Mif Family Cytokines In Innate Immunity And Homeostasis

Author : Richard Bucala,Jürgen Bernhagen
Publisher : Springer
Page : 246 pages
File Size : 40,8 Mb
Release : 2017-06-12
Category : Science
ISBN : 9783319523545

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MIF Family Cytokines in Innate Immunity and Homeostasis by Richard Bucala,Jürgen Bernhagen Pdf

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

Author : Faith H. A. Osier,Jude Ezeh Uzonna
Publisher : Frontiers Media SA
Page : 187 pages
File Size : 53,9 Mb
Release : 2020-07-24
Category : Electronic
ISBN : 9782889638741

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Regulation of Immunity to Parasitic Infections Endemic to Africa by Faith H. A. Osier,Jude Ezeh Uzonna Pdf

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Author : Diana Boraschi,Giselle Penton-Rol,Marita Troye Blomberg,Olukemi Amodu
Publisher : Frontiers Media SA
Page : 848 pages
File Size : 52,6 Mb
Release : 2024-02-13
Category : Medical
ISBN : 9782832544341

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Women in Cytokines and Soluble Mediators in Immunity by Diana Boraschi,Giselle Penton-Rol,Marita Troye Blomberg,Olukemi Amodu Pdf

We are delighted to present the inaugural Frontiers in Immunology “Women in Cytokines and Soluble Mediators in Immunity” series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and Science, Technology, Engineering and Mathematics (STEM) research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.

Author : Dunfang Zhang,Junji Xu,Hiroko Nakatsukasa,Zhi Wang
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 55,7 Mb
Release : 2023-07-03
Category : Medical
ISBN : 9782832527887

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Oral Mucosal Immunity: Homeostasis and Inflammation by Dunfang Zhang,Junji Xu,Hiroko Nakatsukasa,Zhi Wang Pdf

Author : Nicola Fabris
Publisher : Springer Science & Business Media
Page : 473 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468445473

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Immunoregulation by Nicola Fabris Pdf

Immunoregulation is one of the areas which has witnessed the most explosive advances of immunology during the past decade. It is in this area that the current view of the immune system has arisen and developed. There is indeed little doubt that immune reactions are primarily determined by messages which are genera ted within the immune system and passed among different types of immunologie cells. This cell communication not only determines the type, intensity and duration of the response after perturbation of the immune system by exogenous antigens, but it is also essential for preventing autoimmune reactions and their clinical conse quences. In order to assure aperfect balance within the enormous com plexity of the immune system, it is not surprising that multiple self-regulatory mechanisms are organized at different levels, such as antibody feedback, idiotypic-anti-idiotypic responses, suppres sor and helper T cells, lymphokine signals and genetic require ments. A nu mb er of observations in recent years have, however, demonstrated that consistent contributions to the immunological homeostasis are given also by signals generated outside of the immune system, namely,in the central and autonomous nervous system as weIl as in the endocrine apparatus. Furthermore, the interactions between the immune system and the other body homestatic mechanisms seem to be bidirectional: if immunological cells may be targets of neuroendocrinological factors, immunological products seem in turn to contribute to the neuro endocrine homeostasis.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 41,5 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Author : Jean L. Bolognia,Julie V. Schaffer,Lorenzo Cerroni
Publisher : Elsevier Health Sciences
Page : 3312 pages
File Size : 52,7 Mb
Release : 2024-01-20
Category : Medical
ISBN : 9780702084690

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Dermatology - E-Book by Jean L. Bolognia,Julie V. Schaffer,Lorenzo Cerroni Pdf

For dermatology residents and trainees, as well as those in clinical practice, Dermatology is the leading reference for understanding, diagnosing, and treating the full spectrum of skin disease—and is the key resource that residents rely on throughout their training and certification. Widely recognized for its easy-in, easy-out approach, this revised 5th Edition turns complex information into user-friendly visual content through the use of clear, templated chapters, digestible artwork, and easy-to-follow algorithms and tables. This two-volume masterwork provides complete, authoritative coverage of basic science, clinical practice of both adult and pediatric dermatology, dermatopathology, and dermatologic surgery—more than any other source, making it the gold standard reference in the field today. Simplifies complex content in a highly accessible, highly visual manner, with 1,100+ tables; 2,600+ figures, including numerous disease classification algorithms as well as diagnostic and therapeutic pathways; and over 1,500 additional figures and tables online. Utilizes weighted differential diagnosis tables and a “ladder” approach to therapeutic interventions. Any additional digital ancillary content may publish up to 6 weeks following the publication date. Features an intuitive organization and color-coded sections that allow for easy and rapid access to the information you need. Retains an emphasis on clinicopathologic correlations, with photomicrographs demonstrating key histologic findings adjacent to clinical images of the same disorder. Contains updated treatment information throughout, including immune checkpoint inhibitors, JAK inhibitors, and monoclonal antibodies for a wide range of conditions such as psoriasis, atopic dermatitis, alopecia areata, vitiligo, and skin cancers. Provides up-to-date information on genetic and molecular markers and next-generation sequencing as it applies to dermatologists. Features new videos, including cryosurgical and suturing techniques, treatment of rhinophyma via electrosection, and neuromodulator treatment of axillary hyperhidrosis. Includes new WHO classifications of skin tumors, new FDA pregnancy drug labeling, and new ACR/EULAR criteria for vasculitis and lupus erythematosus. Includes new sections on confocal microscopy and artificial intelligence.

Author : Jean L. Bolognia,Julie V. Schaffer,Lorenzo Cerroni
Publisher : Elsevier Health Sciences
Page : 2752 pages
File Size : 42,5 Mb
Release : 2017-10-22
Category : Medical
ISBN : 9780702063428

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Dermatology E-Book by Jean L. Bolognia,Julie V. Schaffer,Lorenzo Cerroni Pdf

With more complete, authoritative coverage of basic science, clinical practice of both adult and pediatric dermatology, dermatopathology, and dermatologic surgery than you'll find in any other source, Dermatology, 4th Edition, is the gold-standard reference in the field today. Drs. Jean L. Bolognia, Julie V. Schaffer, and Lorenzo Cerroni bring their considerable knowledge and experience to this two-volume masterwork, ensuring its reliability and usefulness for both residents and practitioners. Provides the in-depth, expert information you need to address challenges you face in practice across all subspecialties – including medical dermatology, pediatric dermatology, dermatopathology, dermatologic surgery, and cosmetic dermatology. Uses the famous "easy-in, easy-out" approach, transforming complex information into more than 1,000 reader-friendly tables and algorithms, along with templated chapter contents for quick recognition and access. Focuses on the essential "need-to-know" basic science information and key references. Brings together an esteemed team of expert editors and contributors that provide a truly global perspective, led by Drs. Jean L. Bolognia, Julie V. Schaffer, and Lorenzo Cerroni. Includes over 4,000 illustrations, with over 2,000 new images in this edition, that provide more examples of skin disorders across different skin types in varying stages of presentation; plus enhanced histologic images that provide a clearer understanding of clinicopathologic correlations for multiple skin disorders. Features 70 brand-new schematics and algorithms to better aid diagnosis, optimize decision making, and improve your approach to each patient. Includes the latest therapy options with supporting evidence-based grading levels.

Author : Pedro H. Gazzinelli-Guimaraes,Anton Götz,Christine Hopp
Publisher : Frontiers Media SA
Page : 195 pages
File Size : 43,5 Mb
Release : 2022-12-05
Category : Medical
ISBN : 9782832508770

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Rising Stars in Parasite Immunology 2021 by Pedro H. Gazzinelli-Guimaraes,Anton Götz,Christine Hopp Pdf

Author : Robert G. Lahita
Publisher : Academic Press
Page : 732 pages
File Size : 54,8 Mb
Release : 2021-07-23
Category : Medical
ISBN : 9780323914888

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Lahita's Systemic Lupus Erythematosus by Robert G. Lahita Pdf

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Author : Ian McConachie
Publisher : Cambridge University Press
Page : 453 pages
File Size : 42,8 Mb
Release : 2006-01-12
Category : Medical
ISBN : 9780521678575

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Handbook of ICU Therapy by Ian McConachie Pdf

Handbook of ICU Therapy provides rapid access to important information on the treatment of the critically ill patient. It comprises a series of 'cutting edge' reviews of the most advanced treatment concepts available in the modern ICU. Whilst assuming a basic knowledge of underlying conditions, it nonetheless outlines key physiological principles where necessary, and critically reviews current literature and best practice. The heart of the book is aimed at providing key practical information on treatment techniques to the busy clinician in an easily accessible style. In addition to conventional drug therapy, ventilator, fluid and physical therapies are also discussed in detail. All of the authors are directly involved in ICU research and practice and are familiar with all of the latest developments in this fast-moving field of medicine.

Author : Edwin L. Cooper
Publisher : Springer
Page : 1048 pages
File Size : 55,7 Mb
Release : 2018-08-07
Category : Medical
ISBN : 9783319767680

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Advances in Comparative Immunology by Edwin L. Cooper Pdf

Immunologists, perhaps understandably, most often concentrate on the human immune system, an anthropocentric focus that has resulted in a dearth of information about the immune function of all other species within the animal kingdom. However, knowledge of animal immune function could help not only to better understand human immunology, but perhaps more importantly, it could help to treat and avoid the blights that affect animals, which consequently affect humans. Take for example the mass death of honeybees in recent years – their demise, resulting in much less pollination, poses a serious threat to numerous crops, and thus the food supply. There is a similar disappearance of frogs internationally, signaling ecological problems, among them fungal infections. This book aims to fill this void by describing and discussing what is known about non-human immunology. It covers various major animal phyla, its chapters organized in a progression from the simplest unicellular organisms to the most complex vertebrates, mammals. Chapters are written by experts, covering the latest findings and new research being conducted about each phylum. Edwin L. Cooper is a Distinguished Professor in the Laboratory of Comparative Immunology, Department of Neurobiology at UCLA’s David Geffen School of Medicine.

Author : Drew Provan,Hillard M. Lazarus
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 51,6 Mb
Release : 2024-03-05
Category : Medical
ISBN : 9781394180479

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Molecular Hematology by Drew Provan,Hillard M. Lazarus Pdf

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Author : Richard Bucala
Publisher : World Scientific
Page : 399 pages
File Size : 49,7 Mb
Release : 2012
Category : Medical
ISBN : 9789814335355

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The MIF Handbook by Richard Bucala Pdf

The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.

Author : Ari Sitaramayya
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 46,7 Mb
Release : 2009-12-02
Category : Science
ISBN : 9783642021121

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Signal Transduction: Pathways, Mechanisms and Diseases by Ari Sitaramayya Pdf

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.