialist practitionerto base effective management and prevention programmes.
Author : G. Crepaldi
Publisher : Springer
Page : 348 pages
File Size : 54,5 Mb
Release : 1987
Category : Medical
ISBN : MSU:31293107735676
Three aspects of diabetes were discussed during the XII Congress of the International Diabetes Federation: diabetic retinopathy, diabetic nephropathy and diabetic neuropathy. This volume presents contributions covering the wide range of physiological changes in patients suffering from diabetes, and current knowledge is reported by specialists in the field.
Author : Neil Ruderman,Joseph Williamson,Michael Brownlee
Publisher : Springer
Page : 307 pages
File Size : 43,8 Mb
Release : 2013-05-27
Category : Medical
ISBN : 9781461475248
It is estimated that 1-5% ofthe world's population is affected by some form of diabetes. Patients with these disorders are highly likely to develop microvas cular pathology in the retina and glomerulus and they are at a 2--6-fold greater risk for atherosclerotic vascular disease than individuals without diabetes. In addition, hypertension is far more prevalent in patients with diabetes than in the general population. As a consequence of these complications, diabetes is a leading cause of blindness and renal failure in young and middle-aged adults and it is a major risk factor for coronary heart disease, stroke and peripheral vascular disease in the Western world. An understanding of the relationship of these vascular complications to diabetic hyperglycemia has become a critical issue for clinicians in recent years, since the prevalence of diabetes appears to be increasing dramatically world-wide. In addition, it is now possible to achieve improved glycemic control in many patients-although not without incurring other risks. This volume explores two principal hypotheses concerning these complications. One is that hyperglycemia underlies or at least contributes to the pathogenesis of both micro- and macrovascular disease in patients with diabetes. The other is that it does so by producing specific metabolic and biochemical alterations in the vascular wall that lead to abnormalities in its function and ultimately its structure.
Author : Yuanzeng Min,Minglin Ma,Jialin Gao,Hongyu Kuang
Publisher : Frontiers Media SA
Page : 216 pages
File Size : 50,8 Mb
Release : 2023-11-22
Category : Medical
ISBN : 9782832536018
At present, the prevalence of adult diabetes is 8-10%, and the number of diabetic patients in the world is conservatively estimated to be 350 million. Diabetic nephropathy and diabetic retinopathy are the two major microvascular complications of diabetic patients, and their lethality and harm, on the whole, exceed the other two complications, diabetic foot disease and other complications. Among them, the prevalence of diabetic nephropathy is as high as 20-50% in the diabetic population, especially in patients with diabetes for more than 10 years, the prevalence rate can be as high as 70%, and half of them will develop chronic renal damage and renal failure. Diabetic nephropathy is the first cause of renal maintenance dialysis in end-stage renal disease in Europe and the United States. Diabetic retinopathy is also the leading cause of insomnia in diabetic patients. Immune factors have been clearly confirmed to play an important pathogenic role in type 1 diabetes, but the role of immune factors in the pathogenesis of type 2 diabetes remains to be further explored. In addition, we are not clear about the role of immune-involved inflammatory response plays in diabetic microvascular disease, and do not know whether it can be a potential intervention target. Answering these questions will provide important targets to overcome diabetes and effectively prevent the progress of diabetic microvascular complications. The goal of the Research Topic is to explore the immune (inflammation) regulation and mediating mechanisms during the pathogenesis of diabetes and diabetic microvascular complications (diabetic nephropathy, diabetic retinopathy), and to find potential disease intervention targets in related treatments. We welcome manuscripts that include, but are not limited to, the following aspects: ● Immune-Mediated Mechanisms of the Development of Diabetes ● The role of immune-mediated pancreatic β-cell function decline in the development of type 2 diabetes mellitus ● Potential immunotherapy prospects for diabetes ● Involvement and mechanism of immune inflammation in the pathogenesis of diabetic nephropathy ● Immune pathogenic mechanisms in the development of diabetic retinopathy
Author : Kenneth M. Shaw,Michael H. Cummings
Publisher : John Wiley & Sons
Page : 270 pages
File Size : 49,6 Mb
Release : 2005-12-13
Category : Medical
ISBN : 9780470865804
Diabetes is one of the leading causes of morbidity and mortality worldwide. Major complications include nephropathy, neuropathy, retinopathy and heart disease, which affect thousands of diabetics every year. The prevention and treatment of such complications encompass pharmacological, surgical and educational approaches, all of which need to be coordinated for optimal management of people with diabetes. This user-friendly new edition of Diabetes - Chronic Complications (previously called Diabetic Complications) has been completely revised and updated to reflect the rapid developments currently taking place in the field. Each chapter describes the epidemiology, aetiology and management of a particular complication and discusses the organisation and delivery of care. Includes all the major chronic complications of diabetes Presents a practical approach to the treatment of diabetes complications Written by world’s leading experts in the field Features algorithms for screening and treatment of diabetes complications
Author : Michael Johnstone,Aristidis Veves
Publisher : Springer Nature
Page : 1071 pages
File Size : 46,7 Mb
Release : 2023-06-01
Category : Medical
ISBN : 9783031131776
This third edition of the book offers an up-to-date review of Diabetes Mellitus with a focus on both Micro- and Macrovascular Disease. The text includes a review of the basic concepts of : Diabetes and Vascular Disease, including Endothelial Dysfunction; The Effect of Insulin on the Vascular System; The Mechanism of Atherosclerosis in Diabetes Mellitus and the Role of Inflammation on the Vascular Tree; and The Role of the Renin-Angiotensin-Aldosteronism on Diabetes Mellitus. Chapters will discuss the Genetics of Type 2 Diabetes Mellitus as well as the Metabolic Syndrome. Other chapters discuss the Risk Factors of Diabetes and Vascular Disease, including Hypertension; Dyslipidemia; and Thrombosis. The book also reviews Microcirculation; Diabetic Nephropathy; Diabetic Retinopathy; as well as the Epidemiology, Diagnosis, and Treatment of Peripheral Vascular Disease; Diabetes and Coronary Artery Disease; Diabetes and Percutaneous Interventions; Diabetes and Cardiac Surgery; and Diabetes and Heart Failure. Chapters conclude with a review of the present-day Treatment of the Diabetic Patient. Diabetes and Cardiovascular Disease, 3rd Edition, offers practicing physicians a cutting-edge scientific and clinical review of diabetic cardiovascular disease, providing both a deeper understanding of its pathology and all the day-to-day practical knowledge needed to treat patients effectively.
Author : Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent
Publisher : World Bank Publications
Page : 466 pages
File Size : 43,6 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9781464805202
Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.
Author : Debasis Bagchi,Sreejayan Nair
Publisher : Academic Press
Page : 553 pages
File Size : 41,6 Mb
Release : 2012-01-31
Category : Health & Fitness
ISBN : 9780123850836
Diabetes mellitus affects approximately 20 million people in the US, or nearly 7% of the population. It is expected to increase by 70% within the next 25 years, and numerous epidemiologic studies have demonstrated that type 2 diabetes increases the risk of cardiovascular morbidity and mortality. It is estimated to cost over $92 billion in health care costs and lost productivity. The increased risk is due to the detrimental vascular effects of prolonged exposure to a hyperglycemic, oxidant-rich environment yielding associated cardiovascular risk factors: atherosclerosis, hypertension and clotting abnormalities. Hypertension and dyslipidemia in diabetic patients produces substantial decreases in cardiovascular and microvascular diseases. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome provides an overview of the current epidemic, outlines the consequences of this crisis and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. The contributing experts from around the world give this book relevant and up-to-date global approaches to the critical consequences of metabolic syndrome and make it an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes. Scientific discussion of the epidemiology and pathophysiology of the relationship between diabetes and metabolic syndrome Includes coverage of Pre-diabetes conditions plus both Type I and Type II Diabetes Presents both prevention and treatment options
Author : Richard I. G. Holt,Clive Cockram,Allan Flyvbjerg,Barry J. Goldstein
Publisher : John Wiley & Sons
Page : 1104 pages
File Size : 47,9 Mb
Release : 2017-03-06
Category : Medical
ISBN : 9781118912027
Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.
Author : Anca Pantea Stoian
Publisher : BoD – Books on Demand
Page : 442 pages
File Size : 41,7 Mb
Release : 2021-09-22
Category : Medical
ISBN : 9781838819033
Diabetes mellitus is a metabolic disease characterized by chronic high blood glucose levels. Of the various types of diabetes, type 2 diabetes is increasing in prevalence due to obesity, aging, sedentarism, and other factors. This book presents a novel approach to preventing and treating type 2 diabetes. Chapters cover such topics as diagnosis, pathogenesis, management, lifestyle and nutritional intervention, and systems to support early diagnosis and prevention of prediabetes.
Author : Gautam V. Shrikhande,James F. McKinsey
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 46,6 Mb
Release : 2012-10-19
Category : Medical
ISBN : 9781627031578
In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.
Author : Samy I. McFarlane,George L. Bakris
Publisher : Springer Science & Business Media
Page : 196 pages
File Size : 46,5 Mb
Release : 2012-10-19
Category : Medical
ISBN : 9781603273572
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.