Mitochondria As Targets For Phytochemicals In Cancer Prevention And Therapy

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Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy

Dhyan Chandra
Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy Book PDF

Author : Dhyan Chandra
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 55,9 Mb
Release : 2013-12-11
Category : Science
ISBN : 9781461493266

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Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy by Dhyan Chandra Pdf

This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.

Dietary Phytochemicals in Cancer Prevention and Treatment

American Institute for Cancer Research
Dietary Phytochemicals in Cancer Prevention and Treatment Book PDF

Author : American Institute for Cancer Research
Publisher : Springer Science & Business Media
Page : 349 pages
File Size : 43,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461303992

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Dietary Phytochemicals in Cancer Prevention and Treatment by American Institute for Cancer Research Pdf

The sixth annual research conference of the American Institute for Cancer Research was held August 31 and September 1, 1995, at the Loews L'Enfant Plaza Hotel in Washing ton, DC. In view of the promising leads in the diet/nutrition and cancer research field, the conference was devoted to "Dietary Phytochemicals in Cancer Prevention and Treatment. " The number of sessions was increased over that in previous conferences in order to accommodate the topics of interest. The conference overview, entitled "Plants and Cancer: Food, Fiber, and Phytochemicals," provided a framework for the following sessions. In addition, the attendees were reminded that for several decades epidemiologists have noted a lower risk of lung, esophageal, stomach, and colon cancer in populations consuming diets high in fruits and vegetables. However, isolation and ingestion of individual protective factors are not the preferred action since the complexity of the food and the matrix in which nutritional factors are embedded are important. The individual sessions then provided more insight as to why eating fruits and vegetables is associated with a lower risk of cancer. The first of these sessions was on "Isothiocyanates" that induce both the Phase I and Phase II enzymes that increase detoxification and conjugation reactions, thus causing more rapid removal of any xenobiotic or carcinogen. Thus, less carcinogen is available for interaction with DNA or other critical cellular macromolecules.

Phytochemicals

Venketeshwer Rao,Leticia Rao
Phytochemicals Book PDF

Author : Venketeshwer Rao,Leticia Rao
Publisher : BoD – Books on Demand
Page : 351 pages
File Size : 50,9 Mb
Release : 2015-09-30
Category : Science
ISBN : 9789535121701

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Phytochemicals by Venketeshwer Rao,Leticia Rao Pdf

Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.

Mitochondrial Dysfunction and Nanotherapeutics

Marcos Roberto de Oliveira
Mitochondrial Dysfunction and Nanotherapeutics Book PDF

Author : Marcos Roberto de Oliveira
Publisher : Academic Press
Page : 602 pages
File Size : 49,7 Mb
Release : 2021-07-15
Category : Science
ISBN : 9780323886185

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Mitochondrial Dysfunction and Nanotherapeutics by Marcos Roberto de Oliveira Pdf

Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. Contains detailed information on mitochondrial dysfunction Reviews our current understanding of the role of mitochondria in aging Includes coverage of specific conditions, including sports and affective disorders, among others Discusses mitochondria targeted delivery of therapeutic compounds

Phytochemicals from Medicinal Plants

Hafiz Ansar Rasul Suleria,Megh R. Goyal,Masood Sadiq Butt
Phytochemicals from Medicinal Plants Book PDF

Author : Hafiz Ansar Rasul Suleria,Megh R. Goyal,Masood Sadiq Butt
Publisher : CRC Press
Page : 30 pages
File Size : 53,6 Mb
Release : 2019-11-15
Category : Medical
ISBN : 9780429511806

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Phytochemicals from Medicinal Plants by Hafiz Ansar Rasul Suleria,Megh R. Goyal,Masood Sadiq Butt Pdf

Phytochemicals from Medicinal Plants: Scope, Applications and Potential Health Claims explores the importance of medicinal plants and their potential benefits for human health. This book looks at bioactive compounds from medicinal plants, the health benefits of bioactive compounds, the applications of plant-based products in the food and pharmaceutical industries. The first section discusses available sources of bioactive compounds from medicinal plants, biochemistry, structural composition, potential biological activities, and how bioactive molecules are isolated from medicinal plants. The authors examine the applications of bioactive molecules from a health perspective, looking at the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany/and medicinal properties, and also present a novel dietary approach for disease management. The book goes on to examine the plant-based products are used and can be used in various sectors of the food and pharmaceutical industries.

Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I

Rajesh Kumar Singh
Key Heterocyclic Cores for Smart Anticancer Drug Design Part I Book PDF

Author : Rajesh Kumar Singh
Publisher : Bentham Science Publishers
Page : 285 pages
File Size : 47,6 Mb
Release : 2022-07-05
Category : Medical
ISBN : 9789815040081

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Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I by Rajesh Kumar Singh Pdf

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)

Gene Expression and Control

Fumiaki Uchiumi
Gene Expression and Control Book PDF

Author : Fumiaki Uchiumi
Publisher : BoD – Books on Demand
Page : 202 pages
File Size : 45,5 Mb
Release : 2019-04-17
Category : Medical
ISBN : 9781789855173

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Gene Expression and Control by Fumiaki Uchiumi Pdf

Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."

Nutraceuticals and Cancer

Fazlul H. Sarkar
Nutraceuticals and Cancer Book PDF

Author : Fazlul H. Sarkar
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 42,6 Mb
Release : 2011-11-22
Category : Medical
ISBN : 9400726309

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Nutraceuticals and Cancer by Fazlul H. Sarkar Pdf

This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.

Natural Products for Cancer Prevention and Therapy

Anupam Bishayee,Mukerrem Betul Yerer-Aycan
Natural Products for Cancer Prevention and Therapy Book PDF

Author : Anupam Bishayee,Mukerrem Betul Yerer-Aycan
Publisher : MDPI
Page : 285 pages
File Size : 55,9 Mb
Release : 2018-11-07
Category : Electronic books
ISBN : 9783038973102

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Natural Products for Cancer Prevention and Therapy by Anupam Bishayee,Mukerrem Betul Yerer-Aycan Pdf

This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Sajal Chakraborti
Handbook of Oxidative Stress in Cancer Therapeutic Aspects Book PDF

Author : Sajal Chakraborti
Publisher : Springer Nature
Page : 4078 pages
File Size : 49,5 Mb
Release : 2022-09-28
Category : Medical
ISBN : 9789811654220

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by Sajal Chakraborti Pdf

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Life Over Cancer

Keith Block
Life Over Cancer Book PDF

Author : Keith Block
Publisher : Bantam
Page : 610 pages
File Size : 49,5 Mb
Release : 2009-04-21
Category : Health & Fitness
ISBN : 9780553801149

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Life Over Cancer by Keith Block Pdf

Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.

Chemoprevention of Cancer

Daniel W. Nixon
Chemoprevention of Cancer Book PDF

Author : Daniel W. Nixon
Publisher : CRC Press
Page : 160 pages
File Size : 40,8 Mb
Release : 1994-11-08
Category : Medical
ISBN : 0849368502

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Chemoprevention of Cancer by Daniel W. Nixon Pdf

Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs

Ruili Huang,Menghang Xia
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs Book PDF

Author : Ruili Huang,Menghang Xia
Publisher : Frontiers Media SA
Page : 104 pages
File Size : 54,6 Mb
Release : 2017-07-05
Category : Electronic book
ISBN : 9782889451975

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Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs by Ruili Huang,Menghang Xia Pdf

Tens of thousands of chemicals are released into the environment every day. High-throughput screening (HTS) has offered a more efficient and cost-effective alternative to traditional toxicity tests that can profile these chemicals for potential adverse effects with the aim to prioritize a manageable number for more in depth testing and to provide clues to mechanism of toxicity. The Tox21 program, a collaboration between the National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP), the U.S. Environmental Protection Agency’s (EPA) National Center for Computational Toxicology (NCCT), the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS), and the U.S. Food and Drug Administration (FDA), has generated quantitative high-throughput screening (qHTS) data on a library of 10K compounds, including environmental chemicals and drugs, against a panel of nuclear receptor and stress response pathway assays during its production phase (phase II). The Tox21 Challenge, a worldwide modeling competition, was launched that asks a “crowd” of researchers to use these data to elucidate the extent to which the interference of biochemical and cellular pathways by compounds can be inferred from chemical structure data. In the Challenge participants were asked to model twelve assays related to nuclear receptor and stress response pathways using the data generated against the Tox21 10K compound library as the training set. The computational models built within this Challenge are expected to improve the community’s ability to prioritize novel chemicals with respect to potential concern to human health. This research topic presents the resulting computational models with good predictive performance from this Challenge.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 490 pages
File Size : 43,8 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Plants that Fight Cancer, Second Edition

Spyridon E. Kintzios,Maria G. Barberaki
Plants that Fight Cancer Second Edition Book PDF

Author : Spyridon E. Kintzios,Maria G. Barberaki
Publisher : CRC Press
Page : 504 pages
File Size : 49,7 Mb
Release : 2019-06-26
Category : Science
ISBN : 9780429616174

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Plants that Fight Cancer, Second Edition by Spyridon E. Kintzios,Maria G. Barberaki Pdf

An increasing amount of cancer research is being directed towards the investigation of plant-derived anticancer compounds, many of which have been used in traditional herbal treatments for centuries. Plants that Fight Cancer is an up-to-date, extensive review of plant genera and species with documented anti-tumor and anti-leukaemic properties. Following an overview of the disease and the diverse methods of therapy and clinical testing, the book provides a detailed examination of the plants whose compounds are currently used in conventional cancer treatment, the species which show the greatest potential as future candidates, and other species with established anticancer properties. The third section explores each of more than 150 terrestrial plant genera and species, with a review of their traditional uses, mythology, botany, active ingredients, and product applications, along with photographs and illustrations and an analysis of expected results and risks. The text closes with a discussion of algal extracts and isolated metabolites with anticancer activity, a summary of published research for each species, and chemical structures of the most important compounds.