Modeling And Control Of Infectious Diseases In The Host

Author : Esteban A. Hernandez-Vargas
Publisher : Academic Press
Page : 256 pages
File Size : 47,8 Mb
Release : 2019-02-15
Category : Technology & Engineering
ISBN : 9780128130520

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Modeling and Control of Infectious Diseases in the Host by Esteban A. Hernandez-Vargas Pdf

Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases Presents a theoretic approach to schedule drug treatments

Author : Christon J. Hurst
Publisher : Springer
Page : 286 pages
File Size : 48,7 Mb
Release : 2017-08-31
Category : Science
ISBN : 9783319606163

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Modeling the Transmission and Prevention of Infectious Disease by Christon J. Hurst Pdf

This volume focuses on blocking disease transmission and the ecological perspective of pathogens and pathogenic processes. The chapters on blocking transmission cover the environmental safety of space flight, biocides and biocide resistance, as well as infection control in healthcare facilities. The book also offers insights into the ecological aspects of infectious disease, introducing the reader to the role of indigenous gut microbiota in maintaining human health and current discussions on environmentally encountered bacterial and fungal pathogens including species that variously cause the necrotizing skin disease Buruli ulcer and coccidioidomycosis. Further, it explores the influenza A virus as an example for understanding zoonosis. It is a valuable resource for microbiologists and biomedical scientists alike.

Author : Matt J. Keeling,Pejman Rohani
Publisher : Princeton University Press
Page : 385 pages
File Size : 45,5 Mb
Release : 2011-09-19
Category : Science
ISBN : 9781400841035

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Modeling Infectious Diseases in Humans and Animals by Matt J. Keeling,Pejman Rohani Pdf

For epidemiologists, evolutionary biologists, and health-care professionals, real-time and predictive modeling of infectious disease is of growing importance. This book provides a timely and comprehensive introduction to the modeling of infectious diseases in humans and animals, focusing on recent developments as well as more traditional approaches. Matt Keeling and Pejman Rohani move from modeling with simple differential equations to more recent, complex models, where spatial structure, seasonal "forcing," or stochasticity influence the dynamics, and where computer simulation needs to be used to generate theory. In each of the eight chapters, they deal with a specific modeling approach or set of techniques designed to capture a particular biological factor. They illustrate the methodology used with examples from recent research literature on human and infectious disease modeling, showing how such techniques can be used in practice. Diseases considered include BSE, foot-and-mouth, HIV, measles, rubella, smallpox, and West Nile virus, among others. Particular attention is given throughout the book to the development of practical models, useful both as predictive tools and as a means to understand fundamental epidemiological processes. To emphasize this approach, the last chapter is dedicated to modeling and understanding the control of diseases through vaccination, quarantine, or culling. Comprehensive, practical introduction to infectious disease modeling Builds from simple to complex predictive models Models and methodology fully supported by examples drawn from research literature Practical models aid students' understanding of fundamental epidemiological processes For many of the models presented, the authors provide accompanying programs written in Java, C, Fortran, and MATLAB In-depth treatment of role of modeling in understanding disease control

Author : Esteban A. Hernandez-Vargas
Publisher : Academic Press
Page : 256 pages
File Size : 49,6 Mb
Release : 2019-02-14
Category : Technology & Engineering
ISBN : 9780128131114

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Modeling and Control of Infectious Diseases in the Host by Esteban A. Hernandez-Vargas Pdf

Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases Presents a theoretic approach to schedule drug treatments

Author : Institute of Medicine,Board on Global Health,Committee on Emerging Microbial Threats to Health in the 21st Century
Publisher : National Academies Press
Page : 397 pages
File Size : 40,5 Mb
Release : 2003-08-25
Category : Medical
ISBN : 9780309185547

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Microbial Threats to Health by Institute of Medicine,Board on Global Health,Committee on Emerging Microbial Threats to Health in the 21st Century Pdf

Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.

Author : Edwin Michael,Robert C. Spear
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 42,9 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441960641

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Modelling Parasite Transmission and Control by Edwin Michael,Robert C. Spear Pdf

It is clear that many fascinating problems still remain to be addressed in parasite transmission modelling, from better understanding of transmission processes and natural history of infection to investigating the impact of ecological and spatial scales, climate change, host immunity and social behaviour, parasite-host evolutionary dynamics and parasite community ecology on parasite transmission. This book captures some of the advances made in recent years and provides indications of ways forward for addressing these questions by shedding light on developments in conceptual frameworks and modelling tools as well as the emergence of new data forms for aiding model construction, testing and analysis. Another important advance has been the parallel development of robust computationally-intensive statistical methods to allow model testing and parameterization by aiding the fitting of models to complex data. This is an exciting area of work, which we believe will broaden the scope of mathematical modelling in investigating parasite transmission processes. In particular, we expect this advance will now allow modellers to begin the successful development and analysis of mechanistically-rich models of parasite transmission that will facilitate better integration of the variety of mechanisms increasingly recognized as important in simultaneously affecting transmission, including abiotic processes, trophic and evolutionary interactions, movement in space, and behaviour and even physiology of the individual. We foresee a continuing bright future for using mathematical modelling to clarify parasite transmission dynamics and address problems related to effective parasite control. Ultimately, through this improved application of models to research and management, we expect that parasite control would be an achievable goal bringing benefits to a vast number of our fellow human beings.

Author : Roy M. Anderson,Robert M. May
Publisher : Oxford University Press
Page : 772 pages
File Size : 41,5 Mb
Release : 1991
Category : Medical
ISBN : 019854040X

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Infectious Diseases of Humans by Roy M. Anderson,Robert M. May Pdf

This book deals with infectious diseases -- viral, bacterial, protozoan and helminth -- in terms of the dynamics of their interaction with host populations. The book combines mathematical models with extensive use of epidemiological and other data. This analytic framework is highly useful for the evaluation of public health strategies aimed at controlling or eradicating particular infections. Such a framework is increasingly important in light of the widespread concern for primary health care programs aimed at such diseases as measles, malaria, river blindness, sleeping sickness, and schistosomiasis, and the advent of AIDS/HIV and other emerging viruses. Throughout the book, the mathematics is used as a tool for thinking clearly about fundamental and applied problems having to do with infectious diseases. The book is divided into two parts, one dealing with microparasites (viruses, bacteria and protozoans) and the other with macroparasites (helminths and parasitic arthropods). Each part begins with simple models, developed in a biologically intuitive way, and then goes on to develop more complicated and realistic models as tools for public health planning. The book synthesizes previous work in this rapidly growing field (much of which is scattered between the ecological and the medical literature) with a good deal of new material.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 46,7 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1368423718

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Modeling Disease Spread and Control by Anonim Pdf

Mathematical models are useful tools to understand the epidemiology and agent-host interaction of diseases. They are developed and applied since over a century, but with increasing computer capacity, they become increasingly prominent as part of evidence based decision making. Mathematical models are frequently used to construct preparedness and contingency plans for highly contagious diseases such as foot-and-mouth disease. This allows proposing effective strategies to control the spread of the disease in case of an incursion, and avails useful tools to support decision making during an outbreak. They are also used to monitor, prevent and control endemic diseases within populations or farms. In addition, mathematical models improve our understanding of the contact structure between farms, pointing out risky elements in the contact network for disease introduction or further spread within the population. This Research Topic presents valuable studies presenting different aspects and implementations of mathematical modeling for disease spread and control in the veterinary field. The areas covered include model construction, network analysis, tools for decision makers, and cost-effective control of endemic diseases.

Author : Marta Wayne,Benjamin Bolker
Publisher : OUP Oxford
Page : 144 pages
File Size : 44,9 Mb
Release : 2015-06-25
Category : Medical
ISBN : 9780191002823

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Infectious Disease: A Very Short Introduction by Marta Wayne,Benjamin Bolker Pdf

As doctors and biologists have learned, to their dismay, infectious disease is a moving target: new diseases emerge every year, old diseases evolve into new forms, and ecological and socioeconomic upheavals change the transmission pathways by which disease spread. By taking an approach focused on the general evolutionary and ecological dynamics of disease, this Very Short Introduction provides a general conceptual framework for thinking about disease. Ecology and evolution provide the keys to answering the 'where', 'why', 'how', and 'what' questions about any particular infectious disease: where did it come from? How is it transmitted from one person to another, and why are some individuals more susceptible than others? What biochemical, ecological, and evolutionary strategies can be used to combat the disease? Is it more effective to block transmission at the population level, or to block infection at the individual level? Through a series of case studies, Benjamin Bolker and Marta L. Wayne introduce the major ideas of infectious disease in a clear and thoughtful way, emphasising the general principles of infection, the management of outbreaks, and the evolutionary and ecological approaches that are now central to much research about infectious disease. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Author : Piero Manfredi,Alberto D'Onofrio
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 44,7 Mb
Release : 2013-01-04
Category : Mathematics
ISBN : 9781461454748

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Modeling the Interplay Between Human Behavior and the Spread of Infectious Diseases by Piero Manfredi,Alberto D'Onofrio Pdf

This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.

Author : Madeline Drexler
Publisher : Unknown
Page : 128 pages
File Size : 45,5 Mb
Release : 2024-06-26
Category : Electronic
ISBN : OCLC:1125923228

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What You Need to Know about Infectious Disease by Madeline Drexler Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Ottar N. Bjørnstad
Publisher : Springer
Page : 312 pages
File Size : 49,5 Mb
Release : 2018-10-30
Category : Medical
ISBN : 9783319974873

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Epidemics by Ottar N. Bjørnstad Pdf

This book is designed to be a practical study in infectious disease dynamics. The book offers an easy to follow implementation and analysis of mathematical epidemiology. The book focuses on recent case studies in order to explore various conceptual, mathematical, and statistical issues. The dynamics of infectious diseases shows a wide diversity of pattern. Some have locally persistent chains-of-transmission, others persist spatially in ‘consumer-resource metapopulations’. Some infections are prevalent among the young, some among the old and some are age-invariant. Temporally, some diseases have little variation in prevalence, some have predictable seasonal shifts and others exhibit violent epidemics that may be regular or irregular in their timing. Models and ‘models-with-data’ have proved invaluable for understanding and predicting this diversity, and thence help improve intervention and control. Using mathematical models to understand infectious disease dynamics has a very rich history in epidemiology. The field has seen broad expansions of theories as well as a surge in real-life application of mathematics to dynamics and control of infectious disease. The chapters of Epidemics: Models and Data using R have been organized in a reasonably logical way: Chapters 1-10 is a mix and match of models, data and statistics pertaining to local disease dynamics; Chapters 11-13 pertains to spatial and spatiotemporal dynamics; Chapter 14 highlights similarities between the dynamics of infectious disease and parasitoid-host dynamics; Finally, Chapters 15 and 16 overview additional statistical methodology useful in studies of infectious disease dynamics. This book can be used as a guide for working with data, models and ‘models-and-data’ to understand epidemics and infectious disease dynamics in space and time.

Author : Dean T. Jamison,Hellen Gelband,Susan Horton,Prabhat Jha,Charles N. Mock,Rachel Nugent
Publisher : World Bank Publications
Page : 426 pages
File Size : 41,8 Mb
Release : 2017-12-06
Category : Medical
ISBN : 9781464805288

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Disease Control Priorities, Third Edition (Volume 9) by Dean T. Jamison,Hellen Gelband,Susan Horton,Prabhat Jha,Charles N. Mock,Rachel Nugent Pdf

As the culminating volume in the DCP3 series, volume 9 will provide an overview of DCP3 findings and methods, a summary of messages and substantive lessons to be taken from DCP3, and a further discussion of cross-cutting and synthesizing topics across the first eight volumes. The introductory chapters (1-3) in this volume take as their starting point the elements of the Essential Packages presented in the overview chapters of each volume. First, the chapter on intersectoral policy priorities for health includes fiscal and intersectoral policies and assembles a subset of the population policies and applies strict criteria for a low-income setting in order to propose a "highest-priority" essential package. Second, the chapter on packages of care and delivery platforms for universal health coverage (UHC) includes health sector interventions, primarily clinical and public health services, and uses the same approach to propose a highest priority package of interventions and policies that meet similar criteria, provides cost estimates, and describes a pathway to UHC.

Author : Ottar N. Bjørnstad
Publisher : Unknown
Page : 312 pages
File Size : 45,6 Mb
Release : 2018
Category : Emerging infectious diseases
ISBN : 3319974882

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Epidemics by Ottar N. Bjørnstad Pdf

This book is designed to be a practical study in infectious disease dynamics. The book offers an easy to follow implementation and analysis of mathematical epidemiology. The book focuses on recent case studies in order to explore various conceptual, mathematical, and statistical issues. The dynamics of infectious diseases shows a wide diversity of pattern. Some have locally persistent chains-of-transmission, others persist spatially in 'consumer-resource metapopulations'. Some infections are prevalent among the young, some among the old and some are age-invariant. Temporally, some diseases have little variation in prevalence, some have predictable seasonal shifts and others exhibit violent epidemics that may be regular or irregular in their timing. Models and 'models-with-data' have proved invaluable for understanding and predicting this diversity, and thence help improve intervention and control. Using mathematical models to understand infectious disease dynamics has a very rich history in epidemiology. The field has seen broad expansions of theories as well as a surge in real-life application of mathematics to dynamics and control of infectious disease. The chapters of Epidemics: Models and Data using R have been organized in a reasonably logical way: Chapters 1-10 is a mix and match of models, data and statistics pertaining to local disease dynamics; Chapters 11-13 pertains to spatial and spatiotemporal dynamics; Chapter 14 highlights similarities between the dynamics of infectious disease and parasitoid-host dynamics; Finally, Chapters 15 and 16 overview additional statistical methodology useful in studies of infectious disease dynamics. This book can be used as a guide for working with data, models and 'models-and-data' to understand epidemics and infectious disease dynamics in space and time.