Mitochondrial Function In Lung Health And Disease

Author : Viswanathan Natarajan,Narasimham L. Parinandi
Publisher : Springer
Page : 222 pages
File Size : 53,6 Mb
Release : 2014-07-26
Category : Medical
ISBN : 9781493908295

Get Book

Mitochondrial Function in Lung Health and Disease by Viswanathan Natarajan,Narasimham L. Parinandi Pdf

Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

Author : Lawrence H. Lash,Dean P. Jones
Publisher : Elsevier
Page : 528 pages
File Size : 43,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483218618

Get Book

Mitochondrial Dysfunction by Lawrence H. Lash,Dean P. Jones Pdf

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Author : Carolyn D. Berdanier
Publisher : CRC Press
Page : 640 pages
File Size : 51,6 Mb
Release : 2005-06-09
Category : Medical
ISBN : 9781420028843

Get Book

Mitochondria in Health and Disease by Carolyn D. Berdanier Pdf

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Author : Sabzali Javadov,Andrey V Kozlov,Amadou K S Camara
Publisher : Unknown
Page : 434 pages
File Size : 44,6 Mb
Release : 2020-09-04
Category : Electronic
ISBN : 3039363840

Get Book

Mitochondria in Health and Diseases by Sabzali Javadov,Andrey V Kozlov,Amadou K S Camara Pdf

Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Author : Sten Orrenius,Lester Packer,Enrique Cadenas
Publisher : CRC Press
Page : 530 pages
File Size : 47,8 Mb
Release : 2012-06-20
Category : Medical
ISBN : 9781439880029

Get Book

Mitochondrial Signaling in Health and Disease by Sten Orrenius,Lester Packer,Enrique Cadenas Pdf

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Author : David D. Tyler
Publisher : Unknown
Page : 584 pages
File Size : 48,9 Mb
Release : 1992
Category : Mitochondria
ISBN : STANFORD:36105003067415

Get Book

The Mitochondrion in Health and Disease by David D. Tyler Pdf

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 55,7 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

Get Book

How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Andrea Urbani,Mohan Babu
Publisher : Springer Nature
Page : 277 pages
File Size : 54,5 Mb
Release : 2019-08-26
Category : Science
ISBN : 9789811383670

Get Book

Mitochondria in Health and in Sickness by Andrea Urbani,Mohan Babu Pdf

Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

Author : Richard A. Johnston,Benjamin T. Suratt
Publisher : Academic Press
Page : 0 pages
File Size : 40,6 Mb
Release : 2018-09-29
Category : Medical
ISBN : 0128135530

Get Book

Mechanisms and Manifestations of Obesity in Lung Disease by Richard A. Johnston,Benjamin T. Suratt Pdf

Mechanisms and Manifestations of Obesity in Lung Disease is a complete resource on the epidemiology and molecular mechanisms related to obesity and lung disease. Obesity has not simply changed the epidemiology of pulmonary disease, it has had a profound impact on the pathophysiology of common pulmonary diseases. As the obesity epidemic has taken hold throughout the developed world, scientists and clinicians are now challenged with identifying the mechanisms by which obesity alters lung health and the pathogenesis of lung diseases. This book is an important new resource for both clinicians and scientists dealing with these new health problems in pulmonary medicine.

Author : Venkataramana K Sidhaye,Michael Koval
Publisher : Academic Press
Page : 276 pages
File Size : 46,8 Mb
Release : 2017-03-09
Category : Medical
ISBN : 9780128038819

Get Book

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease by Venkataramana K Sidhaye,Michael Koval Pdf

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Author : Gilles Gouspillou,Russell T. Hepple
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 47,8 Mb
Release : 2017-02-09
Category : Electronic book
ISBN : 9782889450732

Get Book

Mitochondria in Skeletal Muscle Health, Aging and Diseases by Gilles Gouspillou,Russell T. Hepple Pdf

Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells.

Author : James A. Dykens,Yvonne Will
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 49,7 Mb
Release : 2008-09-11
Category : Science
ISBN : 9780470372524

Get Book

Drug-Induced Mitochondrial Dysfunction by James A. Dykens,Yvonne Will Pdf

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

Author : Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publisher : BoD – Books on Demand
Page : 498 pages
File Size : 50,9 Mb
Release : 2018-08-29
Category : Medical
ISBN : 9781789236743

Get Book

Mitochondrial Diseases by Eylem Taskin,Celal Guven,Yusuf Sevgiler Pdf

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Author : Roberta A. Gottlieb
Publisher : Academic Press
Page : 240 pages
File Size : 54,7 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780123851024

Get Book

Autophagy in Health and Disease by Roberta A. Gottlieb Pdf

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Author : Bernhard Kadenbach
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 40,7 Mb
Release : 2012-06-23
Category : Medical
ISBN : 9781461435730

Get Book

Mitochondrial Oxidative Phosphorylation by Bernhard Kadenbach Pdf

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.